Marina Guizzetti, Ph.D.

  • Professor of Behavioral Neuroscience, School of Medicine
  • Director, Behavioral Neuroscience Graduate Program, School of Medicine
  • Behavioral Neuroscience Graduate Program, School of Medicine
  • Neuroscience Graduate Program, School of Medicine

Biography

Research Interests

The focus of the Guizzetti lab has been the investigation of physiological and pathological mechanisms involving astrocytes and astrocyte-neuron interactions in the developing and adult brain. We are studying mechanisms of neuronal structural plasticity modulated by extracellular matrix proteins and extracellular matrix protease systems produced by astrocytes. The emphasis of our studies is on mechanisms affected by developmental ethanol exposure as in Fetal Alcohol Spectrum Disorders, and by alcohol drinking in adults as in Alcohol Use Disorders. Our areas of expertise include glial cell biology, molecular biology, and epigenetics. Since factors released by astrocytes affecting neuronal functions include glycoproteins and lipids (lipoproteins), our research interests extend into glycobiology and lipid research. We use both in vivo and in vitro models to address our questions. Our more recent research focuses on the study of the in vivo astrocyte translatome, astrocyte nuclear transcriptome, and astrocyte epigenome in alcohol-dependence and fetal alcohol.

Phone
503-220-8262 x58618

Education and training

  • Degrees

    • M.S., 1987, University of Pavia
    • Ph.D., 1993, University of Milan

Areas of interest

  • Glia
  • Astrocytes
  • Fetal alcohol spectrum disorders
  • Neuronal development
  • Extracellular matrix
  • Neurite outgrowth
  • Chondroitin sulfate proteoglycans

Publications

Publications

  • Effects of alcohol and PARP inhibition on RNA ribosomal engagement in cortical excitatory neurons

    Frontiers in Molecular Neuroscience
    1. Harish R. Krishnan
    2. Gian Paolo Vallerini
    3. Hannah E. Gavin
    4. Marina Guizzetti
    5. Hooriyah S. Rizavi
    6. David P. Gavin
    7. Rajiv P. Sharma
  • Ethanol-induced transcriptional and translational changes in Aldh1l1-Egfp/Rpl10a cortical astrocyte cultures

    Frontiers in Neuroscience
    1. Joel G. Hashimoto
    2. Xiaolu Zhang
    3. Marina Guizzetti
  • Sex differences in hippocampal structural plasticity and glycosaminoglycan disaccharide levels after neonatal handling

    Experimental Neurology
    1. Joel G. Hashimoto
    2. Mo L. Singer
    3. Calla M. Goeke
    4. Fuming Zhang
    5. Yuefan Song
    6. Ke Xia
    7. Robert J. Linhardt
    8. Marina Guizzetti
  • Synaptogenesis by Cholinergic Stimulation of Astrocytes

    Neurochemical Research
    1. Pamela J. Roqué
    2. Andrés Barria
    3. Xiaolu Zhang
    4. Joel G. Hashimoto
    5. Lucio G. Costa
    6. Marina Guizzetti
  • Astrocyte tissue plasminogen activator expression during brain development and its role in pyramidal neuron neurite outgrowth

    Neuroscience Letters
    1. Calla M. Goeke
    2. Xiaolu Zhang
    3. Joel G. Hashimoto
    4. Marina Guizzetti
  • Characterization of Glycosaminoglycan Disaccharide Composition in Astrocyte Primary Cultures and the Cortex of Neonatal Rats

    Neurochemical Research
    1. Xiaolu Zhang
    2. Joel G. Hashimoto
    3. Xiaorui Han
    4. Fuming Zhang
    5. Robert J. Linhardt
    6. Marina Guizzetti
  • Early life sleep disruption alters glutamate and dendritic spines in prefrontal cortex and impairs cognitive flexibility in prairie voles

    Current Research in Neurobiology
    1. Carolyn E. Jones
    2. Alex Q. Chau
    3. Randall J. Olson
    4. Cynthia Moore
    5. Peyton T. Wickham
    6. Niyati Puranik
    7. Marina Guizzetti
    8. Hung Cao
    9. Charles K. Meshul
    10. Miranda M. Lim
  • Effects of ethanol-and choline-treated astrocytes on hippocampal neuron neurite outgrowth in vitro

    Science Progress
    1. Calla M. Goeke
    2. Joel G. Hashimoto
    3. Marina Guizzetti
    4. Annabella Vitalone
  • Extracellular ATP-Induced Alterations in Extracellular H+ Fluxes From Cultured Cortical and Hippocampal Astrocytes

