Markus Grompe, M.D.

  • Professor of Pediatrics, School of Medicine
  • Molecular and Medical Genetics Graduate Program, School of Medicine
  • Cancer Biology Graduate Program, School of Medicine
  • Program in Molecular and Cellular Biosciences, School of Medicine

Biography

Dr. Markus Grompe is the Ray Hickey Professor and Director of the Papé Family Pediatric Research Institute at Oregon Health & Science University in Portland, Oregon, USA. His research has focused on the use of in vivo selection to enhance gene and cell transplantation therapy for inherited diseases. Hepatic stem cells and their use in therapeutic liver repopulation are a main focus. To study the properties of human cells in a physiologic setting the laboratory has developed murine models supporting the expansion of human stem cells in transgenic mice.  These humanized mice are an ideal platform for the development for novel therapeutics, including small molecules, gene therapy vectors and cells. He has published over 200 peer-reviewed articles and holds numerous patents.

Education and training

  • Degrees

    • M.D., 1983, University of Ulm Medical School

  • Residency

    • Pediatrics, Oregon Health & Science University, Portland, 1987

  • Fellowship

    • Genetics, Baylor College of Medicine, Houston, TX, 1991

  • Certifications

    • Clinical Genetics

Memberships and associations:

  • Diplomat of the American Board of Human Genetics

Publications

Elsevier pure profile

Publications

  • AAV capsid prioritization in normal and steatotic human livers maintained by machine perfusion

    Nature biotechnology
    1. Jae Jun Kim
    2. Simone N.T. Kurial
    3. Pervinder K. Choksi
    4. Miguel Nunez
    5. Tyler Lunow-Luke
    6. Jan Bartel
    7. Julia Driscoll
    8. Chris L. Her
    9. Simaron Dhillon
    10. William Yue
    11. Abhishek Murti
    12. Tin Mao
    13. Julian N. Ramos
    14. Amita Tiyaboonchai
    15. Markus Grompe
    16. Aras N. Mattis
    17. Shareef M. Syed
    18. Bruce M. Wang
    19. Jacquelyn J. Maher
    20. Garrett R. Roll
    21. Holger Willenbring

  • Complete correction of murine phenylketonuria by selection-enhanced hepatocyte transplantation

    Hepatology
    1. Anne Vonada
    2. Leslie Wakefield
    3. Michael Martinez
    4. Cary O. Harding
    5. Markus Grompe
    6. Amita Tiyaboonchai

  • Long-term combination therapy with metformin and oxymetholone in a Fanconi anemia mouse model

    Pediatric Blood and Cancer
    1. Craig Dorrell
    2. Alexander M. Peters
    3. Qing-Shuo Zhang
    4. Niveditha Balaji
    5. Kevin Baradar
    6. Makiko Mochizuki-Kashio
    7. Angela Major
    8. Milton Finegold
    9. Chih Wei Liu
    10. Kun Lu
    11. Markus Grompe

  • A DNA methylation atlas of normal human cell types

    Nature
    1. Netanel Loyfer
    2. Judith Magenheim
    3. Ayelet Peretz
    4. Gordon Cann
    5. Joerg Bredno
    6. Agnes Klochendler
    7. Ilana Fox-Fisher
    8. Sapir Shabi-Porat
    9. Merav Hecht
    10. Tsuria Pelet
    11. Joshua Moss
    12. Zeina Drawshy
    13. Hamed Amini
    14. Patriss Moradi
    15. Sudharani Nagaraju
    16. Dvora Bauman
    17. David Shveiky
    18. Shay Porat
    19. Uri Dior
    20. Gurion Rivkin
    21. Omer Or
    22. Nir Hirshoren
    23. Einat Carmon
    24. Alon Pikarsky
    25. Abed Khalaileh
    26. Gideon Zamir
    27. Ronit Grinbaum
    28. Machmud Abu Gazala
    29. Ido Mizrahi
    30. Noam Shussman
    31. Amit Korach
    32. Ori Wald
    33. Uzi Izhar
    34. Eldad Erez
    35. Vladimir Yutkin
    36. Yaacov Samet
    37. Devorah Rotnemer Golinkin
    38. Kirsty L. Spalding
    39. Henrik Druid
    40. Peter Arner
    41. A. M.James Shapiro
    42. Markus Grompe
    43. Alex Aravanis
    44. Oliver Venn
    45. Arash Jamshidi
    46. Ruth Shemer
    47. Yuval Dor
    48. Benjamin Glaser
    49. Tommy Kaplan

