Robert M. Duvoisin, Ph.D.

  • Professor of Chemical Physiology and Biochemistry, School of Medicine
  • Graduate Program in Biomedical Sciences, School of Medicine

Biography

Glutamate is the major excitatory neurotransmitter in the vertebrate central nervous system. In addition to its role in normal brain processes, such as learning and memory, imbalances in glutamatergic function can result in excitotoxic neuronal cell death, epileptic seizures or psychiatric diseases. Glutamate stimulates two classes of receptors: 1) glutamate-gated ion channels, so called ionotropic receptors, which are subdivided into the NMDA, AMPA, and kainate types, and 2) G protein-coupled metabotropic glutamate receptors (mGluRs). Research in the Duvoisin lab is currently focused on group-III mGluRs, a subset of related mGluRs that are selectively activated by L-2-amino-4-phosphonobutyric acid (L-AP4, also abbreviated APB). Group-III mGluRs comprise mGluR4, -R6, -R7, and -R8.

Education and training

  • Degrees

    • Ph.D., 1987, University of Geneva,
  • Fellowship

    • Postdoctoral Fellow, The Salk Institute, La Jolla, CA, 1987-1991

Areas of interest

  • Retinal neurobiology
  • Metabotropic
  • Glutamate receptors

Publications

Publications

  • Case report

    Frontiers in Medicine
    1. Ryan M. Mosavi-Hecht
    2. Paul Yang
    3. Barrett Heyer
    4. Christopher R. Rosenberg
    5. Elizabeth White
    6. Elizabeth G. Berry
    7. Robert M. Duvoisin
    8. Catherine W. Morgans
  • Effects of Paraquat, Dextran Sulfate Sodium, and Irradiation on Behavioral and Cognitive Performance and the Gut Microbiome in A53T and A53T-L444P Mice

    Genes
    1. Ariel Chaklai
    2. Abigail O’Neil
    3. Shrey Goel
    4. Nick Margolies
    5. Destine Krenik
    6. Ruby Perez
    7. Kat Kessler
    8. Elizabeth Staltontall
    9. Hong Ki Yoon
    10. Montzerrat Pantoja
    11. Keaton Stagaman
    12. Kristin Kasschau
    13. Vivek Unni
    14. Robert Duvoisin
    15. Thomas Sharpton
    16. Jacob Raber
  • A sign-inverted receptive field of inhibitory interneurons provides a pathway for ON-OFF interactions in the retina

    Nature communications
    1. Andrew Jo
    2. Sercan Deniz
    3. Jian Xu
    4. Robert M. Duvoisin
    5. Steven H. DeVries
    6. Yongling Zhu
  • Light-dependent changes in the outer plexiform layer of the mouse retina

    Frontiers in Ophthalmology
    1. Tammie L. Haley
    2. Ryan M. Hecht
    3. Gaoying Ren
    4. James R. Carroll
    5. Sue A. Aicher
    6. Robert M. Duvoisin
    7. Catherine W. Morgans
  • Mice Lacking Gpr179 with Complete Congenital Stationary Night Blindness Are a Good Model for Myopia

    International journal of molecular sciences
    1. Baptiste Wilmet
    2. Jacques Callebert
    3. Robert Duvoisin
    4. Ruben Goulet
    5. Christophe Tourain
    6. Christelle Michiels
    7. Helen Frederiksen
    8. Frank Schaeffel
    9. Olivier Marre
    10. José Alain Sahel
    11. Isabelle Audo
    12. Serge Picaud
    13. Christina Zeitz
  • Trophoblast glycoprotein is required for efficient synaptic vesicle exocytosis from retinal rod bipolar cells

    Frontiers in Cellular Neuroscience
    1. Colin M. Wakeham
    2. Qing Shi
    3. Gaoying Ren
    4. Tammie L. Haley
    5. Robert M. Duvoisin
    6. Henrique von Gersdorff
    7. Catherine W. Morgans
  • Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation

    Journal of Experimental Medicine
    1. Marcel S. Woo
    2. Friederike Ufer
    3. Nicola Rothammer
    4. Giovanni Di Liberto
    5. Lars Binkle
    6. Undine Haferkamp
    7. Jana K. Sonner
    8. Jan Broder Engler
    9. Sönke Hornig
    10. Simone Bauer
    11. Ingrid Wagner
    12. Kristof Egervari
    13. Jacob Raber
    14. Robert M. Duvoisin
    15. Ole Pless
    16. Doron Merkler
    17. Manuel A. Friese
  • Identification and characterization of novel TRPM1 autoantibodies from serum of patients with melanoma-associated retinopathy

    PloS one
    1. Juliette Varin
    2. Margaret M. Reynolds
    3. Nassima Bouzidi
    4. Sarah Tick
    5. Juliette Wohlschlegel
    6. Ondine Becquart
    7. Christelle Michiels
    8. Olivier Dereure
    9. Robert M. Duvoisin
    10. Catherine W. Morgans
    11. José Alain Sahe
    12. Quentin Samaran
    13. Bernard Guillot
    14. José S. Pulido
    15. Isabelle Audo
    16. Christina Zeitz
  • Suppression of cGMP-dependent photoreceptor cytotoxicity with mycophenolate is neuroprotective in murine models of retinitis Pigmentosa

    Investigative Ophthalmology and Visual Science
    1. Paul Yang
    2. Rachel Lockard
    3. Hope Titus
    4. Jordan Hiblar
    5. Kyle Weller
    6. Dahlia Wafai
    7. Richard G. Weleber
    8. Robert M. Duvoisin
    9. Catherine W. Morgans
    10. Mark E. Pennesi
  • TRPM1 autoantibodies in melanoma patients without self-reported visual symptoms

    Investigative Ophthalmology and Visual Science
    1. Robert M. Duvoisin
    2. Gaoying Ren
    3. Tammie L. Haley
    4. Matthew H. Taylor
    5. Catherine W. Morgans
  • Effects of sub-chronic MPTP exposure on behavioral and cognitive performance and the microbiome of wild-type and mGlu8 knockout female and male mice

    Frontiers in Behavioral Neuroscience
    1. Eileen Ruth S. Torres
    2. Tunde Akinyeke
    3. Keaton Stagaman
    4. Robert M. Duvoisin
    5. Charles K. Meshul
    6. Thomas J. Sharpton
    7. Jacob Raber
  • Autoantibodies in Melanoma-Associated retinopathy recognize an Epitope conserved between TRPM1 and TRPM3

    Investigative Ophthalmology and Visual Science
    1. Robert M. Duvoisin
    2. Tammie L. Haley
    3. Gaoying Ren
    4. Iwona Strycharska-Orczyk
    5. James P. Bonaparte
    6. Catherine W. Morgans
  • The future of graduate and postdoctoral training in the biosciences

    eLife
    1. Peter Hitchcock
    2. Ambika Mathur
    3. Jabbar Bennett
    4. Patricia Cameron
    5. Christine Chow
    6. Philip Clifford
    7. Robert Duvoisin
    8. Andrew Feig
    9. Kevin Finneran
    10. Diane M. Klotz
    11. Richard McGee
    12. Mary O’Riordan
    13. Christine Pfund
    14. Christopher Pickett
    15. Nancy Schwartz
    16. Nancy E. Street
    17. Elizabeth Watkins
    18. Jonathan Wiest
    19. David Engelke
  • Fragile X Mental Retardation Protein expression in the retina is regulated by light

    Experimental Eye Research
    1. E. M. Guimarães-Souza
    2. O. Perche
    3. C. W. Morgans
    4. R. M. Duvoisin
    5. K. C. Calaza
  • LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation

    European Journal of Neuroscience
    1. Marion Neuillé
    2. Catherine W. Morgans
    3. Yan Cao
    4. Elise Orhan
    5. Christelle Michiels
    6. José Alain Sahel
    7. Isabelle Audo
    8. Robert M. Duvoisin
    9. Kirill A. Martemyanov
    10. Christina Zeitz
  • The effect of PKCα on the light response of rod bipolar cells in the mouse retina

