Shelley Barton, Ph.D.

  • Co-Director, CEDAR, OHSU Knight Cancer Institute, School of Medicine

Biography

Michelle (Shelley) Barton serves CEDAR as a Co-Director, primarily focusing on the biology space and working with CEDAR teams. She recently moved from the MD Anderson Cancer Center, where she was a Professor in the Department of Epigenetics and Molecular Carcinogenesis and Dean of the UT MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences. Shelley’s scientific expertise is in cancer epigenetics and gene regulation. As Dean of the Graduate School, she implemented many programs to increase the diversity of the student body, support an enriched sense of community, and improve training in the skills needed for extramural funding and career development.

Shelley received her Ph.D. in Biochemistry from the University of Illinois, Urbana-Champaign. She did her postdoctoral training at The Salk Institute for Biological Studies.  

Publications

Selected publications

  • Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer.  Nature Communications 2021.  Shah VV, Duncan AD, Jiang S, Stratton, SA, Allton, KL, Yam, C, Jain, A, Krause, PM, Lu, Y, Cai, S, Tu, Y, Zhou, X, Zhang, X, Jiang, Y, Carroll, CL, Kang, Z, Liu, B,  Shen, J, Gagea, MI, Huo, L, Gilcrease, M, Powell, PT, Guo, M, Stephan, C, Davies, PJ, Parker-Thornburg, J, Lozano, G, Behringer, RR, Piwnica-Worms, H, Chang, JT, Moulder,
  • Cross-talk between chromatin acetylation and SUMOylation of tripartite motif-containing protein 24 (TRIM24) impacts cell adhesion. J Biol Chem 2018. Appikonda S, Thakkar KN, Shah PK, Dent SYR, Andersen JN, Barton MC. 
  • TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation. Oncogene 2017. J Li, Y Xi, W Li, RL McCarthy, SA Stratton, W Zou, W Li, SY Dent, AK Jain, MC Barton.
  • Rapid monoisotopic cisplatin based barcoding for multiplexed mass cytometry. Sci Rep 2017 McCarthy RL, Mak DH, Burks JK, Barton MC. 
  • LncPRESS1 Is a p53-Regulated LncRNA that Safeguards Pluripotency by Disrupting SIRT6-Mediated De-acetylation of Histone H3K56. Molecular Cell 2016 Jain AK, Xi Y, McCarthy R, Allton K, Akdemir KC, Patel LR, Aronow B, Lin C, Li W, Yang L, Barton MC. 
  • TRIM24 links glucose metabolism with transformation of human mammary epithelial cells. Oncogene 2014 Pathiraja TN, Thakkar KN, Jiang S, Stratton S, Liu Z, Gagea M, Shi X, Shah PK, Phan L, Lee MH, Andersen J, Stampfer M, Barton MC. 
  • TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice. J Hepatology 2014 Jiang S, Minter LC, Stratton SA, Yang P, Abbas HA, Akdemir ZC, Pant V, Post S, Gagea M, Lee RG, Lozano G, Barton MC. 
  • TRIM24 is a p53-induced E3-ubiquitin ligase that undergoes ATM-mediated phosphorylation and autodegradation during DNA damage. Mol Cell Biol 2014 Jain AK, Allton K, Duncan AD, Barton MC. 
  • Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells. Nucleic Acids Res 2013 Akdemir KC, Jain AK, Allton K, Aronow B, Xu X, Cooney AJ, Li W, Barton MC. 
  • p53 regulates a mitotic transcription program and determines ploidy in normal mouse liver. Hepatology 2013 Kurinna S, Stratton SA, Coban Z, Schumacher JM, Grompe M, Duncan AW, Barton MC. 

Publications