Robert M. Duvoisin, Ph.D.
- Professor of Chemical Physiology and Biochemistry, School of Medicine
- Graduate Program in Biomedical Sciences, School of Medicine
Biography
Glutamate is the major excitatory neurotransmitter in the vertebrate central nervous system. In addition to its role in normal brain processes, such as learning and memory, imbalances in glutamatergic function can result in excitotoxic neuronal cell death, epileptic seizures or psychiatric diseases. Glutamate stimulates two classes of receptors: 1) glutamate-gated ion channels, so called ionotropic receptors, which are subdivided into the NMDA, AMPA, and kainate types, and 2) G protein-coupled metabotropic glutamate receptors (mGluRs). Research in the Duvoisin lab is currently focused on group-III mGluRs, a subset of related mGluRs that are selectively activated by L-2-amino-4-phosphonobutyric acid (L-AP4, also abbreviated APB). Group-III mGluRs comprise mGluR4, -R6, -R7, and -R8.
Education and training
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Degrees
- Ph.D., 1987, University of Geneva,
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Fellowship
- Postdoctoral Fellow, The Salk Institute, La Jolla, CA, 1987-1991
Areas of interest
- Retinal neurobiology
- Metabotropic
- Glutamate receptors
Additional information
Publications
Publications
Case report
Frontiers in MedicineEffects of Paraquat, Dextran Sulfate Sodium, and Irradiation on Behavioral and Cognitive Performance and the Gut Microbiome in A53T and A53T-L444P Mice
GenesA sign-inverted receptive field of inhibitory interneurons provides a pathway for ON-OFF interactions in the retina
Nature communicationsLight-dependent changes in the outer plexiform layer of the mouse retina
Frontiers in OphthalmologyMice Lacking Gpr179 with Complete Congenital Stationary Night Blindness Are a Good Model for Myopia
International journal of molecular sciencesTrophoblast glycoprotein is required for efficient synaptic vesicle exocytosis from retinal rod bipolar cells
Frontiers in Cellular NeuroscienceNeuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation
Journal of Experimental MedicineIdentification and characterization of novel TRPM1 autoantibodies from serum of patients with melanoma-associated retinopathy
PloS oneSuppression of cGMP-dependent photoreceptor cytotoxicity with mycophenolate is neuroprotective in murine models of retinitis Pigmentosa
Investigative Ophthalmology and Visual ScienceTRPM1 autoantibodies in melanoma patients without self-reported visual symptoms
Investigative Ophthalmology and Visual ScienceEffects of sub-chronic MPTP exposure on behavioral and cognitive performance and the microbiome of wild-type and mGlu8 knockout female and male mice
Frontiers in Behavioral NeuroscienceAutoantibodies in Melanoma-Associated retinopathy recognize an Epitope conserved between TRPM1 and TRPM3
Investigative Ophthalmology and Visual ScienceThe future of graduate and postdoctoral training in the biosciences
eLifeFragile X Mental Retardation Protein expression in the retina is regulated by light
Experimental Eye ResearchLRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation
European Journal of NeuroscienceThe effect of PKCα on the light response of rod bipolar cells in the mouse retina
Investigative Ophthalmology and Visual ScienceTRPM3 expression in mouse retina
PloS oneVoriconazole, an antifungal triazol that causes visual side effects, is an inhibitor of TRPM1 and TRPM3 channels
Investigative Ophthalmology and Visual ScienceCharacterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric disorders
Journal of Pharmacology and Experimental TherapeuticsDiagnosis of occult melanoma using transient receptor potential melastatin 1 (TRPM1) autoantibody testing
OphthalmologyDifferential modulation of retinal ganglion cell light responses by orthosteric and allosteric metabotropic glutamate receptor 8 compounds
NeuropharmacologyRelated functions of mGlu4 and mGlu8
Pharmacology Biochemistry and BehaviorRole of mGluR4 in acquisition of fear learning and memory
NeuropharmacologySerum TRPM1 Autoantibodies from Melanoma Associated Retinopathy Patients Enter Retinal ON-Bipolar Cells and Attenuate the Electroretinogram in Mice
PloS oneMeasures of anxiety, sensorimotor function, and memory in male and female mGluR4 -/- mice
Behavioural Brain ResearchMGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner
NeuropsychopharmacologyOpposing roles of mGluR8 in measures of anxiety involving non-social and social challenges
Behavioural Brain Research