Melanie Harriff, Ph.D.

  • Associate Professor of Medicine, Division of Pulmonary and Critical Care Medicine, School of Medicine

Biography

Melanie Harriff received her Ph.D. in Molecular and Cellular Biology in 2007 from Oregon State University in the laboratories of Luiz Bermudez and Michael Kent. Following a year-long postdoctoral research position in the laboratory of Gary Thomas at the Vollum Institute at Oregon Health & Sciences University, Harriff worked as a postdoctoral research fellow in the Department of Pulmonary and Critical Care Medicine at OHSU, in the laboratory of David Lewinsohn. She joined the Research Department at the Portland VA Medical Center as a Research Microbiologist in 2011, and is also an Associate Professor in the Department of Pulmonary and Critical Care Medicine at OHSU.

Education and training

  • Degrees

    • Ph.D., 2007, Oregon State University

  • Fellowship

    • Postdoctoral Fellowship, Oregon Health & Science University, 2011

Publications

Publications

  • Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation

    Communications Biology
    1. Corinna A. Kulicke
    2. Gwendolyn M. Swarbrick
    3. Nicole A. Ladd
    4. Meghan Cansler
    5. Megan Null
    6. Aneta Worley
    7. Chance Lemon
    8. Tania Ahmed
    9. Joshua Bennett
    10. Taylor N. Lust
    11. Chelsea M. Heisler
    12. Megan E. Huber
    13. Jason R. Krawic
    14. Laurisa M. Ankley
    15. Savannah K. McBride
    16. Fikadu G. Tafesse
    17. Andrew J. Olive
    18. William H. Hildebrand
    19. Deborah A. Lewinsohn
    20. Erin J. Adams
    21. David M. Lewinsohn
    22. Melanie J. Harriff

  • Chronic Obstructive Pulmonary Disease and Cigarette Smoke Lead to Dysregulated Mucosal-associated Invariant T-Cell Activation

    American journal of respiratory cell and molecular biology
    1. Megan E. Huber
    2. Emily Larson
    3. Taylor N. Lust
    4. Chelsea M. Heisler
    5. Melanie J. Harriff

  • Phagocytosis is a primary determinant of pulmonary clearance of clinical Klebsiella pneumoniae isolates

    Frontiers in Cellular and Infection Microbiology
    1. Rick van der Geest
    2. Hongye Fan
    3. Hernán F. Peñaloza
    4. William G. Bain
    5. Zeyu Xiong
    6. Naina Kohli
    7. Emily Larson
    8. Mara L.G. Sullivan
    9. Jonathan M. Franks
    10. Donna B. Stolz
    11. Ryota Ito
    12. Kong Chen
    13. Yohei Doi
    14. Melanie J. Harriff
    15. Janet S. Lee

  • Augmentation of the Riboflavin-Biosynthetic Pathway Enhances Mucosa-Associated Invariant T (MAIT) Cell Activation and Diminishes Mycobacterium tuberculosis Virulence

    mBio
    1. Ruchi Jain Dey
    2. Bappaditya Dey
    3. Melanie Harriff
    4. Elizabeth T. Canfield
    5. David M. Lewinsohn
    6. William R. Bishai

  • Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells

    Scientific Reports
    1. Haihong Jin
    2. Nicole A. Ladd
    3. Andrew M. Peev
    4. Gwendolyn M. Swarbrick
    5. Meghan Cansler
    6. Megan Null
    7. Christopher T. Boughter
    8. Curtis McMurtrey
    9. Aaron Nilsen
    10. Karen M. Dobos
    11. William H. Hildebrand
    12. Deborah A. Lewinsohn
    13. Erin J. Adams
    14. David M. Lewinsohn
    15. Melanie J. Harriff

  • Construction and validation of an ultraviolet germicidal irradiation system using locally available components

    PloS one
    1. Eric Schnell
    2. Elham Karamooz
    3. Melanie J. Harriff
    4. Jane E. Yates
    5. Christopher Pfeiffer
    6. Stephen M. Smith

