Shoukhrat Mitalipov, Ph.D.
- Professor, Oregon National Primate Research Center
- Professor of Obstetrics and Gynecology, School of Medicine
- Professor and Director, Center for Embryonic Cell & Gene Therapy
- Program in Molecular and Cellular Biosciences, School of Medicine
Biography
Shoukhrat Mitalipov is the Director of the OHSU Center for Embryonic Cell and Gene Therapy. He is also a Professor in the Division of Reproductive & Developmental Sciences of Oregon National Primate Research Center. After receiving his Ph.D. degree, he came to Utah State University in 1995 to conduct his postdoctoral training in developmental biology. Dr. Mitalipov joined OHSU in 1998.
Education and training
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Degrees
- M.S., 1987, Timiriasev Academy
- Ph.D., 1994, Research Center for Medical Genetics, Russian Academy of Medical Sciences
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Fellowship
- Postdoctoral Fellow, Dept of Animal, Dairy and Veterinary Sciences, Utah State University, 1995-1998
- Postdoctoral Fellow, Institute of Human Genetics, Muenster University, Muenster, Germany, 1995
Areas of interest
- Gamete and Embryo Biology
- Mitochondrial Genetics
- Special focus on Germline Gene Therapy
Additional information
Honors and awards
- 2013 – Recognized by journal Nature as top 10 people who mattered in 2013
- 2010 – Recipient of the 2010 Discovery Award, The Medical Research Foundation of Oregon
- 2010 – Recipient of 2010 Women’s Health Research Award, the Center for Women’s Health, Circle of Giving
- 1995 – Fellowship award, Exchange Visitor Program “Cooperation in Applied Sciences and Technologies (CAST)”. Development of culture system to maintain pluripotency of bovine embryonic stem cells. Utah State University.
- 2017 - Recipient of “Thousand Talents Plan” Award in China in the category of the Recruitment Program for Foreign Experts
Publications
Selected publications
- Ma H, Marti-Gutierrez N, Park SW, Wu J, Lee Y, Suzuki K, Koski A, Ji D, Hayama T, Ahmed R, Darby H, Van Dyken C, Li Y, Kang E, Park AR, Kim D, Kim ST, Gong J, Gu Y, Xu X, Battaglia D, Krieg SA, Lee DM, Wu DH, Wolf DP, Heitner SB, Belmonte JCI, Amato P, Kim JS, Kaul S, Mitalipov S. Correction of a pathogenic gene mutation in human embryos. Nature. 2017;548(7668):413-419. PMID: 28783728.
- Kang E, Wu J, Gutierrez NM, Koski A, Tippner-Hedges R, Agaronyan K, Platero-Luengo A, Martinez-Redondo P, Ma H, Lee Y, Hayama T, Van Dyken C, Wang X, Luo S, Ahmed R, Li Y, Ji D, Kayali R, Cinnioglu C, Olson S, Jensen J, Battaglia D, Lee D, Wu D, Huang T, Wolf DP, Temiakov D, Belmonte JC, Amato P, Mitalipov S. Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations. Nature. 2016;540(7632):270-275. PMID: 27919073.
- Kang E, Wang X, Tippner-Hedges R, Ma H, Folmes CD, Gutierrez NM, Lee Y, Van Dyken C, Ahmed R, Li Y, Koski A, Hayama T, Luo S, Harding CO, Amato P, Jensen J, Battaglia D, Lee D, Wu D, Terzic A, Wolf DP, Huang T, Mitalipov S. Age-Related Accumulation of Somatic Mitochondrial DNA Mutations in Adult-Derived Human iPSCs. Cell Stem Cell. 2016;18(5):625-636. PMID: 27151456.
- Ma H, Folmes CD, Wu J, Morey R, Mora-Castilla S, Ocampo A, Ma L, Poulton J, Wang X, Ahmed R, Kang E, Lee Y, Hayama T, Li Y, Van Dyken C, Gutierrez NM, Tippner-Hedges R, Koski A, Mitalipov N, Amato P, Wolf DP, Huang T, Terzic A, Laurent LC, Izpisua Belmonte JC, Mitalipov S. Metabolic rescue in pluripotent cells from patients with mtDNA disease. Nature. 2015;524(7564):234-238. PMID: 26176921.
- Ma H, Morey R, O'Neil RC, He Y, Daughtry B, Schultz MD, Hariharan M, Nery JR, Castanon R, Sabatini K, Thiagarajan RD, Tachibana M, Kang E, Tippner-Hedges R, Ahmed R, Gutierrez NM, Van Dyken C, Polat A, Sugawara A, Sparman M, Gokhale S, Amato P, Wolf DP, Ecker JR, Laurent LC, Mitalipov S. Abnormalities in human pluripotent cells due to reprogramming mechanisms. Nature. 2014;511(7508):177-183. PMCID: PMC4898064.
