Matthew Butler, Ph.D.

  • Associate Professor, Oregon Institute of Occupational Health Sciences
  • Behavioral Neuroscience Graduate Program, School of Medicine

Biography

I have a broad interest in how biological clocks are synchronized in organisms, and how these affect physiology and behavior. I have a particular interest in how shift work increases the risk for disease. Current efforts employ behavioral and physiological approaches in order to investigate the following:

1)    Androgen receptors and sex differences in the biological clock
2)    The effects of shift work on fertility
3)    Sleep epidemiology

Education and training

  • Degrees

    • A.B., 1999, Dept. of Ecology and Evolutionary Biology, Princeton University
    • Ph.D., 2007, Dept. of Integrative Biology, U.C. Berkeley

Memberships and associations:

  • Society for Research on Biological Rhythms
  • American Association of Sleep Medicine
  • Sleep Research Society
  • Society for Neuroscience

Areas of interest

  • Biological rhythms and health
  • Neuroendocrinology of sex differences
  • Sleep epidemiology

Publications

Selected publications

  • Grygoryev D, Rountree MR, Rwatambuga F, Ohlrich A, Kukino A, Butler MP, Allen CN, Turker MS. In Press. Rapid response and slow recovery of the H3K4me3 epigenomic marker in the liver after a light-mediated phase advance of the circadian clock. Journal of Biological Rhythms.
  • Thosar SS, Butler MP, Shea SA. In Press. Role of the circadian system in cardiovascular disease. Journal of Clinical Investigation.
  • Butler MP, Smales C, Wu H, Hussain MV, Mohamed YA, Morimoto M, Shea SA. 2015. The circadian system contributes to apnea lengthening across the night in obstructive sleep apnea. Sleep 38: 1793-1801.
  • Butler MP, Karatsoreos IN, LeSauter J, Silver R. 2012. Dose-dependent effects of androgens on the circadian timing system and its response to light. Endocrinology. 153: 2344-2352.
  • Butler MP, Silver R.  2011. Divergent photic thresholds in the non-image forming visual system: entrainment, masking, and pupillary light reflex. Proceedings of the Royal Society B: Biological Sciences. 278: 745-750.

Publications

  • Identifying an acceptable number of ambulatory blood pressure measurements for accuracy of average blood pressure and nocturnal dipping status

    American Journal of Physiology - Heart and Circulatory Physiology
    1. Leandro Campos de Brito
    2. Sean P.M. Rice
    3. Nicole P. Bowles
    4. Matthew P. Butler
    5. Andrew W. McHill
    6. Jonathan Emens
    7. Steven A. Shea
    8. Saurabh S. Thosar
  • Obesity alters the circadian profiles of energy metabolism and glucose regulation in humans

    Obesity
    1. Andrew W. McHill
    2. Saurabh S. Thosar
    3. Nicole P. Bowles
    4. Matthew P. Butler
    5. Omar Ordaz-Johnson
    6. Jonathan S. Emens
    7. Jonathan Q. Purnell
    8. Melanie Gillingham
    9. Steven A. Shea
  • Sleep fragmentation induces heart failure in a hypertrophic cardiomyopathy mouse model by altering redox metabolism

    iScience
    1. Karthikeyan Bose
    2. Radhika Agrawal
    3. Thiagarajan Sairam
    4. Jessenya Mil
    5. Matthew P. Butler
    6. Perundurai S. Dhandapany
  • The potential role of chronic pain and the polytrauma clinical triad in predicting prodromal PD

    Clinical Parkinsonism and Related Disorders
    1. Lee E. Neilson
    2. Nadir M. Balba
    3. Jonathan E. Elliott
    4. Gregory D. Scott
    5. Scott D. Mist
    6. Matthew P. Butler
    7. Mary M. Heinricher
    8. Miranda M. Lim
  • A closer look at yoga nidra- early randomized sleep lab investigations

    Journal of Psychosomatic Research
    1. Erica Sharpe
    2. Matthew P. Butler
    3. Jesse Clark-Stone
    4. Ramin Soltanzadeh
    5. Ripu Jindal
    6. Douglas Hanes
    7. Ryan Bradley
  • Chronological distribution of readings in ambulatory blood-pressure monitoring exams affects the nighttime average and the magnitude of blood-pressure dipping

