Ov D. Slayden, Ph.D.

  • Professor, Oregon National Primate Research Center
  • Adjunct Professor of Obstetrics and Gynecology, School of Medicine

Biography

Ov D. Slayden, Ph.D. is a Professor in the Division of Developmental and Reproductive Sciences at the Oregon National Primate Research Center and has a joint appointment in the Department of Obstetrics and Gynecology, OHSU. Dr. Slayden received his B.A. and M.A. degrees in Biology from Sonoma State University and earned a Ph.D. in Biochemistry and Animal Science at Oregon State University. Dr. Slayden moved to the Primate Center in 1991 after receiving a Reproductive Biology Training Fellowship through the Department of Physiology at OHSU.

Dr. Slayden conducts research on contraception and reproductive tract disorders, including irregular menstrual bleeding, endometriosis, and polycystic ovarian syndrome (PCOS). His laboratory is 100% invested in studies on nonhuman primates (NHPs), including macaques and baboons. Their broad premise is that a better understanding of disorders that underlie NHP reproductive tract physiology can be leveraged to improve overall reproductive health for women. Their studies bridge the gap between bench research and clinical trials in women and are supported by a combination of NIH, foundation, and pharmaceutical grants. These grants involve identifying and developing novel hormonal and non-hormonal contraception, assessing and treating heavy menstrual bleeding, and novel therapies to image and ablate endometriotic lesions. Techniques employed by the laboratory include: in vivo experiments in NHPs, NHP cell culture, histology, immunohistochemistry, laser capture microdissection, and quantitative real-time PCR.   They also perform non-invasive imaging, including contrast-enhanced ultrasound, PET imaging, and dynamic contrast MRI on NHPs.

Education and training

  • Degrees

    • B.A., 1979, Sonoma State University
    • M.A., 1984, Sonoma State University
    • Ph.D., 1991, Oregon State University
  • Fellowship

    • Postdoctoral Fellowship, Oregon National Primate Research Center, OHSU, 1992

Memberships and associations:

  • American Association for Advancement of Science
  • American Association for Cell Biology
  • American Society for Reproductive Medicine
  • American Society of Mammalogists
  • Endocrine Society
  • Sigma Xi, Oregon State University Chapter
  • Society for the Study of Reproductive Investigation
  • Society for the Study of Reproduction
  • World Endometriosis Society

Areas of interest

  • Endometriosis
  • Contraception
  • PCOS
  • Menstrual Bleeding
  • Hormonal Regulation of the Reproductive Tract

Honors and awards

  • 2007 Technology Innovation Award, Oregon Health & Science University: A Top 10 Sponsored Research Awardee
  • 2008 -2010 Technology Innovation Award, Oregon Health & Science University: A Top Five Sponsored Research Awardee
  • 2011, 2013-16 Technology Innovation Award, Oregon Health & Science University: A Top Sponsored Research Awardee
  • 2017-2022 ASRM Star Award; Recognition for at least nine out of ten successive years presenting at ASRM Scientific Congresses