  • Alternative splicing of MR1 regulates antigen presentation to MAIT cells

    Scientific Reports
    1. Gitanjali A. Narayanan
    2. Abhinav Nellore
    3. Jessica Tran
    4. Aneta H. Worley
    5. Erin W. Meermeier
    6. Elham Karamooz
    7. Megan E. Huber
    8. Regina Kurapova
    9. Fikadu G. Tafesse
    10. Melanie J. Harriff
    11. David M. Lewinsohn

  • Rab6 regulates recycling and retrograde trafficking of MR1 molecules

    Scientific Reports
    1. Megan E. Huber
    2. Regina Kurapova
    3. Chelsea M. Heisler
    4. Elham Karamooz
    5. Fikadu G. Tafesse
    6. Melanie J. Harriff

  • MR1 recycling and blockade of endosomal trafficking reveal distinguishable antigen presentation pathways between Mycobacterium tuberculosis infection and exogenously delivered antigens

    Scientific Reports
    1. Elham Karamooz
    2. Melanie J. Harriff
    3. Gitanjali A. Narayanan
    4. Aneta Worley
    5. David M. Lewinsohn

  • MAIT cells and microbial immunity

    Immunology and Cell Biology
    1. Erin W. Meermeier
    2. Melanie J. Harriff
    3. Elham Karamooz
    4. David M. Lewinsohn

  • MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage

    Science Immunology
    1. Melanie J. Harriff
    2. Curtis McMurtrey
    3. Cara A. Froyd
    4. Haihong Jin
    5. Meghan Cansler
    6. Megan Null
    7. Aneta Worley
    8. Erin W. Meermeier
    9. Gwendolyn Swarbrick
    10. Aaron Nilsen
    11. Deborah A. Lewinsohn
    12. William Hildebrand
    13. Erin J. Adams
    14. David M. Lewinsohn

  • Riboflavin metabolism variation among clinical isolates of streptococcus pneumoniae results in differential activation of mucosal-Associated invariant T cells

    American journal of respiratory cell and molecular biology
    1. Nadine Hartmann
    2. Curtis McMurtrey
    3. Michelle L. Sorensen
    4. Megan E. Huber
    5. Regina Kurapova
    6. Fadie T. Coleman
    7. Joseph P. Mizgerd
    8. William Hildebrand
    9. Mitchell Kronenberg
    10. David M. Lewinsohn
    11. Melanie J. Harriff

  • Role of MAIT cells in pulmonary bacterial infection

    Molecular Immunology
    1. Nadine Hartmann
    2. Melanie J. Harriff
    3. Curtis P. McMurtrey
    4. William H. Hildebrand
    5. David M. Lewinsohn
    6. Mitchell Kronenberg

  • HLA-E Presents Glycopeptides from the Mycobacterium tuberculosis Protein MPT32 to Human CD8+ T cells

    Scientific Reports
    1. Melanie J. Harriff
    2. Lisa M. Wolfe
    3. Gwendolyn Swarbrick
    4. Megan Null
    5. Meghan E. Cansler
    6. Elizabeth T. Canfield
    7. Todd Vogt
    8. Katelynne Gardner Toren
    9. Wei Li
    10. Mary Jackson
    11. Deborah A. Lewinsohn
    12. Karen M. Dobos
    13. David M. Lewinsohn

  • MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates

    Mucosal Immunology
    1. J. M. Greene
    2. P. Dash
    3. S. Roy
    4. C. McMurtrey
    5. W. Awad
    6. J. S. Reed
    7. K. B. Hammond
    8. S. Abdulhaqq
    9. H. L. Wu
    10. B. J. Burwitz
    11. B. F. Roth
    12. D. W. Morrow
    13. J. C. Ford
    14. G. Xu
    15. J. Y. Bae
    16. H. Crank
    17. A. W. Legasse
    18. T. H. Dang
    19. H. Y. Greenaway
    20. M. Kurniawan
    21. M. C. Gold
    22. M. J. Harriff
    23. D. A. Lewinsohn
    24. B. S. Park
    25. M. K. Axthelm
    26. J. J. Stanton
    27. S. G. Hansen
    28. L. J. Picker
    29. V. Venturi
    30. W. Hildebrand
    31. P. G. Thomas
    32. D. M. Lewinsohn
    33. E. J. Adams
    34. J. B. Sacha

