Nabil J. Alkayed, M.D., Ph.D
- Professor of Anesthesiology and Perioperative Medicine, School of Medicine
- Neuroscience Graduate Program, School of Medicine
- Program in Molecular and Cellular Biosciences, School of Medicine
Biography
Dr. Nabil Alkayed is a Professor of Anesthesiology & Perioperative Medicine, Neurology, Neurological Surgery, Cardiovascular Medicine and Physiology & Pharmacology at Oregon Health & Science University (OHSU). He holds The James Metcalfe Chair in Cardiovascular Research, and serves as Director of Research at The Knight Cardiovascular Institute (KCVI). Dr. Alkayed grew up in Amman, Jordan. He received his MD degree from Stavropol State Medical Academy in Stavropol, Russia, and a PhD in Physiology from the Medical College of Wisconsin, Milwaukee, WI. He completed a postdoctoral fellowship at Johns Hopkins University School of Medicine, where he also held his first faculty appointment as Assistant Professor and later promoted to Associate Professor of Anesthesiology & Critical Care Medicine. In 2004, he relocated to OHSU as a tenured Associate Professor, and in 2008, he was promoted to Full Professor in Anesthesiology & Perioperative Medicine and Physiology and Pharmacology. In 2011, he became the Vice Chair of Anesthesiology, and in 2016, Director of Research at KCVI. He is a member of the Association of University Anesthesiologists (AUA) and an elected Fellow of the American Heart Association (AHA) Stroke Council. He has published more than 120 scientific papers related to his work on experimental stroke and vascular cognitive impairment. He served on the Editorial Boards of prominent journals in the fields of stroke and vascular biology, including Stroke, American Journal of Physiology-Heart & Circulation, Journal of Cerebral Blood Flow & Metabolism and Translational Stroke Research. His research program is funded by 2 R01 grants from the NIH, a small business grant and a T32 training grant. He is an active member of grant review panels at the National Institute of Health (NIH) and the American Heart Association (AHA). He is a member of the College of CSR Reviewers. He is Director of the KCVI T32 Training in Translational Science and Cardiovascular Medicine, and has mentored many students, fellows and junior faculty, who went on to develop their own independent research careers.
Education and training
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Degrees
- M.D., 1986, Stavropol State Medical Academy
- Ph.D., 1996, Medical College of Wisconsin
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Fellowship
- Postdoctoral Fellowship in Cerebral Ischemia, Johns Hopkins University, Baltimore, MD, 1996-1998
Memberships and associations:
- American Physiological Society Society for NeuroscienceFellow of the American Heart Association Stroke CouncilInternational Soceity of Cerebral Blood Flow and MetabolismAssociation of University Anesthesiologists
Publications
Publications
Basic Science and Pathogenesis
Alzheimer's & dementia : the journal of the Alzheimer's AssociationBlood-Brain Barrier
StrokeMetabolomics of repetitive myocardial stunning in chronic multivessel coronary artery stenosis
Journal of PhysiologyThe Association between EPHX1 Gene Polymorphisms and Lung Cancer among Jordanian People
Asian Pacific Journal of Cancer PreventionFluid dynamics in aging-related dementias
Neurobiology of DiseaseGPR39 Knockout Worsens Microcirculatory Response to Experimental Stroke in a Sex-Dependent Manner
Translational Stroke ResearchLow-Intensity Ultrasound Reduces Brain Infarct Size by Upregulating Phosphorylated Endothelial Nitric Oxide in Mouse Model of Middle Cerebral Artery Occlusion
Ultrasound in Medicine and BiologySex Difference in Capillary Reperfusion after Transient Middle Cerebral Artery Occlusion in Diabetic Mice
StrokeThe Ever-Evolving Concept of the Neurovascular Unit
StrokeVascular Biology of Dementia
StrokeA Double-Blind, Randomized, Placebo-Controlled Trial of Soluble Epoxide Hydrolase Inhibition in Patients with Aneurysmal Subarachnoid Hemorrhage
Neurocritical CareA Novel Model of Tobacco Smoke–Mediated Aortic Injury
Vascular and Endovascular SurgeryControl of coronary vascular resistance by eicosanoids via a novel GPCR
American Journal of Physiology - Cell PhysiologyEicosanoid ratios are associated with hemorrhage severity and predict development of delayed cerebral ischemia following subarachnoid hemorrhage
Brain HemorrhagesGPR39 Deficiency Impairs Memory and Alters Oxylipins and Inflammatory Cytokines Without Affecting Cerebral Blood Flow in a High-Fat Diet Mouse Model of Cognitive Impairment
Frontiers in Cellular NeuroscienceProteomic profiling of concurrently isolated primary microvascular endothelial cells, pericytes, and vascular smooth muscle cells from adult mouse heart
Scientific ReportsRole of Endothelial Cells and Platelets in COVID-Related Cerebrovascular Events
StrokeRole of Endothelial STAT3 in Cerebrovascular Function and Protection from Ischemic Brain Injury
International journal of molecular sciencesAge-dependent transcriptional alterations in cardiac endothelial cells
Physiological genomicsGene-Specific DNA methylation linked to postoperative cognitive dysfunction in apolipoprotein E3 and E4 mice
Journal of Alzheimer's DiseaseGPR39 localization in the aging human brain and correlation of expression and polymorphism with vascular cognitive impairment
Alzheimer's and Dementia: Translational Research and Clinical InterventionsMapping the Molecular Architecture Required for Lipid-Binding Pockets Using a Subset of Established and Orphan G-Protein Coupled Receptors
Journal of Chemical Information and Modeling(Phospho)Proteomic dataset of ischemia- and ultrasound- stimulated mouse cardiac endothelial cells in vitro
Data in BriefPhosphoproteomic response of cardiac endothelial cells to ischemia and ultrasound
Biochimica et Biophysica Acta - Proteins and ProteomicsPlasma Oxylipins
Frontiers in Cardiovascular Medicine