Publications

• A histochemical approach to activity-based copper sensing reveals cuproplasia-dependent vulnerabilities in cancer

  Proceedings of the National Academy of Sciences of the United States of America Jan 21, 2025
  1. Marco S. Messina
  2. Laura Torrente
  3. Aidan T. Pezacki
  4. Hanna I. Humpel
  5. Erin L. Li
  6. Sophia G. Miller
  7. Odette Verdejo-Torres
  8. Teresita Padilla-Benavides
  9. Donita C. Brady
  10. David W. Killilea
  11. Alison N. Killilea
  12. Martina Ralle
  13. Nathan P. Ward
  14. Jun Ohata
  15. Gina M. DeNicola
  16. Christopher J. Chang

• Studies of Slc30a10 Deficiency in Mice Reveal That Intestinal Iron Transporters Dmt1 and Ferroportin Transport Manganese

  CMGH Jan 2025
  1. Milankumar Prajapati
  2. Jared Z. Zhang
  3. Grace S. Chong
  4. Lauren Chiu
  5. Courtney J. Mercadante
  6. Heather L. Kowalski
  7. Olga Antipova
  8. Barry Lai
  9. Martina Ralle
  10. Brian P. Jackson
  11. Tracy Punshon
  12. Shuling Guo
  13. Mariam Aghajan
  14. Thomas B. Bartnikas

• An Activity-Based Sensing Approach to Multiplex Mapping of Labile Copper Pools by Stimulated Raman Scattering

  Journal of the American Chemical Society 2024
  1. Yishu Jiang
  2. Elsy El Khoury
  3. Aidan T. Pezacki
  4. Naixin Qian
  5. Miku Oi
  6. Laura Torrente
  7. Sophia G. Miller
  8. Martina Ralle
  9. Gina M. DeNicola
  10. Wei Min
  11. Christopher J. Chang

• A tandem activity-based sensing and labeling strategy reveals antioxidant response element regulation of labile iron pools

  Proceedings of the National Academy of Sciences of the United States of America Jul 9, 2024
  1. Aidan T. Pezacki
  2. Ryan L. Gonciarz
  3. Toshitaka Okamura
  4. Carson D. Matier
  5. Laura Torrente
  6. Ke Cheng
  7. Sophia G. Miller
  8. Martina Ralle
  9. Nathan P. Ward
  10. Gina M. DeNicola
  11. Adam R. Renslo
  12. Christopher J. Chang

• ATP7A-dependent copper sequestration contributes to termination of β-CATENIN signaling during early adipogenesis

  Molecular Metabolism Feb 2024
  1. H. Yang
  2. E. Kabin
  3. Y. Dong
  4. X. Zhang
  5. M. Ralle
  6. S. Lutsenko

• Copper levels in cervical mucus of copper intrauterine device users versus non-users

  International Journal of Gynecology and Obstetrics May 2024
  1. Leo L. Han
  2. Alison B. Edelman
  3. Oluwadamilola Sosanya
  4. Bharti Garg
  5. Vivia Chi
  6. Martina Ralle

• Evaluating mineral biomarkers as mediators and moderators of behavioural improvements in a randomised controlled trial of multinutrients for children with attention-deficit/hyperactivity disorder

  British Journal of Nutrition 2024
  1. Lisa M. Robinette
  2. Jeanette M. Johnstone
  3. Priya Srikanth
  4. Alisha M. Bruton
  5. Martina Ralle
  6. Hayleigh K. Ast
  7. Ryan D. Bradley
  8. Brenda Leung
  9. L. Eugene Arnold
  10. Irene E. Hatsu

• Water soluble azide functionalized cobalt oxide nanoparticles

  Journal of Nanoparticle Research Oct 2024
  1. Christian Scott
  2. Sophia Miller
  3. Pierre Moenne-Loccoz
  4. Craig Eliot Barnes
  5. Martina Ralle

• FDX1-dependent and independent mechanisms of elesclomol-mediated intracellular copper delivery