- Kang E, Wu G, Ma H, Li Y, Tippner-Hedges R, Tachibana M, Sparman M, Wolf DP, Scholer HR, Mitalipov S. Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos. Nature. 2014;509(7498):101-104. PMCID: PMC4124901.
- Tachibana M, Amato P, Sparman M, Gutierrez NM, Tippner-Hedges R, Ma H, Kang E, Fulati A, Lee HS, Sritanaudomchai H, Masterson K, Larson J, Eaton D, Sadler-Fredd K, Battaglia D, Lee D, Wu D, Jensen J, Patton P, Gokhale S, Stouffer RL, Wolf D, Mitalipov S. Human embryonic stem cells derived by somatic cell nuclear transfer. Cell. 2013;153(6):1228-1238. PMCID: PMC3772789.
- Tachibana M, Amato P, Sparman M, Woodward J, Sanchis DM, Ma H, Gutierrez NM, Tippner-Hedges R, Kang E, Lee HS, Ramsey C, Masterson K, Battaglia D, Lee D, Wu D, Jensen J, Patton P, Gokhale S, Stouffer R, Mitalipov S. Towards germline gene therapy of inherited mitochondrial diseases. Nature. 2013;493(7434):627-631. PMCID: PMC3561483.
- Tachibana M, Sparman M, Sritanaudomchai H, Ma H, Clepper L, Woodward J, Li Y, Ramsey C, Kolotushkina O, Mitalipov S. Mitochondrial gene replacement in primate offspring and embryonic stem cells. Nature. 2009;461(7262):367-372. PMCID: PMC2774772.
- Kang E, Wu J, Gutierrez NM, Koski A, Tippner-Hedges R, Agaronyan K, Platero-Luengo A, Martinez-Redondo P, Ma H, Lee Y, Hayama T, Van Dyken C, Wang X, Luo S, Ahmed R, Li Y, Ji D, Kayali R, Cinnioglu C, Olson S, Jensen J, Battaglia D, Lee D, Wu D, Huang T, Wolf DP, Temiakov D, Belmonte JC, Amato P, Mitalipov S. Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations. Nature. 2016;540(7632):270-275. PMID: 27919073.
Publications
Comparison of Natural Killer Cells Differentiated from Various Pluripotent Stem Cells
International journal of molecular sciencesInduction of somatic cell haploidy by premature cell division
Science AdvancesReduced anti-Müllerian hormone action in cumulus-oocyte complexes is beneficial for oocyte maturation without affecting oocyte competence
Frontiers in EndocrinologyFirst pilot study of maternal spindle transfer for the treatment of repeated in vitro fertilization failures in couples with idiopathic infertility
Fertility and sterilityLimitations of gene editing assessments in human preimplantation embryos
Nature communicationsMolecular basis for maternal inheritance of human mitochondrial DNA
Nature geneticsHaploidy in somatic cells is induced by mature oocytes in mice
Communications BiologyHorizontal mtDNA transfer between cells is common during mouse development
iScienceGermline transmission of donor, maternal and paternal mtDNA in primates
Human ReproductionMatrix-free 3D culture supports human follicular development from the unilaminar to the antral stage in vitro yielding morphologically normal metaphase II oocytes
Human ReproductionDeleterious mtDNA mutations are common in mature oocytes
Biology of reproductionThe Rho-associated kinase inhibitor fasudil can replace Y-27632 for use in human pluripotent stem cell research
PloS oneHuman cleaving embryos enable robust homozygotic nucleotide substitutions by base editors
Genome biologyAllogeneic iPSC-derived RPE cell graft failure following transplantation into the subretinal space in nonhuman primates
Investigative Ophthalmology and Visual ScienceGermline and somatic mtDNA mutations in mouse aging
PloS oneMa et al. reply
NatureSarcomere Gene Mutation correction
European heart journalStage-specific modulation of antimüllerian hormone promotes primate follicular development and oocyte maturation in the matrix-free three-dimensional culture
Fertility and sterilityConcise Review
Stem CellsCorrection of a pathogenic gene mutation in human embryos
NatureFunctional Human Oocytes Generated by Transfer of Polar Body Genomes
Cell Stem CellMolecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs
Proceedings of the National Academy of Sciences of the United States of AmericaAge-related accumulation of somatic mitochondrial DNA mutations in adult-derived human ipscs
Cell Stem CellIncompatibility between Nuclear and Mitochondrial Genomes Contributes to an Interspecies Reproductive Barrier
Cell Metabolism