Martha Neuringer, Ph.D.

  • Professor, Oregon National Primate Research Center
  • Research Associate Professor of Ophthalmology, School of Medicine
  • Neuroscience Graduate Program, School of Medicine

Biography

Dr. Neuringer’s major areas of research include 1) the development and characterization of nonhuman primate models of retinal diseases, including age-related macular degeneration, the leading cause of vision loss in the elderly, and photoreceptor degenerations; 2) preclinical studies of gene and cell-based therapies for retinal disease; 3) the role of nutritional factors – particularly omega-3 fatty acids and carotenoids – in retinal and brain development, aging and disease; and 4) cognitive development and aging.

Dr. Neuringer’s laboratory has done pioneering work on the roles of nutritional factors in visual system development, aging and retinal disease, including the actions of carotenoids and omega-3 fatty acids. The current primary focus of her research program is the creation of translational nonhuman primate models of retinal degenerative diseases to facilitate better understanding of disease mechanisms and preclinical testing of potential gene and cell-based therapies. Her laboratory has identified and characterized naturally-occurring nonhuman primate models of retinal disease including age-related macular degeneration, Batten disease and Bardet-Biedl syndrome. Her preclinical studies of retinal gene therapy for several inherited retinal diseases have helped to provide the basis for human clinical trials.

Education and training

  • Degrees

    • B.A., 1966, Harvard/Radcliffe
    • Ph.D., 1971, Harvard University
  • Fellowship

    • Postdoctoral Fellowship, ONPRC

Memberships and associations:

  • Association for Research in Vision and Ophthalmology
  • Society for Neuroscience
  • International Society for Eye Research
  • American Society of Gene and Cell Therapy
  • American Society for Nutrition
  • International Carotenoid Society (Fellow)

Areas of interest

  • Nonhuman primate models of retinal disease
  • Gene and cell therapies for retinal disease
  • Nutritional factors in development and aging of the retina and brain
  • Cognitive aging

Honors and awards

  • OHSU Distinguished Science Educator Award, 2003
  • International Life Sciences Institute: Certificate of Achievement for one of 20 most cited papers in 70-year history of Nutrition Reviews
  • OHSU Technology Innovation/Industry Collaboration Award, 2012 and 2014
  • Fellow, International Carotenoid Society, 2017
  • Stein Innovation Award from Research to Prevent Blindness, 2018
  • Helen Keller Vision Award from Pacific NW Lions Club, 2019
  • OHSU Research and Innovation Award, 2020, 2023

Publications

Publications

  • Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization

    Angiogenesis
    1. Gideon Obasanmi
    2. Manjosh Uppal
    3. Jing Z. Cui
    4. Jeanne Xi
    5. Myeong Jin Ju
    6. Jun Song
    7. Eleanor To
    8. Siqi Li
    9. Wania Khan
    10. Darian Cheng
    11. John Zhu
    12. Lyden Irani
    13. Isa Samad
    14. Julie Zhu
    15. Hyung Suk Yoo
    16. Alexandre Aubert
    17. Jonathan Stoddard
    18. Martha Neuringer
    19. David J. Granville
    20. Joanne A. Matsubara
  • Preformed Vesicle Approach to LNP Manufacturing Enhances Retinal mRNA Delivery

    Small
    1. Yulia Eygeris
    2. Michael I. Henderson
    3. Allison G. Curtis
    4. Antony Jozić
    5. Jonathan Stoddard
    6. Rene Reynaga
    7. Kathleen R. Chirco
    8. Grace Li Na Su
    9. Martha Neuringer
    10. Andreas K. Lauer
    11. Renee C. Ryals
    12. Gaurav Sahay
  • Thiophene-based lipids for mRNA delivery to pulmonary and retinal tissues

    Proceedings of the National Academy of Sciences of the United States of America
    1. Yulia Eygeris
    2. Mohit Gupta
    3. Jeonghwan Kim
    4. Antony Jozic
    5. Milan Gautam
    6. Jonas Renner
    7. Dylan Nelson
    8. Elissa Bloom
    9. Adam Tuttle
    10. Jonathan Stoddard
    11. Rene Reynaga
    12. Martha Neuringer
    13. Andreas K. Lauer
    14. Renee C. Ryals
    15. Gaurav Sahay
  • Wide-field OCT angiography for non-human primate retinal imaging