Publications

Selected publications

  • Bishop CV, Takahashi DL, Luo F, Sidener H, Martin LD, Gao L, Fei SS, Hennebold JD, Slayden OD.  The combined impact of testosterone and Western-style diet on endometriosis severity and progression in rhesus macaques†.  Biol Reprod. 2023 Jan 14;108(1):72-80. doi: 10.1093/biolre/ioac183. PMID: 36173894
  • Park Y, Demessie AA, Luo A, Taratula OR, Moses AS, Do P, Campos L, Jahangiri Y, Wyatt CR, Albarqi HA, Farsad K, Slayden OD, Taratula O.  Targeted Nanoparticles with High Heating Efficiency for the Treatment of Endometriosis with Systemically Delivered Magnetic Hyperthermia.   Small. 2022 Jun;18(24):e2107808. doi: 10.1002/smll.202107808.  Epub 2022 Apr 17. PMID: 35434932
  • Slayden OD, Luo F, Bishop CV. Physiological Action of Progesterone in the Nonhuman Primate Oviduct.  Cells. 2022 May 3;11(9):1534. doi: 10.3390/cells11091534. PMID: 35563839.
  • Moses AS, Demessie AA, Taratula O, Korzun T, Slayden OD, Taratula O. Nanomedicines for Endometriosis: Lessons Learned from Cancer Research. Small. 2021 Jan 25:e2004975. doi: 10.1002/smll.202004975. Epub ahead of print. PMID: 33491876.
  • Bishop CV, Takahashi D, Mishler E, Slayden OD, Roberts CT, Hennebold J, True C. Individual and combined effects of 5-year exposure to hyperandrogenemia and Western-style diet on metabolism and reproduction in female rhesus macaques. Hum Reprod. 2021 Jan 25;36(2):444-454. doi:10.1093/humrep/deaa321. PMID: 33313720; PMCID: PMC7829549.
  • Slayden OD, Friason FKE, Bond KR, Mishler EC. Hormonal regulation of oviductal glycoprotein 1 (OVGP1; MUC9) in the rhesus macaque cervix. J Med Primatol. 2018 Dec;47(6):362-370. doi: 10.1111/jmp.12357. Epub 2018 Jul 4. PMID: 29971796; PMCID: PMC6234059.
  • Bishop CV, Stouffer RL, Takahashi DL, Mishler EC, Wilcox MC, Slayden OD, True CA. Chronic hyperandrogenemia and western-style diet beginning at puberty reduces fertility and increases metabolic dysfunction during pregnancy in young adult, female macaques. Hum Reprod. 2018 Apr 1;33(4):694-705. doi: 10.1093/humrep/dey013. PMID: 29401269; PMCID: PMC6454458.
  • Bishop CV, Mishler EC, Takahashi DL, Reiter TE, Bond KR, True CA, Slayden OD, Stouffer RL. Chronic hyperandrogenemia in the presence and absence of a western-style diet impairs ovarian and uterine structure/function in young adult rhesus monkeys. Hum Reprod. 2018 Jan 1;33(1):128-139. doi: 10.1093/humrep/dex338. PMID: 29190387; PMCID: PMC5850861.
  • Jensen JT, Hanna C, Mishler E, Lim JY, Slayden OD. Effect of menstrual cycle phase and hormonal treatments on evaluation of tubal patency in baboons. J Med Primatol. 2018 Feb;47(1):40-45. doi: 10.1111/jmp.12317. Epub 2017 Oct 24. PMID: 29063622; PMCID: PMC5771854.
  • True CA, Takahashi DL, Burns SE, Mishler EC, Bond KR, Wilcox MC, Calhoun AR, Bader LA, Dean TA, Ryan ND, Slayden OD, Cameron JL, Stouffer RL. Chronic combined hyperandrogenemia and westernstyle diet in young female rhesus macaques causes greater metabolic impairments compared to either treatment alone. Hum Reprod. 2017 Sep 1;32(9):1880-1891. doi: 10.1093/humrep/dex246. PMID: 28854721; PMCID: PMC5850848.

Publications

  • Targeted nanoparticles for imaging and therapy of endometriosis

    Biology of reproduction
    1. Ov Slayden
    2. Fangzhou Luo
    3. Youngrong Park
    4. Abraham S. Moses
    5. Ananiya A. Demessie
    6. Prem Singh
    7. Tetiana Korzun
    8. Olena Taratula
    9. Oleh Taratula
  • Uterine Uptake of Estrogen and Progestogen-Based Radiotracers in Rhesus Macaques with Endometriosis

    Molecular Imaging and Biology
    1. Rachel C. Wilson
    2. Jeanne M. Link
    3. Yueh Z. Lee
    4. Jorge D. Oldan
    5. Steven L. Young
    6. Ov D. Slayden
  • A protocol for creating endometriosis in rhesus macaques (Macaca mulatta)

    Journal of medical primatology
    1. Ov D. Slayden
    2. Fangzhou Luo
    3. Lauren D. Lauren
  • The combined impact of testosterone and Western-style diet on endometriosis severity and progression in rhesus macaques

    Biology of reproduction
    1. Cecily V. Bishop
    2. Diana L. Takahashi
    3. Fangzhou Luo
    4. Heather Sidener
    5. Lauren Drew Martin
    6. Lina Gao
    7. Suzanne S. Fei
    8. Jon D. Hennebold
    9. Ov D. Slayden
  • Utilizing Contrast-Enhanced Ultrasonography with Phosphatidylserine Microbubbles to Detect Placental Inflammation in Rhesus Macaques

