Large-scale chromosomal rearrangements are a major source of genetic variation
bring about speciation
and are hallmarks of human disease. However
the mechanisms underlying their occurrence and subsequent fixation are not entirely understood. Using a comparative genomics approach
I investigate how specific genomic and epigenetic features lead to chromosomal rearrangements and the outcome of these events on species evolution and pathology. To this end
I have been using the gibbon genome as a model as these small apes have accumulated an unusually high number of evolutionary chromosomal rearrangements.