Michael I. Henderson, B.A.

  • Ph.D. Candidate, Biomedical Engineering Graduate Program, School of Medicine
  • Member, CEDAR, OHSU Knight Cancer Institute, School of Medicine

Biography

Michael Henderson is a biomedical engineering Ph.D. student and a CEDAR member after earning his bachelor's degree in biochemistry and molecular biology from Carroll College. Before joining OHSU, he worked under the tutelage of Dr. Gaurav Sahay at Oregon State University and studied gene delivery using lipid nanoparticles. His previous research experience spans chemical synthesis for clean energy storage, rational drug design, non-viral therapeutics for cystic fibrosis, cold storage of mRNA vaccines, mRNA delivery to the eye, and mRNA lipid nanoparticles as a platform for adjuvant therapies. Co-mentored by Dr. Stuart Ibsen and Dr. Adem Yildirim, he is developing methods to improve immunotherapies efficacy and enrich liquid biopsy using non-invasive responsive nanomaterials and protein blockers. His extracurricular passions include photography, mountaineering, and regional-international health outreach.

Education and training

  • Degrees

    • B.A., 2021, Carroll College

Memberships and associations:

  • Biomedical Engineering Society (BMES), 2023 - Present
  • American Association for Cancer Research (AACR), 2023 - Present

Areas of interest

  • Cancer Nanomedicine
  • Theraputic Ultrasound
  • Immunoengineering
  • Translational Drug Delivery/Gene Therapy

Additional information

Honors and awards

  • Best Poster, Oregon Bioengineering Symposium, 2023
  • National Academies of Sciences Ford Fellowship Honorable Mention, 2023
  • Ted R. Lilley CURE Program Student-Mentor Award, 2019, 2023
  • Best Poster Presentation, OHSU RNAissance Meeting, 2022
  • Carroll College Service Leadership Scholar, 2016-2020

Publications

Selected publications

  • Eygeris, Yulia; Henderson, Michael; Curtis, Allison; Jozić, Antony; Stoddard, Jonathan; Reynaga, Rene; Chirco, Kathleen; Su, Grace; Neuringer, Martha; Lauer, Andreas; Ryals, Renee; Sahay, Gaurav. "Preformed Vesicle Approach to LNP Manufacturing Enhances Retinal mRNA Delivery." Small, (2024).
  • Henderson, Michael; Eygeris, Yulia; Jozić, Antony; Herrera, Marco; Sahay, Gaurav. "Leveraging Biological Buffers for Efficient Messenger RNA Delivery via Lipid Nanoparticles." Molecular Pharmaceutics, (2022).
  • Mukherjee, Anindit; Macdonald, Kelvin; Kim, Jeonghwan; Henderson, Michael; Eygeris, Yulia; Sahay, Gaurav. "Engineered mutant α-ENaC subunit mRNA delivered by lipid nanoparticles reduces amiloride currents in cystic fibrosis–based cell and mice models." Sciences Advances, (2020).

Publications