Young Hwan Chang, Ph.D. (he/him)

  • Associate Professor of Computational Biology Program, School of Medicine
  • Associate Professor of Biomedical Engineering, School of Medicine
  • Biomedical Engineering Graduate Program, School of Medicine
  • OHSU Center for Spatial Systems Biomedicine, School of Medicine
  • OHSU Knight Cancer Institute, School of Medicine

Biography

Our ongoing research focuses on establishing a comprehensive framework for quantifying multi-scale imaging. We place particular emphasis on creating an innovative image analysis tool designed to elucidate the spatial distribution of cancer cells and their interactions. To achieve this, we will employ cutting-edge machine learning and deep learning techniques, adapting them for thorough exploratory data analysis through rigorous data integration.

In our laboratory, we foster an environment where student researchers and staff are empowered to take ownership of their work, actively contributing to the generation of multiple conference presentations and journal articles annually. Our lab ethos values passionate and self-motivated team players.

Beyond the confines of the lab, I take pleasure in exploring the trails of Portland with my dog and little one.

Education and training

  • Degrees

    • B.S., 2002, Aerospace Engineering, Korea Advanced Institute of Science and Technology
    • M.S., 2004, Aerospace Engineering, Korea Advanced Institute of Science and Technology
    • Ph.D., 2013, Mechanical Engineering (Control, Systems Theory), UC Berkeley

Memberships and associations:

  • Editorial board for Computerized Medical Imaging and Graphics (2019-present)

Areas of interest

  • Quantitative image analysis, Data-driven system identification, Control theory, Machine learning

Honors and awards

  • CRUK-OHSU Spark Award (2018)

Publications

Publications

  • AxonFinder

    Heliyon
    1. Kaoutar Ait-Ahmad
    2. Cigdem Ak
    3. Guillaume Thibault
    4. Young Hwan Chang
    5. Sebnem Ece Eksi
  • Circulating Neoplastic-Immune Hybrid Cells Are Biomarkers of Occult Metastasis and Treatment Response in Pancreatic Cancer

    Cancers
    1. Ranish K. Patel
    2. Michael Parappilly
    3. Hannah C. Farley
    4. Emile J. Latour
    5. Lei G. Wang
    6. Ashvin M. Nair
    7. Ethan S. Lu
    8. Zachary Sims
    9. Byung Park
    10. Katherine Nelson
    11. Skye C. Mayo
    12. Gordon B. Mills
    13. Brett C. Sheppard
    14. Young Hwan Chang
    15. Summer L. Gibbs
    16. Adel Kardosh
    17. Charles D. Lopez
    18. Melissa H. Wong
  • Exploratory Analyses of Circulating Neoplastic-Immune Hybrid Cells as Prognostic Biomarkers in Advanced Intrahepatic Cholangiocarcinoma

    International journal of molecular sciences
    1. Ranish K. Patel
    2. Michael S. Parappilly
    3. Brett S. Walker
    4. Robert T. Heussner
    5. Alice Fung
    6. Young Hwan Chang
    7. Adel Kardosh
    8. Charles D. Lopez
    9. Skye C. Mayo
    10. Melissa H. Wong
  • MIM-CyCIF

    Communications Biology
    1. Zachary Sims
    2. Gordon B. Mills
    3. Young Hwan Chang
  • Multiplex imaging of localized prostate tumors reveals altered spatial organization of AR-positive cells in the microenvironment

    iScience
    1. Çiğdem Ak
    2. Zeynep Sayar
    3. Guillaume Thibault
    4. Erik A. Burlingame
    5. M. J. Kuykendall
    6. Jennifer Eng
    7. Alex Chitsazan
    8. Koei Chin
    9. Andrew C. Adey
    10. Christopher Boniface
    11. Paul T. Spellman
    12. George V. Thomas
    13. Ryan P. Kopp
    14. Emek Demir
    15. Young Hwan Chang
    16. Vasilis Stavrinides
    17. Sebnem Ece Eksi
  • Quantitative image analysis pipeline for detecting circulating hybrid cells in immunofluorescence images with human-level accuracy

    Cytometry Part A
    1. Robert T. Heussner
    2. Riley M. Whalen
    3. Ashley Anderson
    4. Heather Theison
    5. Joseph Baik
    6. Summer Gibbs
    7. Melissa H. Wong
    8. Young Hwan Chang
  • Quantitative multiplex immunohistochemistry reveals inter-patient lymphovascular and immune heterogeneity in primary cutaneous melanoma

    Frontiers in immunology
    1. Julia Femel
    2. Cameron Hill
    3. Irineu Illa Bochaca
    4. Jamie L. Booth
    5. Tina G. Asnaashari
    6. Maria M. Steele
    7. Ata S. Moshiri
    8. Hyungrok Do
    9. Judy Zhong
    10. Iman Osman
    11. Sancy A. Leachman
    12. Takahiro Tsujikawa
    13. Kevin P. White
    14. Young H. Chang
    15. Amanda W. Lund
  • Suppression of dystroglycan function accompanies pancreatic acinar-to-ductal metaplasia and favours dysplasia development

