Oleg Varlamov, M.D., Ph.D.

  • Assistant Professor, Oregon National Primate Research Center
  • Assistant Professor of Graduate Program in Biomedical Sciences, School of Medicine
  • Director of Integrated Pathology Core, Oregon National Primate Research Center

Biography

Dr. Oleg Varlamov, M.D., Ph.D., is an Assistant Professor in the Division of Metabolic Health & Disease at the Oregon National Primate Research Center. Dr. Varlamov holds a degree in medical biochemistry from Pirogov Russian National Research Medical University and a doctorate in molecular pharmacology from the Albert Einstein College of Medicine. He completed his postdoctoral training at the Memorial Sloan Kettering Cancer Center in the laboratory of James Rothman, Ph.D.

Since 2009, Dr. Varlamov has been a faculty member at the ONPRC, where his research centers on adipose tissue function in both healthy and diseased states. A significant focus of his work is delving into the consequences of maternal obesity on fetal development and hematopoiesis. Dr. Varlamov's research contributions extend to unraveling the intricate role of sex hormones in adipose tissue function and investigating how dietary factors impact physiological aspects related to conditions like obesity.

Education and training

  • Degrees

    • M.D., 1993, Pirogov Russian National Research Medical University
    • Ph.D., 1998, Albert Einstein College of Medicine

Areas of interest

  • Obesity and immune system
  • Adipose tissue structure and function
  • Fetal programming and hematopoiesis
  • Hyperandrogenemia and PCOS

Additional information

Publications

Publications

  • Adipose Tissue Analysis Toolkit (ATAT) for automated analysis of adipocyte size and extracellular matrix in white adipose tissue

    Obesity
    1. Jacob J. Robino
    2. Alexander P. Plekhanov
    3. Qingzhang Zhu
    4. Michael D. Jensen
    5. Philipp E. Scherer
    6. Charles T. Roberts
    7. Oleg Varlamov

  • Aging human abdominal subcutaneous white adipose tissue at single cell resolution

    Aging Cell
    1. K. L. Whytock
    2. A. Divoux
    3. Y. Sun
    4. M. F. Pino
    5. G. Yu
    6. C. A. Jin
    7. J. J. Robino
    8. A. Plekhanov
    9. O. Varlamov
    10. S. R. Smith
    11. M. J. Walsh
    12. L. M. Sparks

  • Effect of metabolic status on response to SIV infection and antiretroviral therapy in nonhuman primates

    JCI Insight
    1. Gabriela Webb
    2. Kristin A. Sauter
    3. Diana Takahashi
    4. Melissa Kirigiti
    5. Lindsay Bader
    6. Sarah R. Lindsley
    7. Hannah Blomenkamp
    8. Cicely Zaro
    9. Molly Shallman
    10. Casey McGuire
    11. Heather Hofmeister
    12. Uriel Avila
    13. Cleiton Pessoa
    14. Joseph M. Hwang
    15. Allyson McCullen
    16. Matthew Humkey
    17. Jason Reed
    18. Lina Gao
    19. Lee Winchester
    20. Courtney V. Fletcher
    21. Oleg Varlamov
    22. Todd T. Brown
    23. Jonah B. Sacha
    24. Paul Kievit
    25. Charles T. Roberts

  • Removal of endothelial surface-associated von villebrand factor suppresses accelerate datherosclerosis after myocardial infarction

    Journal of translational medicine
    1. Koya Ozawa
    2. William Packwood
    3. Matthew A. Muller
    4. Yue Qi
    5. Aris Xie
    6. Oleg Varlamov
    7. Owen J. McCarty
    8. Dominic Chung
    9. José A. López
    10. Jonathan R. Lindner

  • Elevated LDL Cholesterol Increases Microvascular Endothelial VWF and Thromboinflammation after Myocardial Infarction

    Arteriosclerosis, thrombosis, and vascular biology
    1. Koya Ozawa
    2. William Packwood
    3. Oleg Varlamov
    4. Matthew Muller
    5. Aris Xie
    6. Melinda D. Wu
    7. Rue Jen Abraham-Fan
    8. José A. López
    9. Jonathan R. Lindner

  • Maternal diet alters long-term innate immune cell memory in fetal and juvenile hematopoietic stem and progenitor cells in nonhuman primate offspring

