Melanie B. Gillingham, Ph.D., R.D., L.D.

  • Professor of Molecular and Medical Genetics, School of Medicine
  • Director, Master's Program, Graduate Programs in Human Nutrition, School of Medicine
  • Molecular and Medical Genetics Graduate Program, School of Medicine
  • Graduate Programs in Human Nutrition, School of Medicine
  • Pediatrics, School of Medicine
  • Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, School of Medicine
  • Program in Molecular and Cellular Biosciences, School of Medicine

Education and training

  • Degrees

    • B.F.A., 1990, Texas Christian University
    • B.S., 1990, Texas Christian University
    • M.S., 1992, University of Oklahoma Health Science Center
    • Ph.D., 2000, University of Wisconsin-Madison

  • Fellowship

    • Post-doctoral Fellowship, OHSU Department of Molecular and Medical Genetics, 2001-2006

  • Certifications

    • Certificate in Human Investigations, OHSU 2005

Memberships and associations:

  • Genetic Metabolic Dietitians International (GMDI), President 2017-2019
  • Society of Inherited Metabolic Diseases (SIMD), Member, Board of Directors 2013-2016
  • American Society of Nutrition, member
  • Academy of Nutrition and Dietetics, member
  • AND Pediatrics Nutrition Practice Group, Research Awards and Chair 2015
  • AND SCAN, member
  • AND Research DPG, member

Areas of interest

  • Fatty acid oxidation, disorders, and essential fatty acids
  • Sports nutrition
  • Insulin resistance
  • Nutritional laboratory assessment
  • Retinopathy of LCHAD deficiency

Publications

Publications

  • D-BHB supplementation before moderate-intensity exercise suppresses lipolysis and selectively blunts exercise-induced long-chain acylcarnitine increase in pilot study of patients with long-chain fatty acid oxidation disorders

    Molecular Genetics and Metabolism
    1. Ashley N. Gregor
    2. Philippe Delerive
    3. Bernard Cuenoud
    4. Irina Monnard
    5. Karine Redeuil
    6. Cary Harding
    7. Melanie B. Gillingham

  • A proposal for an updated staging system for LCHADD retinopathy

    Ophthalmic Genetics
    1. Nida Wongchaisuwat
    2. Melanie B. Gillingham
    3. Paul Yang
    4. Lesley Everett
    5. Ashley Gregor
    6. Cary O. Harding
    7. Jose Alain Sahel
    8. Ken K. Nischal
    9. Hannah L. Scanga
    10. Danielle Black
    11. Jerry Vockley
    12. Georgianne Arnold
    13. Mark E. Pennesi

  • Associations between daily step count classifications and continuous glucose monitoring metrics in adults with type 1 diabetes

    Diabetologia
    1. Lauren V. Turner
    2. Martin Chase Marak
    3. Robin L. Gal
    4. Peter Calhoun
    5. Zoey Li
    6. Peter G. Jacobs
    7. Mark A. Clements
    8. Corby K. Martin
    9. Francis J. Doyle
    10. Susana R. Patton
    11. Jessica R. Castle
    12. Melanie B. Gillingham
    13. Roy W. Beck
    14. Michael R. Rickels
    15. Michael C. Riddell

  • Cardiac phenotype in adolescents and young adults with long-chain 3-hydroxyacyl CoA dehydrogenase (LCHAD) deficiency

    Genetics in Medicine
    1. Gabriela Elizondo
    2. Ajesh Saini
    3. Cesar Gonzalez de Alba
    4. Ashley Gregor
    5. Cary O. Harding
    6. Melanie B. Gillingham
    7. Jeffrey M. Vinocur

  • Combining uncertainty-aware predictive modeling and a bedtime Smart Snack intervention to prevent nocturnal hypoglycemia in people with type 1 diabetes on multiple daily injections

    Journal of the American Medical Informatics Association
    1. Clara Mosquera-Lopez
    2. Valentina Roquemen-Echeverri
    3. Nichole S. Tyler
    4. Susana R. Patton
    5. Mark A. Clements
    6. Corby K. Martin
    7. Michael C. Riddell
    8. Robin L. Gal
    9. Melanie Gillingham
    10. Leah M. Wilson
    11. Jessica R. Castle
    12. Peter G. Jacobs

  • Decline in Isotope Dilution Space Ratio Above Age 60 Could Affect Energy Estimates Using the Doubly Labeled Water Method

