Pierre T. Moenne-Loccoz, Ph.D.

  • Professor of Chemical Physiology and Biochemistry, School of Medicine

Biography

University of Oregon, Postdoctoral Research Associate, Department of Chemistry, 1990-92

University College London, Department of Biology, 1992-93

Oregon Graduate Institute, Department of Biochemistry and Molecular Biology, 1993-96

OHSU/OGI School of Science & Engineering, Research Scientist, 1996-1999; Research Assistant Professor, 1999-2000; Assistant Professor, 2000-2007

OHSU, Institute of Environmental Health, Associate Professor, 2007-2018

Research interests: Structure-function relationships within proteins. Metalloenzymes and hemoproteins. Spectroscopic studies of enzymatic active sites, cofactors, and metal clusters. Reaction intermediates within catalysis. Nitric oxide in bioinorganic chemistry.

Education and training

  • Degrees

    • Ph.D., 1989, University Pierre & Marie Curie, Paris VI

Areas of interest

  • Bioinorganic chemistry & metalloenzymes
  • Nitric oxide biochemistry
  • Hemoprotein & heme trafficking
  • Molecular spectroscopies, kinetics, & mechanistic studies

Publications

Selected publications

  • Albert, T., Moënne-Loccoz, P. (2022) Spectroscopic characterization of a diferric mycobacterial hemerythrin-like protein with unprecedented reactivity toward nitric oxide. J. Am. Chem. Soc. 144, 17611-17621.  
  • Bhadra, M., Albert, T., Franke, A., Josef, V., Ivanovic-Burmazovic, I., Swart, M., Moënne-Loccoz, P., Karlin, K. D. (2023) Reductive coupling of nitric oxide by Cu(I): stepwise formation of mono and dinitrosyl complexes en route to a cupric hyponitrite intermediate, J. Am. Chem. Soc. 145, 2230-2242

Publications

  • A single outer-sphere amino-acid substitution turns on the NO reactivity of a hemerythrin-like protein

    Chemical Science
    1. Therese Albert
    2. Natasha Pence
    3. Fangfang Zhong
    4. Ekaterina V. Pletneva
    5. Pierre Möenne-Loccoz
  • The activation of the metal-containing regulatory protein NiaR from Thermotoga maritima by its effector, nicotinic acid

    Journal of Biological Inorganic Chemistry
    1. Wai Chung Dorothy Cheng
    2. Yuxin Li
    3. Maileen Nakashima
    4. Pierre Moënne-Loccoz
    5. Katherine W. Rush
    6. Arthur Glasfeld
  • A Nonheme Iron(III) Superoxide Complex Leads to Sulfur Oxygenation

    Journal of the American Chemical Society
    1. Sudha Yadav
    2. Vishal Yadav
    3. Maxime A. Siegler
    4. Pierre Moënne-Loccoz
    5. Guy N.L. Jameson
    6. David P. Goldberg
  • Vibrational analyses of the reaction of oxymyoglobin with NO using a photolabile caged NO donor at cryogenic temperatures

    Journal of Inorganic Biochemistry
    1. Therese Albert
    2. Arun Kumar
    3. Jonathan Caranto
    4. Pierre Moënne-Loccoz
  • Water soluble azide functionalized cobalt oxide nanoparticles

    Journal of Nanoparticle Research
    1. Christian Scott
    2. Sophia Miller
    3. Pierre Moenne-Loccoz
    4. Craig Eliot Barnes
    5. Martina Ralle
  • Hydrogen atom abstraction by a high-spin [FeIII=S] complex

    Chem
    1. Juan A. Valdez-Moreira
    2. Duleeka C. Wannipurage
    3. Maren Pink
    4. Veronica Carta
    5. Pierre Moënne-Loccoz
    6. Joshua Telser
    7. Jeremy M. Smith
  • Oxygen versus Sulfur Coordination in Cobalt Superoxo Complexes