    American Journal of Physiology - Heart and Circulatory Physiology
    1. Leandro C. Brito
    2. Nicole P. Bowles
    3. Andrew W. McHill
    4. Sean P.M. Rice
    5. Matthew P. Butler
    6. Jonathan Emens
    7. Steven A. Shea
    8. Saurabh S. Thosar
  • Mistimed restricted feeding disrupts circadian rhythms of male mating behavior and female preovulatory LH surges in mice

    Hormones and Behavior
    1. Ayaka Kukino
    2. Thijs J. Walbeek
    3. Lori J. Sun
    4. Alexander T. Watt
    5. Jin Ho Park
    6. Alexander S. Kauffman
    7. Matthew P. Butler
  • Photosensitivity Is Associated with Chronic Pain following Traumatic Brain Injury

    Journal of neurotrauma
    1. Nadir M. Balba
    2. Alisha A. Mcbride
    3. Megan L. Callahan
    4. Scott D. Mist
    5. Kim Jones
    6. Matthew P. Butler
    7. Miranda Lim
    8. Mary M. Heinricher
  • The circadian system modulates the cortisol awakening response in humans

    Frontiers in Neuroscience
    1. Nicole P. Bowles
    2. Saurabh S. Thosar
    3. Matthew P. Butler
    4. Noal A. Clemons
    5. La Troy D. Robinson
    6. Omar H. Ordaz
    7. Maya X. Herzig
    8. Andrew W. McHill
    9. Sean P.M. Rice
    10. Jonathan Emens
    11. Steven A. Shea
  • A Closer Look at Yoga Nidra

    International journal of yoga therapy
    1. Erica Sharpe
    2. Alison Lacombe
    3. Matthew P. Butler
    4. Douglas Hanes
    5. Ryan Bradley
  • Different Methods for Traumatic Brain Injury Diagnosis Influence Presence and Symptoms of Post-Concussive Syndrome in United States Veterans

    Journal of neurotrauma
    1. Jonathan E. Elliott
    2. Nadir M. Balba
    3. Alisha A. McBride
    4. Megan L. Callahan
    5. Kendall T. Street
    6. Matthew P. Butler
    7. Mary M. Heinricher
    8. Miranda M. Lim
  • Non-REM apnea and hypopnea duration varies across population groups and physiologic traits

    American journal of respiratory and critical care medicine
    1. Priya V. Borker
    2. Michelle Reid
    3. Tamar Sofer
    4. Matthew P. Butler
    5. Ali Azarbarzin
    6. Heming Wang
    7. Andrew Wellman
    8. Scott A. Sands
    9. Susan Redline
  • Sleep efficiency is inversely associated with brachial artery diameter and morning blood pressure in midlife adults, with a potential sex-effect

    Nature and Science of Sleep
    1. Saurabh S. Thosar
    2. Daniel Chess
    3. Nicole P. Bowles
    4. Andrew W. McHill
    5. Matthew P. Butler
    6. Jonathan S. Emens
    7. Steven A. Shea
  • Circadian rhythm in negative affect

    Psychiatry Research
    1. Jonathan S. Emens
    2. Alec M. Berman
    3. Saurabh S. Thosar
    4. Matthew P. Butler
    5. Sally A. Roberts
    6. Noal A. Clemons
    7. Maya X. Herzig
    8. Andrew W. McHill
    9. Miki Morimoto
    10. Nicole P. Bowles
    11. Steven A. Shea
  • Effects of obstructive sleep apnea on endogenous circadian rhythms assessed during relaxed wakefulness; an exploratory analysis

    Chronobiology International
    1. Matthew P. Butler
    2. Saurabh S. Thosar
    3. Carolina Smales
    4. Pamela N. DeYoung
    5. Huijuan Wu
    6. Mohammad V. Hussain
    7. Miki Morimoto
    8. Kun Hu
    9. Frank A.J.L. Scheer
    10. Steven A. Shea
  • Natural food intake patterns have little synchronizing effect on peripheral circadian clocks