  Proceedings of the National Academy of Sciences of the United States of America Mar 7, 2023
  1. Mohammad Zulkifli
  2. Amy N. Spelbring
  3. Yuteng Zhang
  4. Shivatheja Soma
  5. Si Chen
  6. Luxi Li
  7. Trung Le
  8. Vinit Shanbhag
  9. Michael J. Petris
  10. Tai Yen Chen
  11. Martina Ralle
  12. David P. Barondeau
  13. Vishal M. Gohil

• α-lipoic acid ameliorates consequences of copper overload by up-regulating selenoproteins and decreasing redox misbalance

  Proceedings of the National Academy of Sciences of the United States of America 2023
  1. Ekaterina Kabin
  2. Yixuan Dong
  3. Shubhrajit Roy
  4. Julia Smirnova
  5. Joshua W. Smith
  6. Martina Ralle
  7. Kelly Summers
  8. Haojun Yang
  9. Som Dev
  10. Yu Wang
  11. Benjamin Devenney
  12. Robert N. Cole
  13. Peep Palumaa
  14. Svetlana Lutsenko

• Interactions between copper homeostasis and the fungal cell wall affect copper stress resistance

  PLoS pathogens Jun 2022
  1. Corinna Probst
  2. Sarela Garcia-Santamarina
  3. Jacob T. Brooks
  4. Inge Van Der Kloet
  5. Oliver Baars
  6. Martina Ralle
  7. Dennis J. Thiele
  8. J. Andrew Alspaugh

• Single-cell visualization and quantification of trace metals in Chlamydomonas lysosome-related organelles

  Proceedings of the National Academy of Sciences of the United States of America Apr 20, 2021
  1. Stefan Schmollinger
  2. Si Chen
  3. Daniela Strenkert
  4. Colleen Hui
  5. Martina Ralle
  6. Sabeeha S. Merchant

• The contact activation inhibitor AB023 in heparin-free hemodialysis

  Blood Dec 2, 2021
  1. Christina U. Lorentz
  2. Erik I. Tucker
  3. Norah G. Verbout
  4. Joseph J. Shatzel
  5. Sven R. Olson
  6. Brandon D. Markway
  7. Michael Wallisch
  8. Martina Ralle
  9. Monica T. Hinds
  10. Owen J.T. McCarty
  11. David Gailani
  12. Jeffrey I. Weitz
  13. András Gruber

• Transcription factor-driven alternative localization of Cryptococcus neoformans superoxide dismutase

  Journal of Biological Chemistry Jan 1, 2021
  1. Aaron D. Smith
  2. Sarela Garcia-Santamarina
  3. Martina Ralle
  4. David R. Loiselle
  5. Timothy A. Haystead
  6. Dennis J. Thiele

• Altered copper homeostasis underlies sensitivity of hepatocellular carcinoma to copper chelation

  Metallomics Dec 2020
  1. Caroline I. Davis
  2. Xingxing Gu
  3. Ryan M. Kiefer
  4. Martina Ralle
  5. Terence P. Gade
  6. Donita C. Brady

• Analysis of Wilson disease mutations revealed that interactions between different ATP7B mutants modify their properties

  Scientific Reports Dec 1, 2020
  1. Shubhrajit Roy
  2. Courtney J. McCann
  3. Martina Ralle
  4. Kunal Ray
  5. Jharna Ray
  6. Svetlana Lutsenko
  7. Samuel Jayakanthan

• Copper Modulation and Memory Impairment due to Hippocampal Tau Pathology

  Journal of Alzheimer's Disease 2020
  1. Christopher J. Harris
  2. Nora E. Gray
  3. Maya Caruso
  4. Marguex Hunter
  5. Martina Ralle
  6. Joseph F. Quinn

• Lanthanide-Binding Tags for 3D X-ray Imaging of Proteins in Cells at Nanoscale Resolution

  Journal of the American Chemical Society Feb 5, 2020
  1. Tiffany W. Victor
  2. Katherine H. O'Toole
  3. Lindsey M. Easthon
  4. Mingyuan Ge
  5. Randy J. Smith
  6. Xiaojing Huang
  7. Hanfei Yan
  8. Yong S. Chu
  9. Si Chen
  10. Doga Gursoy
  11. Martina Ralle
  12. Barbara Imperiali
  13. Karen N. Allen
  14. Lisa M. Miller