    Frontiers in Cellular Neuroscience
    1. Ji in Vivien Choi
    2. Boriana K. Tchernookova
    3. Wasan Kumar
    4. Lech Kiedrowski
    5. Calla Goeke
    6. Marina Guizzetti
    7. John Larson
    8. Matthew A. Kreitzer
    9. Robert Paul Malchow
  • Chronic chemogenetic stimulation of the nucleus accumbens produces lasting reductions in binge drinking and ameliorates alcohol-related morphological and transcriptional changes

    Brain Sciences
    1. Dar’Ya Y. Pozhidayeva
    2. Sean P. Farris
    3. Calla M. Goeke
    4. Evan J. Firsick
    5. Kayla G. Townsley
    6. Marina Guizzetti
    7. Angela R. Ozburn
  • Modulation of Poly ADP Ribose Polymerase (PARP) Levels and Activity by Alcohol Binge-Like Drinking in Male Mice

    Neuroscience
    1. Gian Paolo Vallerini
    2. You Hong Cheng
    3. Kayla A. Chase
    4. Rajiv P. Sharma
    5. Handojo Kusumo
    6. Shivani Khakhkhar
    7. Douglas L. Feinstein
    8. Marina Guizzetti
    9. David P. Gavin
  • Binge ethanol drinking produces sexually divergent and distinct changes in nucleus accumbens signaling cascades and pathways in adult C57BL/6J mice

    Frontiers in Genetics
    1. Deborah A. Finn
    2. Joel G. Hashimoto
    3. Debra K. Cozzoli
    4. Melinda L. Helms
    5. Michelle A. Nipper
    6. Moriah N. Kaufman
    7. Kristine M. Wiren
    8. Marina Guizzetti
  • Neonatal Ethanol and Choline Treatments Alter the Morphology of Developing Rat Hippocampal Pyramidal Neurons in Opposite Directions

    Neuroscience
    1. C. M. Goeke
    2. M. L. Roberts
    3. J. G. Hashimoto
    4. D. A. Finn
    5. M. Guizzetti
  • Plasminogen activator system homeostasis and its dysregulation by ethanol in astrocyte cultures and the developing brain

    Neuropharmacology
    1. Clare J. Wilhelm
    2. Joel G. Hashimoto
    3. Melissa L. Roberts
    4. Xiaolu Zhang
    5. Calla M. Goeke
    6. Shelley H. Bloom
    7. Marina Guizzetti
  • Stable histone methylation changes at proteoglycan network genes following ethanol exposure

    Frontiers in Genetics
    1. David P. Gavin
    2. Joel G. Hashimoto
    3. Nathan H. Lazar
    4. Lucia Carbone
    5. John C. Crabbe
    6. Marina Guizzetti
  • Prefrontal cortex expression of chromatin modifier genes in male WSP and WSR mice changes across ethanol dependence, withdrawal, and abstinence

    Alcohol
    1. Joel G. Hashimoto
    2. David P. Gavin
    3. Kristine M. Wiren
    4. John C. Crabbe
    5. Marina Guizzetti
  • Ethanol-induced changes in poly (ADP ribose) polymerase and neuronal developmental gene expression

    Neuropharmacology
    1. David P. Gavin
    2. Handojo Kusumo
    3. Rajiv P. Sharma
    4. Marina Guizzetti
  • Decline in arylsulfatase B and Increase in chondroitin 4-sulfotransferase combine to increase chondroitin 4-sulfate in traumatic brain injury

    Journal of neurochemistry
    1. Sumit Bhattacharyya
    2. Xiaolu Zhang
    3. Leo Feferman
    4. David Johnson
    5. Frank C. Tortella
    6. Marina Guizzetti
    7. Joanne K. Tobacman
  • Gadd45b and N-methyl-d-aspartate induced DNA demethylation in postmitotic neurons

    Epigenomics
    1. David P. Gavin
    2. Handojo Kusumo
    3. Rajiv P. Sharma
    4. Marina Guizzetti
    5. Alessandro Guidotti
    6. Subhash C. Pandey
  • Arylsulfatase B modulates neurite outgrowth via astrocyte chondroitin-4-sulfate

    GLIA
    1. Xiaolu Zhang
    2. Sumit Bhattacharyya
    3. Handojo Kusumo
    4. Charles R. Goodlett
    5. Joanne K. Tobacman
    6. Marina Guizzetti