    BMC Biology
    1. Xiaobin Xie
    2. Ayaka Kukino
    3. Haley E. Calcagno
    4. Alec M. Berman
    5. Joseph P. Garner
    6. Matthew P. Butler
  • Apnea-hypopnea event duration predicts mortality in men and women in the sleep heart health study

    American journal of respiratory and critical care medicine
    1. Matthew P. Butler
    2. Jeffery T. Emch
    3. Michael Rueschman
    4. Scott A. Sands
    5. Steven A. Shea
    6. Andrew Wellman
    7. Susan Redline
  • Circadian Rhythm of Vascular Function in Midlife Adults

    Arteriosclerosis, thrombosis, and vascular biology
    1. Saurabh S. Thosar
    2. Alec M. Berman
    3. Maya X. Herzig
    4. Andrew W. McHill
    5. Nicole P. Bowles
    6. Christine M. Swanson
    7. Noal A. Clemons
    8. Matthew P. Butler
    9. Aaron A. Clemons
    10. Jonathan S. Emens
    11. Steven A. Shea
  • Circadian disruption of food availability significantly reduces reproductive success in mice

    Hormones and Behavior
    1. Shivam Swamy
    2. Xiaobin Xie
    3. Ayaka Kukino
    4. Haley E. Calcagno
    5. Michael R. Lasarev
    6. Jin Ho Park
    7. Matthew P. Butler
  • Rapid Response and Slow Recovery of the H3K4me3 Epigenomic Marker in the Liver after Light-mediated Phase Advances of the Circadian Clock

    Journal of biological rhythms
    1. Dmytro Grygoryev
    2. Michael R. Rountree
    3. Furaha Rwatambuga
    4. Anna Ohlrich
    5. Ayaka Kukino
    6. Matthew P. Butler
    7. Charles N. Allen
    8. Mitchell S. Turker
  • ATS core curriculum 2016

    Annals of the American Thoracic Society
    1. Jay S. Balachandran
    2. Carey C. Thomson
    3. Dezmond B. Sumter
    4. Anita V. Shelgikar
    5. Philippe Lachapelle
    6. Sushmita Pamidi
    7. Michael Fall
    8. Chitra Lal
    9. Ridhwan Y. Baba
    10. Neomi Shah
    11. Barry G. Fields
    12. Kathleen Sarmiento
    13. Matthew P. Butler
    14. Steven A. Shea
    15. Janelle V. Baptiste
    16. Katherine M. Sharkey
    17. Tisha Wang
  • Dorsomedial hypothalamic lesions counteract decreases in locomotor activity in male Syrian hamsters transferred from long to short day lengths

    Journal of biological rhythms
    1. Stephan G. Jarjisian
    2. Matthew P. Butler
    3. Matthew J. Paul
    4. Ned J. Place
    5. Brian J. Prendergast
    6. Lance J. Kriegsfeld
    7. Irving Zucker
  • Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes

    Sleep
    1. Deanna M. Arble
    2. Joseph Bass
    3. Cecilia Diniz Behn
    4. Matthew P. Butler
    5. Etienne Challet
    6. Charles Czeisler
    7. Christopher M. Depner
    8. Joel Elmquist
    9. Paul Franken
    10. Michael A. Grandner
    11. Erin C. Hanlon
    12. Alex C. Keene
    13. Michael J. Joyner
    14. Ilia Karatsoreos
    15. Philip A. Kern
    16. Samuel Klein
    17. Christopher J. Morris
    18. Allan I. Pack
    19. Satchidananda Panda
    20. Louis J. Ptacek
    21. Naresh M. Punjabi
    22. Paolo Sassone-Corsi
    23. Frank A. Scheer
    24. Richa Saxena
    25. Elizabeth R. Seaquest
    26. Matthew S. Thimgan
    27. Eve Van Cauter
    28. Kenneth P. Wright
  • Suprachiasmatic nucleus as the site of androgen action on circadian rhythms

    Hormones and Behavior
    1. Zina Model
    2. Matthew P. Butler
    3. Joseph LeSauter
    4. Rae Silver