Robert L. Eil, M.D.

  • Assistant Professor of Surgery, Division of Surgical Oncology, School of Medicine

Biography

As a surgeon, Dr. Eil cares for patients who have cancers of the liver, bile ducts and pancreas. As a scientist, Dr. Eil studies immunotherapy for these types of cancer. Immunotherapy supports the body’s natural immune response to cancer. Dr. Eil worked for three years at the National Cancer Institute. While there, he made discoveries about how immune cells fight cancer. This research is helping scientists understand and treat cancer. He brings his surgical and scientific knowledge together at OHSU for patients with liver and pancreatic cancer.

Dr. Eil and his wife have two young children. They enjoy traveling and spending time outside as a family.

Education and training

  • Degrees

    • B.S., 2005, Tulane University
    • M.D., 2010, University of North Carolina School of Medicine

  • Residency

    • General Surgery, OHSU, 2010-2018

  • Fellowship

    • Tumor Immunology & Immunotherapy, Surgery Branch, National Cancer Institute, NIH, 2013-2016
    • Complex General Surgical Oncology, Memorial Sloan Kettering Cancer Center, 2018-2020

  • Certifications

    • American Board of Surgery, 2019
    • Complex General Surgical Oncology, 2021

Areas of interest

  • Cholangiocarcinoma
  • Colorectal Liver Metastasis
  • Tumor induced immune suppression
  • T cell ion transport
  • T cell engineering
  • Translational science
  • Investigator initiated clinical trials

Additional information

Honors and awards

  • Resident Paper of the Year, OHSU, 2017
  • Thoracic Surgery Resident of the Year, OHSU, 2017

Publications

Elsevier pure profile

Publications

  • A Modified Floxuridine Reduced-Dose Protocol for Patients with Unresectable Colorectal Liver Metastases Treated with Hepatic Arterial Infusion

    Annals of surgical oncology
    1. Issac R. Schwantes
    2. Ranish K. Patel
    3. Adel Kardosh
    4. Jillian Paxton
    5. Robert Eil
    6. Emerson Y. Chen
    7. Flavio G. Rocha
    8. Emile Latour
    9. Guillaume Pegna
    10. Charles D. Lopez
    11. Skye C. Mayo

  • Hepatic signal transducer and activator of transcription-3 signalling drives early-stage pancreatic cancer cachexia via suppressed ketogenesis

    Journal of Cachexia, Sarcopenia and Muscle
    1. Paige C. Arneson-Wissink
    2. Heike Mendez
    3. Katherine Pelz
    4. Jessica Dickie
    5. Alexandra Q. Bartlett
    6. Beth L. Worley
    7. Stephanie M. Krasnow
    8. Robert Eil
    9. Aaron J. Grossberg

  • Intracellular K+ Limits T-cell Exhaustion and Preserves Antitumor Function

    Cancer Immunology Research
    1. Camille Collier
    2. Kelly Wucherer
    3. Matthew McWhorter
    4. Chelsea Jenkins
    5. Alexandra Bartlett
    6. Rahul Roychoudhuri
    7. Robert Eil

  • Hepatectomy is associated with improved oncologic outcomes in recurrent colorectal liver metastases

    Surgery (United States)
    1. Thomas L. Sutton
    2. Liam H. Wong
    3. Brett S. Walker
    4. Elizabeth N. Dewey
    5. Robert Eil
    6. Charles Lopez
    7. Adel Kardosh
    8. Emerson Chen
    9. Flavio Rocha
    10. Kevin Billingsley
    11. Skye C. Mayo

  • Surgical timing after preoperative chemotherapy is associated with oncologic outcomes in resectable colorectal liver metastases

    Journal of surgical oncology
    1. Thomas L. Sutton
    2. Liam H. Wong
    3. Brett S. Walker
    4. Elizabeth N. Dewey
    5. Robert L. Eil
    6. Uchechukwu Ibewuike
    7. Emerson Y. Chen
    8. Flavio G. Rocha
    9. Kevin Billingsley
    10. Skye C. Mayo

  • CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function

    Immunology
    1. Sarah K. Whiteside
    2. Francis M. Grant
    3. David S. Gyori
    4. Alberto G. Conti
    5. Charlotte J. Imianowski
    6. Paula Kuo
    7. Rabab Nasrallah
    8. Firas Sadiyah
    9. Sergio A. Lira
    10. Frank Tacke
    11. Robert L. Eil
    12. Oliver T. Burton
    13. James Dooley
    14. Adrian Liston
    15. Klaus Okkenhaug
    16. Jie Yang
    17. Rahul Roychoudhuri

  • Conventional hepatic arterial anatomy? Novel findings and insights of a multi-disciplinary hepatic arterial infusion pump program

    American journal of surgery
    1. Brett S. Walker
    2. Thomas L. Sutton
    3. Robert L. Eil
    4. Elena K. Korngold
    5. Kenneth J. Kolbeck
    6. Kevin Billingsley
    7. Skye C. Mayo

  • Surgical and oncologic outcomes following repeat hepatic resection of colorectal liver metastasis

    American journal of surgery
    1. Liam H. Wong
    2. Thomas L. Sutton
    3. Brett S. Walker
    4. Charles D. Lopez
    5. Adel Kardosh
    6. Robert L. Eil
    7. Emerson Y. Chen
    8. Kevin Billingsley
    9. Skye C. Mayo

  • BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression

    Journal of Experimental Medicine
    1. Francis M. Grant
    2. Jie Yang
    3. Rabab Nasrallah
    4. James Clarke
    5. Firas Sadiyah
    6. Sarah K. Whiteside
    7. Charlotte J. Imianowski
    8. Paula Kuo
    9. Panagiota Vardaka
    10. Tihomir Todorov
    11. Nordin Zandhuis
    12. Ilinca Patrascan
    13. David F. Tough
    14. Kohei Kometani
    15. Robert Eil
    16. Tomohiro Kurosaki
    17. Klaus Okkenhaug
    18. Rahul Roychoudhuri

  • Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies

    Cancer Cell
    1. Devikala Gurusamy
    2. Amanda N. Henning
    3. Tori N. Yamamoto
    4. Zhiya Yu
    5. Nikolaos Zacharakis
    6. Sri Krishna
    7. Rigel J. Kishton
    8. Suman K. Vodnala
    9. Arash Eidizadeh
    10. Li Jia
    11. Christine M. Kariya
    12. Mary A. Black
    13. Robert Eil
    14. Douglas C. Palmer
    15. Jenny H. Pan
    16. Madhusudhanan Sukumar
    17. Shashank J. Patel
    18. Nicholas P. Restifo

  • T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy

    Journal of Clinical Investigation
    1. Tori N. Yamamoto
    2. Ping Hsien Lee
    3. Suman K. Vodnala
    4. Devikala Gurusamy
    5. Rigel J. Kishton
    6. Zhiya Yu
    7. Arash Eidizadeh
    8. Robert Eil
    9. Jessica Fioravanti
    10. Luca Gattinoni
    11. James N. Kochenderfer
    12. Terry J. Fry
    13. Bulent Arman Aksoy
    14. Jeffrey E. Hammerbacher
    15. Anthony C. Cruz
    16. Richard M. Siegel
    17. Nicholas P. Restifo
    18. Christopher A. Klebanoff

  • T cell stemness and dysfunction in tumors are triggered by a common mechanism

    Science
    1. Suman Kumar Vodnala
    2. Robert Eil
    3. Rigel J. Kishton
    4. Madhusudhanan Sukumar
    5. Tori N. Yamamoto
    6. Ngoc Han Ha
    7. Ping Hsien Lee
    8. Min Hwa Shin
    9. Shashank J. Patel
    10. Zhiya Yu
    11. Douglas C. Palmer
    12. Michael J. Kruhlak
    13. Xiaojing Liu
    14. Jason W. Locasale
    15. Jing Huang
    16. Rahul Roychoudhuri
    17. Toren Finkel
    18. Christopher A. Klebanoff
    19. Nicholas P. Restifo

  • Identification of essential genes for cancer immunotherapy

    Nature
    1. Shashank J. Patel
    2. Neville E. Sanjana
    3. Rigel J. Kishton
    4. Arash Eidizadeh
    5. Suman K. Vodnala
    6. Maggie Cam
    7. Jared J. Gartner
    8. Li Jia
    9. Seth M. Steinberg
    10. Tori N. Yamamoto
    11. Anand S. Merchant
    12. Gautam U. Mehta
    13. Anna Chichura
    14. Ophir Shalem
    15. Eric Tran
    16. Robert Eil
    17. Madhusudhanan Sukumar
    18. Eva Perez Guijarro
    19. Chi Ping Day
    20. Paul Robbins
    21. Steve Feldman
    22. Glenn Merlino
    23. Feng Zhang
    24. Nicholas P. Restifo

  • Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy

    JCI Insight
    1. Christopher A. Klebanoff
    2. Joseph G. Crompton
    3. Anthony J. Leonardi
    4. Tori N. Yamamoto
    5. Smita S. Chandran
    6. Robert L. Eil
    7. Madhusudhanan Sukumar
    8. Suman K. Vodnala
    9. Jinhui Hu
    10. Yun Ji
    11. David Clever
    12. Mary A. Black
    13. Devikala Gurusamy
    14. Michael J. Kruhlak
    15. Ping Jin
    16. David F. Stroncek
    17. Luca Gattinoni
    18. Steven A. Feldman
    19. Nicholas P. Restifo

  • Novel "Elements" of immune suppression within the tumor microenvironment

    Cancer Immunology Research
    1. Devikala Gurusamy
    2. David Clever
    3. Robert Eil
    4. Nicholas P. Restifo

  • BACH2 regulates CD8 + T cell differentiation by controlling access of AP-1 factors to enhancers

    Nature Immunology
    1. Rahul Roychoudhuri
    2. David Clever
    3. Peng Li
    4. Yoshiyuki Wakabayashi
    5. Kylie M. Quinn
    6. Christopher A. Klebanoff
    7. Yun Ji
    8. Madhusudhanan Sukumar
    9. Robert L. Eil
    10. Zhiya Yu
    11. Rosanne Spolski
    12. Douglas C. Palmer
    13. Jenny H. Pan
    14. Shashank J. Patel
    15. Derek C. Macallan
    16. Giulia Fabozzi
    17. Han Yu Shih
    18. Yuka Kanno
    19. Akihiko Muto
    20. Jun Zhu
    21. Luca Gattinoni
    22. John J. O'Shea
    23. Klaus Okkenhaug
    24. Kazuhiko Igarashi
    25. Warren J. Leonard
    26. Nicholas P. Restifo

  • Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction

    Nature communications
    1. Anthony C. Cruz
    2. Madhu Ramaswamy
    3. Claudia Ouyang
    4. Christopher A. Klebanoff
    5. Prabuddha Sengupta
    6. Tori N. Yamamoto
    7. Françoise Meylan
    8. Stacy K. Thomas
    9. Nathan Richoz
    10. Robert Eil
    11. Susan Price
    12. Rafael Casellas
    13. V. Koneti Rao
    14. Jennifer Lippincott-Schwartz
    15. Nicholas P. Restifo
    16. Richard M. Siegel

  • Ionic immune suppression within the tumour microenvironment limits T cell effector function

    Nature
    1. Robert Eil
    2. Suman K. Vodnala
    3. David Clever
    4. Christopher A. Klebanoff
    5. Madhusudhanan Sukumar
    6. Jenny H. Pan
    7. Douglas C. Palmer
    8. Alena Gros
    9. Tori N. Yamamoto
    10. Shashank J. Patel
    11. Geoffrey C. Guittard
    12. Zhiya Yu
    13. Valentina Carbonaro
    14. Klaus Okkenhaug
    15. David S. Schrump
    16. W. Marston Linehan
    17. Rahul Roychoudhuri
    18. Nicholas P. Restifo

  • Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy

    Journal of Clinical Investigation
    1. Christopher A. Klebanoff
    2. Christopher D. Scott
    3. Anthony J. Leonardi
    4. Tori N. Yamamoto
    5. Anthony C. Cruz
    6. Claudia Ouyang
    7. Madhu Ramaswamy
    8. Rahul Roychoudhuri
    9. Yun Ji
    10. Robert L. Eil
    11. Madhusudhanan Sukumar
    12. Joseph G. Crompton
    13. Douglas C. Palmer
    14. Zachary A. Borman
    15. David Clever
    16. Stacy K. Thomas
    17. Shashankkumar Patel
    18. Zhiya Yu
    19. Pawel Muranski
    20. Hui Liu
    21. Ena Wang
    22. Francesco M. Marincola
    23. Alena Gros
    24. Luca Gattinoni
    25. Steven A. Rosenberg
    26. Richard M. Siegel
    27. Nicholas P. Restifo

  • Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy

    Cell Metabolism
    1. Madhusudhanan Sukumar
    2. Jie Liu
    3. Gautam U. Mehta
    4. Shashank J. Patel
    5. Rahul Roychoudhuri
    6. Joseph G. Crompton
    7. Christopher A. Klebanoff
    8. Yun Ji
    9. Peng Li
    10. Zhiya Yu
    11. Greg D. Whitehill
    12. David Clever
    13. Robert L. Eil
    14. Douglas C. Palmer
    15. Suman Mitra
    16. Mahadev Rao
    17. Keyvan Keyvanfar
    18. David S. Schrump
    19. Ena Wang
    20. Francesco M. Marincola
    21. Luca Gattinoni
    22. Warren J. Leonard
    23. Pawel Muranski
    24. Toren Finkel
    25. Nicholas P. Restifo

  • Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche

    Cell
    1. David Clever
    2. Rahul Roychoudhuri
    3. Michael G. Constantinides
    4. Michael H. Askenase
    5. Madhusudhanan Sukumar
    6. Christopher A. Klebanoff
    7. Robert L. Eil
    8. Heather D. Hickman
    9. Zhiya Yu
    10. Jenny H. Pan
    11. Douglas C. Palmer
    12. Anthony T. Phan
    13. John Goulding
    14. Luca Gattinoni
    15. Ananda W. Goldrath
    16. Yasmine Belkaid
    17. Nicholas P. Restifo

  • Significance of preoperative radiographic pancreatic density in predicting pancreatic fistula after surgery for pancreatic neuroendocrine tumors

    American journal of surgery
    1. Yasmine Assadipour
    2. Saïd C. Azoury
    3. Nicholas N. Schaub
    4. Young Hong
    5. Robert Eil
    6. Suzanne M. Inchauste
    7. Seth M. Steinberg
    8. Aradhana M. Venkatesan
    9. Steven K. Libutti
    10. Marybeth S. Hughes

  • Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics

    Cancer Research
    1. Joseph G. Crompton
    2. Madhusudhanan Sukumar
    3. Rahul Roychoudhuri
    4. David Clever
    5. Alena Gros
    6. Robert L. Eil
    7. Eric Tran
    8. Ken Ichi Hanada
    9. Zhiya Yu
    10. Douglas C. Palmer
    11. Sid P. Kerkar
    12. Ryan D. Michalek
    13. Trevor Upham
    14. Anthony Leonardi
    15. Nicolas Acquavella
    16. Ena Wang
    17. Francesco M. Marincola
    18. Luca Gattinoni
    19. Pawel Muranski
    20. Mark S. Sundrud
    21. Christopher A. Klebanoff
    22. Steven A. Rosenberg
    23. Douglas T. Fearon
    24. Nicholas P. Restifo

  • Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance

    Journal of Experimental Medicine
    1. Douglas C. Palmer
    2. Geoffrey C. Guittard
    3. Zulmarie Franco
    4. Joseph G. Crompton
    5. Robert L. Eil
    6. Shashank J. Patel
    7. Yun Ji
    8. Nicholas Van Panhuys
    9. Christopher A. Klebanoff
    10. Madhusudhanan Sukumar
    11. David Clever
    12. Anna Chichura
    13. Rahul Roychoudhuri
    14. Rajat Varma
    15. Ena Wang
    16. Luca Gattinoni
    17. Francesco M. Marincola
    18. Lakshmi Balagopalan
    19. Lawrence E. Samelson
    20. Nicholas P. Restifo

  • Nomogram for predicting the benefit of neoadjuvant chemoradiotherapy for patients with esophageal cancer

    Cancer
    1. Robert Eil
    2. Brian S. Diggs
    3. Samuel Wang
    4. James Dolan
    5. John G. Hunter
    6. Charles R. Thomas

  • Traumatic ventricular septal defect resulting in severe pulmonary hypertension

    Journal of Surgical Case Reports
    1. Joseph G. Crompton
    2. Benjamin A. Nacev
    3. Trevor Upham
    4. Saïd C. Azoury
    5. Robert Eil
    6. Duke E. Cameron
    7. Adil H. Haider