Philip J. S. Stork, M.D.

  • Professor, Vollum Institute
  • Senior Scientist, Vollum Institute
  • Cancer Biology Graduate Program, School of Medicine
  • Cell and Developmental Biology Graduate Program, School of Medicine
  • Neuroscience Graduate Program, School of Medicine
  • OHSU Knight Cancer Institute, School of Medicine
  • Program in Molecular and Cellular Biosciences, School of Medicine

Biography

Philip Stork earned his M.D. at Columbia University in 1984 and went on to a residency in Pathology at Harvard Medical School and a fellowship at Tufts-New England Medical Center. He became an assistant professor in the Department of Pathology at Tufts in 1988. Stork was appointed as an assistant scientist at the Vollum Institute in 1990, was promoted to scientist in 1997 and senior scientist in 2005. He holds a joint appointment in the Department of Cell, Developmental and Cancer Biology in OHSU's School of Medicine.

Dr. Stork and his colleagues use molecular and biochemical approaches to understand how hormones and growth factors convey signals from the outside of a cell to the nucleus to induce cellular responses. Over the past few years, the Stork laboratory has tried to understand a fundamental question in the field of signal transduction: how can qualitative changes in the magnitude and duration of a single signaling cascade lead to qualitative changes in the cellular response?

Education and training

  • Degrees

    • B.S., 1977, Harvard University
    • M.S., 1978, Stanford University
    • M.D., 1984, Columbia University

Memberships and associations:

  • Editorial Board, Molecular Cell Biology, 2008-2020

Areas of interest

  • small G proteins
  • MAP kinase
  • B-Raf

Additional information

Publications

Publications

  • Local and dynamic regulation of neuronal glycolysis in vivo

    Proceedings of the National Academy of Sciences of the United States of America
    1. Aaron D. Wolfe
    2. John N. Koberstein
    3. Chadwick B. Smith
    4. Melissa L. Stewart
    5. Ian J. Gonzalez
    6. Marc Hammarlund
    7. Anthony A. Hyman
    8. Philip J.S. Stork
    9. Richard H. Goodman
    10. Daniel A. Colón-Ramos

  • Monitoring glycolytic dynamics in single cells using a fluorescent biosensor for fructose 1,6-bisphosphate

    Proceedings of the National Academy of Sciences of the United States of America
    1. John N. Koberstein
    2. Melissa L. Stewart
    3. Chadwick B. Smith
    4. Andrei I. Tarasov
    5. Frances M. Ashcroft
    6. Philip J.S. Stork
    7. Richard H. Goodman

  • High-throughput single-particle tracking reveals 1 nested membrane domains that dictate krasg12d 2 diffusion and trafficking

    eLife
    1. Yerim Lee
    2. Carey Phelps
    3. Tao Huang
    4. Barmak Mostofian
    5. Lei Wu
    6. Ying Zhang
    7. Kai Tao
    8. Young Hwan Chang
    9. Philip J.S. Stork
    10. Joe W. Gray
    11. Daniel M. Zuckerman
    12. Xiaolin Nan

  • Proceedings of the fifth international RASopathies symposium

    American Journal of Medical Genetics, Part A
    1. Katherine A. Rauen
    2. Lisa Schoyer
    3. Lisa Schill
    4. Beth Stronach
    5. John Albeck
    6. Brage S. Andresen
    7. Hélène Cavé
    8. Michelle Ellis
    9. Steven M. Fruchtman
    10. Bruce D. Gelb
    11. Christopher C. Gibson
    12. Karen Gripp
    13. Erin Hefner
    14. William Y.C. Huang
    15. Maxim Itkin
    16. Bronwyn Kerr
    17. Corinne M. Linardic
    18. Martin McMahon
    19. Beverly Oberlander
    20. Ethan Perlstein
    21. Nancy Ratner
    22. Leslie Rogers
    23. Annette Schenck
    24. Suma Shankar
    25. Stanislav Shvartsman
    26. David A. Stevenson
    27. Edward C. Stites
    28. Philip J.S. Stork
    29. Cheng Sun
    30. Marc Therrien
    31. Erik M. Ullian
    32. Brigitte C. Widemann
    33. Erika Yeh
    34. Giuseppe Zampino
    35. Martin Zenker
    36. William Timmer
    37. Frank McCormick

  • Analysis of K-Ras interactions by biotin ligase tagging

    Cancer Genomics and Proteomics
    1. Christopher Ritchie
    2. Andrew Mack
    3. Logan Harper
    4. Ayna Alfadhli
    5. Philip J.S. Stork
    6. Xiaolin Nan
    7. Eric Barklis

  • Liberated PKA Catalytic Subunits Associate with the Membrane via Myristoylation to Preferentially Phosphorylate Membrane Substrates

    Cell Reports
    1. Shane E. Tillo
    2. Wei Hong Xiong
    3. Maho Takahashi
    4. Sheng Miao
    5. Adriana L. Andrade
    6. Dale A. Fortin
    7. Guang Yang
    8. Maozhen Qin
    9. Barbara F. Smoody
    10. Philip J.S. Stork
    11. Haining Zhong

  • Phosphorylation of Rap1 by cAMP-dependent protein kinase (PKA) creates a binding site for KSR to sustain ERK activation by cAMP

    Journal of Biological Chemistry
    1. Maho Takahashi
    2. Yanping Li
    3. Tara J. Dillon
    4. Philip J.S. Stork

  • Phosphorylation of the C-Raf N region promotes Raf dimerization

    Molecular and cellular biology
    1. Maho Takahashi
    2. Yanping Li
    3. Tara J. Dillon
    4. Yumi Kariya
    5. Philip J.S. Stork

  • ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis in adrenal medullary cells

    Cellular Signalling
    1. Yutaro Obara
    2. Ryusuke Nagasawa
    3. Wataru Nemoto
    4. Michael J. Pellegrino
    5. Maho Takahashi
    6. Beth A. Habecker
    7. Philip J.S. Stork
    8. Osamu Ichiyanagi
    9. Hiromi Ito
    10. Yoshihiko Tomita
    11. Kuniaki Ishii
    12. Norimichi Nakahata

  • Protein kinase A-independent Ras protein activation cooperates with Rap1 protein to mediate activation of the extracellular signal-regulated kinases (ERK) by cAMP

    Journal of Biological Chemistry
    1. Yanping Li
    2. Tara J. Dillon
    3. Maho Takahashi
    4. Keith T. Earley
    5. Philip J.S. Stork

  • Unexpected maturation of PI3K and MAPK-ERK signaling in fetal ovine cardiomyocytes

    American Journal of Physiology - Heart and Circulatory Physiology
    1. N. N. Chattergoon
    2. S. Louey
    3. P. J. Stork
    4. G. D. Giraud
    5. K. L. Thornburg

  • B-Raf is required for positive selection and survival of DP cells, but not for negative selection of SP cells

    International Immunology
    1. Tara J. Dillon
    2. Maho Takahashi
    3. Yanping Li
    4. Srilatha Tavisala
    5. Susan E. Murray
    6. Amy E. Moran
    7. David C. Parker
    8. Philip J.S. Stork

  • N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence

    Proceedings of the National Academy of Sciences of the United States of America
    1. Zhiping Wang
    2. Yuangang Liu
    3. Maho Takahashi
    4. Kathryn Van Hook
    5. Kerstin M. Kampa-Schittenhelm
    6. Brett C. Sheppard
    7. Rosalie C. Sears
    8. Philip J.S. Stork
    9. Charles D. Lopez

  • Protein kinase a-dependent phosphorylation of Rap1 regulates its membrane localization and cell migration

    Journal of Biological Chemistry
    1. Maho Takahashi
    2. Tara J. Dillon
    3. Chang Liu
    4. Yumi Kariya
    5. Zhiping Wang
    6. Philip J.S. Stork

  • Ras-mutant cancer cells display B-Raf binding to ras that activates extracellular signal-regulated kinase and is inhibited by protein kinase a phosphorylation

    Journal of Biological Chemistry
    1. Yanping Li
    2. Maho Takahashi
    3. Philip J.S. Stork

  • XAllosteric activation of functionally asymmetric RAF kinase dimers

    Cell
    1. Jiancheng Hu
    2. Edward C. Stites
    3. Haiyang Yu
    4. Elizabeth A. Germino
    5. Hiruy S. Meharena
    6. Philip J.S. Stork
    7. Alexandr P. Kornev
    8. Susan S. Taylor
    9. Andrey S. Shaw

  • Mid-gestation ovine cardiomyocytes are vulnerable to mitotic suppression by thyroid hormone

    Reproductive Sciences
    1. Natasha N. Chattergoon
    2. Samantha Louey
    3. Philip Stork
    4. George D. Giraud
    5. Kent L. Thornburg

  • Thyroid hormone drives fetal cardiomyocyte maturation

    FASEB Journal
    1. Natasha N. Chattergoon
    2. George D. Giraud
    3. Samantha Louey
    4. Philip Stork
    5. Abigail L. Fowden
    6. Kent L. Thornburg

  • The interaction of Epac1 and ran promotes Rap1 activation at the nuclear envelope

    Molecular and cellular biology
    1. Chang Liu
    2. Maho Takahashi
    3. Yanping Li
    4. Tara J. Dillon
    5. Stefanie Kaech
    6. Philip J.S. Stork

  • ERK5 activity is required for nerve growth factor-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells

    Journal of Biological Chemistry
    1. Yutaro Obara
    2. Arata Yamauchi
    3. Shin Takehara
    4. Wataru Nemoto
    5. Maho Takahashi
    6. Philip J.S. Stork
    7. Norimichi Nakahata

  • Ras is required for the cyclic AMP-dependent activation of Rap1 via Epac2

    Molecular and cellular biology
    1. Chang Liu
    2. Maho Takahashi
    3. Yanping Li
    4. Shuang Song
    5. Tara J. Dillon
    6. Ujwal Shinde
    7. Philip J.S. Stork

  • Putting on the RITz.

    Science's STKE : signal transduction knowledge environment
    1. Stefanie Kaech
    2. Gary Banker
    3. Phillip Stork

  • The requirement of Ras and Rap1 for the activation of ERKs by cAMP, PACAP, and KCl in cerebellar granule cells

    Journal of neurochemistry
    1. Yutaro Obara
    2. Angela M. Horgan
    3. Philip J.S. Stork

  • Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation

    Molecular and cellular biology
    1. Zhiping Wang
    2. Tara J. Dillon
    3. Viji Pokala
    4. Snigdha Mishra
    5. Kirstin Labudda
    6. Brian Hunter
    7. Philip J.S. Stork

  • Sustained activation of extracellular signal-regulated kinase by nerve growth factor regulates c-fos protein stabilization and transactivation in PC12 cells

    Journal of neurochemistry
    1. Michael J. Pellegrino
    2. Philip J.S. Stork

  • Directing NGF's actions

    Nature Cell Biology
    1. Philip J. Stork

  • Ras-independent activation of ERK signaling via the Torso receptor tyrosine kinase is mediated by Rap1

    Current Biology
    1. Snigdha Mishra
    2. Sarah M. Smolik
    3. Michael A. Forte
    4. Philip J.S. Stork