    Journal of Nutrition
    1. William W. Wong
    2. John R. Speakman
    3. Philip N. Ainslie
    4. Liam J. Anderson
    5. Leonore Arab
    6. Issad Baddou
    7. Kweku Bedu-Addo
    8. Ellen E. Blaak
    9. Stephane Blanc
    10. Alberto G. Bonomi
    11. Carlijn VC Bouten
    12. Pascal Bovet
    13. Maciej S. Buchowski
    14. Nancy F. Butte
    15. Stefan G. Camps
    16. Regina Casper
    17. Graeme L. Close
    18. Lisa H. Colbert
    19. Jamie A. Cooper
    20. Sai K. Das
    21. Peter SW Davies
    22. Simon Eaton
    23. Ulf Ekelund
    24. Catherine Hambly
    25. Asmaa El Hamdouchi
    26. Sonja Entringer
    27. Barry W. Fudge
    28. Melanie Gillingham
    29. Annelies H. Goris
    30. Micheal Gurven
    31. Marije B. Hoos
    32. Sumei Hu
    33. Annemiek Joosen
    34. Peter T. Katzmarzyk
    35. Kitty P. Kempen
    36. Misaka Kimura
    37. William E. Kraus
    38. Robert F. Kushner
    39. Christel L. Larsson
    40. James C. Morehen
    41. James P. Morton
    42. Marian L. Neuhouser
    43. Theresa A. Nicklas
    44. Robert M. Ojiambo
    45. Kirsi H. Pietilainen
    46. Yannis P. Pitsiladis
    47. Guy Plasqui
    48. Ross L. Prentice
    49. Roberto Rabinovich
    50. Susan B. Racette

  • Early diagnosis and treatment by newborn screening (NBS) or family history is associated with improved visual outcomes for long-chain 3-hydroxyacylCoA dehydrogenase deficiency (LCHADD) chorioretinopathy

    Journal of inherited metabolic disease
    1. Melanie B. Gillingham
    2. Dongseok Choi
    3. Ashley Gregor
    4. Nida Wongchaisuwat
    5. Danielle Black
    6. Hannah L. Scanga
    7. Ken K. Nischal
    8. Jose Alain Sahel
    9. Georgianne Arnold
    10. Jerry Vockley
    11. Cary O. Harding
    12. Mark E. Pennesi

  • Factors Affecting Reproducibility of Change in Glucose During Exercise

    Journal of Diabetes Science and Technology
    1. Zoey Li
    2. Peter Calhoun
    3. Michael R. Rickels
    4. Robin L. Gal
    5. Roy W. Beck
    6. Peter G. Jacobs
    7. Mark A. Clements
    8. Susana R. Patton
    9. Jessica R. Castle
    10. Corby K. Martin
    11. Melanie B. Gillingham
    12. Francis J. Doyle
    13. Michael C. Riddell

  • iPSC-Derived LCHADD Retinal Pigment Epithelial Cells Are Susceptible to Lipid Peroxidation and Rescued by Transfection of a Wildtype AAV-HADHA Vector

    Investigative ophthalmology & visual science
    1. Tiffany DeVine
    2. Gabriela Elizondo
    3. Garen Gaston
    4. Shannon J. Babcock
    5. Dietrich Matern
    6. Mikhail S. Shchepinov
    7. Mark E. Pennesi
    8. Cary O. Harding
    9. Melanie B. Gillingham

  • Obesity alters the circadian profiles of energy metabolism and glucose regulation in humans

    Obesity
    1. Andrew W. McHill
    2. Saurabh S. Thosar
    3. Nicole P. Bowles
    4. Matthew P. Butler
    5. Omar Ordaz-Johnson
    6. Jonathan S. Emens
    7. Jonathan Q. Purnell
    8. Melanie Gillingham
    9. Steven A. Shea

  • Patient-reported visual function outcomes agree with visual acuity and ophthalmologist-graded scoring of visual function among patients with long-chain 3-hydroxyacylcoA dehydrogenase deficiency (LCHADD)

    Molecular Genetics and Metabolism Reports
    1. Ashley N. Gregor
    2. Danielle Black
    3. Nida Wongchaisuwat
    4. Mark Pennesi
    5. Melanie B. Gillingham

  • The Association Between Diet Quality and Glycemic Outcomes Among People with Type 1 Diabetes

