Oleg Varlamov, M.D., Ph.D.
- Assistant Professor, Oregon National Primate Research Center
- Assistant Professor of Graduate Program in Biomedical Sciences, School of Medicine
- Director of Integrated Pathology Core, Oregon National Primate Research Center
Biography
Dr. Oleg Varlamov, M.D., Ph.D., is an Assistant Professor in the Division of Metabolic Health & Disease at the Oregon National Primate Research Center. Dr. Varlamov holds a degree in medical biochemistry from Pirogov Russian National Research Medical University and a doctorate in molecular pharmacology from the Albert Einstein College of Medicine. He completed his postdoctoral training at the Memorial Sloan Kettering Cancer Center in the laboratory of James Rothman, Ph.D.
Since 2009, Dr. Varlamov has been a faculty member at the ONPRC, where his research centers on adipose tissue function in both healthy and diseased states. A significant focus of his work is delving into the consequences of maternal obesity on fetal development and hematopoiesis. Dr. Varlamov's research contributions extend to unraveling the intricate role of sex hormones in adipose tissue function and investigating how dietary factors impact physiological aspects related to conditions like obesity.
Education and training
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Degrees
- M.D., 1993, Pirogov Russian National Research Medical University
- Ph.D., 1998, Albert Einstein College of Medicine
Areas of interest
- Obesity and immune system
- Adipose tissue structure and function
- Fetal programming and hematopoiesis
- Hyperandrogenemia and PCOS
Additional information
Publications
Publications
Adipose Tissue Analysis Toolkit (ATAT) for automated analysis of adipocyte size and extracellular matrix in white adipose tissue
ObesityAging human abdominal subcutaneous white adipose tissue at single cell resolution
Aging CellEffect of metabolic status on response to SIV infection and antiretroviral therapy in nonhuman primates
JCI InsightRemoval of endothelial surface-associated von villebrand factor suppresses accelerate datherosclerosis after myocardial infarction
Journal of translational medicineElevated LDL Cholesterol Increases Microvascular Endothelial VWF and Thromboinflammation after Myocardial Infarction
Arteriosclerosis, thrombosis, and vascular biologyMaternal diet alters long-term innate immune cell memory in fetal and juvenile hematopoietic stem and progenitor cells in nonhuman primate offspring
Cell ReportsMaternal obesity blunts antimicrobial responses in fetal monocytes
eLifeWestern-style diet in the presence of elevated circulating testosterone induces adipocyte hypertrophy without proinflammatory responses in rhesus macaques
American Journal of Reproductive ImmunologyAdipocyte mesenchymal transition contributes to mammary tumor progression
Cell ReportsDeficient Caveolin-1 Synthesis in Adipocytes Stimulates Systemic Insulin-Independent Glucose Uptake via Extracellular Vesicles
DiabetesMaternal Western-style diet remodels the transcriptional landscape of fetal hematopoietic stem and progenitor cells in rhesus macaques
Stem Cell ReportsReduced Proteolytic Cleavage of von Willebrand Factor Leads to Aortic Valve Stenosis and Load-Dependent Ventricular Remodeling
JACC: Basic to Translational ScienceSingle-Cell Sorting of Non-human Primate Adipocytes with Large-particle Flow Cytometry
Current ProtocolsDaily Ethanol Drinking Followed by an Abstinence Period Impairs Bone Marrow Niche and Mitochondrial Function of Hematopoietic Stem/Progenitor Cells in Rhesus Macaques
Alcoholism: Clinical and Experimental ResearchProteolysis of Von Willebrand Factor Influences Inflammatory Endothelial Activation and Vascular Compliance in Atherosclerosis
JACC: Basic to Translational ScienceShort-term caloric restriction attenuates obesity- induced pro-inflammatory response in male rhesus macaques
NutrientsSpatial and biochemical interactions between bone marrow adipose tissue and hematopoietic stem and progenitor cells in rhesus macaques
BoneSynergistic Effects of Hyperandrogenemia and Obesogenic Western-style Diet on Transcription and DNA Methylation in Visceral Adipose Tissue of Nonhuman Primates
Scientific ReportsSynergistic Effects of Hyperandrogenemia and Obesogenic Western-style Diet on Transcription and DNA Methylation in Visceral Adipose Tissue of Nonhuman Primates
Scientific ReportsMolecular Imaging of VWF (von Willebrand Factor) and Platelet Adhesion in Postischemic Impaired Microvascular Reflow
Circulation. Cardiovascular imagingCombined androgen excess and Western-style diet accelerates adipose tissue dysfunction in young adult, female nonhuman primates
Human ReproductionLong-lasting effect of obesity on skeletal muscle transcriptome
BMC GenomicsWestern-style diet, sex steroids and metabolism
Biochimica et Biophysica Acta - Molecular Basis of DiseasePerpetuating effects of androgen deficiency on insulin resistance
International Journal of ObesityReal-time tracking of BODIPY-C12 long-chain fatty acid in human term placenta reveals unique lipid dynamics in cytotrophoblast cells
PloS oneCell-Autonomous heterogeneity of nutrient uptake in white adipose tissue of rhesus macaques
EndocrinologyAutistic children display elevated urine levels of bovine casomorphin-7 immunoreactivity
PeptidesReal-time detection of snare complex assembly with fret using the tetracysteine system
Methods in Molecular Biology