Mary Logan, Ph.D.

  • Associate Professor of Neurology, School of Medicine
  • Ken and Ginger Harrison Term Professor in Neuroscience Research, Jungers Center for Neurosciences Research
  • Neuroscience Graduate Program, School of Medicine
  • Jungers Center for Neurosciences Research

Biography

Dr. Logan joined the Jungers Center as an Assistant Professor of Neurology in September 2010 and was promoted to Associate Professor in 2017.

After working at NPS Pharmaceuticals, Inc. in Salt Lake City for several years, Dr. Logan entered graduate school at the University of Utah where she did her Ph.D. thesis work with Monica Vetter studying gene transcription networks that regulate nervous system development. She then joined Marc Freeman’s lab at the University of Massachusetts Medical School in Worcester, MA as a postdoctoral fellow to explore immunological activity of glial cells in the fruit fly Drosophila melanogaster. Her work has identified signaling pathways that control glial cell recognition and phagocytosis of degenerating axons, which occurs following trauma, including ischemia and degenerative diseases such as multiple sclerosis. Dr. Logan will continue to take advantage of fly genetics to examine new molecules involved in neuronal-glial interactions in the healthy and diseased brain.

Education and training

  • Degrees

    • Ph.D., 2005, University of Utah

Publications

Publications

  • Brain inflammation triggers macrophage invasion across the blood-brain barrier in Drosophila during pupal stages

    Science Advances
    1. Bente Winkler
    2. Dominik Funke
    3. Billel Benmimoun
    4. Pauline Spéder
    5. Simone Rey
    6. Mary A. Logan
    7. Christian Klämbt

  • Engulfed by glia

    Journal of Neuroscience
    1. Stephan Raiders
    2. Taeho Han
    3. Nicole Scott-Hewitt
    4. Sarah Kucenas
    5. Deborah Lew
    6. Mary A. Logan
    7. Aakanksha Singhvi

  • C8orf46 homolog encodes a novel protein Vexin that is required for neurogenesis in Xenopus laevis

    Developmental Biology
    1. Kathryn B. Moore
    2. Mary A. Logan
    3. Issam Aldiri
    4. Jacqueline M. Roberts
    5. Michael Steele
    6. Monica L. Vetter

  • A novel Drosophila injury model reveals severed axons are cleared through a draper/MMP-1 signaling cascade

    eLife
    1. Maria D. Purice
    2. Arpita Ray
    3. Eva Jolanda Münzel
    4. Bernard J. Pope
    5. Daniel J. Park
    6. Sean D. Speese
    7. Mary A. Logan

  • Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling

    Nature communications
    1. Tsai Yi Lu
    2. Jennifer M. MacDonald
    3. Lukas J. Neukomm
    4. Amy E. Sheehan
    5. Rachel Bradshaw
    6. Mary A. Logan
    7. Marc R. Freeman

  • Complement-Related Regulates Autophagy in Neighboring Cells

    Cell
    1. Lin Lin
    2. Frederico S.L.M. Rodrigues
    3. Christina Kary
    4. Alicia Contet
    5. Mary Logan
    6. Richard H.G. Baxter
    7. Will Wood
    8. Eric H. Baehrecke

  • Fragile phagocytes

    The Journal of cell biology
    1. Mary A. Logan

  • Glial draper rescues Aβ toxicity in a Drosophila model of Alzheimer’s disease

    Journal of Neuroscience
    1. Arpita Ray
    2. Sean D. Speese
    3. Mary A. Logan

  • Protein phosphatase 4 coordinates glial membrane recruitment and phagocytic clearance of degenerating axons in Drosophila

    Cell Death and Disease
    1. Lilly M. Winfree
    2. Sean D. Speese
    3. Mary A. Logan

  • Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activity

    Nature communications
    1. Maria D. Purice
    2. Sean D. Speese
    3. Mary A. Logan

  • Insulin-like Signaling Promotes Glial Phagocytic Clearance of Degenerating Axons through Regulation of Draper

    Cell Reports
    1. Derek T. Musashe
    2. Maria D. Purice
    3. Sean D. Speese
    4. Johnna Doherty
    5. Mary A. Logan