    Inorganic Chemistry
    1. Jesse B. Gordon
    2. Therese Albert
    3. Sudha Yadav
    4. Jithin Thomas
    5. Maxime A. Siegler
    6. Pierre Moënne-Loccoz
    7. David P. Goldberg
  • Reductive Coupling of Nitric Oxide by Cu(I)

    Journal of the American Chemical Society
    1. Mayukh Bhadra
    2. Therese Albert
    3. Alicja Franke
    4. Verena Josef
    5. Ivana Ivanović-Burmazović
    6. Marcel Swart
    7. Pierre Moënne-Loccoz
    8. Kenneth D. Karlin
  • An Iron(III) Superoxide Corrole from Iron(II) and Dioxygen

    Angewandte Chemie - International Edition
    1. Jireh Joy D. Sacramento
    2. Therese Albert
    3. Maxime Siegler
    4. Pierre Moënne-Loccoz
    5. David P. Goldberg
  • Direct Reduction of NO to N2O by a Mononuclear Nonheme Thiolate Ligated Iron(II) Complex via Formation of a Metastable {FeNO}7Complex

    Inorganic Chemistry
    1. Aniruddha Dey
    2. Therese Albert
    3. Richard Y. Kong
    4. Samantha N. Macmillan
    5. Pierre Moënne-Loccoz
    6. Kyle M. Lancaster
    7. David P. Goldberg
  • Distinct roles of the Na+ binding sites in the allosteric coupling mechanism of the glutamate transporter homolog, GltPh

    Proceedings of the National Academy of Sciences of the United States of America
    1. Erika A. Riederer
    2. Pierre Moënne-Loccoz
    3. Francis I. Valiyaveetil
  • Influence of the Interdomain Interface on Structural and Redox Properties of Multiheme Proteins

    Inorganic Chemistry
    1. Fangfang Zhong
    2. Therese Albert
    3. Pierre Moënne-Loccoz
    4. Ekaterina V. Pletneva
  • Insight into the Spatial Arrangement of the Lysine Tyrosylquinone and Cu2+ in the Active Site of Lysyl Oxidase-like 2

    International journal of molecular sciences
    1. Alex A. Meier
    2. Hee Jung Moon
    3. Sinan Sabuncu
    4. Priya Singh
    5. Trey A. Ronnebaum
    6. Siyu Ou
    7. Justin T. Douglas
    8. Timothy A. Jackson
    9. Pierre Moënne-Loccoz
    10. Minae Mure
  • Mechanism of substrate inhibition in cytochrome-c dependent NO reductases from denitrifying bacteria (cNORs)

    Journal of Inorganic Biochemistry
    1. Hirotoshi Matsumura
    2. Abayomi S. Faponle
    3. Peter Leon Hagedoorn
    4. Takehiko Tosha
    5. Sam P. de Visser
    6. Pierre Moënne-Loccoz
  • Spectroscopic Characterization of a Diferric Mycobacterial Hemerythrin-Like Protein with Unprecedented Reactivity toward Nitric Oxide

    Journal of the American Chemical Society
    1. Therese Albert
    2. Pierre Moënne-Loccoz
  • A Nonheme Mononuclear {FeNO}7 Complex that Produces N2O in the Absence of an Exogenous Reductant

    Angewandte Chemie - International Edition
    1. Aniruddha Dey
    2. Jesse B. Gordon
    3. Therese Albert
    4. Sinan Sabuncu
    5. Maxime A. Siegler
    6. Samantha N. MacMillan
    7. Kyle M. Lancaster
    8. Pierre Moënne-Loccoz
    9. David P. Goldberg
  • A Reactive, Photogenerated High-Spin (S = 2) FeIV(O) Complex via O2Activation

    Journal of the American Chemical Society
    1. Jesse B. Gordon
    2. Therese Albert
    3. Aniruddha Dey
    4. Sinan Sabuncu
    5. Maxime A. Siegler
    6. Eckhard Bill
    7. Pierre Moënne-Loccoz
    8. David P. Goldberg
  • Artificial Metalloproteins with Dinuclear Iron-Hydroxido Centers

