Sanjiv Kaul, M.D.

  • Professor of Medicine, Division of Cardiovascular Medicine, School of Medicine
  • Ernest C. Swigert Professor of Cardiovascular Medicine

Biography

Dr. Kaul is the previous Head of cardiovascular division at OHSU and the founding director of the Knight Cardiovascular Institute. He is the Past-president of the American Society of Echocardiography. He specializes in coronary artery disease and imaging of the heart, especially echocardiography and nuclear cardiology. Dr. Kaul has spent many years caring for patients, teaching and mentoring other cardiologists and doing research. His work has been published in many medical and scientific journals, and he has served as an editor and reviewer for other heart researchers’ projects and grants. He was awarded the outstanding Investigator award of the American Federation of Clinical Research, the Distinguished Scientist Award of the American College of Cardiology and the James B. Herrick Award of the American Heart Association.

Today, Dr. Kaul spends most of his time in research. He has co-founded two companies: Vasocardea and Orcorazon. Vasocardea is developing drugs to treat diseases that affect small blood vessels in the heart. Orcorazon is developing a total artificial heart.

Education and training

  • Residency

    • Internal medicine - University of Vermont, Burlington, Vt.

  • Fellowship

    • Cardiology - Wadsworth VA Medical Center, UCLA, Los Angeles, Calif.
    • Cardiology - Massachusetts General Hospital, Harvard Medical School, Boston, Mass.

  • Certifications

    • American Board of Internal Medicine, internal medicine

Memberships and associations:

  • American Society for Clinical Investigation
  • Association of American Physicians
  • American Clinical and Climatological Association
  • Association of University Cardiologists
  • American College of Cardiology
  • American Heart Association
  • American Society of Echocardiography

Publications

Elsevier pure profile

Selected publications

  • Kaul S, Newell JB, Chesler DA, Pohost GM, Okada RD, Guiney TE, Boucher CA: Value of computer ana­lysis of exercise thallium images in the noninvasive detection of coronary artery disease.  JAMA 255:508?511, 1986.
  • Sabia PJ, Powers ER, Ragosta M, Sarembock IJ, Burwell LR, Kaul S:  An association between collateral blood flow and myocardial viability in patients with recent myocardial infarction. N Engl J Med 327:1825-1831, 1992.  
  • Wei K, Jayaweera AR Firoozan S, Linka A, Skyba DM, Kaul S: Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion.  Circulation 97:473-483, 1998.
  • Firoozan S, Wei K, Linka A, Skyba D, Goodman NC, Kaul S: A canine model of chronic ischemic cardio­­myo­pathy: characterization of regional flow-function relations.  Am J Physiol 276:H446-H455, 1999.  
  • Jayaweera AR, Wei K, Coggins M, Bin JP, Goodman C, Kaul S: Role of capillaries in determining coronary blood flow reserve: New insights using myocardial contrast echocardiography.  Am J Physiol 277:H2363-H2372, 1999.
  • Wei K, Le E, Min JP, Coggins M, Goodman NC, Kaul S: Mechanism of Reversible 99mTc-sestamibi Perfusion Defects During Pharmacologically-Induced Coronary Vasodilatation.  Am J Physiol 280;H1896-H1904, 2001.  
  • Kaul S, Senior R, Dittrich H, Raval U, Khattar R, Lahiri A:  Detection of coronary artery disease using myocardial contrast echocardiography: comparison with 99mTc-sestamibi single photon emission computed tomography.  Circulation 96:785-792, 1997.
  • Leong-Poi H, Coggins M, Sklenar J, Jayaweera AR, Wang X, Kaul S:Role of Collateral Blood Flow in the Apparent Disparity Between the Extent of Abnormal Wall Thickening and Perfusion Defect Size During Acute Myocardial Infarction and Demand Ischemia.  J Am Coll Cardiol 45:565-572, 2005.  
  • Wei K, Tong KL, Belcik T, Rafter P, Ragosta M, Kaul S: Detection of Non-critical Coronary Stenosis at Rest                 With Myocardial Contrast Echocardiography.  Circulation 112:1154-1160, 2005.
  • Bin, JP, Doctor A, Lindner JR, Leong-Poi H, Fisher NG, Le ED, Hendersen EH, Christiansen J, Kaul S: Effects of Nitroglycerin on Erythrocyte Rheology and Oxygen Unloading:Novel Role of S-Nitrosohemoglobin in Relieving Myocardial Ischemia.  Circulation 113:2502-2508, 2006.