• Metallothioneins regulate ATP7A trafficking and control cell viability during copper deficiency and excess

  Scientific Reports Dec 1, 2020
  1. Nikita Gudekar
  2. Vinit Shanbhag
  3. Yanfang Wang
  4. Martina Ralle
  5. Gary A. Weisman
  6. Michael J. Petris

• 4′-Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN

  EMBO Molecular Medicine Jan 1, 2019
  1. Suh Young Jeong
  2. Penelope Hogarth
  3. Andrew Placzek
  4. Allison M. Gregory
  5. Rachel Fox
  6. Dolly Zhen
  7. Jeffrey Hamada
  8. Marianne van der Zwaag
  9. Roald Lambrechts
  10. Haihong Jin
  11. Aaron Nilsen
  12. Jared Cobb
  13. Thao Pham
  14. Nora Gray
  15. Martina Ralle
  16. Megan Duffy
  17. Leila Schwanemann
  18. Puneet Rai
  19. Alison Freed
  20. Katrina Wakeman
  21. Randall L. Woltjer
  22. Ody C.M. Sibon
  23. Susan J. Hayflick

• Hemozoin produced by mammals confers heme tolerance

  eLife Oct 2019
  1. Rini H. Pek
  2. Xiaojing Yuan
  3. Nicole Rietzschel
  4. Jianbing Zhang
  5. Laurie Jackson
  6. Eiji Nishibori
  7. Ana Ribeiro
  8. William Simmons
  9. Jaya Jagadeesh
  10. Hiroshi Sugimoto
  11. Md Zahidul Alam
  12. Lisa Garrett
  13. Malay Haldar
  14. Martina Ralle
  15. John D. Phillips
  16. David M. Bodine
  17. Iqbal Hamza

• Localization of the locus coeruleus in the mouse brain

  Journal of Visualized Experiments Mar 2019
  1. Katharina Schmidt
  2. Bilal Bari
  3. Martina Ralle
  4. Clorissa Washington-Hughes
  5. Abigael Muchenditsi
  6. Evan Maxey
  7. Svetlana Lutsenko

• Manganese co-localizes with calcium and phosphorus in Chlamydomonas acidocalcisomes and is mobilized in manganese-deficient conditions

  Journal of Biological Chemistry Nov 15, 2019
  1. Munkhtsetseg Tsednee
  2. Madeli Castruita
  3. Patrice A. Salomé
  4. Ajay Sharma
  5. Brianne E. Lewis
  6. Stefan R. Schmollinger
  7. Daniela Strenkert
  8. Kristen Holbrook
  9. Marisa S. Otegui
  10. Kaustav Khatua
  11. Sayani Das
  12. Ankona Datta
  13. Si Chen
  14. Christina Ramon
  15. Martina Ralle
  16. Peter K. Weber
  17. Timothy L. Stemmler
  18. Jennifer Pett-Ridge
  19. Brian M. Hoffman
  20. Sabeeha S. Merchant

• Obesity is associated with copper elevation in serum and tissues

  Metallomics Aug 2019
  1. Haojun Yang
  2. Chin Nung Liu
  3. Risa M. Wolf
  4. Martina Ralle
  5. Som Dev
  6. Hannah Pierson
  7. Frederic Askin
  8. Kimberley E. Steele
  9. Thomas H. Magnuson
  10. Michael A. Schweitzer
  11. G. William Wong
  12. Svetlana Lutsenko

• Altered zinc balance in the Atp7b^−/− mouse reveals a mechanism of copper toxicity in Wilson disease

  Metallomics Nov 2018
  1. Kelsey A. Meacham
  2. María Paz Cortés
  3. Eve M. Wiggins
  4. Alejandro Maass
  5. Mauricio Latorre
  6. Martina Ralle
  7. Jason L. Burkhead

• ATP7A and ATP7B copper transporters have distinct functions in the regulation of neuronal dopamine--hydroxylase

  Journal of Biological Chemistry Dec 28, 2018
  1. Katharina Schmidt
  2. Martina Ralle
  3. Thomas Schaffer
  4. Samuel Jayakanthan
  5. Bilal Bari
  6. Abigael Muchenditsi
  7. Svetlana Lutsenko