Pierre T. Moenne-Loccoz, Ph.D.
- Professor of Chemical Physiology and Biochemistry, School of Medicine
Biography
University of Oregon, Postdoctoral Research Associate, Department of Chemistry, 1990-92
University College London, Department of Biology, 1992-93
Oregon Graduate Institute, Department of Biochemistry and Molecular Biology, 1993-96
OHSU/OGI School of Science & Engineering, Research Scientist, 1996-1999; Research Assistant Professor, 1999-2000; Assistant Professor, 2000-2007
OHSU, Institute of Environmental Health, Associate Professor, 2007-2018
Research interests: Structure-function relationships within proteins. Metalloenzymes and hemoproteins. Spectroscopic studies of enzymatic active sites, cofactors, and metal clusters. Reaction intermediates within catalysis. Nitric oxide in bioinorganic chemistry.
Education and training
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Degrees
- Ph.D., 1989, University Pierre & Marie Curie, Paris VI
Areas of interest
- Bioinorganic chemistry & metalloenzymes
- Nitric oxide biochemistry
- Hemoprotein & heme trafficking
- Molecular spectroscopies, kinetics, & mechanistic studies
Publications
Selected publications
- Albert, T., Moënne-Loccoz, P. (2022) Spectroscopic characterization of a diferric mycobacterial hemerythrin-like protein with unprecedented reactivity toward nitric oxide. J. Am. Chem. Soc. 144, 17611-17621.
- Bhadra, M., Albert, T., Franke, A., Josef, V., Ivanovic-Burmazovic, I., Swart, M., Moënne-Loccoz, P., Karlin, K. D. (2023) Reductive coupling of nitric oxide by Cu(I): stepwise formation of mono and dinitrosyl complexes en route to a cupric hyponitrite intermediate, J. Am. Chem. Soc. 145, 2230-2242
Publications
A single outer-sphere amino-acid substitution turns on the NO reactivity of a hemerythrin-like protein
Chemical ScienceThe activation of the metal-containing regulatory protein NiaR from Thermotoga maritima by its effector, nicotinic acid
Journal of Biological Inorganic ChemistryA Nonheme Iron(III) Superoxide Complex Leads to Sulfur Oxygenation
Journal of the American Chemical SocietyVibrational analyses of the reaction of oxymyoglobin with NO using a photolabile caged NO donor at cryogenic temperatures
Journal of Inorganic BiochemistryWater soluble azide functionalized cobalt oxide nanoparticles
Journal of Nanoparticle ResearchHydrogen atom abstraction by a high-spin [FeIII=S] complex
ChemOxygen versus Sulfur Coordination in Cobalt Superoxo Complexes
Inorganic ChemistryReductive Coupling of Nitric Oxide by Cu(I)
Journal of the American Chemical SocietyAn Iron(III) Superoxide Corrole from Iron(II) and Dioxygen
Angewandte Chemie - International EditionDirect Reduction of NO to N2O by a Mononuclear Nonheme Thiolate Ligated Iron(II) Complex via Formation of a Metastable {FeNO}7Complex
Inorganic ChemistryDistinct roles of the Na+ binding sites in the allosteric coupling mechanism of the glutamate transporter homolog, GltPh
Proceedings of the National Academy of Sciences of the United States of AmericaInfluence of the Interdomain Interface on Structural and Redox Properties of Multiheme Proteins
Inorganic ChemistryInsight into the Spatial Arrangement of the Lysine Tyrosylquinone and Cu2+ in the Active Site of Lysyl Oxidase-like 2
International journal of molecular sciencesMechanism of substrate inhibition in cytochrome-c dependent NO reductases from denitrifying bacteria (cNORs)
Journal of Inorganic BiochemistrySpectroscopic Characterization of a Diferric Mycobacterial Hemerythrin-Like Protein with Unprecedented Reactivity toward Nitric Oxide
Journal of the American Chemical SocietyA Nonheme Mononuclear {FeNO}7 Complex that Produces N2O in the Absence of an Exogenous Reductant
Angewandte Chemie - International EditionA Reactive, Photogenerated High-Spin (S = 2) FeIV(O) Complex via O2Activation
Journal of the American Chemical SocietyArtificial Metalloproteins with Dinuclear Iron-Hydroxido Centers
Journal of the American Chemical SocietyAxial Heme Coordination by the Tyr-His Motif in the Extracellular Hemophore HasAp Is Critical for the Release of Heme to the HasR Receptor of Pseudomonas aeruginosa
BiochemistryStepwise nitrosylation of the nonheme iron site in an engineered azurin and a molecular basis for nitric oxide signaling mediated by nonheme iron proteins
Chemical ScienceStructures of Gating Intermediates in a K+ channell
Journal of molecular biologySulfide Oxidation by 2,6-Bis[hydroxyl(methyl)amino]-4-morpholino-1,3,5-triazinatodioxomolybdenum(VI)
Inorganic ChemistryStabilization of the Dinitrogen Analogue, Phosphorus Nitride
ACS Central ScienceActivation of Dioxygen by a Mononuclear Nonheme Iron Complex
Journal of the American Chemical SocietyA Nonheme Thiolate-Ligated Cobalt Superoxo Complex
Journal of the American Chemical SocietyDirect Resonance Raman Characterization of a Peroxynitrito Copper Complex Generated from O2 and NO and Mechanistic Insights into Metal-Mediated Peroxynitrite Decomposition
Angewandte Chemie - International EditionMononuclear, nonheme, high-spin {FeNO}7/8 complexes supported by a sterically encumbered N4S-T.
Inorganic Chemistry