    Current Developments in Nutrition
    1. Melanie B. Gillingham
    2. Martin Chase Marak
    3. Michael C. Riddell
    4. Peter Calhoun
    5. Robin L. Gal
    6. Susana R. Patton
    7. Peter G. Jacobs
    8. Jessica R. Castle
    9. Mark A. Clements
    10. Francis J. Doyle
    11. Michael R. Rickels
    12. Corby K. Martin

  • The LCHADD Mouse Model Recapitulates Early-Stage Chorioretinopathy in LCHADD Patients

    Investigative Ophthalmology and Visual Science
    1. Shannon J. Babcock
    2. Allison G. Curtis
    3. Garen Gaston
    4. Gabriela Elizondo
    5. Melanie B. Gillingham
    6. Renee C. Ryals

  • A G1528C Hadha knock-in mouse model recapitulates aspects of human clinical phenotypes for long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency

    Communications Biology
    1. Garen Gaston
    2. Shannon Babcock
    3. Renee Ryals
    4. Gabriela Elizondo
    5. Tiffany DeVine
    6. Dahlia Wafai
    7. William Packwood
    8. Sarah Holden
    9. Jacob Raber
    10. Jonathan R. Lindner
    11. Mark E. Pennesi
    12. Cary O. Harding
    13. Melanie B. Gillingham

  • Examining the Acute Glycemic Effects of Different Types of Structured Exercise Sessions in Type 1 Diabetes in a Real-World Setting

    Diabetes care
    1. Michael C. Riddell
    2. Zoey Li
    3. Robin L. Gal
    4. Peter Calhoun
    5. Peter G. Jacobs
    6. Mark A. Clements
    7. Corby K. Martin
    8. Francis J. Doyle
    9. Susana R. Patton
    10. Jessica R. Castle
    11. Melanie B. Gillingham
    12. Roy W. Beck
    13. Michael R. Rickels

  • Greater male variability in daily energy expenditure develops through puberty

    Biology Letters
    1. Lewis G. Halsey
    2. Vincent Careau
    3. Philip N. Ainslie
    4. Heliodoro Alemán-Mateo
    5. Lene F. Andersen
    6. Liam J. Anderson
    7. Leonore Arab
    8. Issad Baddou
    9. Linda Bandini
    10. Kweku Bedu-Addo
    11. Ellen E. Blaak
    12. Stephane Blanc
    13. Alberto G. Bonomi
    14. Carlijn V.C. Bouten
    15. Pascal Bovet
    16. Soren Brage
    17. Maciej S. Buchowski
    18. Nancy Butte
    19. Stephan G. Camps
    20. Regian Casper
    21. Graeme L. Close
    22. Lisa H. Colbert
    23. Jamie A. Cooper
    24. Richard Cooper
    25. Prasangi Dabare
    26. Sai Krupa Das
    27. Peter S.W. Davies
    28. Sanjoy Deb
    29. Christine Delisle Nyström
    30. William Dietz
    31. Lara R. Dugas
    32. Simon Eaton
    33. Ulf Ekelund
    34. Asmaa El Hamdouchi
    35. Sonja Entringer
    36. Terrence Forrester
    37. Barry W. Fudge
    38. Melanie Gillingham
    39. Annelies H. Goris
    40. Michael Gurven
    41. Hinke Haisma
    42. Catherine Hambly
    43. Daniel Hoffman
    44. Marije B. Hoos
    45. Sumei Hu
    46. Noorjehan Joonas
    47. Annemiek Joosen
    48. Peter Katzmarzyk
    49. Kitty P. Kempen
    50. Misaka Kimura
    51. William E. Kraus
    52. Wantanee Kriengsinyos
    53. Rebecca Kuriyan
    54. Robert F. Kushner
    55. Estelle V. Lambert
    56. Pulani Lanerolle
    57. Christel L. Larsson
    58. Nader Lessan
    59. Marie Löf
    60. Corby Martin
    61. Eric Matsiko
    62. Gerwin A. Meijer
    63. James C. Morehen
    64. James P. Morton
    65. Aviva Must
    66. Marian Neuheuser
    67. Theresa A. Nicklas
    68. Robert M. Ojiambo
    69. Kirsi H. Pietilainen
    70. Yannis P. Pitsiladis
    71. Jacob Plange-Rhule
    72. Guy Plasqui
    73. Ross L. Prentice
    74. Roberto Rabinovich
    75. Susan B. Racette
    76. David A. Raichen
    77. Eric Ravussin
    78. Leanne Redman
    79. John J. Reilly
    80. Rebecca Reynolds
    81. Susan Roberts
    82. Jennifer C. Rood
    83. Dulani Samaranayake
    84. Luís B. Sardinha
    85. Albertine J. Scuitt
    86. Analiza M. Silva
    87. Srishti Sinha
    88. Anders M. Sjödin
    89. Eric Stice
    90. Albert Stunkard
    91. Samuel S. Urlacher
    92. Mauro Eduardo Valencia
    93. Giulio Valenti
    94. Ludo M. Van Etten
    95. Edgar A. Van Mil
    96. Jeanine A. Verbunt
    97. Jonathan C.K. Wells
    98. George Wilson
    99. Brian Wood
    100. Tsukasa Yoshida
    101. Xueying Zhang
    102. Alexia Murphy-Alford
    103. Cornelia Loechl
    104. Amy Luke
    105. Herman Pontzer
    106. Jennifer Rood
    107. Hiroyuki Sagayama
    108. Klaas R. Westerterp
    109. William W. Wong
    110. Yosuke Yamada
    111. John R. Speakman

