Louis Jeffrey Picker, M.D.
- Professor, VGTI-Vaccine and Gene Therapy Institute
- Molecular Microbiology and Immunology Graduate Program, School of Medicine
- Program in Molecular and Cellular Biosciences, School of Medicine
Biography
Louis Picker graduated from UCLA with a B.S. in bacteriology in 1978 and took his M.D. degree at the University of California at San Francisco in 1982. After residency training in pathology at Beth Israel Hospital, Boston, and postdoctoral training in immunology at Stanford University Medical Center, he was appointed assistant professor and then associate professor of pathology at the University of Texas Southwestern Medical Center at Dallas. In 1999 he came to OHSU and ONPRC as professor of pathology/molecular microbiology and immunology in the OHSU School of Medicine and head of the Division of Pathobiology and Immunology.
Education and training
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Degrees
- B.S., 1978, UCLA
- M.D., 1982, UCSF
Areas of interest
- Human and primate T cell biology
- Immunologic Memory
- Vaccine Development
Publications
Selected publications
- Burwitz BJ, Malouli D, Bimber BN, Reed JS, Ventura AB,Hancock MH, Uebelhoer LS, Bhusari A, Hammond KB, Espinosa Trethewy RG, Klug A, Legasse AW, Axthelm MK, Nelson JA, Park BS, Streblow DN, Hansen SG, Picker LJ,Früh K, Sacha JB. Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques. PLoS Pathog. 2016 Nov 9;12(11):e1006014. doi:10.1371/journal.ppat.1006014.[PMID: 27829026]
- Ranasinghe S, Lamothe PA, Soghoian DZ, Kazer SW, Cole MB,Shalek AK, Yosef N, Jones RB, Donaghey F, Nwonu C, Jani P, Clayton GM, CrawfordF, White J, Montoya A, Power K, Allen TM, Streeck H, Kaufmann DE, Picker LJ,Kappler JW, Walker BD; Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit ClonalExpansion. Immunity.2016 Oct 18;45(4):917-930. doi:10.1016/j.immuni.2016.09.015. [PMID: 27760342]
- Greene JM, Dash P, Roy S, McMurtrey C, Awad W, Reed JS,Hammond KB, Abdulhaqq S, Wu HL, Burwitz BJ, Roth BF, Morrow DW, Ford JC, Xu G,Bae JY, Crank H, Legasse AW, Dang TH, Greenaway HY, Kurniawan M, Gold MC, Harriff MJ, Lewinsohn DA, Park BS, Axthelm MK, Stanton JJ, Hansen SG, PickerLJ, Venturi V, Hildebrand W, Thomas PG, Lewinsohn DM, Adams EJ, Sacha JB; MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates. Mucosal
- Theiler J, Yoon H, Yusim K, Picker LJ, Fruh K, Korber B. Epigraph:A Vaccine Design Tool Applied to an HIV Therapeutic Vaccine and a Pan-Filo virus Vaccine. Sci Rep. 2016 Oct 5;6:33987. doi: 10.1038/srep33987.[PMID: 27703185]
- Sturgill ER, Malouli D, Hansen SG, Burwitz BJ, Seo S,Schneider CL, Womack JL, Verweij MC, Ventura AB, Bhusari A, Jeffries KM,Legasse AW, Axthelm MK, Hudson AW, Sacha JB, Picker LJ, Früh K. Natural KillerCell Evasion Is Essential for Infection by Rhesus Cytomegalovirus. PLoS Pathog.2016 Aug 31;12(8):e1005868. doi: 10.1371/journal.ppat.1005868.[PMID: 27580123]
Publications
Anti–PD-1 chimeric antigen receptor T cells efficiently target SIV-infected CD4+ T cells in germinal centers
Journal of Clinical InvestigationCD8+ T cell targeting of tumor antigens presented by HLA-E
Science AdvancesCytomegalovirus vaccine vector-induced effector memory CD4 + T cells protect cynomolgus macaques from lethal aerosolized heterologous avian influenza challenge
Nature communicationsEarly antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir
PLoS pathogensFunctional genomic analysis of the 68-1 RhCMV-Mycobacteria tuberculosis vaccine reveals an IL-15 response signature that is conserved with vector attenuation
Frontiers in immunologyHuman cytomegalovirus UL18 prevents priming of MHC-E– and MHC-II–restricted CD8+ T cells
Science ImmunologyImpact of alemtuzumab-mediated lymphocyte depletion on SIV reservoir establishment and persistence
PLoS pathogensPre-challenge gut microbial signature predicts RhCMV/SIV vaccine efficacy in rhesus macaques
Microbiology SpectrumViral escape mutations do not account for non-protection from SIVmac239 challenge in RhCMV/SIV vaccinated rhesus macaques
Frontiers in immunologyLate gene expression-deficient cytomegalovirus vectors elicit conventional T cells that do not protect against SIV
JCI InsightMarked skewing of entire T-cell memory compartment occurs only in a minority of CMV-infected individuals and is unrelated to the degree of memory subset skewing among CMV-specific T-cells
Frontiers in immunologyAlternative splicing and genetic variation of mhc-e
Communications BiologyBFF and cellhashR
BioinformaticsCytomegalovirus-vaccine-induced unconventional T cell priming and control of SIV replication is conserved between primate species
Cell Host and MicrobeMyeloid cell tropism enables MHC-E-restricted CD8+ T cell priming and vaccine efficacy by the RhCMV/SIV vaccine
Science ImmunologyRapamycin limits CD4+ T cell proliferation in simian immunodeficiency virus-infected rhesus macaques on antiretroviral therapy
Journal of Clinical InvestigationThe ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription
PLoS pathogensCD8+T cells fail to limit SIV reactivation following ART withdrawal until after viral amplification
Journal of Clinical InvestigationCytomegaloviral determinants of CD8+T cell programming and RhCMV/SIV vaccine efficacy
Science ImmunologyEvaluating a new class of AKT/mTOR activators for HIV latency-reversing activity ex vivo and in vivo
Journal of virologyHLA-E-restricted, Gag-specific CD8+T cells can suppress HIV-1 infection, offering vaccine opportunities
Science ImmunologyIdentification and Characterization of Antigen-Specific CD8+ T Cells Using Surface-Trapped TNF-a and Single-Cell Sequencing
Journal of ImmunologyImmune inactivation of anti-simian immunodeficiency virus chimeric antigen receptor T cells in rhesus macaques
Molecular Therapy Methods and Clinical DevelopmentInterleukin-15 response signature predicts RhCMV/SIV vaccine efficacy
PLoS pathogensModulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy
ScienceTGFβ restricts expansion, survival, and function of T cells within the tuberculous granuloma
Cell Host and MicrobeUltra-low Dose Aerosol Infection of Mice with Mycobacterium tuberculosis More Closely Models Human Tuberculosis
Cell Host and MicrobeIn vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome
PLoS pathogensIn vivo validation of the viral barcoding of simian immunodeficiency virus SIVmac239 and the development of new barcoded SIV and subtype B and C simian-human immunodeficiency viruses
Journal of virology