Matthew Butler, Ph.D.
- Associate Professor, Oregon Institute of Occupational Health Sciences
- Behavioral Neuroscience Graduate Program, School of Medicine
Biography
I have a broad interest in how biological clocks are synchronized in organisms, and how these affect physiology and behavior. I have a particular interest in how shift work increases the risk for disease. Current efforts employ behavioral and physiological approaches in order to investigate the following:
1) Androgen receptors and sex differences in the biological clock
2) The effects of shift work on fertility
3) Sleep epidemiology
Education and training
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Degrees
- A.B., 1999, Dept. of Ecology and Evolutionary Biology, Princeton University
- Ph.D., 2007, Dept. of Integrative Biology, U.C. Berkeley
Memberships and associations:
- Society for Research on Biological Rhythms
- American Association of Sleep Medicine
- Sleep Research Society
- Society for Neuroscience
Areas of interest
- Biological rhythms and health
- Neuroendocrinology of sex differences
- Sleep epidemiology
Additional information
Publications
Selected publications
- Grygoryev D, Rountree MR, Rwatambuga F, Ohlrich A, Kukino A, Butler MP, Allen CN, Turker MS. In Press. Rapid response and slow recovery of the H3K4me3 epigenomic marker in the liver after a light-mediated phase advance of the circadian clock. Journal of Biological Rhythms.
- Thosar SS, Butler MP, Shea SA. In Press. Role of the circadian system in cardiovascular disease. Journal of Clinical Investigation.
- Butler MP, Smales C, Wu H, Hussain MV, Mohamed YA, Morimoto M, Shea SA. 2015. The circadian system contributes to apnea lengthening across the night in obstructive sleep apnea. Sleep 38: 1793-1801.
- Butler MP, Karatsoreos IN, LeSauter J, Silver R. 2012. Dose-dependent effects of androgens on the circadian timing system and its response to light. Endocrinology. 153: 2344-2352.
- Butler MP, Silver R. 2011. Divergent photic thresholds in the non-image forming visual system: entrainment, masking, and pupillary light reflex. Proceedings of the Royal Society B: Biological Sciences. 278: 745-750.
Publications
Identifying an acceptable number of ambulatory blood pressure measurements for accuracy of average blood pressure and nocturnal dipping status
American Journal of Physiology - Heart and Circulatory PhysiologyObesity alters the circadian profiles of energy metabolism and glucose regulation in humans
ObesitySleep fragmentation induces heart failure in a hypertrophic cardiomyopathy mouse model by altering redox metabolism
iScienceThe potential role of chronic pain and the polytrauma clinical triad in predicting prodromal PD
Clinical Parkinsonism and Related DisordersA closer look at yoga nidra- early randomized sleep lab investigations
Journal of Psychosomatic ResearchChronological distribution of readings in ambulatory blood-pressure monitoring exams affects the nighttime average and the magnitude of blood-pressure dipping
American Journal of Physiology - Heart and Circulatory PhysiologyMistimed restricted feeding disrupts circadian rhythms of male mating behavior and female preovulatory LH surges in mice
Hormones and BehaviorPhotosensitivity Is Associated with Chronic Pain following Traumatic Brain Injury
Journal of neurotraumaThe circadian system modulates the cortisol awakening response in humans
Frontiers in NeuroscienceA Closer Look at Yoga Nidra
International journal of yoga therapyDifferent Methods for Traumatic Brain Injury Diagnosis Influence Presence and Symptoms of Post-Concussive Syndrome in United States Veterans
Journal of neurotraumaNon-REM apnea and hypopnea duration varies across population groups and physiologic traits
American journal of respiratory and critical care medicineSleep efficiency is inversely associated with brachial artery diameter and morning blood pressure in midlife adults, with a potential sex-effect
Nature and Science of SleepCircadian rhythm in negative affect
Psychiatry ResearchEffects of obstructive sleep apnea on endogenous circadian rhythms assessed during relaxed wakefulness; an exploratory analysis
Chronobiology InternationalNatural food intake patterns have little synchronizing effect on peripheral circadian clocks
BMC BiologyApnea-hypopnea event duration predicts mortality in men and women in the sleep heart health study
American journal of respiratory and critical care medicineCircadian Rhythm of Vascular Function in Midlife Adults
Arteriosclerosis, thrombosis, and vascular biologyCircadian disruption of food availability significantly reduces reproductive success in mice
Hormones and BehaviorRapid Response and Slow Recovery of the H3K4me3 Epigenomic Marker in the Liver after Light-mediated Phase Advances of the Circadian Clock
Journal of biological rhythmsATS core curriculum 2016
Annals of the American Thoracic SocietyDorsomedial hypothalamic lesions counteract decreases in locomotor activity in male Syrian hamsters transferred from long to short day lengths
Journal of biological rhythmsImpact of Sleep and Circadian Disruption on Energy Balance and Diabetes
SleepSuprachiasmatic nucleus as the site of androgen action on circadian rhythms
Hormones and Behavior