    Investigative Ophthalmology and Visual Science
    1. Wei Hong Xiong
    2. Ji Jie Pang
    3. Mark E. Pennesi
    4. Robert M. Duvoisin
    5. Samuel M. Wu
    6. Catherine W. Morgans
  • TRPM3 expression in mouse retina

    PloS one
    1. R. Lane Brown
    2. Wei Hong Xiong
    3. James H. Peters
    4. Merve Tekmen-Clark
    5. Iwona Strycharska-Orczyk
    6. Brian T. Reed
    7. Catherine W. Morgans
    8. Robert M. Duvoisin
  • Voriconazole, an antifungal triazol that causes visual side effects, is an inhibitor of TRPM1 and TRPM3 channels

    Investigative Ophthalmology and Visual Science
    1. Wei Hong Xiong
    2. R. Lane Brown
    3. Brian Reed
    4. Neal S. Burke
    5. Robert M. Duvoisin
    6. Catherine W. Morgans
  • Characterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric disorders

    Journal of Pharmacology and Experimental Therapeutics
    1. Mikhail Kalinichev
    2. Emmanuel Le Poul
    3. Christelle Boléa
    4. Françoise Girard
    5. Brice Campo
    6. Massimiliano Fonsi
    7. Isabelle Royer-Urios
    8. Susan E. Browne
    9. Jason M. Uslaner
    10. Matthew J. Davis
    11. Jacob Raber
    12. Robert Duvoisin
    13. Simon T. Bate
    14. Ian J. Reynolds
    15. Sonia Poli
    16. Sylvain Celanire
  • Diagnosis of occult melanoma using transient receptor potential melastatin 1 (TRPM1) autoantibody testing

    Ophthalmology
    1. Monica D. Dalal
    2. Catherine W. Morgans
    3. Robert M. Duvoisin
    4. Elizabeth A. Gamboa
    5. Brett G. Jeffrey
    6. Sunir J. Garg
    7. Chi Chao Chan
    8. H. Nida Sen
  • Differential modulation of retinal ganglion cell light responses by orthosteric and allosteric metabotropic glutamate receptor 8 compounds

    Neuropharmacology
    1. Brian T. Reed
    2. Catherine W. Morgans
    3. Robert M. Duvoisin
  • Related functions of mGlu4 and mGlu8

    Pharmacology Biochemistry and Behavior
    1. Matthew J. Davis
    2. Robert M. Duvoisin
    3. Jacob Raber
  • Role of mGluR4 in acquisition of fear learning and memory

    Neuropharmacology
    1. Matthew J. Davis
    2. Ovidiu D. Iancu
    3. Francine C. Acher
    4. Blair M. Stewart
    5. Massarra A. Eiwaz
    6. Robert M. Duvoisin
    7. Jacob Raber
  • Serum TRPM1 Autoantibodies from Melanoma Associated Retinopathy Patients Enter Retinal ON-Bipolar Cells and Attenuate the Electroretinogram in Mice

    PloS one
    1. Wei Hong Xiong
    2. Robert M. Duvoisin
    3. Grazyna Adamus
    4. Brett G. Jeffrey
    5. Celia Gellman
    6. Catherine W. Morgans
  • Measures of anxiety, sensorimotor function, and memory in male and female mGluR4 -/- mice

    Behavioural Brain Research
    1. Matthew J. Davis
    2. Tammie Haley
    3. Robert M. Duvoisin
    4. Jacob Raber
  • MGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner

    Neuropsychopharmacology
    1. Heather B. Gosnell
    2. Yuval Silberman
    3. Brad A. Grueter
    4. Robert M. Duvoisin
    5. Jacob Raber
    6. Danny G. Winder
  • Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges

    Behavioural Brain Research
    1. Robert M. Duvoisin
    2. Laura Villasana
    3. Matthew J. Davis
    4. Danny G. Winder
    5. Jacob Raber