Manideep Chavali, Ph.D.

  • Assistant Professor of Pediatrics, School of Medicine
  • First Tech Federal Credit Union Distinguished Scholar in Pediatrics Innovation

Biography

Dr. Manideep Chavali is an Assistant Professor in the Department of Pediatrics and the Papé Family Pediatric Research Institute. His lab is interested in understanding cellular and molecular mechanisms of myelination and how they are disrupted in neurological injuries and neurodegeneration. Manideep was previously a postdoctoral fellow with Dr. David Rowitch at the University of California, San Francisco in the Department of Regeneration Medicine, and the Newborn Brain Research Institute from 2016-2022. His research at UCSF focused on understanding how oligodendrocyte progenitor cells orchestrate white matter angiogenesis during CNS development and how this process is altered in neonatal brain injuries associated with preterm birth and congenital heart disease. He received his Ph.D. from Stony Brook University in 2016 and obtained his Bachelor’s degree from National Institute of Technology, Warangal, India in 2009.

Education and training

  • Degrees

    • B.S., 2009, National Institute of Technology
    • M.S., 2012, Stony Brook University
    • Ph.D., 2016, Stony Brook University

Areas of interest

  • Glial-Vascular and Neuron-Glial Interactions During CNS Development
  • Injury and Disease

Honors and awards

  • NIH/NINDS K99/R00 Pathway to Independence Award, 2020
  • Early Career Development Award, Cerebral Palsy Alliance Research Foundation, 2018
  • Congenital Heart Defect Research Award, The Children’s Heart Foundation, 2018
  • American Heart Association Postdoctoral Fellowship, 2017

Publications

Selected publications

  • M Chavali, MJ Uolla-Navas, P Pérez-Borredá, JMG Verdugo, PS McQuillen, EJ Huang and DH Rowitch (2020). Wnt-Dependent Oligodendroglial-Endothelial Interactions Regulate White Matter Vascularization and Attenuate Injury. Neuron 108, 1-16.
  • M Chavali, M Klingener, AG Kokkosis, Y Garkun, S Felong, A Maffei, A Aguirre (2018) Non-Canonical Wnt Signaling Regulates Neural Stem Cell Quiescence During Homeostasis and After Demyelination.  Nature Communications 9 p 36.
  • D Velmeshev, M Chavali, T Nowakowski, M Bhade, S Mayer, N Goyal, B Alvarado, WRM Leon, S Wang, M Speir, M Haeussler, DH Rowitch, A Alvarez-Buylla, E Huang, M Paredes and A Kriegstein. Molecular Diversity and Lineage Commitment of Human Interneuron Progenitors. Submitted; BioRxiv 2021.05.13.444045.
  • V Nguyen, M Chavali, A Larpthaveesarp, S Kodali, G Gonzalez, R Franklin, DH Rowitch and F Gonzalez (2021). Sonic Hedgehog Pathway Agonist SAG is Neuroprotective in Neonatal Stroke. Pediatric Research s41390-021-01408-7
  • H Nobuta, N Yang, Yi-Han Ng, S Marro, M Chavali, J Stockley, D Killilea, P Walter, C Zhao, P Huie, S Goldman, A Kriegstein, R Franklin, DH Rowitch, M Wernig (2019). Oligodendrocyte Death in Pelizaeus-Merzbacher Disease is Rescued by Iron Chelation. Cell Stem Cell Vol. 25, 4, p531–541.
  • JK Ellis, SF Sorrells, S Mikhailova, M Chavali, S Chang, K Sabeur, P McQuillen, DH Rowitch (2019) Ferret Brain Possesses Young Interneuron Collections Equivalent to Human Postnatal Migratory Streams.  Journal of Comparative Neurology 10.1002/cne.24711.
  • F Birey, M Kloc, M Chavali, I Hussein, M Wilson, DJ Christoffel, T Chen, MA Frohman, JK Robinson, SJ Russo, A Maffei and A Aguirre (2015) Genetic and Stress-Induced Loss of NG2 Glia Triggers Emergence of Depressive-like Behaviors through Reduced Secretion of FGF2. Neuron 88, 941–956.

