Nabil J. Alkayed, M.D., Ph.D

  • Professor of Anesthesiology and Perioperative Medicine, School of Medicine
  • Neuroscience Graduate Program, School of Medicine
  • Program in Molecular and Cellular Biosciences, School of Medicine

Biography

Dr. Nabil Alkayed is a Professor of Anesthesiology & Perioperative Medicine, Neurology, Neurological Surgery, Cardiovascular Medicine and Physiology & Pharmacology at Oregon Health & Science University (OHSU). He holds The James Metcalfe Chair in Cardiovascular Research, and serves as Director of Research at The Knight Cardiovascular Institute (KCVI). Dr. Alkayed grew up in Amman, Jordan. He received his MD degree from Stavropol State Medical Academy in Stavropol, Russia, and a PhD in Physiology from the Medical College of Wisconsin, Milwaukee, WI. He completed a postdoctoral fellowship at Johns Hopkins University School of Medicine, where he also held his first faculty appointment as Assistant Professor and later promoted to Associate Professor of Anesthesiology & Critical Care Medicine. In 2004, he relocated to OHSU as a tenured Associate Professor, and in 2008, he was promoted to Full Professor in Anesthesiology & Perioperative Medicine and Physiology and Pharmacology. In 2011, he became the Vice Chair of Anesthesiology, and in 2016, Director of Research at KCVI. He is a member of the Association of University Anesthesiologists (AUA) and an elected Fellow of the American Heart Association (AHA) Stroke Council. He has published more than 120 scientific papers related to his work on experimental stroke and vascular cognitive impairment. He served on the Editorial Boards of prominent journals in the fields of stroke and vascular biology, including Stroke, American Journal of Physiology-Heart & Circulation, Journal of Cerebral Blood Flow & Metabolism and Translational Stroke Research. His research program is funded by 2 R01 grants from the NIH, a small business grant and a T32 training grant. He is an active member of grant review panels at the National Institute of Health (NIH) and the American Heart Association (AHA). He is a member of the College of CSR Reviewers. He is Director of the KCVI T32 Training in Translational Science and Cardiovascular Medicine, and has mentored many students, fellows and junior faculty, who went on to develop their own independent research careers.

Education and training

  • Degrees

    • M.D., 1986, Stavropol State Medical Academy
    • Ph.D., 1996, Medical College of Wisconsin
  • Fellowship

    • Postdoctoral Fellowship in Cerebral Ischemia, Johns Hopkins University, Baltimore, MD, 1996-1998

Memberships and associations:

  • American Physiological Society Society for NeuroscienceFellow of the American Heart Association Stroke CouncilInternational Soceity of Cerebral Blood Flow and MetabolismAssociation of University Anesthesiologists

Publications

Publications

  • Basic Science and Pathogenesis

    Alzheimer's & dementia : the journal of the Alzheimer's Association
    1. Mackenzie N. Kehmeier
    2. Alexandra Famiano
    3. Thomas A. Leonhardt
    4. Sky J. Ferguson
    5. Nabil J. Alkayed
    6. Ashley E. Walker
  • Blood-Brain Barrier

    Stroke
    1. Nabil J. Alkayed
  • Metabolomics of repetitive myocardial stunning in chronic multivessel coronary artery stenosis

    Journal of Physiology
    1. D. Elizabeth Le
    2. Nabil J. Alkayed
    3. Zhiping Cao
    4. Natasha Chattergoon
    5. Manuel Garcia-Jaramillo
    6. Kent Thornburg
    7. Sanjiv Kaul
  • The Association between EPHX1 Gene Polymorphisms and Lung Cancer among Jordanian People

    Asian Pacific Journal of Cancer Prevention
    1. Tamara E. Al-Qudah
    2. Said Ismail
    3. Dana Abdeen
    4. Nidaa A. Ababneh
    5. Faisal Khatib
    6. Mohamed K. Al-Essa
    7. Feras Hawari
    8. Nathir Obeidat
    9. Nabil J. Alkayed
    10. Yanal Shafagoj
  • Fluid dynamics in aging-related dementias

    Neurobiology of Disease
    1. Thierno M. Bah
    2. Dominic A. Siler
    3. Aseel H. Ibrahim
    4. Justin S. Cetas
    5. Nabil J. Alkayed
  • GPR39 Knockout Worsens Microcirculatory Response to Experimental Stroke in a Sex-Dependent Manner