  • Fanconi anemia-isogenic head and neck cancer cell line pairs

    International Journal of Cancer
    1. Hiep Tai Nguyen
    2. Weiliang Tang
    3. Andrew L.H. Webster
    4. Jeffrey R. Whiteaker
    5. Christopher M. Chandler
    6. Ricardo Errazquin
    7. Khashayar Roohollahi
    8. Madeline Fritzke
    9. Elizabeth E. Hoskins
    10. Erica Jonlin
    11. Leslie Wakefield
    12. Lucas B. Sullivan
    13. Eleanor Y. Chen
    14. Josephine Dorsman
    15. Ruud Brakenhoff
    16. Amanda G. Paulovich
    17. Markus Grompe
    18. Ramon Garcia-Escudero
    19. Susanne I. Wells
    20. Agata Smogorzewska
    21. Raymond J. Monnat

  • In vivo tracing of the Cytokeratin 14 lineages using self-cleaving guide RNAs and CRISPR/Cas9

    Developmental Biology
    1. Amita Tiyaboonchai
    2. Leslie Wakefield
    3. Anne Vonada
    4. Catherine L. May
    5. Craig Dorrell
    6. David Enicks
    7. Anusha Sairavi
    8. Klaus H. Kaestner
    9. Markus Grompe

  • Rapid in vivo multiplexed editing (RIME) of the adult mouse liver

    Hepatology
    1. Takeshi Katsuda
    2. Hector Cure
    3. Jonathan Sussman
    4. Kamen P. Simeonov
    5. Christopher Krapp
    6. Zoltan Arany
    7. Markus Grompe
    8. Ben Z. Stanger

  • Replication stress increases mitochondrial metabolism and mitophagy in FANCD2 deficient fetal liver hematopoietic stem cells

    Frontiers in Oncology
    1. Makiko Mochizuki-Kashio
    2. Noriko Otsuki
    3. Kota Fujiki
    4. Sherif Abdelhamd
    5. Peter Kurre
    6. Markus Grompe
    7. Atsushi Iwama
    8. Kayoko Saito
    9. Ayako Nakamura-Ishizu

  • Strong ubiquitous micro-promoters for recombinant adeno-associated viral vectors

    Molecular Therapy Methods and Clinical Development
    1. Sunghee Chai
    2. Leslie Wakefield
    3. Mason Norgard
    4. Bin Li
    5. David Enicks
    6. Daniel L. Marks
    7. Markus Grompe

  • The DNA methylome of human vascular endothelium and its use in liquid biopsies

    Med
    1. Ayelet Peretz
    2. Netanel Loyfer
    3. Sheina Piyanzin
    4. Bracha Lea Ochana
    5. Daniel Neiman
    6. Judith Magenheim
    7. Agnes Klochendler
    8. Zeina Drawshy
    9. Ilana Fox-Fisher
    10. Ori Fridlich
    11. Joshua Moss
    12. Daniel Cohen
    13. Hai Zemmour
    14. Gordon Cann
    15. Joerg Bredno
    16. Oliver Venn
    17. Batia Avni
    18. Tural Alekberli
    19. Yaacov Samet
    20. Amit Korach
    21. Ori Wald
    22. Vladimir Yutkin
    23. Uzi Izhar
    24. Nir Pillar
    25. Markus Grompe
    26. Zvi Fridlender
    27. Ariel Rokach
    28. David Planer
    29. Giora Landesberg
    30. Benjamin Glaser
    31. Ruth Shemer
    32. Tommy Kaplan
    33. Yuval Dor

  • Development of a Beta Cell-Specific Expression Control Element for Recombinant Adeno-Associated Virus

    Human Gene Therapy
    1. Sunghee Chai
    2. Youngjin Kim
    3. Feorillo Galivo
    4. Craig Dorrell
    5. Leslie Wakefield
    6. Jeffrey Posey
    7. Amanda M. Ackermann
    8. Klaus H. Kaestner
    9. Matthias Hebrok
    10. Markus Grompe

  • Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice

    Cell Reports
    1. Mohammad Kabbani
    2. Eleftherios Michailidis
    3. Sandra Steensels
    4. Clifton G. Fulmer
    5. Joseph M. Luna
    6. Jérémie Le Pen
    7. Matteo Tardelli
    8. Brandon Razooky
    9. Inna Ricardo-Lax
    10. Chenhui Zou
    11. Briana Zeck
    12. Ansgar F. Stenzel
    13. Corrine Quirk
    14. Lander Foquet
    15. Alison W. Ashbrook
    16. William M. Schneider
    17. Serkan Belkaya
    18. Gadi Lalazar
    19. Yupu Liang
    20. Meredith Pittman
    21. Lindsey Devisscher
    22. Hiroshi Suemizu
    23. Neil D. Theise
    24. Luis Chiriboga
    25. David E. Cohen
    26. Robert Copenhaver
    27. Markus Grompe
    28. Philip Meuleman
    29. Baran A. Ersoy
    30. Charles M. Rice
    31. Ype P. de Jong

