P. Holland Alday, M.D., Ph.D

  • Assistant Professor of Medicine, Division of Infectious Diseases, School of Medicine
  • VA Portland Health Care System

Biography

Dr. Alday is interested in the development of new drugs for parasitic infections. His current work focuses on advancing several compounds identified as having nanomolar activity against Toxoplasma gondii in a screen of the Global Health Chemical Diversity Library. This screen identified over 70 such hit compounds, and he is currently engaged in mechanistic and in vivo studies to identify the most promising early leads from these hits. He also works with Stone Doggett, MD and Mike Riscoe, PhD, on the development of endochin-like quinolones (ELQs), which are extremely potent inhibitors of T. gondii, Plasmodium spp and Babesia spp both in vitro and in vivo.

Education and training

  • Degrees

    • B.S., 2000, Georgia Institute of Technology
    • M.D., 2009, University of Mississippi Medical Center
    • Ph.D., 2009, University of Mississippi Medical Center

  • Residency

    • Internal Medicine, University of Utah, 2012

  • Fellowship

    • Infectious Diseases, Oregon Health & Science University, 2014

  • Certifications

    • American Board of Internal Medicine, Internal Medicine, 2013
    • American Board of Internal Medicine, Infectious Diseases, 2014

Publications

Selected publications

  • Alday PH, Bruzual I, Nilsen A, Pou S, Winter R, Ben Mamoun C, Riscoe MK, Doggett JS. Genetic Evidence for Cytochrome b Qi Site Inhibition by 4(1H)-Quinolone-3-Diarylethers and Antimycin in Toxoplasma gondii. Antimicrob Agents Chemother. 2017 Feb;61(2). PubMed PMID: 27919897.
  • Alday PH, Doggett JS. Drugs in development for toxoplasmosis: advances, challenges, and current status. Drug Des Devel Ther. 2017;11:273-293. PubMed PMID: 28182168.
  • Alday PH, Correia JJ. Macromolecular interaction of halichondrin B analogues eribulin (E7389) and ER-076349 with tubulin by analytical ultracentrifugation. Biochemistry. 2009 Aug 25;48(33):7927-38. PubMed PMID: 19586046.
  • Correia JJ, Alday PH, Sherwood P, Stafford WF. Effect of kinetics on sedimentation velocity profiles and the role of intermediates. Methods Enzymol. 2009;467:135-61. PubMed PMID: 19897092. 

Publications