Publications

  • Metabolomics of repetitive myocardial stunning in chronic multivessel coronary artery stenosis

    Journal of Physiology
    1. D. Elizabeth Le
    2. Nabil J. Alkayed
    3. Zhiping Cao
    4. Natasha Chattergoon
    5. Manuel Garcia-Jaramillo
    6. Kent Thornburg
    7. Sanjiv Kaul

  • Association of Serum Calcium and Phosphate With Incident Cardiovascular Disease in Patients With Hypoparathyroidism

    American Journal of Cardiology
    1. Sanjiv Kaul
    2. Olulade Ayodele
    3. Kristina Chen
    4. Erin E. Cook
    5. Elyse Swallow
    6. Lars Rejnmark
    7. Elvira O. Gosmanova

  • Limitations of gene editing assessments in human preimplantation embryos

    Nature communications
    1. Dan Liang
    2. Aleksei Mikhalchenko
    3. Hong Ma
    4. Nuria Marti Gutierrez
    5. Tailai Chen
    6. Yeonmi Lee
    7. Sang Wook Park
    8. Rebecca Tippner-Hedges
    9. Amy Koski
    10. Hayley Darby
    11. Ying Li
    12. Crystal Van Dyken
    13. Han Zhao
    14. Keliang Wu
    15. Jingye Zhang
    16. Zhenzhen Hou
    17. Seongjun So
    18. Jongsuk Han
    19. Jumi Park
    20. Chong Jai Kim
    21. Kai Zong
    22. Jianhui Gong
    23. Yilin Yuan
    24. Ying Gu
    25. Yue Shen
    26. Susan B. Olson
    27. Hui Yang
    28. David Battaglia
    29. Thomas O’Leary
    30. Sacha A. Krieg
    31. David M. Lee
    32. Diana H. Wu
    33. P. Barton Duell
    34. Sanjiv Kaul
    35. Jin Soo Kim
    36. Stephen B. Heitner
    37. Eunju Kang
    38. Zi Jiang Chen
    39. Paula Amato
    40. Shoukhrat Mitalipov

  • Low-Intensity Ultrasound Reduces Brain Infarct Size by Upregulating Phosphorylated Endothelial Nitric Oxide in Mouse Model of Middle Cerebral Artery Occlusion

    Ultrasound in Medicine and Biology
    1. Catherine M. Davis
    2. Azzdine Y. Ammi
    3. Wenbin Zhu
    4. Carmen Methner
    5. Zhiping Cao
    6. David Giraud
    7. Nabil J. Alkayed
    8. Randy L. Woltjer
    9. Sanjiv Kaul

  • Recent Trends in Hypoparathyroidism-Related Inpatient and Emergency Department Admissions and Costs in the United States

    Journal of the Endocrine Society
    1. Sanjiv Kaul
    2. Elvira O. Gosmanova
    3. Felicia Castriota
    4. Abby Hitchens
    5. Sean Candrilli
    6. Rohan Parikh
    7. Elizabeth Esterberg
    8. Olulade Ayodele

  • Control of coronary vascular resistance by eicosanoids via a novel GPCR

    American Journal of Physiology - Cell Physiology
    1. Sanjiv Kaul
    2. Anthony P. Barnes
    3. Nabil J. Alkayed
    4. Zhiping Cao
    5. Zu Yuan Qian
    6. Shanthi Nagarajan
    7. Xuehong Liu
    8. Jonathan W. Nelson
    9. Fuchun Xie
    10. Bingbing Li
    11. Wei Fan
    12. Lijuan Liu
    13. Marjorie R. Grafe
    14. Xiangshu Xiao
    15. Catherine M. Davis