    Journal of Pathology
    1. Ge Huang
    2. Luke Ternes
    3. Christian Lanciault
    4. Kevin MacPherson-Hawthorne
    5. Young Hwan Chang
    6. Rosalie C. Sears
    7. John L. Muschler
  • Ultra high content analyses of circulating and tumor associated hybrid cells reveal phenotypic heterogeneity

    Scientific Reports
    1. Riley M. Whalen
    2. Ashley N. Anderson
    3. Jocelyn A. Jones
    4. Zachary Sims
    5. Young Hwan Chang
    6. Michel A. Nederlof
    7. Melissa H. Wong
    8. Summer L. Gibbs
  • 3D multiplexed tissue imaging reconstruction and optimized region of interest (ROI) selection through deep learning model of channels embedding

    Frontiers in Bioinformatics
    1. Erik Burlingame
    2. Luke Ternes
    3. Jia Ren Lin
    4. Yu An Chen
    5. Eun Na Kim
    6. Joe W. Gray
    7. Young Hwan Chang
  • Dual-modality imaging of immunofluorescence and imaging mass cytometry for whole-slide imaging and accurate segmentation

    Cell Reports Methods
    1. Eun Na Kim
    2. Phyllis Zixuan Chen
    3. Dario Bressan
    4. Monika Tripathi
    5. Ahmad Miremadi
    6. Massimiliano di Pietro
    7. Lisa M. Coussens
    8. Gregory J. Hannon
    9. Rebecca C. Fitzgerald
    10. Lizhe Zhuang
    11. Young Hwan Chang
  • Morphodynamical cell state description via live-cell imaging trajectory embedding

    Communications Biology
    1. Jeremy Copperman
    2. Sean M. Gross
    3. Young Hwan Chang
    4. Laura M. Heiser
    5. Daniel M. Zuckerman
  • MYC Deregulation and PTEN Loss Model Tumor and Stromal Heterogeneity of Aggressive Triple-Negative Breast Cancer

    Nature communications
    1. Zinab O. Doha
    2. Xiaoyan Wang
    3. Nicholas L. Calistri
    4. Jennifer Eng
    5. Colin J. Daniel
    6. Luke Ternes
    7. Eun Na Kim
    8. Carl Pelz
    9. Michael Munks
    10. Courtney Betts
    11. Sunjong Kwon
    12. Elmar Bucher
    13. Xi Li
    14. Trent Waugh
    15. Zuzana Tatarova
    16. Dylan Blumberg
    17. Aaron Ko
    18. Nell Kirchberger
    19. Jennifer A. Pietenpol
    20. Melinda E. Sanders
    21. Ellen M. Langer
    22. Mu Shui Dai
    23. Gordon Mills
    24. Koei Chin
    25. Young Hwan Chang
    26. Lisa M. Coussens
    27. Joe W. Gray
    28. Laura M. Heiser
    29. Rosalie C. Sears
  • T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control

    Nature Immunology
    1. Maria M. Steele
    2. Abhinav Jaiswal
    3. Ines Delclaux
    4. Ian D. Dryg
    5. Dhaarini Murugan
    6. Julia Femel
    7. Sunny Son
    8. Haley du Bois
    9. Cameron Hill
    10. Sancy A. Leachman
    11. Young H. Chang
    12. Lisa M. Coussens
    13. Niroshana Anandasabapathy
    14. Amanda W. Lund
  • A multi-encoder variational autoencoder controls multiple transformational features in single-cell image analysis

    Communications Biology
    1. Luke Ternes
    2. Mark Dane
    3. Sean Gross
    4. Marilyne Labrie
    5. Gordon Mills
    6. Joe Gray
    7. Laura Heiser
    8. Young Hwan Chang
  • An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer

    Cell Reports Medicine
    1. Brett E. Johnson
    2. Allison L. Creason
    3. Jayne M. Stommel
    4. Jamie M. Keck
    5. Swapnil Parmar
    6. Courtney B. Betts
    7. Aurora Blucher
    8. Christopher Boniface
    9. Elmar Bucher
    10. Erik Burlingame
    11. Todd Camp
    12. Koei Chin
    13. Jennifer Eng
    14. Joseph Estabrook
    15. Heidi S. Feiler
    16. Michael B. Heskett
    17. Zhi Hu
    18. Annette Kolodzie
    19. Ben L. Kong
    20. Marilyne Labrie
    21. Jinho Lee
    22. Patrick Leyshock
    23. Souraya Mitri
    24. Janice Patterson
    25. Jessica L. Riesterer
    26. Shamilene Sivagnanam
    27. Julia Somers
    28. Damir Sudar
    29. Guillaume Thibault
    30. Benjamin R. Weeder
    31. Christina Zheng
    32. Xiaolin Nan
    33. Reid F. Thompson
    34. Laura M. Heiser
    35. Paul T. Spellman
    36. George Thomas
    37. Emek Demir
    38. Young Hwan Chang
    39. Lisa M. Coussens
    40. Alexander R. Guimaraes
    41. Christopher Corless
    42. Jeremy Goecks
    43. Raymond Bergan
    44. Zahi Mitri
    45. Gordon B. Mills
    46. Joe W. Gray
  • A PDE Model of Breast Tumor Progression in MMTV-PyMT Mice