    Cell Reports
    1. Michael J. Nash
    2. Evgenia Dobrinskikh
    3. Taylor K. Soderborg
    4. Rachel C. Janssen
    5. Diana L. Takahashi
    6. Tyler A. Dean
    7. Oleg Varlamov
    8. Jon D. Hennebold
    9. Maureen Gannon
    10. Kjersti M. Aagaard
    11. Carrie E. McCurdy
    12. Paul Kievit
    13. Bryan C. Bergman
    14. Kenneth L. Jones
    15. Eric M. Pietras
    16. Stephanie R. Wesolowski
    17. Jacob E. Friedman

  • Maternal obesity blunts antimicrobial responses in fetal monocytes

    eLife
    1. Suhas Sureshchandra
    2. Brianna M. Doratt
    3. Norma Mendza
    4. Oleg Varlamov
    5. Monica Rincon
    6. Nicole E. Marshall
    7. Ilhem Messaoudi

  • Western-style diet in the presence of elevated circulating testosterone induces adipocyte hypertrophy without proinflammatory responses in rhesus macaques

    American Journal of Reproductive Immunology
    1. Benjamin J. Burwitz
    2. Sofiya Yusova
    3. Jacob J. Robino
    4. Diana Takahashi
    5. Addie Luo
    6. Ov D. Slayden
    7. Cecily V. Bishop
    8. Jon D. Hennebold
    9. Charles T. Roberts
    10. Oleg Varlamov

  • Adipocyte mesenchymal transition contributes to mammary tumor progression

    Cell Reports
    1. Qingzhang Zhu
    2. Yi Zhu
    3. Chelsea Hepler
    4. Qianbin Zhang
    5. Jiyoung Park
    6. Christy Gliniak
    7. Gervaise H. Henry
    8. Clair Crewe
    9. Dawei Bu
    10. Zhuzhen Zhang
    11. Shangang Zhao
    12. Thomas Morley
    13. Na Li
    14. Dae Seok Kim
    15. Douglas Strand
    16. Yingfeng Deng
    17. Jacob J. Robino
    18. Oleg Varlamov
    19. Ruth Gordillo
    20. Mikhail G. Kolonin
    21. Christine M. Kusminski
    22. Rana K. Gupta
    23. Philipp E. Scherer

  • Deficient Caveolin-1 Synthesis in Adipocytes Stimulates Systemic Insulin-Independent Glucose Uptake via Extracellular Vesicles

    Diabetes
    1. Clair Crewe
    2. Shiuhwei Chen
    3. Dawei Bu
    4. Christy M. Gliniak
    5. Ingrid Wernstedt Asterholm
    6. Xin Xin Yu
    7. Nolwenn Joffin
    8. Camila O. de Souza
    9. Jan Bernd Funcke
    10. Da Young Oh
    11. Oleg Varlamov
    12. Jacob J. Robino
    13. Ruth Gordillo
    14. Philipp E. Scherer

  • Maternal Western-style diet remodels the transcriptional landscape of fetal hematopoietic stem and progenitor cells in rhesus macaques

    Stem Cell Reports
    1. Suhas Sureshchandra
    2. Chi N. Chan
    3. Jacob J. Robino
    4. Lindsay K. Parmelee
    5. Michael J. Nash
    6. Stephanie R. Wesolowski
    7. Eric M. Pietras
    8. Jacob E. Friedman
    9. Diana Takahashi
    10. Weining Shen
    11. Xiwen Jiang
    12. Jon D. Hennebold
    13. Devorah Goldman
    14. William Packwood
    15. Jonathan R. Lindner
    16. Charles T. Roberts
    17. Benjamin J. Burwitz
    18. Ilhem Messaoudi
    19. Oleg Varlamov

  • Reduced Proteolytic Cleavage of von Willebrand Factor Leads to Aortic Valve Stenosis and Load-Dependent Ventricular Remodeling

    JACC: Basic to Translational Science
    1. Koya Ozawa
    2. Matthew A. Muller
    3. Oleg Varlamov
    4. Matthew W. Hagen
    5. William Packwood
    6. Terry K. Morgan
    7. Aris Xie
    8. Claudia S. López
    9. Dominic Chung
    10. Junmei Chen
    11. José A. López
    12. Jonathan R. Lindner

  • Single-Cell Sorting of Non-human Primate Adipocytes with Large-particle Flow Cytometry

    Current Protocols
    1. Jacob J. Robino
    2. Yongwoon Kim
    3. Oleg Varlamov

  • Daily Ethanol Drinking Followed by an Abstinence Period Impairs Bone Marrow Niche and Mitochondrial Function of Hematopoietic Stem/Progenitor Cells in Rhesus Macaques

    Alcoholism: Clinical and Experimental Research
    1. Oleg Varlamov

  • Proteolysis of Von Willebrand Factor Influences Inflammatory Endothelial Activation and Vascular Compliance in Atherosclerosis