  • Metformin for treatment of cytopenias in children and young adults with Fanconi anemia

    Blood Advances
    1. Jessica A. Pollard
    2. Elissa Furutani
    3. Shanshan Liu
    4. Erica Esrick
    5. Laurie E. Cohen
    6. Jacob Bledsoe
    7. Chih Wei Liu
    8. Kun Lu
    9. Maria Jose Ramirez de Haro
    10. Jordi Surrallés
    11. Maggie Malsch
    12. Ashley Kuniholm
    13. Ashley Galvin
    14. Myriam Armant
    15. Annette S. Kim
    16. Kaitlyn Ballotti
    17. Lisa Moreau
    18. Yu Zhou
    19. Daria Babushok
    20. Farid Boulad
    21. Clint Carroll
    22. Helge Hartung
    23. Amy Hont
    24. Taizo Nakano
    25. Tim Olson
    26. Sei Gyung Sze
    27. Alexis A. Thompson
    28. Marcin W. Wlodarski
    29. Xuesong Gu
    30. Towia A. Libermann
    31. Alan D'Andrea
    32. Markus Grompe
    33. Edie Weller
    34. Akiko Shimamura

  • Self-cleaving guide RNAs enable pharmacological selection of precise gene editing events in vivo

    Nature communications
    1. Amita Tiyaboonchai
    2. Anne Vonada
    3. Jeffrey Posey
    4. Carl Pelz
    5. Leslie Wakefield
    6. Markus Grompe

  • AAV integration in human hepatocytes

    Molecular Therapy
    1. Dhwanil A. Dalwadi
    2. Andrea Calabria
    3. Amita Tiyaboonchai
    4. Jeffrey Posey
    5. Willscott E. Naugler
    6. Eugenio Montini
    7. Markus Grompe

  • Cancer stem cells

    Annals of the New York Academy of Sciences
    1. Jennifer Cable
    2. Duanqing Pei
    3. Lola M. Reid
    4. Xin Wei Wang
    5. Sonam Bhatia
    6. Panagiotis Karras
    7. Jan Joseph Melenhorst
    8. Markus Grompe
    9. Justin D. Lathia
    10. Erwei Song
    11. Calvin J. Kuo
    12. Ning Zhang
    13. Richard M. White
    14. Stephanie Ky Ma
    15. Lichun Ma
    16. Y. Rebecca Chin
    17. Michael M. Shen
    18. Irene Oi Lin Ng
    19. Klaus H. Kaestner
    20. Lei Zhou
    21. Shaheen Sikandar
    22. Clemens A. Schmitt
    23. Wei Guo
    24. Carmen Chak Lui Wong
    25. Junfang Ji
    26. Dean G. Tang
    27. Anna Dubrovska
    28. Chunzhang Yang
    29. Wolf R. Wiedemeyer
    30. Irving L. Weissman

  • Dynamic Transcriptional and Epigenetic Changes Drive Cellular Plasticity in the Liver

    Hepatology
    1. Allyson J. Merrell
    2. Tao Peng
    3. Jinyang Li
    4. Kathryn Sun
    5. Bin Li
    6. Takeshi Katsuda
    7. Markus Grompe
    8. Kai Tan
    9. Ben Z. Stanger

  • Generation of functional ciliated cholangiocytes from human pluripotent stem cells

    Nature communications
    1. Mina Ogawa
    2. Jia Xin Jiang
    3. Sunny Xia
    4. Donghe Yang
    5. Avrilynn Ding
    6. Onofrio Laselva
    7. Marcela Hernandez
    8. Changyi Cui
    9. Yuichiro Higuchi
    10. Hiroshi Suemizu
    11. Craig Dorrell
    12. Markus Grompe
    13. Christine E. Bear
    14. Shinichiro Ogawa

  • Induced Liver Regeneration Enhances CRISPR/Cas9-Mediated Gene Repair in Tyrosinemia Type 1

    Human Gene Therapy
    1. Qing-Shuo Zhang
    2. Amita Tiyaboonchai
    3. Sean Nygaard
    4. Kevin Baradar
    5. Angela Major
    6. Niveditha Balaji
    7. Markus Grompe

