Michael Axthelm, D.V.M., Ph.D.
- Associate Professor, Oregon National Primate Research Center
Biography
Dr. Axthelm completed his D.V.M. degree and pathology residency program at Kansas State University and is a board-certified veterinary anatomic pathologist. He then went to the Ohio State University for postdoctoral training and received his Ph.D. in viral pathogenesis degree in 1985. He was an assistant professor at the Ohio State University College of Veterinary Medicine until joining the Primate Research Center staff in 1986. Currently, Dr. Axthelm is an associate scientist in the Division of Pathobiology and Immunology, Oregon National Primate Research Center, and Senior Scientist in the Vaccine and Gene Therapy Institute.
Current research projects include 1) investigation of the role of T cell dynamics in simian immunodeficiency virus (SIV) infection, and delineation of viral mechanisms of pathogenesis targeting these dynamics, 2) development of rhesus cytomegalovirus-vectored vaccines for SIV, 3) evaluating mucosal vaccine strategies against SIV/HIV, 4) vaccine strategies for emerging viral and bacterial diseases and 5) identification and characterization of new viral agents and viral-associated disease states in nonhuman primates, which currently include spontaneous multiple sclerosis-like demyelinating encephalomyelitis associated with a novel gammma-2 herpesvirus, and progressive multifocal leukoencephalopathy in immunosuppressed macaques associated with variant simian virus 40 polyomavirus.
Publications
Publications
Generation of chimeric forms of rhesus macaque rhadinovirus expressing KSHV envelope glycoproteins gH and gL for utilization in an NHP model of infection
Journal of virologyA model of lymphocryptovirus-associated post-transplant lymphoproliferative disorder in immunosuppressed Mauritian cynomolgus macaques
PLoS pathogensAnti–PD-1 chimeric antigen receptor T cells efficiently target SIV-infected CD4+ T cells in germinal centers
Journal of Clinical InvestigationCD8+ T cell targeting of tumor antigens presented by HLA-E
Science AdvancesDevelopment of a hydrogen peroxide-inactivated vaccine that protects against viscerotropic yellow fever in a non-human primate model
Cell Reports MedicineEarly antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir
PLoS pathogensImpact of alemtuzumab-mediated lymphocyte depletion on SIV reservoir establishment and persistence
PLoS pathogensMultivalent MVA-vectored vaccine elicits EBV neutralizing antibodies in rhesus macaques that reduce EBV infection in humanized mice
Frontiers in immunologyAllogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected ART-suppressed macaques
ImmunityIdentification of Vancomycin Resistance in Methicillin-resistant Staphylococcus aureus in two macaque species and decolonization and long-term prevention of recolonization in Cynomolgus Macaques (Macaca fascicularis)
Frontiers in immunologyMayaro virus pathogenesis and immunity in rhesus macaques
PLoS neglected tropical diseasesTherapeutic neutralizing monoclonal antibody administration protects against lethal yellow fever virus infection
Science translational medicineAntimicrobial prophylaxis does not improve post-surgical outcomes in SIV/SHIV-uninfected or SIV/SHIV-infected macaques (Macaca mulatta and Macaca fascicularis) based on a retrospective analysis
PloS oneCytomegalovirus-vaccine-induced unconventional T cell priming and control of SIV replication is conserved between primate species
Cell Host and MicrobeMyeloid cell tropism enables MHC-E-restricted CD8+ T cell priming and vaccine efficacy by the RhCMV/SIV vaccine
Science ImmunologyOptimization and use of near infrared imaging to guide lymph node collection in rhesus macaques (Macaca mulatta)
Journal of medical primatologyRapamycin limits CD4+ T cell proliferation in simian immunodeficiency virus-infected rhesus macaques on antiretroviral therapy
Journal of Clinical InvestigationThe ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription
PLoS pathogensCD8+T cells fail to limit SIV reactivation following ART withdrawal until after viral amplification
Journal of Clinical InvestigationCytomegaloviral determinants of CD8+T cell programming and RhCMV/SIV vaccine efficacy
Science ImmunologyInterleukin-15 response signature predicts RhCMV/SIV vaccine efficacy
PLoS pathogensMitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques
PLoS pathogensModified Adenovirus Prime-Protein Boost Clade C HIV Vaccine Strategy Results in Reduced Viral DNA in Blood and Tissues Following Tier 2 SHIV Challenge
Frontiers in immunologyModulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy
ScienceMyelin-specific T cells in animals with Japanese macaque encephalomyelitis
Annals of Clinical and Translational NeurologyTerumo spectra optia leukapheresis of cynomolgus macaques for hematopoietic stem cell and T cell collection
Journal of Clinical ApheresisTGFβ restricts expansion, survival, and function of T cells within the tuberculous granuloma
Cell Host and MicrobeUltra-low Dose Aerosol Infection of Mice with Mycobacterium tuberculosis More Closely Models Human Tuberculosis
Cell Host and MicrobeIn vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome
PLoS pathogens