Timothy J. Nice, Ph.D.

  • Associate Professor of Molecular Microbiology and Immunology, School of Medicine
  • Molecular Microbiology and Immunology Graduate Program, School of Medicine
  • Program in Molecular and Cellular Biosciences, School of Medicine

Biography

Education

2009 - Molecular and Cellular Biology, Ph.D., University of California at Berkeley
2003 - Genetics, Cell Biology, and Development, B.S., University of Minnesota - Twin Cities

Experience

2022 - present - Associate Professor, Molecular Microbiology and Immunology, OHSU
2015 - 2022 - Assistant Professor, Molecular Microbiology and Immunology, OHSU
2010 - 2015 - Postdoctoral Fellow, Washington University in Saint Louis

Biography

Timothy Nice, Ph.D., is an assistant professor in the department of molecular microbiology and immunology. His research focuses on host-microbe interactions in the intestine.

The Nice Lab is interested in identifying virus and host genes that determine the outcome of intestinal infection. Understanding the basic functions of these genes in infection and immunity reveal viral and host strategies for survival. Additionally, the lab is interested in how virus-bacteria interactions between the diverse array of microbes that inhabit our intestine impact microbial persistence and the anti-microbial immune response. 

Publications

Publications

  • Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda

    Cell Reports
    1. Bryan Ramirez Reyes
    2. Shelby Madden
    3. Kimberly A. Meyer
    4. Brenden Bartsch
    5. Austin P. Wright
    6. David A. Constant
    7. Timothy J. Nice

  • Homeostatic pockets of interferon lambda-stimulated gene production in the intestine are associated with localized exposure to bacterial microbiota

    Gut Microbes
    1. David A. Constant
    2. Jacob A. Van Winkle
    3. Kimberly A. Meyer
    4. Shelby R. Madden
    5. Bryan Ramirez Reyes
    6. Timothy J. Nice

  • Immunostimulatory effects of Streptococcus sanguinis extracellular membrane vesicles protect oral gingival epithelial cells from periodontal pathobiont damage

    Infection and Immunity
    1. Emily Helliwell
    2. Isabella Rauch
    3. Tim Nice
    4. Justin Merritt
    5. Jens Kreth

  • Norovirus co-opts NINJ1 for selective protein secretion

    Science Advances
    1. Jaewon Song
    2. Li Zhang
    3. Seokoh Moon
    4. Ariana Fang
    5. Guoxun Wang
    6. Newsha Gheshm
    7. Skylar A. Loeb
    8. Paul Cao
    9. Joselynn R. Wallace
    10. Mia Madel Alfajaro
    11. Madison S. Strine
    12. Wandy L. Beatty
    13. Amanda M. Jamieson
    14. Robert C. Orchard
    15. Bridget A. Robinson
    16. Timothy J. Nice
    17. Craig B. Wilen
    18. Anthony Orvedahl
    19. Tiffany A. Reese
    20. Sanghyun Lee

  • Interferon regulatory factor 6 (IRF6) determines intestinal epithelial cell development and immunity

    Mucosal Immunology
    1. Austin P. Wright
    2. Sydney Harris
    3. Shelby Madden
    4. Bryan Ramirez Reyes
    5. Ethan Mulamula
    6. Alexis Gibson
    7. Isabella Rauch
    8. David A. Constant
    9. Timothy J. Nice

  • The gut protist Tritrichomonas arnold restrains virus-mediated loss of oral tolerance by modulating dietary antigen-presenting dendritic cells

    Immunity
    1. Luzmariel Medina Sanchez
    2. Magdalena Siller
    3. Yanlin Zeng
    4. Pamela H. Brigleb
    5. Kishan A. Sangani
    6. Ariadna S. Soto
    7. Clarisse Engl
    8. Colin R. Laughlin
    9. Mohit Rana
    10. Lauren Van Der Kraak
    11. Surya P. Pandey
    12. Mackenzie J. Bender
    13. Britney Fitzgerald
    14. Lee Hedden
    15. Kay Fiske
    16. Gwen M. Taylor
    17. Austin P. Wright
    18. Isha D. Mehta
    19. Syed A. Rahman
    20. Heather J. Galipeau
    21. Steven J. Mullett
    22. Stacy L. Gelhaus
    23. Simon C. Watkins
    24. Premysl Bercik
    25. Timothy J. Nice
    26. Bana Jabri
    27. Marlies Meisel
    28. Jishnu Das
    29. Terence S. Dermody
    30. Elena F. Verdú
    31. Reinhard Hinterleitner