  • T cell recognition of Mycobacterium tuberculosis peptides presented by HLA-E derived from infected human cells

    PloS one
    1. Curtis McMurtrey
    2. Melanie J. Harriff
    3. Gwendolyn M. Swarbrick
    4. Amanda Duncan
    5. Meghan Cansler
    6. Megan Null
    7. Wilfried Bardet
    8. Kenneth W. Jackson
    9. Deborah A. Lewinsohn
    10. William Hildebrand
    11. David M. Lewinsohn

  • The Mycobacterium tuberculosis MmpL11 cell wall lipid transporter is important for biofilm formation, intracellular growth, and nonreplicating persistence

    Infection and Immunity
    1. Catherine C. Wright
    2. Fong Fu Hsu
    3. Eusondia Arnett
    4. Jennifer L. Dunaj
    5. Patrick M. Davidson
    6. Sophia A. Pacheco
    7. Melanie J. Harriff
    8. David M. Lewinsohn
    9. Larry S. Schlesinger
    10. Georgiana E. Purdy

  • Endosomal MR1 Trafficking Plays a Key Role in Presentation of Mycobacterium tuberculosis Ligands to MAIT Cells

    PLoS pathogens
    1. Melanie J. Harriff
    2. Elham Karamooz
    3. Ansen Burr
    4. Wilmon F. Grant
    5. Elizabeth T. Canfield
    6. Michelle L. Sorensen
    7. Luis F. Moita
    8. David M. Lewinsohn

  • Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens

    Nature communications
    1. Erin W. Meermeier
    2. Bruno F. Laugel
    3. Andrew K. Sewell
    4. Alexandra J. Corbett
    5. Jamie Rossjohn
    6. James McCluskey
    7. Melanie J. Harriff
    8. Tamera Franks
    9. Marielle C. Gold
    10. David M. Lewinsohn

  • Human lung epithelial cells contain Mycobacterium tuberculosis in a late endosomal vacuole and are efficiently recognized by CD8+ T Cells

    PloS one
    1. Melanie J. Harriff
    2. Meghan E. Cansler
    3. Katelynne Gardner Toren
    4. Elizabeth T. Canfield
    5. Stephen Kwak
    6. Marielle C. Gold
    7. David M. Lewinsohn

  • TAP mediates import of Mycobacterium tuberculosis-derived peptides into phagosomes and facilitates loading onto HLA-I

    PloS one
    1. Melanie J. Harriff
    2. Sven Burgdorf
    3. Christian Kurts
    4. Emmanuel J.H.J. Wiertz
    5. Deborah A. Lewinsohn
    6. David M. Lewinsohn

  • Human mucosal associated invariant T cells detect bacterially infected cells

    PLoS Biology
    1. Marielle C. Gold
    2. Stefania Cerri
    3. Susan Smyk-Pearson
    4. Meghan E. Cansler
    5. Todd M. Vogt
    6. Jacob Delepine
    7. Ervina Winata
    8. Gwendolyn M. Swarbrick
    9. Wei Jen Chua
    10. Yik Y.L. Yu
    11. Olivier Lantz
    12. Matthew S. Cook
    13. Megan D. Null
    14. David B. Jacoby
    15. Melanie J. Harriff
    16. Deborah A. Lewinsohn
    17. Ted H. Hansen
    18. David M. Lewinsohn

  • Mycobacterium avium genes MAV-5138 and MAV-3679 are transcriptional regulators that play a role in invasion of epithelial cells, in part by their regulation of CipA, a putative surface protein interacting with host cell signaling pathways

    Journal of bacteriology
    1. Melanie J. Harriff
    2. Lia Danelishvili
    3. Martin Wu
    4. Cara Wilder
    5. Michael McNamara
    6. Michael L. Kent
    7. Luiz E. Bermudez

  • The Mycobacterium tuberculosis Phagosome Is a HLA-I Processing Competent Organelle

    PLoS pathogens
    1. Jeff E. Grotzke
    2. Melanie J. Harriff
    3. Anne C. Siler
    4. Dawn Nolt
    5. Jacob Delepine
    6. Deborah A. Lewinsohn
    7. David M. Lewinsohn