  • Optical coherence tomography angiography of choroidal neovascularization in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD)

    American Journal of Ophthalmology Case Reports
    1. Nida Wongchaisuwat
    2. Jie Wang
    3. Paul Yang
    4. Lesley Everett
    5. Ashley Gregor
    6. Jose Alain Sahel
    7. Ken K. Nischal
    8. Mark E. Pennesi
    9. Melanie B. Gillingham
    10. Yali Jia

  • Resting and total energy expenditure of patients with long-chain fatty acid oxidation disorders (LC-FAODs)

    Molecular Genetics and Metabolism
    1. James P. DeLany
    2. Angela Horgan
    3. Ashley Gregor
    4. Jerry Vockley
    5. Cary O. Harding
    6. Melanie B. Gillingham

  • The Effect of Preoperative Carbohydrate Intake on Length of Stay and Postoperative Recovery Following Laparoscopic Living Donor Nephrectomy

    Journal of Renal Nutrition
    1. Morgan Kuiper
    2. Melanie Gillingham
    3. Julie Martin
    4. Daniella Gardner
    5. Sandra Van Calcar

  • The Type 1 Diabetes and EXercise Initiative

    Diabetes Technology and Therapeutics
    1. Simon Bergford
    2. Michael C. Riddell
    3. Peter G. Jacobs
    4. Zoey Li
    5. Robin L. Gal
    6. Mark A. Clements
    7. Francis J. Doyle
    8. Corby K. Martin
    9. Susana R. Patton
    10. Jessica R. Castle
    11. Melanie B. Gillingham
    12. Roy W. Beck
    13. Michael R. Rickels
    14. Peter Calhoun

  • Total daily energy expenditure has declined over the past three decades due to declining basal expenditure, not reduced activity expenditure

    Nature Metabolism
    1. John R. Speakman
    2. Jasper M.A. de Jong
    3. Srishti Sinha
    4. Klaas R. Westerterp
    5. Yosuke Yamada
    6. Hiroyuki Sagayama
    7. Philip N. Ainslie
    8. Liam J. Anderson
    9. Lenore Arab
    10. Kweku Bedu-Addo
    11. Stephane Blanc
    12. Alberto G. Bonomi
    13. Pascal Bovet
    14. Soren Brage
    15. Maciej S. Buchowski
    16. Nancy F. Butte
    17. Stefan G.J.A. Camps
    18. Jamie A. Cooper
    19. Richard Cooper
    20. Sai Krupa Das
    21. Peter S.W. Davies
    22. Lara R. Dugas
    23. Ulf Ekelund
    24. Sonja Entringer
    25. Terrence Forrester
    26. Barry W. Fudge
    27. Melanie Gillingham
    28. Santu Ghosh
    29. Annelies H. Goris
    30. Michael Gurven
    31. Lewis G. Halsey
    32. Catherine Hambly
    33. Hinke H. Haisma
    34. Daniel Hoffman
    35. Sumei Hu
    36. Annemiek M. Joosen
    37. Jennifer L. Kaplan
    38. Peter Katzmarzyk
    39. William E. Kraus
    40. Robert F. Kushner
    41. William R. Leonard
    42. Marie Löf
    43. Corby K. Martin
    44. Eric Matsiko
    45. Anine C. Medin
    46. Erwin P. Meijer
    47. Marian L. Neuhouser
    48. Theresa A. Nicklas
    49. Robert M. Ojiambo
    50. Kirsi H. Pietiläinen
    51. Jacob Plange-Rhule
    52. Guy Plasqui
    53. Ross L. Prentice
    54. Susan B. Racette
    55. David A. Raichlen
    56. Eric Ravussin
    57. Leanne M. Redman
    58. Susan B. Roberts
    59. Michael C. Rudolph
    60. Luis B. Sardinha
    61. Albertine J. Schuit
    62. Analiza M. Silva
    63. Eric Stice
    64. Samuel S. Urlacher
    65. Giulio Valenti
    66. Ludo M. Van Etten
    67. Edgar A. Van Mil
    68. Brian M. Wood
    69. Jack A. Yanovski
    70. Tsukasa Yoshida
    71. Xueying Zhang
    72. Alexia J. Murphy-Alford
    73. Cornelia U. Loechl
    74. Anura Kurpad
    75. Amy H. Luke
    76. Herman Pontzer
    77. Matthew S. Rodeheffer
    78. Jennifer Rood
    79. Dale A. Schoeller
    80. William W. Wong