  • T helper 1 effector memory CD4+ T cells protect the skin from poxvirus infection

    Cell Reports
    1. Jake C. Harbour
    2. Mahmoud Abdelbary
    3. John B. Schell
    4. Samantha P. Fancher
    5. Jack J. McLean
    6. Taylen J. Nappi
    7. Susan Liu
    8. Timothy J. Nice
    9. Zheng Xia
    10. Klaus Früh
    11. Jeffrey C. Nolz

  • Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium

    eLife
    1. Jacob A. Van Winkle
    2. Stefan T. Peterson
    3. Elizabeth A. Kennedy
    4. Michael J. Wheadon
    5. Harshad Ingle
    6. Chandni Desai
    7. Rachel Rodgers
    8. David A. Constant
    9. Austin P. Wright
    10. Lena Li
    11. Maxim N. Artyomov
    12. Sanghyun Lee
    13. Megan T. Baldridge
    14. Timothy J. Nice

  • Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- And NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells

    Infection and Immunity
    1. Nawar Naseer
    2. Jenna Zhang
    3. Renate Bauer
    4. David A. Constant
    5. Timothy J. Nice
    6. Igor E. Brodsky
    7. Isabella Rauch
    8. Sunny Shin

  • Transcriptional and Cytotoxic Responses of Human Intestinal Organoids to IFN Types I, II, and III

    ImmunoHorizons
    1. David A. Constant
    2. Jacob A. Van Winkle
    3. Eden VanderHoek
    4. Simone E. Dekker
    5. M. Anthony Sofia
    6. Emilie Regner
    7. Nir Modiano
    8. V. Liana Tsikitis
    9. Timothy J. Nice

  • A small RNA is functional in Escherichia fergusonii despite containing a large insertion

    Microbiology (United Kingdom)
    1. Austin P. Wright
    2. H. Auguste Dutcher
    3. Brianna Butler
    4. Timothy J. Nice
    5. Rahul Raghavan

  • CD300lf conditional knockout mouse reveals strain-specific cellular tropism of murine norovirus

    Journal of virology
    1. Vincent R. Graziano
    2. Mia Madel Alfajaro
    3. Cameron O. Schmitz
    4. Renata B. Filler
    5. Madison S. Strine
    6. Jin Wei
    7. Leon L. Hsieh
    8. Megan T. Baldridge
    9. Timothy J. Nice
    10. Sanghyun Lee
    11. Robert C. Orchard
    12. Craig B. Wilena

  • Norovirus evolution in immunodeficient mice reveals potentiated pathogenicity via a single nucleotide change in the viral capsid

    PLoS pathogens
    1. Forrest C. Walker
    2. Ebrahim Hassan
    3. Stefan T. Peterson
    4. Rachel Rodgers
    5. Lawrence A. Schriefer
    6. Cassandra E. Thompson
    7. Yuhao Li
    8. Gowri Kalugotla
    9. Carla Blum-Johnston
    10. Dylan Lawrence
    11. Broc T. McCune
    12. Vincent R. Graziano
    13. Larissa Lushniak
    14. Sanghyun Lee
    15. Alexa N. Roth
    16. Stephanie M. Karst
    17. Timothy J. Nice
    18. Jonathan J. Miner
    19. Craig B. Wilen
    20. Megan T. Baldridge

  • Myoviridae phage PDX kills enteroaggregative Escherichia coli without human microbiome dysbiosis

    Journal of Medical Microbiology
    1. Leah C.S. Cepko
    2. Eliotte E. Garling
    3. Madeline J. Dinsdale
    4. William P. Scott
    5. Loralee Bandy
    6. Tim Nice
    7. Joshua Faber-Hammond
    8. Jay L. Mellies

  • Selective Interferon Responses of Intestinal Epithelial Cells Minimize Tumor Necrosis Factor Alpha Cytotoxicity

    Journal of virology
    1. Jacob A. van Winkle
    2. David A. Constant
    3. Lena Li
    4. Timothy J. Nice

  • A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis

    Cell Host and Microbe
    1. Sanghyun Lee
    2. Hejun Liu
    3. Craig B. Wilen
    4. Zoi E. Sychev
    5. Chandni Desai
    6. Barry L. Hykes
    7. Robert C. Orchard
    8. Broc T. McCune
    9. Ki Wook Kim
    10. Timothy J. Nice
    11. Scott A. Handley
    12. Megan T. Baldridge
    13. Gaya K. Amarasinghe
    14. Herbert W. Virgin