    JACC: Basic to Translational Science
    1. Koya Ozawa
    2. Matthew A. Muller
    3. Oleg Varlamov
    4. Hagai Tavori
    5. William Packwood
    6. Paul A. Mueller
    7. Aris Xie
    8. Zaverio Ruggeri
    9. Dominic Chung
    10. José A. López
    11. Jonathan R. Lindner

  • Short-term caloric restriction attenuates obesity- induced pro-inflammatory response in male rhesus macaques

    Nutrients
    1. Hollis Wright
    2. Mithila Handu
    3. Allen Jankeel
    4. Ilhem Messaoudi
    5. Oleg Varlamov

  • Spatial and biochemical interactions between bone marrow adipose tissue and hematopoietic stem and progenitor cells in rhesus macaques

    Bone
    1. Oleg Varlamov

  • Synergistic Effects of Hyperandrogenemia and Obesogenic Western-style Diet on Transcription and DNA Methylation in Visceral Adipose Tissue of Nonhuman Primates

    Scientific Reports
    1. Lucia Carbone
    2. Brett A. Davis
    3. Suzanne S. Fei
    4. Ashley White
    5. Kimberly A. Nevonen
    6. Diana Takahashi
    7. Amanda Vinson
    8. Cadence True
    9. Charles T. Roberts
    10. Oleg Varlamov

  • Synergistic Effects of Hyperandrogenemia and Obesogenic Western-style Diet on Transcription and DNA Methylation in Visceral Adipose Tissue of Nonhuman Primates

    Scientific Reports
    1. Oleg Varlamov

  • Molecular Imaging of VWF (von Willebrand Factor) and Platelet Adhesion in Postischemic Impaired Microvascular Reflow

    Circulation. Cardiovascular imaging
    1. Koya Ozawa
    2. William Packwood
    3. Oleg Varlamov
    4. Yue Qi
    5. Aris Xie
    6. Melinda D. Wu
    7. Zaverio Ruggeri
    8. Jose A. López
    9. Jonathan R. Lindner

  • Combined androgen excess and Western-style diet accelerates adipose tissue dysfunction in young adult, female nonhuman primates

    Human Reproduction
    1. Oleg Varlamov
    2. Cecily V. Bishop
    3. Mithila Handu
    4. Diana Takahashi
    5. Sathya Srinivasan
    6. Ashley White
    7. Charles T. Roberts

  • Long-lasting effect of obesity on skeletal muscle transcriptome

    BMC Genomics
    1. Ilhem Messaoudi
    2. Mithila Handu
    3. Maham Rais
    4. Suhas Sureshchandra
    5. Byung S. Park
    6. Suzanne S. Fei
    7. Hollis Wright
    8. Ashley E. White
    9. Ruhee Jain
    10. Judy L. Cameron
    11. Kerri M. Winters-Stone
    12. Oleg Varlamov

  • Western-style diet, sex steroids and metabolism

    Biochimica et Biophysica Acta - Molecular Basis of Disease
    1. Oleg Varlamov

  • Perpetuating effects of androgen deficiency on insulin resistance

    International Journal of Obesity
    1. J. L. Cameron
    2. R. Jain
    3. M. Rais
    4. A. E. White
    5. T. M. Beer
    6. P. Kievit
    7. K. Winters-Stone
    8. I. Messaoudi
    9. O. Varlamov

  • Real-time tracking of BODIPY-C12 long-chain fatty acid in human term placenta reveals unique lipid dynamics in cytotrophoblast cells

    PloS one
    1. Kevin Kolahi
    2. Samantha Louey
    3. Oleg Varlamov
    4. Kent Thornburg

  • Cell-Autonomous heterogeneity of nutrient uptake in white adipose tissue of rhesus macaques

    Endocrinology
    1. Oleg Varlamov
    2. Michael Chu
    3. Anda Cornea
    4. Harini Sampath
    5. Charles T. Roberts

  • Autistic children display elevated urine levels of bovine casomorphin-7 immunoreactivity

    Peptides
    1. Oleg Sokolov
    2. Natalya Kost
    3. Olga Andreeva
    4. Ekaterina Korneeva
    5. Viktor Meshavkin
    6. Yulia Tarakanova
    7. Aleksander Dadayan
    8. Yurii Zolotarev
    9. Sergei Grachev
    10. Inna Mikheeva
    11. Oleg Varlamov
    12. Andrey Zozulya

  • Real-time detection of snare complex assembly with fret using the tetracysteine system

    Methods in Molecular Biology
    1. Oleg Varlamov