    Translational Stroke Research
    1. Yifan Xu
    2. Wenri H. Zhang
    3. Elyse M. Allen
    4. Lev M. Fedorov
    5. Anthony P. Barnes
    6. Zu Yuan Qian
    7. Thierno Madjou Bah
    8. Yuandong Li
    9. Ruikang K. Wang
    10. Robert E. Shangraw
    11. Nabil J. Alkayed
  • Low-Intensity Ultrasound Reduces Brain Infarct Size by Upregulating Phosphorylated Endothelial Nitric Oxide in Mouse Model of Middle Cerebral Artery Occlusion

    Ultrasound in Medicine and Biology
    1. Catherine M. Davis
    2. Azzdine Y. Ammi
    3. Wenbin Zhu
    4. Carmen Methner
    5. Zhiping Cao
    6. David Giraud
    7. Nabil J. Alkayed
    8. Randy L. Woltjer
    9. Sanjiv Kaul
  • Sex Difference in Capillary Reperfusion after Transient Middle Cerebral Artery Occlusion in Diabetic Mice

    Stroke
    1. Wenbin Zhu
    2. Catherine M. Davis
    3. Elyse M. Allen
    4. Sarah L. Feller
    5. Thierno M. Bah
    6. Robert E. Shangraw
    7. Ruikang K. Wang
    8. Nabil J. Alkayed
  • The Ever-Evolving Concept of the Neurovascular Unit

    Stroke
    1. Nabil J. Alkayed
    2. Marilyn J. Cipolla
  • Vascular Biology of Dementia

    Stroke
    1. Marilyn J. Cipolla
    2. Nabil J. Alkayed
  • A Double-Blind, Randomized, Placebo-Controlled Trial of Soluble Epoxide Hydrolase Inhibition in Patients with Aneurysmal Subarachnoid Hemorrhage

    Neurocritical Care
    1. Ross P. Martini
    2. Dominic Siler
    3. Justin Cetas
    4. Nabil J. Alkayed
    5. Elyse Allen
    6. Miriam M. Treggiari
  • A Novel Model of Tobacco Smoke–Mediated Aortic Injury

    Vascular and Endovascular Surgery
    1. Amir F. Azarbal
    2. Tana Repella
    3. Eric Carlson
    4. Elise C. Manalo
    5. Braden Palanuk
    6. Nasibeh Vatankhah
    7. Keith Zientek
    8. Douglas R. Keene
    9. Wenri Zhang
    10. Cherrie Z. Abraham
    11. Gregory L. Moneta
    12. Gregory J. Landry
    13. Nabil J. Alkayed
    14. Lynn Y. Sakai
  • Control of coronary vascular resistance by eicosanoids via a novel GPCR

    American Journal of Physiology - Cell Physiology
    1. Sanjiv Kaul
    2. Anthony P. Barnes
    3. Nabil J. Alkayed
    4. Zhiping Cao
    5. Zu Yuan Qian
    6. Shanthi Nagarajan
    7. Xuehong Liu
    8. Jonathan W. Nelson
    9. Fuchun Xie
    10. Bingbing Li
    11. Wei Fan
    12. Lijuan Liu
    13. Marjorie R. Grafe
    14. Xiangshu Xiao
    15. Catherine M. Davis
  • Eicosanoid ratios are associated with hemorrhage severity and predict development of delayed cerebral ischemia following subarachnoid hemorrhage

    Brain Hemorrhages
    1. Dominic A. Siler
    2. Alexa M. Semonche
    3. Ravi Samatham
    4. Jesse J. Liu
    5. Ross P. Martini
    6. Nabil J. Alkayed
    7. Holly E. Hinson
    8. Justin S. Cetas
  • GPR39 Deficiency Impairs Memory and Alters Oxylipins and Inflammatory Cytokines Without Affecting Cerebral Blood Flow in a High-Fat Diet Mouse Model of Cognitive Impairment

    Frontiers in Cellular Neuroscience
    1. Thierno M. Bah
    2. Elyse M. Allen
    3. Manuel Garcia-Jaramillo
    4. Ruby Perez
    5. Yalda Zarnegarnia
    6. Catherine M. Davis
    7. Madeline B. Bloom
    8. Armando A. Magana
    9. Jaewoo Choi
    10. Gerd Bobe
    11. Martin M. Pike
    12. Jacob Raber
    13. Claudia S. Maier
    14. Nabil J. Alkayed
  • Proteomic profiling of concurrently isolated primary microvascular endothelial cells, pericytes, and vascular smooth muscle cells from adult mouse heart