    Biomedical Optics Express
    1. Xiang Wei
    2. Tristan T. Hormel
    3. Laurie Renner
    4. Martha Neuringer
    5. Yali Jia
  • Development of a translatable gene augmentation therapy for CNGB1-retinitis pigmentosa

    Molecular Therapy
    1. Laurence M. Occelli
    2. Lena Zobel
    3. Jonathan Stoddard
    4. Johanna Wagner
    5. Nathaniel Pasmanter
    6. Janice Querubin
    7. Lauren M. Renner
    8. Rene Reynaga
    9. Paige A. Winkler
    10. Kelian Sun
    11. Luis Felipe L.P. Marinho
    12. Catherine R. O'Riordan
    13. Amy Frederick
    14. Andreas Lauer
    15. Stephen H. Tsang
    16. William W. Hauswirth
    17. Trevor J. McGill
    18. Martha Neuringer
    19. Stylianos Michalakis
    20. Simon M. Petersen-Jones
  • Early-in-life isoflurane exposure alters resting-state functional connectivity in juvenile non-human primates

    British journal of anaesthesia
    1. Viola Neudecker
    2. Jose F. Perez-Zoghbi
    3. Oscar Miranda-Domínguez
    4. Katie J. Schenning
    5. Julian SB Ramirez
    6. A. J. Mitchell
    7. Anders Perrone
    8. Eric Earl
    9. Sam Carpenter
    10. Lauren D. Martin
    11. Kristine Coleman
    12. Martha Neuringer
    13. Christopher D. Kroenke
    14. Gregory A. Dissen
    15. Damien A. Fair
    16. Ansgar M. Brambrink
  • Genetic variants in melanogenesis proteins TYRP1 and TYR are associated with the golden rhesus macaque phenotype

    G3: Genes, Genomes, Genetics
    1. Samuel M. Peterson
    2. Marina M. Watowich
    3. Lauren M. Renner
    4. Samantha Martin
    5. Emma Offenberg
    6. Amanda Lea
    7. Michael J. Montague
    8. James P. Higham
    9. Noah Snyder-Mackler
    10. Martha Neuringer
    11. Betsy Ferguson
  • Glial, Neuronal, Vascular, Retinal Pigment Epithelium, and Inflammatory Cell Damage in a New Western Diet–Induced Primate Model of Diabetic Retinopathy

    American Journal of Pathology
    1. Tailoi Chan-Ling
    2. Ping Hu
    3. Sergio Li Calzi
    4. Jeff Warner
    5. Nasir Uddin
    6. Mariana DuPont
    7. Martha Neuringer
    8. Paul Kievit
    9. Lauren Renner
    10. Jonathan Stoddard
    11. Renee Ryals
    12. Michael E. Boulton
    13. Trevor McGill
    14. Maria B. Grant
  • Peptide-guided lipid nanoparticles deliver mRNA to the neural retina of rodents and nonhuman primates

    Science Advances
    1. Marco Herrera-Barrera
    2. Renee C. Ryals
    3. Milan Gautam
    4. Antony Jozic
    5. Madeleine Landry
    6. Tetiana Korzun
    7. Mohit Gupta
    8. Chris Acosta
    9. Jonathan Stoddard
    10. Rene Reynaga
    11. Wayne Tschetter
    12. Nick Jacomino
    13. Oleh Taratula
    14. Conroy Sun
    15. Andreas K. Lauer
    16. Martha Neuringer
    17. Gaurav Sahay
  • Carotenoids improve the development of cerebral cortical networks in formula-fed infant macaques

    Scientific Reports
    1. Oscar Miranda-Dominguez
    2. Julian S.B. Ramirez
    3. A. J. Mitchell
    4. Anders Perrone
    5. Eric Earl
    6. Sam Carpenter
    7. Eric Feczko
    8. Alice Graham
    9. Sookyoung Jeon
    10. Neal J. Cohen
    11. Laurie Renner
    12. Martha Neuringer
    13. Matthew J. Kuchan
    14. John W. Erdman
    15. Damien Fair
  • CRISPR/Cas9 editing of the MYO7A gene in rhesus macaque embryos to generate a primate model of Usher syndrome type 1B