Publications

  • Neuroinflammatory reactive astrocyte formation correlates with adverse outcomes in perinatal white matter injury

    GLIA
    1. Patricia Renz
    2. Marel Steinfort
    3. Valérie Haesler
    4. Vera Tscherrig
    5. Eric J. Huang
    6. Manideep Chavali
    7. Shane Liddelow
    8. David H. Rowitch
    9. Daniel Surbek
    10. Andreina Schoeberlein
    11. Amanda Brosius Lutz
  • Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination

    Journal of Clinical Investigation
    1. Hannah Kapell
    2. Luca Fazio
    3. Julia Dyckow
    4. Sophia Schwarz
    5. Andrés Cruz-Herranz
    6. Christina Mayer
    7. Joaquin Campos
    8. Elisa D’Este
    9. Wiebke Möbius
    10. Christian Cordano
    11. Anne Katrin Pröbstel
    12. Marjan Gharagozloo
    13. Amel Zulji
    14. Venu Narayanan Naik
    15. Anna Delank
    16. Manuela Cerina
    17. Thomas Müntefering
    18. Celia Lerma-Martin
    19. Jana K. Sonner
    20. Jung Hyung Sin
    21. Paul Disse
    22. Nicole Rychlik
    23. Khalida Sabeur
    24. Manideep Chavali
    25. Rajneesh Srivastava
    26. Matthias Heidenreich
    27. Kathryn C. Fitzgerald
    28. Guiscard Seebohm
    29. Christine Stadelmann
    30. Bernhard Hemmer
    31. Michael Platten
    32. Thomas J. Jentsch
    33. Maren Engelhardt
    34. Thomas Budde
    35. Klaus Armin Nave
    36. Peter A. Calabresi
    37. Manuel A. Friese
    38. Ari J. Green
    39. Claudio Acuna
    40. David H. Rowitch
    41. Sven G. Meuth
    42. Lucas Schirmer
  • Neuroprotective effects of Sonic hedgehog agonist SAG in a rat model of neonatal stroke

    Pediatric Research
    1. Vien Nguyen
    2. Manideep Chavali
    3. Amara Larpthaveesarp
    4. Srikirti Kodali
    5. Ginez Gonzalez
    6. Robin J.M. Franklin
    7. David H. Rowitch
    8. Fernando Gonzalez
  • Wnt-Dependent Oligodendroglial-Endothelial Interactions Regulate White Matter Vascularization and Attenuate Injury

    Neuron
    1. Manideep Chavali
    2. Maria José Ulloa-Navas
    3. Pedro Pérez-Borredá
    4. Jose Manuel Garcia-Verdugo
    5. Patrick S. McQuillen
    6. Eric J. Huang
    7. David H. Rowitch
  • Ferret brain possesses young interneuron collections equivalent to human postnatal migratory streams

    Journal of Comparative Neurology
    1. Justin K. Ellis
    2. Shawn F. Sorrells
    3. Sasha Mikhailova
    4. Manideep Chavali
    5. Sandra Chang
    6. Khalida Sabeur
    7. Patrick Mcquillen
    8. David H. Rowitch
  • Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation

    Cell Stem Cell
    1. Hiroko Nobuta
    2. Nan Yang
    3. Yi Han Ng
    4. Samuele G. Marro
    5. Khalida Sabeur
    6. Manideep Chavali
    7. John H. Stockley
    8. David W. Killilea
    9. Patrick B. Walter
    10. Chao Zhao
    11. Philip Huie
    12. Steven A. Goldman
    13. Arnold R. Kriegstein
    14. Robin J.M. Franklin
    15. David H. Rowitch
    16. Marius Wernig
  • Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination

    Nature communications
    1. Manideep Chavali
    2. Michael Klingener
    3. Alexandros G. Kokkosis
    4. Yury Garkun
    5. Sylwia Felong
    6. Arianna Maffei
    7. Adan Aguirre
  • Genetic and Stress-Induced Loss of NG2 Glia Triggers Emergence of Depressive-like Behaviors through Reduced Secretion of FGF2

    Neuron
    1. Fikri Birey
    2. Michelle Kloc
    3. Manideep Chavali
    4. Israa Hussein
    5. Michael Wilson
    6. Daniel J. Christoffel
    7. Tony Chen
    8. Michael A. Frohman
    9. John K. Robinson
    10. Scott J. Russo
    11. Arianna Maffei
    12. Adan Aguirre
  • N-Cadherin promotes recruitment and migration of neural progenitor cells from the SVZ neural stem cell niche into demyelinated lesions

    Journal of Neuroscience
    1. Michael Klingener
    2. Manideep Chavali
    3. Jagdeep Singh
    4. Nadia McMillan
    5. Alexandra Coomes
    6. Peter J. Dempsey
    7. Emily I. Chen
    8. Adan Aguirre