    Molecules
    1. Rachel C. Wilson
    2. Jamie O. Lo
    3. Gabriel Romero Jimenez
    4. Jonathan R. Lindner
    5. Ov D. Slayden
    6. Victoria H.J. Roberts
  • Western-style diet in the presence of elevated circulating testosterone induces adipocyte hypertrophy without proinflammatory responses in rhesus macaques

    American Journal of Reproductive Immunology
    1. Benjamin J. Burwitz
    2. Sofiya Yusova
    3. Jacob J. Robino
    4. Diana Takahashi
    5. Addie Luo
    6. Ov D. Slayden
    7. Cecily V. Bishop
    8. Jon D. Hennebold
    9. Charles T. Roberts
    10. Oleg Varlamov
  • Functional evaluation of the cystic fibrosis transmembrane conductance regulator in the endocervix

    Biology of reproduction
    1. Leo Han
    2. MacKenzie Roberts
    3. Addie Luo
    4. Shuhao Wei
    5. Ov D. Slayden
    6. Kelvin D. MacDonald
  • Systemic polidocanol from intravenous or pressurized intrauterine administration produces reversible cardiovascular toxicity

    JVS-Vascular Science
    1. Jeffrey T. Jensen
    2. Philberta Leung
    3. Mackenzie Roberts
    4. Jian Guo
    5. Shan Yao
    6. Emily Mishler
    7. Tanner Grenz
    8. James Hodovan
    9. Ov D. Slayden
    10. Jonathan R. Lindner
  • Targeted Nanoparticles with High Heating Efficiency for the Treatment of Endometriosis with Systemically Delivered Magnetic Hyperthermia

    Small
    1. Youngrong Park
    2. Ananiya A. Demessie
    3. Addie Luo
    4. Olena R. Taratula
    5. Abraham S. Moses
    6. Peter Do
    7. Leonardo Campos
    8. Younes Jahangiri
    9. Cory R. Wyatt
    10. Hassan A. Albarqi
    11. Khashayar Farsad
    12. Ov D. Slayden
    13. Oleh Taratula
  • The Plasminogen Activator System, Glucocorticoid, and Mineralocorticoid Receptors in the Primate Endometrium During Artificial Menstrual Cycles

    Reproductive Sciences
    1. Esra Demirel
    2. Reem Sabouni
    3. Neelima Chandra
    4. Ov D. Slayden
    5. David F. Archer
  • Individual and combined effects of 5-year exposure to hyperandrogenemia and Western-style diet on metabolism and reproduction in female rhesus macaques

    Human Reproduction
    1. Cecily V. Bishop
    2. Diana Takahashi
    3. Emily Mishler
    4. Ov D. Slayden
    5. Charles T. Roberts
    6. Jon Hennebold
    7. Cadence True
  • Longitudinal profiling of the macaque vaginal microbiome reveals similarities to diverse human vaginal communities

    mSystems
    1. Nicholas S. Rhoades
    2. Sara M. Hendrickson
    3. Danielle R. Gerken
    4. Kassandra Martinez
    5. Ov D. Slayden
    6. Mark K. Slifka
    7. Ilhem Messaoudi
  • Low dose dexamethasone as treatment for women with heavy menstrual bleeding

    EBioMedicine
    1. Pamela Warner
    2. Lucy Harriet Ravenscroft Whitaker
    3. Richard Anthony Parker
    4. Christopher John Weir
    5. Anne Douglas
    6. Christian Holm Hansen
    7. Mayank Madhra
    8. Stephen Gilbert Hillier
    9. Philippa Tansy Kemp Saunders
    10. John Peter Iredale
    11. Scott Semple
    12. Ov Daniel Slayden
    13. Brian Robert Walker
    14. Hilary Octavia Dawn Critchley
  • Placental Glucose Uptake in a Nonhuman Primate Model of Western-Style Diet Consumption and Chronic Hyperandrogenemia Exposure