    Scientific Reports
    1. Junghyun Ryu
    2. John P. Statz
    3. William Chan
    4. Fernanda C. Burch
    5. John V. Brigande
    6. Beth Kempton
    7. Edward V. Porsov
    8. Lauren Renner
    9. Trevor McGill
    10. Benjamin J. Burwitz
    11. Carol B. Hanna
    12. Martha Neuringer
    13. Jon D. Hennebold
  • Increased cell stiffness contributes to complement-mediated injury of choroidal endothelial cells in a monkey model of early age-related macular degeneration

    Journal of Pathology
    1. Andrea P. Cabrera
    2. Jonathan Stoddard
    3. Irene Santiago Tierno
    4. Nikolaos Matisioudis
    5. Mahesh Agarwal
    6. Lauren Renner
    7. Neha Palegar
    8. Martha Neuringer
    9. Trevor McGill
    10. Kaustabh Ghosh
  • Infant isoflurane exposure affects social behaviours, but does not impair specific cognitive domains in juvenile non-human primates

    British journal of anaesthesia
    1. Viola Neudecker
    2. Jose F. Perez-Zoghbi
    3. Kristine Coleman
    4. Martha Neuringer
    5. Nicola Robertson
    6. Alexandra Bemis
    7. Bess Glickman
    8. Katie J. Schenning
    9. Damien A. Fair
    10. Lauren D. Martin
    11. Gregory A. Dissen
    12. Ansgar M. Brambrink
  • A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy

    PloS one
    1. Rosemary J. Steinbach
    2. Nicole N. Haese
    3. Jessica L. Smith
    4. Lois M.A. Colgin
    5. Rhonda P. MacAllister
    6. Justin M. Greene
    7. Christopher J. Parkins
    8. J. Beth Kempton
    9. Edward Porsov
    10. Xiaojie Wang
    11. Lauren M. Renner
    12. Trevor J. McGill
    13. Brandy L. Dozier
    14. Craig N. Kreklywich
    15. Takeshi F. Andoh
    16. Marjorie R. Grafe
    17. Heidi L. Pecoraro
    18. Travis Hodge
    19. Robert M. Friedman
    20. Lisa A. Houser
    21. Terry K. Morgan
    22. Peter Stenzel
    23. Jonathan R. Lindner
    24. Robert L. Schelonka
    25. Jonah B. Sacha
    26. Victoria H.J. Roberts
    27. Martha Neuringer
    28. John V. Brigande
    29. Christopher D. Kroenke
    30. Antonio E. Frias
    31. Anne D. Lewis
    32. Meredith A. Kelleher
    33. Alec J. Hirsch
    34. Daniel Neal Streblow
  • Infant rhesus macaque brain α-tocopherol stereoisomer profile is differentially impacted by the source of α-tocopherol in infant formula

    Journal of Nutrition
    1. Matthew J. Kuchan
    2. Katherine M. Ranard
    3. Priyankar Dey
    4. Sookyoung Jeon
    5. Geoff Y. Sasaki
    6. Karen J. Schimpf
    7. Richard S. Bruno
    8. Martha Neuringer
    9. John W. Erdman
  • Bardet-Biedl Syndrome in rhesus macaques

    Experimental Eye Research
    1. Samuel M. Peterson
    2. Trevor J. McGill
    3. Teresa Puthussery
    4. Jonathan Stoddard
    5. Lauren Renner
    6. Anne D. Lewis
    7. Lois M.A. Colgin
    8. Jacqueline Gayet
    9. Xiaojie Wang
    10. Kamm Prongay
    11. Cassandra Cullin
    12. Brandy L. Dozier
    13. Betsy Ferguson
    14. Martha Neuringer
  • New MiniPromoter Ple345 (NEFL) drives strong and specific expression in retinal ganglion cells of mouse and primate retina

