Steven E. Mansoor, M.D., Ph.D.

  • Assistant Professor of Medicine, Division of Cardiovascular Medicine, School of Medicine
  • Assistant Professor of Chemical Physiology and Biochemistry, School of Medicine
  • M.D./Ph.D. Program Committee, School of Medicine

Education and training

  • Degrees

    • B.A., 1997, Reed College
    • M.D., 2009, Oregon Health & Science University
    • Ph.D., 2009, Oregon Health & Science University
  • Residency

    • Internal Medicine, Oregon Health & Science University, 2011
  • Fellowship

    • Cardiology, Oregon Health & Science University, 2017
  • Certifications

    • American Board of Internal Medicine, 2013
    • Board Certified in Cardiovascular Medicine, 2017

Memberships and associations:

  • American Heart Association (AHA)
  • American Society for Clinical Investigation (ASCI)
  • Phi Beta Kappa Society
  • Alpha Omega Alpha Honor Medical Society

Areas of interest

  • Structural biology
  • Ion Channels
  • G-protein coupled receptors
  • Structure-based drug design
  • Purinergic receptors

Publications

Elsevier pure profile

Publications

  • Cryo-EM structures of the human P2X1 receptor reveal subtype-specific architecture and antagonism by supramolecular ligand-binding

    Nature communications
    1. Adam C. Oken
    2. Nicolas E. Lisi
    3. Ismayn A. Ditter
    4. Haoyuan Shi
    5. Nadia A. Nechiporuk
    6. Steven E. Mansoor
  • High-affinity agonism at the P2X7 receptor is mediated by three residues outside the orthosteric pocket

    Nature communications
    1. Adam C. Oken
    2. Nicolas E. Lisi
    3. Ipsita Krishnamurthy
    4. Alanna E. McCarthy
    5. Michael H. Godsey
    6. Arthur Glasfeld
    7. Steven E. Mansoor
  • P2X7 receptors exhibit at least three modes of allosteric antagonism

    Science Advances
    1. Adam C. Oken
    2. Ismayn A. Ditter
    3. Nicolas E. Lisi
    4. Ipsita Krishnamurthy
    5. Michael H. Godsey
    6. Steven E. Mansoor
  • Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization

    Cell
    1. Alanna E. McCarthy
    2. Craig Yoshioka
    3. Steven E. Mansoor
  • X-ray structures define human P2X 3 receptor gating cycle and antagonist action

    Nature
    1. Steven E. Mansoor
    2. Wei
    3. Wout Oosterheert
    4. Mrinal Shekhar
    5. Emad Tajkhorshid
    6. Eric Gouaux
  • Quincke's pulse

    New England Journal of Medicine
    1. André M. Mansoor
    2. Steven E. Mansoor
  • Distance mapping in proteins using fluorescence spectroscopy

    Biochemistry
    1. Steven E. Mansoor
    2. Mark A. Dewitt
    3. David L. Farrens
  • Rhodopsin self-associates in asolectin liposomes

    Proceedings of the National Academy of Sciences of the United States of America
    1. Steven E. Mansoor
    2. Krzysztof Palczewski
    3. David L. Farrens
  • High-throughput protein structural analysis using site-directed fluorescence labeling and the bimane derivative (2-pyridyl)dithiobimane

    Biochemistry
    1. Steven E. Mansoor
    2. David L. Farrens
  • Mapping proximity within proteins using fluorescence spectroscopy. A study of T4 lysozyme showing that tryptophan residues quench bimane fluorescence

    Biochemistry
    1. Steven E. Mansoor
    2. Hassane S. Mchaourab
    3. David L. Farrens
  • Consensus and Variant cAMP-regulated Enhancers Have Distinct CREB-binding Properties

    Journal of Biological Chemistry
    1. Johanna C. Craig
    2. Maria A. Schumacher
    3. Steven E. Mansoor
    4. David L. Farrens
    5. Richard G. Brennan
    6. Richard H. Goodman
  • Determination of protein secondary structure and solvent accessibility using site-directed fluorescence labeling. Studies of T4 lysozyme using the fluorescent probe monobromobimane

    Biochemistry
    1. Steven E. Mansoor
    2. Hassane S. Mchaourab
    3. David L. Farrens