  • Assessing Mealtime Macronutrient Content

    Diabetes Technology and Therapeutics
    1. Melanie B. Gillingham
    2. Zoey Li
    3. Roy W. Beck
    4. Peter Calhoun
    5. Jessica R. Castle
    6. Mark Clements
    7. Eyal Dassau
    8. Francis J. Doyle
    9. Robin L. Gal
    10. Peter Jacobs
    11. Susana R. Patton
    12. Michael R. Rickels
    13. Michael Riddell
    14. Corby K. Martin

  • Maternal dietary fat intake during pregnancy and newborn body composition

    Journal of Perinatology
    1. Natalie A. Damen
    2. Melanie Gillingham
    3. Joyanna G. Hansen
    4. Kent L. Thornburg
    5. Jonathan Q. Purnell
    6. Nicole E. Marshall

  • More Time in Glucose Range during Exercise Days than Sedentary Days in Adults Living with Type 1 Diabetes

    Diabetes Technology and Therapeutics
    1. Michael C. Riddell
    2. Zoey Li
    3. Roy W. Beck
    4. Robin L. Gal
    5. Peter G. Jacobs
    6. Jessica R. Castle
    7. Melanie B. Gillingham
    8. Mark Clements
    9. Susana R. Patton
    10. Eyal Dassau
    11. Francis J. Doyle
    12. Corby K. Martin
    13. Peter Calhoun
    14. Michael R. Rickels

  • A ketogenic & low-protein diet slows retinal degeneration in rd10 mice

    Translational Vision Science and Technology
    1. Renee C. Ryals
    2. Samuel J. Huang
    3. Dahlia Wafai
    4. Claire Bernert
    5. William Steele
    6. Makayla Six
    7. Shasank Bonthala
    8. Hope Titus
    9. Paul Yang
    10. Melanie Gillingham
    11. Mark E. Pennesi

  • Cardiac tissue citric acid cycle intermediates in exercised very long-chain acyl-CoA dehydrogenase-deficient mice fed triheptanoin or medium-chain triglyceride

    Journal of inherited metabolic disease
    1. Garen Gaston
    2. Jon A. Gangoiti
    3. Shelley Winn
    4. Benjamin Chan
    5. Bruce A. Barshop
    6. Cary O. Harding
    7. Melanie B. Gillingham

  • Effects of fasting, feeding and exercise on plasma acylcarnitines among subjects with CPT2D, VLCADD and LCHADD/TFPD

    Molecular Genetics and Metabolism
    1. Gabriela Elizondo
    2. Dietrich Matern
    3. Jerry Vockley
    4. Cary O. Harding
    5. Melanie B. Gillingham

  • Nutrient intake, body composition, and blood phenylalanine control in children with phenylketonuria compared to healthy controls

    Molecular Genetics and Metabolism Reports
    1. Melissa Sailer
    2. Gabriela Elizondo
    3. Julie Martin
    4. Cary O. Harding
    5. Melanie B. Gillingham

  • Blood cytokine patterns suggest a modest inflammation phenotype in subjects with long-chain fatty acid oxidation disorders

    Physiological reports
    1. Colin S. McCoin
    2. Melanie B. Gillingham
    3. Trina A. Knotts
    4. Jerry Vockley
    5. Kikumi D. Ono-Moore
    6. Michael L. Blackburn
    7. Jennifer E. Norman
    8. Sean H. Adams