    Scientific Reports
    1. Zhiping Cao
    2. Jessica Minnier
    3. Lijuan Liu
    4. Kristin L.Lyon Scott
    5. Ashok P. Reddy
    6. Phillip A. Wilmarth
    7. Larry L. David
    8. Anthony P. Barnes
    9. Marjorie R. Grafe
    10. Sanjiv Kaul
    11. Nabil J. Alkayed
    12. Catherine M. Davis
  • Role of Endothelial Cells and Platelets in COVID-Related Cerebrovascular Events

    Stroke
    1. Nabil J. Alkayed
    2. Marilyn J. Cipolla
  • Role of Endothelial STAT3 in Cerebrovascular Function and Protection from Ischemic Brain Injury

    International journal of molecular sciences
    1. Catherine M. Davis
    2. Kristin Lyon-Scott
    3. Elena V. Varlamov
    4. Wenri H. Zhang
    5. Nabil J. Alkayed
  • Age-dependent transcriptional alterations in cardiac endothelial cells

    Physiological genomics
    1. Uchenna Emechebe
    2. Jonathan W. Nelson
    3. Nabil J. Alkayed
    4. Sanjiv Kaul
    5. Andrew C. Adey
    6. Anthony P. Barnes
  • Gene-Specific DNA methylation linked to postoperative cognitive dysfunction in apolipoprotein E3 and E4 mice

    Journal of Alzheimer's Disease
    1. Katie J. Schenning
    2. Sarah Holden
    3. Brett A. Davis
    4. Amelia Mulford
    5. Kimberly A. Nevonen
    6. Joseph F. Quinn
    7. Jacob Raber
    8. Lucia Carbone
    9. Nabil J. Alkayed
  • GPR39 localization in the aging human brain and correlation of expression and polymorphism with vascular cognitive impairment

    Alzheimer's and Dementia: Translational Research and Clinical Interventions
    1. Catherine M. Davis
    2. Thierno M. Bah
    3. Wenri H. Zhang
    4. Jonathan W. Nelson
    5. Kirsti Golgotiu
    6. Xiao Nie
    7. Farah N. Alkayed
    8. Jennifer M. Young
    9. Randy L. Woltjer
    10. Lisa C. Silbert
    11. Marjorie R. Grafe
    12. Nabil J. Alkayed
  • Mapping the Molecular Architecture Required for Lipid-Binding Pockets Using a Subset of Established and Orphan G-Protein Coupled Receptors

    Journal of Chemical Information and Modeling
    1. Shanthi Nagarajan
    2. Zu Yuan Qian
    3. Parthiban Marimuthu
    4. Nabil J. Alkayed
    5. Sanjiv Kaul
    6. Anthony P. Barnes
  • (Phospho)Proteomic dataset of ischemia- and ultrasound- stimulated mouse cardiac endothelial cells in vitro

    Data in Brief
    1. Uchenna Emechebe
    2. David Giraud
    3. Azzdine Y. Ammi
    4. Kristin L. Scott
    5. Jon M. Jacobs
    6. Jason E. McDermott
    7. Igor V. Dykan
    8. Nabil J. Alkayed
    9. Anthony P. Barnes
    10. Sanjiv Kaul
    11. Catherine M. Davis
  • Phosphoproteomic response of cardiac endothelial cells to ischemia and ultrasound

    Biochimica et Biophysica Acta - Proteins and Proteomics
    1. Uchenna Emechebe
    2. David Giraud
    3. Azzdine Y. Ammi
    4. Kristin L. Scott
    5. Jon M. Jacobs
    6. Jason E. McDermott
    7. Igor V. Dykan
    8. Nabil J. Alkayed
    9. Anthony P. Barnes
    10. Sanjiv Kaul
    11. Catherine M. Davis
  • Plasma Oxylipins

    Frontiers in Cardiovascular Medicine
    1. D. Elizabeth Le
    2. Manuel García-Jaramillo
    3. Gerd Bobe
    4. Armando Alcazar Magana
    5. Ashish Vaswani
    6. Jessica Minnier
    7. Donald B. Jump
    8. Diana Rinkevich
    9. Nabil J. Alkayed
    10. Claudia S. Maier
    11. Sanjiv Kaul