  • Caspase-mediated cleavage of murine norovirus NS1/2 potentiates apoptosis and is required for persistent infection of intestinal epithelial cells

    PLoS pathogens
    1. Bridget A. Robinson
    2. Jacob A. Van Winkle
    3. Broc T. McCune
    4. A. Mack Peters
    5. Timothy J. Nice

  • IFN-I and IL-22 mediate protective effects of intestinal viral infection

    Nature Microbiology
    1. Jessica A. Neil
    2. Yu Matsuzawa-Ishimoto
    3. Elisabeth Kernbauer-Hölzl
    4. Samantha L. Schuster
    5. Stela Sota
    6. Mericien Venzon
    7. Simone Dallari
    8. Antonio Galvao Neto
    9. Ashley Hine
    10. David Hudesman
    11. P’ng Loke
    12. Timothy J. Nice
    13. Ken Cadwell

  • Segmented Filamentous Bacteria Prevent and Cure Rotavirus Infection

    Cell
    1. Zhenda Shi
    2. Jun Zou
    3. Zhan Zhang
    4. Xu Zhao
    5. Juan Noriega
    6. Benyue Zhang
    7. Chunyu Zhao
    8. Harshad Ingle
    9. Kyle Bittinger
    10. Lisa M. Mattei
    11. Andrea J. Pruijssers
    12. Richard K. Plemper
    13. Timothy J. Nice
    14. Megan T. Baldridge
    15. Terence S. Dermody
    16. Benoit Chassaing
    17. Andrew T. Gewirtz

  • HOIL1 is essential for the induction of type I and III interferons by MDA5 and regulates persistent murine norovirus infection

    Journal of virology
    1. Donna A. MacDuff
    2. Megan T. Baldridge
    3. Arwa M. Qaqish
    4. Timothy J. Nice
    5. Azad D. Darbandi
    6. Victoria L. Hartley
    7. Stefan T. Peterson
    8. Jonathan J. Miner
    9. Kazuhiro Iwai
    10. Herbert W. Virgin

  • Persistence of Systemic Murine Norovirus Is Maintained by Inflammatory Recruitment of Susceptible Myeloid Cells

    Cell Host and Microbe
    1. Jacob A. Van Winkle
    2. Bridget A. Robinson
    3. A. Mack Peters
    4. Lena Li
    5. Ruth V. Nouboussi
    6. Matthias Mack
    7. Timothy J. Nice

  • Differentiation and Protective Capacity of Virus-Specific CD8+ T Cells Suggest Murine Norovirus Persistence in an Immune-Privileged Enteric Niche

    Immunity
    1. Vesselin T. Tomov
    2. Olesya Palko
    3. Chi Wai Lau
    4. Ajinkya Pattekar
    5. Yuhang Sun
    6. Ralitza Tacheva
    7. Bertram Bengsch
    8. Sasikanth Manne
    9. Gabriela L. Cosma
    10. Laurence C. Eisenlohr
    11. Timothy J. Nice
    12. Herbert W. Virgin
    13. E. John Wherry

  • Expression of Ifnlr1 on intestinal epithelial cells is critical to the antiviral effects of interferon lambda against norovirus and reovirus

    Journal of virology
    1. Megan T. Baldridge
    2. Sanghyun Lee
    3. Judy J. Brown
    4. Nicole McAllister
    5. Kelly Urbanek
    6. Terence S. Dermody
    7. Timothy J. Nice
    8. Herbert W. Virgin

  • Norovirus Cell Tropism Is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine

    Cell Host and Microbe
    1. Sanghyun Lee
    2. Craig B. Wilen
    3. Anthony Orvedahl
    4. Broc T. McCune
    5. Ki Wook Kim
    6. Robert C. Orchard
    7. Stefan T. Peterson
    8. Timothy J. Nice
    9. Megan T. Baldridge
    10. Herbert W. Virgin

  • Noroviruses co-opt the function of host proteins VAPA and VAPB for replication via a phenylalanine–phenylalanine- acidic-tract-motif mimic in nonstructural viral protein NS1/2

    mBio
    1. Broc T. McCune
    2. Wei Tang
    3. Jia Lu
    4. James B. Eaglesham
    5. Lucy Thorne
    6. Anne E. Mayer
    7. Emily Condiff
    8. Timothy J. Nice
    9. Ian Goodfellow
    10. Andrzej M. Krezel
    11. Herbert W. Virgin