    Human Gene Therapy
    1. Elizabeth M. Simpson
    2. Andrea J. Korecki
    3. Oriol Fornes
    4. Trevor J. McGill
    5. Jorge Luis Cueva-Vargas
    6. Jessica Agostinone
    7. Rachelle A. Farkas
    8. Jack W. Hickmott
    9. Siu Ling Lam
    10. Anthony Mathelier
    11. Lauren M. Renner
    12. Jonathan Stoddard
    13. Michelle Zhou
    14. Adriana Di Polo
    15. Martha Neuringer
    16. Wyeth W. Wasserman
  • 13C-lutein is differentially distributed in tissues of an adult female rhesus macaque following a single oral administration

    Nutrition Research
    1. Sookyoung Jeon
    2. Qiyao Li
    3. Stanislav S. Rubakhin
    4. Jonathan V. Sweedler
    5. Joshua W. Smith
    6. Martha Neuringer
    7. Matthew Kuchan
    8. John W. Erdman
  • The effects of breastfeeding versus formula-feeding on cerebral cortex maturation in infant rhesus macaques

    NeuroImage
    1. Zheng Liu
    2. Martha Neuringer
    3. John W. Erdman
    4. Matthew J. Kuchan
    5. Lauren Renner
    6. Emily E. Johnson
    7. Xiaojie Wang
    8. Christopher D. Kroenke
  • Allogeneic iPSC-derived RPE cell graft failure following transplantation into the subretinal space in nonhuman primates

    Investigative Ophthalmology and Visual Science
    1. Trevor J. McGill
    2. Jonathan Stoddard
    3. Auren M. Renner
    4. Ilhem Messaoudi
    5. Kapil Bharti
    6. Shoukhrat Mitalipov
    7. Andreas Lauer
    8. David J. Wilson
    9. Martha Neuringer
  • Discovery of a CLN7 model of Batten disease in non-human primates

    Neurobiology of Disease
    1. Jodi L. McBride
    2. Martha Neuringer
    3. Betsy Ferguson
    4. Steven G. Kohama
    5. Ian J. Tagge
    6. Robert C. Zweig
    7. Laurie M. Renner
    8. Trevor J. McGill
    9. Jonathan Stoddard
    10. Samuel Peterson
    11. Weiping Su
    12. Larry S. Sherman
    13. Jacqueline S. Domire
    14. Rebecca M. Ducore
    15. Lois M. Colgin
    16. Anne D. Lewis
  • Relationships of carotenoid-related gene expression and serum cholesterol and lipoprotein levels to retina and brain lutein deposition in infant rhesus macaques following 6 months of breastfeeding or formula feeding

    Archives of Biochemistry and Biophysics
    1. Sookyoung Jeon
    2. Martha Neuringer
    3. Matthew J. Kuchan
    4. John W. Erdman
  • The Ultrastructure, Spatial Distribution, and Osmium Tetroxide Binding of Lipofuscin and Melanosomes in Aging Monkey Retinal Epithelium

    Current Eye Research
    1. Peter Gouras
    2. Kristy R. Brown
    3. Julie A. Mattison
    4. Martha Neuringer
    5. Takayuki Nagasaki
    6. Lena Ivert
  • Brain xanthophyll content and exploratory gene expression analysis

    Genes and Nutrition
    1. Emily S. Mohn
    2. John W. Erdman
    3. Martha Neuringer
    4. Matthew J. Kuchan
    5. Elizabeth J. Johnson
  • Carrot solution culture bioproduction of uniformly labeled 13C-lutein and in vivo dosing in non-human primates

    Experimental Biology and Medicine
    1. Joshua W. Smith
    2. Randy B. Rogers
    3. Sookyoung Jeon
    4. Stanislav S. Rubakhin
    5. Lin Wang
    6. Jonathan V. Sweedler
    7. Martha Neuringer
    8. Matthew J. Kuchan
    9. John W. Erdman
  • Cognition in aged rhesus monkeys

    Genes, Brain and Behavior
    1. K. G. Sorwell
    2. L. Renner
    3. A. R. Weiss
    4. M. Neuringer
    5. S. G. Kohama
    6. H. F. Urbanski