Assistant Professor of Medicine, Division of Cardiovascular Medicine, School of Medicine
Education and training
Degrees
Ph.D., 1998, University of Illinois at Champaign-Urbana
Memberships and associations:
American Heart Association
Areas of interest
ion channels, vascular biology, GPCR, hypertension
Publications
Selected publications
Davis CM, Liu X, Alkayed NJ. Cytochrome P450 eicosanoids in cerebrovascular function and disease. Pharmacol Ther. 2017 May 18. pii: S0163-7258(17)30123-7. doi: 10.1016/j.pharmthera.2017.05.004. [Epub ahead of print] Review. PubMed PMID: 28527918.
Liu X, Davis CM, Alkayed NJ. P450 Eicosanoids and Reactive Oxygen Species Interplay in Brain Injury and Neuroprotection.Antioxid Redox Signal. 2017 Apr 20. doi: 10.1089/ars.2017.7056. [Epub ahead of print] PubMed PMID: 28298143.
Liu X, Qian ZY, Xie F, Fan W, Nelson JW, Xiao X, Kaul S, Barnes AP, Alkayed NJ. Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid. Prostaglandins Other Lipid Mediat. 2016 Sep 17. pii: S1098-8823(16)30109-5. doi: 10.1016/j.prostaglandins.2016.09.002. [Epub ahead of print] Review. PubMed PMID: 27649858.
Liu X, Dawson DC. Cystic fibrosis transmembrane conductance regulator (CFTR) potentiators protect G551D but not ΔF508 CFTR from thermal instability. Biochemistry. 2014 Sep 9;53(35):5613-8. doi: 10.1021/bi501007v. Epub 2014 Aug 22. PubMed PMID: 25148434; PubMed Central PMCID: PMC4159205.
Liu X, Grandy DK, Janowsky A. Ractopamine, a livestock feed additive, is a full agonist at trace amine-associated receptor 1. J Pharmacol Exp Ther. 2014 Jul;350(1):124-9. doi: 10.1124/jpet.114.213116. Epub 2014 May 5. PubMed PMID: 24799633; PubMed Central PMCID: PMC4170122.
Liu X, O'Donnell N, Landstrom A, Skach WR, Dawson DC. Thermal instability of ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) channel function: protection by single suppressor mutations and inhibiting channel activity. Biochemistry. 2012 Jun 26;51(25):5113-24. doi: 10.1021/bi300018e. Epub 2012 Jun 15. PubMed PMID: 22680785; PubMed Central PMCID: PMC3402225.
Liu X, Dawson DC. Cystic fibrosis transmembrane conductance regulator: temperature-dependent cysteine reactivity suggests different stable conformers of the conduction pathway. Biochemistry. 2011 Nov 29;50(47):10311-7. doi: 10.1021/bi201176q. Epub 2011 Nov 4. PubMed PMID: 22014307; PubMed Central PMCID: PMC3229303.
Alexander C, Ivetac A, Liu X, Norimatsu Y, Serrano JR, Landstrom A, Sansom M, Dawson DC. Cystic fibrosis transmembrane conductance regulator: using differential reactivity toward channel-permeant and channel-impermeant thiol-reactive probes to test a molecular model for the pore. Biochemistry. 2009 Oct 27;48(42):10078-88. doi: 10.1021/bi901314c. PubMed PMID: 19754156; PubMed Central PMCID: PMC2765204.
Liu X. A possible role for intracellular GSH in spontaneous reaction of a cysteine (T338C) engineered into the Cystic Fibrosis Transmembrane Conductance Regulator. Biometals. 2008 Jun;21(3):277-87. Epub 2007 Sep 12. PubMed PMID: 17849169.
Liu X, Alexander C, Serrano J, Borg E, Dawson DC. Variable reactivity of an engineered cysteine at position 338 in cystic fibrosis transmembrane conductance regulator reflects different chemical states of the thiol. J Biol Chem. 2006 Mar 24;281(12):8275-85. Epub 2006 Jan 24. PubMed PMID: 16436375.