  • Left ventricular assessment with artificial intelligence increases the diagnostic accuracy of stress echocardiography

    European Heart Journal Open
    1. Jamie M. O’Driscoll
    2. William Hawkes
    3. Arian Beqiri
    4. Angela Mumith
    5. Andrew Parker
    6. Ross Upton
    7. Annabelle McCourt
    8. William Woodward
    9. Cameron Dockerill
    10. Nikant Sabharwal
    11. Attila Kardos
    12. Daniel X. Augustine
    13. Katrin Balkhausen
    14. Badrinathan Chandrasekaran
    15. Soroosh Firoozan
    16. Anna Marciniak
    17. Stephen Heitner
    18. Mrinal Yadava
    19. Sanjiv Kaul
    20. Rizwan Sarwar
    21. Rajan Sharma
    22. Gary Woodward
    23. Paul Leeson

  • Lower Risk of Cardiovascular Events in Adult Patients with Chronic Hypoparathyroidism Treated with rhPTH(1–84)

    Advances in Therapy
    1. Olulade Ayodele
    2. Fan Mu
    3. Richard Berman
    4. Elyse Swallow
    5. Lars Rejnmark
    6. Elvira O. Gosmanova
    7. Sanjiv Kaul

  • Persistent Coronary Vasomotor Tone During Myocardial Ischemia Occurs at the Capillary Level and May Involve Pericytes

    Frontiers in Cardiovascular Medicine
    1. D. Elizabeth Le
    2. Yan Zhao
    3. Sanjiv Kaul

  • Proteomic profiling of concurrently isolated primary microvascular endothelial cells, pericytes, and vascular smooth muscle cells from adult mouse heart

    Scientific Reports
    1. Zhiping Cao
    2. Jessica Minnier
    3. Lijuan Liu
    4. Kristin L.Lyon Scott
    5. Ashok P. Reddy
    6. Phillip A. Wilmarth
    7. Larry L. David
    8. Anthony P. Barnes
    9. Marjorie R. Grafe
    10. Sanjiv Kaul
    11. Nabil J. Alkayed
    12. Catherine M. Davis

  • Age-dependent transcriptional alterations in cardiac endothelial cells

    Physiological genomics
    1. Uchenna Emechebe
    2. Jonathan W. Nelson
    3. Nabil J. Alkayed
    4. Sanjiv Kaul
    5. Andrew C. Adey
    6. Anthony P. Barnes

  • Characterization of a pulsatile rotary total artificial heart

    Artificial Organs
    1. Patrick L. Jurney
    2. Jeremy J. Glynn
    3. Igor V. Dykan
    4. Matthew W. Hagen
    5. Sanjiv Kaul
    6. Richard K. Wampler
    7. Monica T. Hinds
    8. George D. Giraud

  • Mapping the Molecular Architecture Required for Lipid-Binding Pockets Using a Subset of Established and Orphan G-Protein Coupled Receptors

    Journal of Chemical Information and Modeling
    1. Shanthi Nagarajan
    2. Zu Yuan Qian
    3. Parthiban Marimuthu
    4. Nabil J. Alkayed
    5. Sanjiv Kaul
    6. Anthony P. Barnes

  • Mechanism and potential treatment of the "no reflow" phenomenon after acute myocardial infarction

    American Journal of Physiology - Heart and Circulatory Physiology
    1. Carmen Methner
    2. Zhiping Cao
    3. Anusha Mishra
    4. Sanjiv Kaul

  • (Phospho)Proteomic dataset of ischemia- and ultrasound- stimulated mouse cardiac endothelial cells in vitro