    Journal of the American Chemical Society
    1. Kelsey R. Miller
    2. Saborni Biswas
    3. Andrew Jasniewski
    4. Alec H. Follmer
    5. Ankita Biswas
    6. Therese Albert
    7. Sinan Sabuncu
    8. Emile L. Bominaar
    9. Michael P. Hendrich
    10. Pierre Moënne-Loccoz
    11. A. S. Borovik
  • Axial Heme Coordination by the Tyr-His Motif in the Extracellular Hemophore HasAp Is Critical for the Release of Heme to the HasR Receptor of Pseudomonas aeruginosa

    Biochemistry
    1. Alecia T. Dent
    2. Marley Brimberry
    3. Therese Albert
    4. William N. Lanzilotta
    5. Pierre Moënne-Loccoz
    6. Angela Wilks
  • Stepwise nitrosylation of the nonheme iron site in an engineered azurin and a molecular basis for nitric oxide signaling mediated by nonheme iron proteins

    Chemical Science
    1. Shiliang Tian
    2. Ruixi Fan
    3. Therese Albert
    4. Rahul L. Khade
    5. Huiguang Dai
    6. Kevin A. Harnden
    7. Parisa Hosseinzadeh
    8. Jing Liu
    9. Mark J. Nilges
    10. Yong Zhang
    11. Pierre Moënne-Loccoz
    12. Yisong Guo
    13. Yi Lu
  • Structures of Gating Intermediates in a K+ channell

    Journal of molecular biology
    1. Ravikumar Reddi
    2. Kimberly Matulef
    3. Erika Riederer
    4. Pierre Moenne-Loccoz
    5. Francis I. Valiyaveetil
  • Sulfide Oxidation by 2,6-Bis[hydroxyl(methyl)amino]-4-morpholino-1,3,5-triazinatodioxomolybdenum(VI)

    Inorganic Chemistry
    1. Cayden X. Bullock
    2. Cooper S. Jamieson
    3. Pierre Moënne-Loccoz
    4. Buck Taylor
    5. Jordan A.M. Gonzalez
    6. Ellie A. Draves
    7. Louis Y. Kuo
  • Stabilization of the Dinitrogen Analogue, Phosphorus Nitride

    ACS Central Science
    1. Jorge L. Martinez
    2. Sean A. Lutz
    3. Daniel M. Beagan
    4. Xinfeng Gao
    5. Maren Pink
    6. Chun Hsing Chen
    7. Veronica Carta
    8. Pierre Moënne-Loccoz
    9. Jeremy M. Smith
  • Activation of Dioxygen by a Mononuclear Nonheme Iron Complex

    Journal of the American Chemical Society
    1. Jesse B. Gordon
    2. Avery C. Vilbert
    3. Ida M. Dimucci
    4. Samantha N. MacMillan
    5. Kyle M. Lancaster
    6. Pierre Moënne-Loccoz
    7. David P. Goldberg
  • A Nonheme Thiolate-Ligated Cobalt Superoxo Complex

    Journal of the American Chemical Society
    1. Jesse B. Gordon
    2. Avery C. Vilbert
    3. Maxime A. Siegler
    4. Kyle M. Lancaster
    5. Pierre Moënne-Loccoz
    6. David P. Goldberg
  • Direct Resonance Raman Characterization of a Peroxynitrito Copper Complex Generated from O2 and NO and Mechanistic Insights into Metal-Mediated Peroxynitrite Decomposition

    Angewandte Chemie - International Edition
    1. Jeffrey J. Liu
    2. Maxime A. Siegler
    3. Kenneth D. Karlin
    4. Pierre Moënne-Loccoz
  • Mononuclear, nonheme, high-spin {FeNO}7/8 complexes supported by a sterically encumbered N4S-T.

    Inorganic Chemistry
    1. Alex M. Confer
    2. Sinan Sabuncu
    3. Maxime A. Siegler
    4. Pierre Moënne-Loccoz
    5. David P. Goldberg