  • dSarm/Sarm1 is required for activation of an injury-induced axon death pathway

    Science
    1. Jeannette M. Osterloh
    2. Jing Yang
    3. Timothy M. Rooney
    4. A. Nicole Fox
    5. Robert Adalbert
    6. Eric H. Powell
    7. Amy E. Sheehan
    8. Michelle A. Avery
    9. Rachel Hackett
    10. Mary A. Logan
    11. Jennifer M. MacDonald
    12. Jennifer S. Ziegenfuss
    13. Stefan Milde
    14. Ying Ju Hou
    15. Carl Nathan
    16. Aihao Ding
    17. Robert H. Brown
    18. Laura Conforti
    19. Michael Coleman
    20. Marc Tessier-Lavigne
    21. Stephan Züchner
    22. Marc R. Freeman

  • Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury

    Nature Neuroscience
    1. Mary A. Logan
    2. Rachel Hackett
    3. Johnna Doherty
    4. Amy Sheehan
    5. Sean D. Speese
    6. Marc R. Freeman

  • Whole genome sequencing and a new bioinformatics platform allow for rapid gene identification in d. melanogaster EMS screens

    Biology
    1. Michael A. Gonzalez
    2. Derek VanBooven
    3. William Hulme
    4. Rick H. Ulloa
    5. Rafael F.Acosta Lebrigio
    6. Jeannette Osterloh
    7. Mary Logan
    8. Marc Freeman
    9. Stephan Zuchner

  • Activation of autophagy during cell death requires the engulfment receptor Draper

    Nature
    1. Christina K. McPhee
    2. Mary A. Logan
    3. Marc R. Freeman
    4. Eric H. Baehrecke

  • Ensheathing glia function as phagocytes in the adult Drosophila brain

    Journal of Neuroscience
    1. Johnna Doherty
    2. Mary A. Logan
    3. Özge E. Taşdemir
    4. Marc R. Freeman

  • Glia and muscle sculpt neuromuscular arbors by engulfing destabilized synaptic boutons and shed presynaptic debris

    PLoS Biology
    1. Yuly Fuentes-Medel
    2. Mary A. Logan
    3. James Ashley
    4. Bulent Ataman
    5. Vivian Budnik
    6. Marc R. Freeman

  • Expression of synaptic vesicle two-related protein SVOP in the developing nervous system of Xenopus laevis

    Developmental Dynamics
    1. Mary A. Logan
    2. Michael R. Steele
    3. Monica L. Vetter

  • Identification of shared transcriptional targets for the proneural bHLH factors Xath5 and XNeuroD

    Developmental Biology
    1. Mary A. Logan
    2. Michael R. Steele
    3. Terence J. Van Raay
    4. Monica L. Vetter

  • TaCRK3 encodes a novel Theileria annulata protein kinase with motifs characteristic of the family of eukaryotic cyclin dependent kinases

    Gene
    1. Jane Kinnaird
    2. Mary Logan
    3. Andrew Tait
    4. Gordon Langsley

  • Loss of matrix metalloproteinase 9 activity in Theileria annulata- attenuated cells is at the transcriptional level and is associated with differentially expressed AP-1 species

    Molecular and Biochemical Parasitology
    1. Rachel Adamson
    2. Mary Logan
    3. Jane Kinnaird
    4. Gordon Langsley
    5. Roger Hall

  • The inositol trisphosphate receptor regulates a 50-second behavioral rhythm in C. elegans

    Cell
    1. Paola Dal Santo
    2. Mary A. Logan
    3. Andrew D. Chisholm
    4. Erik M. Jorgensen

  • Stimulation of calcitonin secretion by calcium receptor activators

    Endocrine
    1. Jeffrey R. Lavigne
    2. Richard J. Zahradnik
    3. Rebecca L. Conklin
    4. Lyssa D. Lambert
    5. Mary A. Logan
    6. Ashutosh Parihar
    7. John Fox

  • Postnatal pup brain dopamine depletion inhibits maternal behavior

    Pharmacology Biochemistry and Behavior
    1. Aaron S. Wilkins
    2. Mary Logan
    3. Priscilla Kehoe

  • The isolation and characterization of genomic and cDNA clones coding for a cdc2-related kinase (ThCRK2) from the bovine protozoan parasite Theileria

    Molecular Microbiology
    1. Jane H. Kinnaird
    2. Mary Logan
    3. Erol Kirvar
    4. Andrew Tait
    5. Mark Carrington

  • A hybrid sigma subunit directs RNA polymerase to a hybrid promoter in Escherichia coli

    Journal of molecular biology
    1. Ashok Kumar
    2. Brenda Grimes
    3. Mary Logan
    4. Stephen Wedgwood
    5. Helen Williamson
    6. Richard S. Hayward