    Data in Brief
    1. Uchenna Emechebe
    2. David Giraud
    3. Azzdine Y. Ammi
    4. Kristin L. Scott
    5. Jon M. Jacobs
    6. Jason E. McDermott
    7. Igor V. Dykan
    8. Nabil J. Alkayed
    9. Anthony P. Barnes
    10. Sanjiv Kaul
    11. Catherine M. Davis

  • Phosphoproteomic response of cardiac endothelial cells to ischemia and ultrasound

    Biochimica et Biophysica Acta - Proteins and Proteomics
    1. Uchenna Emechebe
    2. David Giraud
    3. Azzdine Y. Ammi
    4. Kristin L. Scott
    5. Jon M. Jacobs
    6. Jason E. McDermott
    7. Igor V. Dykan
    8. Nabil J. Alkayed
    9. Anthony P. Barnes
    10. Sanjiv Kaul
    11. Catherine M. Davis

  • Plasma Oxylipins

    Frontiers in Cardiovascular Medicine
    1. D. Elizabeth Le
    2. Manuel García-Jaramillo
    3. Gerd Bobe
    4. Armando Alcazar Magana
    5. Ashish Vaswani
    6. Jessica Minnier
    7. Donald B. Jump
    8. Diana Rinkevich
    9. Nabil J. Alkayed
    10. Claudia S. Maier
    11. Sanjiv Kaul

  • Quantification of microbubble-induced sonothrombolysis in an ex vivo non-human primate model

    Journal of Thrombosis and Haemostasis
    1. Monica T. Hinds
    2. Azzdine Y. Ammi
    3. Jennifer Johnson
    4. Sanjiv Kaul

  • Risk of Cardiovascular Conditions in Patients with Chronic Hypoparathyroidism

    Advances in Therapy
    1. Elvira O. Gosmanova
    2. Kristina Chen
    3. Markus Ketteler
    4. Lars Rejnmark
    5. Fan Mu
    6. Elyse Swallow
    7. Allison Briggs
    8. Nicole Sherry
    9. Sanjiv Kaul

  • Ultrasound therapy for treatment of lower extremity intermittent claudication

    American journal of surgery
    1. Gregory J. Landry
    2. David Louie
    3. David Giraud
    4. Azzdine Y. Ammi
    5. Sanjiv Kaul

  • Effect of thermostable mutations on the neurotensin receptor 1 (NTSR1) activation state

    Journal of Biomolecular Structure and Dynamics
    1. Shanthi Nagarajan
    2. Nabil J. Alkayed
    3. Sanjiv Kaul
    4. Anthony P. Barnes

  • Ranolazine may exert its beneficial effects by increasing myocardial adenosine levels

    American journal of physiology. Heart and circulatory physiology
    1. D. Elizabeth Le
    2. Catherine M. Davis
    3. Kevin Wei
    4. Yan Zhao
    5. Zhiping Cao
    6. Matthew Nugent
    7. Kristin L.Lyon Scott
    8. Lijuan Liu
    9. Shanthi Nagarajan
    10. Nabil J. Alkayed
    11. Sanjiv Kaul

  • Therapeutic Ultrasound Improves Myocardial Blood Flow and Reduces Infarct Size in a Canine Model of Coronary Microthromboembolism

    Journal of the American Society of Echocardiography
    1. Mrinal Yadava
    2. D. Elizabeth Le
    3. Igor V. Dykan
    4. Marjorie R. Grafe
    5. Matthew Nugent
    6. Azzdine Y. Ammi
    7. David Giraud
    8. Yan Zhao
    9. Jessica Minnier
    10. Sanjiv Kaul

  • Pericyte constriction underlies capillary derecruitment during hyperemia in the setting of arterial stenosis

    American Journal of Physiology - Heart and Circulatory Physiology
    1. Carmen Methner
    2. Anusha Mishra
    3. Kirsti Golgotiu
    4. Yuandong Li
    5. Wei Wei
    6. N. David Yanez
    7. Berislav Zlokovic
    8. Ruikang K. Wang
    9. Nabil J. Alkayed
    10. Sanjiv Kaul
    11. Jeffrey J. Iliff