  • Inhibition of TGFβ1 and TGFβ3 promotes hematopoiesis in Fanconi anemia

    Experimental hematology
    1. Alfredo Rodríguez
    2. Chunyu Yang
    3. Elissa Furutani
    4. Benilde García de Teresa
    5. Martha Velázquez
    6. Jessica Filiatrault
    7. Larissa A. Sambel
    8. Tin Phan
    9. Patricia Flores-Guzmán
    10. Silvia Sánchez
    11. Angélica Monsiváis Orozco
    12. Héctor Mayani
    13. Ozge V. Bolukbasi
    14. Anniina Färkkilä
    15. Michael Epperly
    16. Joel Greenberger
    17. Akiko Shimamura
    18. Sara Frías
    19. Markus Grompe
    20. Kalindi Parmar
    21. Alan D. D'Andrea

  • In vitro expansion of cirrhosis derived liver epithelial cells with defined small molecules

    Stem Cell Research
    1. Bin Li
    2. Yuhan Wang
    3. Carl Pelz
    4. Josh Moss
    5. Ruth Shemer
    6. Yuval Dor
    7. Yassmine K. Akkari
    8. Pamela S. Canady
    9. Willscott E. Naugler
    10. Susan Orloff
    11. Markus Grompe

  • Liver Injury Increases the Incidence of HCC following AAV Gene Therapy in Mice

    Molecular Therapy
    1. Dhwanil A. Dalwadi
    2. Laura Torrens
    3. Jordi Abril-Fornaguera
    4. Roser Pinyol
    5. Catherine Willoughby
    6. Jeffrey Posey
    7. Josep M. Llovet
    8. Christian Lanciault
    9. David W. Russell
    10. Markus Grompe
    11. Willscott E. Naugler

  • MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia

    Cell Stem Cell
    1. Alfredo Rodríguez
    2. Kaiyang Zhang
    3. Anniina Färkkilä
    4. Jessica Filiatrault
    5. Chunyu Yang
    6. Martha Velázquez
    7. Elissa Furutani
    8. Devorah Goldman
    9. Benilde García de Teresa
    10. Gilda Garza-Mayén
    11. Kelsey McQueen
    12. Larissa A. Sambel
    13. Bertha Molina
    14. Leda Torres
    15. Marisol González
    16. Eduardo Vadillo
    17. Rosana Pelayo
    18. William Fleming
    19. Markus Grompe
    20. Akiko Shimamura
    21. Sampsa Hautaniemi
    22. Joel Greenberger
    23. Sara Frías
    24. Kalindi Parmar
    25. Alan D. D'Andrea

  • Proliferative polyploid cells give rise to tumors via ploidy reduction

    Nature communications
    1. Tomonori Matsumoto
    2. Leslie Wakefield
    3. Alexander Peters
    4. Myron Peto
    5. Paul Spellman
    6. Markus Grompe

  • Therapeutic liver repopulation by transient acetaminophen selection of gene-modified hepatocytes

    Science translational medicine
    1. Anne Vonada
    2. Amita Tiyaboonchai
    3. Sean Nygaard
    4. Jeffrey Posey
    5. Alexander Mack Peters
    6. Shelley R. Winn
    7. Alessio Cantore
    8. Luigi Naldini
    9. Cary O. Harding
    10. Markus Grompe

  • AAV-Mediated CRISPR/Cas9 Gene Editing in Murine Phenylketonuria

    Molecular Therapy Methods and Clinical Development
    1. Daelyn Y. Richards
    2. Shelley R. Winn
    3. Sandra Dudley
    4. Sean Nygaard
    5. Taylor L. Mighell
    6. Markus Grompe
    7. Cary O. Harding

  • Efficient in vivo editing of OTC-deficient patient-derived primary human hepatocytes

    JHEP Reports
    1. Samantha L. Ginn
    2. Anais K. Amaya
    3. Sophia H.Y. Liao
    4. Erhua Zhu
    5. Sharon C. Cunningham
    6. Michael Lee
    7. Claus V. Hallwirth
    8. Grant J. Logan
    9. Szun S. Tay
    10. Anthony J. Cesare
    11. Hilda A. Pickett
    12. Markus Grompe
    13. Kimberley Dilworth
    14. Leszek Lisowski
    15. Ian E. Alexander

  • Insights From Liver-Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR-Agonist Pharmacodynamics in Humans

    Hepatology
    1. Mirko E. Minniti
    2. Matteo Pedrelli
    3. Lise Lotte Vedin
    4. Anne Sophie Delbès
    5. Raphaël G.P. Denis
    6. Katariina Öörni
    7. Claudia Sala
    8. Chiara Pirazzini
    9. Divya Thiagarajan
    10. Harri J. Nurmi
    11. Markus Grompe
    12. Kevin Mills
    13. Paolo Garagnani
    14. Ewa C.S. Ellis
    15. Stephen C. Strom
    16. Serge H. Luquet
    17. Elizabeth M. Wilson
    18. John Bial
    19. Knut R. Steffensen
    20. Paolo Parini