    Reproductive Sciences
    1. Victoria Roberts
    2. Aaron D. Streblow
    3. Jessica E. Gaffney
    4. Samantha P. Rettke
    5. Antonio E. Frias
    6. Ov D. Slayden
  • Mild hyperandrogenemia in presence/absence of a high-fat, Western-style diet alters secretory phase endometrial transcriptome in nonhuman primates

    F and S Science
    1. Cecily V. Bishop
    2. Fangzhou Luo
    3. Lina Gao
    4. Suzanne S. Fei
    5. Ov D. Slayden
  • Nanoparticle-Based Platform for Activatable Fluorescence Imaging and Photothermal Ablation of Endometriosis

    Small
    1. Abraham S. Moses
    2. Olena R. Taratula
    3. Hyelim Lee
    4. Fangzhou Luo
    5. Tanner Grenz
    6. Tetiana Korzun
    7. Anna St Lorenz
    8. Fahad Y. Sabei
    9. Shay Bracha
    10. Adam W.G. Alani
    11. Ov D. Slayden
    12. Oleh Taratula
  • Chronic hyperandrogenemia and western-style diet beginning at puberty reduces fertility and increases metabolic dysfunction during pregnancy in young adult, female macaques

    Human Reproduction
    1. C. V. Bishop
    2. R. L. Stouffer
    3. D. L. Takahashi
    4. E. C. Mishler
    5. M. C. Wilcox
    6. O. D. Slayden
    7. C. A. True
  • Chronic hyperandrogenemia in the presence and absence of a western-style diet impairs ovarian and uterine structure/function in young adult rhesus monkeys

    Human Reproduction
    1. Cecily V. Bishop
    2. Emily C. Mishler
    3. Diana L. Takahashi
    4. Taylor E. Reiter
    5. Kise R. Bond
    6. Cadence A. True
    7. Ov D. Slayden
    8. Richard L. Stouffer
  • Effect of menstrual cycle phase and hormonal treatments on evaluation of tubal patency in baboons

    Journal of medical primatology
    1. Jeffrey T. Jensen
    2. Carol Hanna
    3. Emily Mishler
    4. Jeong Y. Lim
    5. Ov D. Slayden
  • Hormonal regulation of oviductal glycoprotein 1 (OVGP1; MUC9) in the rhesus macaque cervix

    Journal of medical primatology
    1. Ov Daniel Slayden
    2. Francis Kathryn E. Friason
    3. Kise Rosen Bond
    4. Emily Cathleen Mishler
  • Architectural assessment of rhesus macaque pelvic floor muscles

    International Urogynecology Journal
    1. Amanda M. Stewart
    2. Mark S. Cook
    3. Mary C. Esparza
    4. Ov D. Slayden
    5. Marianna Alperin
  • Chronic combined hyperandrogenemia and western-style diet in young female rhesus macaques causes greater metabolic impairments compared to either treatment alone

    Human Reproduction
    1. C. A. True
    2. D. L. Takahashi
    3. S. E. Burns
    4. E. C. Mishler
    5. K. R. Bond
    6. M. C. Wilcox
    7. A. R. Calhoun
    8. L. A. Bader
    9. T. A. Dean
    10. N. D. Ryan
    11. O. D. Slayden
    12. J. L. Cameron
    13. R. L. Stouffer
  • Intravenous neutralization of vascular endothelial growth factor reduces vascular function/permeability of the ovary and prevents development of OHSS-like symptoms in rhesus monkeys

    Journal of Ovarian Research
    1. C. V. Bishop
    2. D. M. Lee
    3. O. D. Slayden
    4. X. Li
  • Plasma cell survival in the absence of B cell memory

    Nature communications
    1. Erika Hammarlund
    2. Archana Thomas
    3. Ian J. Amanna
    4. Lindsay A. Holden
    5. Ov D. Slayden
    6. Byung Park
    7. Lina Gao
    8. Mark K. Slifka
  • Polidocanol induced tubal occlusion in nonhuman primates

    Contraception
    1. Ov D. Slayden
    2. Dong Ock Lee
    3. Shan Yao
    4. Jeffrey T. Jensen
  • Transcervical administration of polidocanol foam prevents pregnancy in female baboons

    Contraception
    1. Jeffrey T. Jensen
    2. Carol Hanna
    3. Shan Yao
    4. Emily Thompson
    5. Cassondra Bauer
    6. Ov D. Slayden