    Journal of Personalized Medicine
    1. Navid Mohammad Mirzaei
    2. Zuzana Tatarova
    3. Wenrui Hao
    4. Navid Changizi
    5. Alireza Asadpoure
    6. Ioannis K. Zervantonakis
    7. Yu Hu
    8. Young Hwan Chang
    9. Leili Shahriyari
  • Circulating Neoplastic-Immune Hybrid Cells Predict Metastatic Progression in Uveal Melanoma

    Cancers
    1. Michael S. Parappilly
    2. Yuki Chin
    3. Riley M. Whalen
    4. Ashley N. Anderson
    5. Trinity S. Robinson
    6. Luke Strgar
    7. Thomas L. Sutton
    8. Patrick Conley
    9. Christopher Klocke
    10. Summer L. Gibbs
    11. Young Hwan Chang
    12. Guanming Wu
    13. Melissa H. Wong
    14. Alison H. Skalet
  • Computational multiplex panel reduction to maximize information retention in breast cancer tissue microarrays

    PLoS computational biology
    1. Luke Ternes
    2. Jia Ren Lin
    3. Yu An Chen
    4. Joe W. Gray
    5. Young Hwan Chang
  • Deciphering the Immune Complexity in Esophageal Adenocarcinoma and Pre-Cancerous Lesions With Sequential Multiplex Immunohistochemistry and Sparse Subspace Clustering Approach

    Frontiers in immunology
    1. Srinand Sundaram
    2. Eun Na Kim
    3. Georgina M. Jones
    4. Shamilene Sivagnanam
    5. Monika Tripathi
    6. Ahmad Miremadi
    7. Massimiliano Di Pietro
    8. Lisa M. Coussens
    9. Rebecca C. Fitzgerald
    10. Young Hwan Chang
    11. Lizhe Zhuang
  • Exploring approaches for predictive cancer patient digital twins

    Frontiers in Digital Health
    1. Eric A. Stahlberg
    2. Mohamed Abdel-Rahman
    3. Boris Aguilar
    4. Alireza Asadpoure
    5. Robert A. Beckman
    6. Lynn L. Borkon
    7. Jeffrey N. Bryan
    8. Colleen M. Cebulla
    9. Young Hwan Chang
    10. Ansu Chatterjee
    11. Jun Deng
    12. Sepideh Dolatshahi
    13. Olivier Gevaert
    14. Emily J. Greenspan
    15. Wenrui Hao
    16. Tina Hernandez-Boussard
    17. Pamela R. Jackson
    18. Marieke Kuijjer
    19. Adrian Lee
    20. Paul Macklin
    21. Subha Madhavan
    22. Matthew D. McCoy
    23. Navid Mohammad Mirzaei
    24. Talayeh Razzaghi
    25. Heber L. Rocha
    26. Leili Shahriyari
    27. Ilya Shmulevich
    28. Daniel G. Stover
    29. Yi Sun
    30. Tanveer Syeda-Mahmood
    31. Jinhua Wang
    32. Qi Wang
    33. Ioannis Zervantonakis
  • Investigating key cell types and molecules dynamics in PyMT mice model of breast cancer through a mathematical model

    PLoS computational biology
    1. Navid Mohammad Mirzaei
    2. Navid Changizi
    3. Alireza Asadpoure
    4. Sumeyye Su
    5. Dilruba Sofia
    6. Zuzana Tatarova
    7. Ioannis K. Zervantonakis
    8. Young Hwan Chang
    9. Leili Shahriyari
  • A mathematical model of breast tumor progression based on immune infiltration

    Journal of Personalized Medicine
    1. Navid Mohammad Mirzaei
    2. Sumeyye Su
    3. Dilruba Sofia
    4. Maura Hegarty
    5. Mohamed H. Abdel-Rahman
    6. Alireza Asadpoure
    7. Colleen M. Cebulla
    8. Young Hwan Chang
    9. Wenrui Hao
    10. Pamela R. Jackson
    11. Adrian V. Lee
    12. Daniel G. Stover
    13. Zuzana Tatarova
    14. Ioannis K. Zervantonakis
    15. Leili Shahriyari
  • Genomic alterations during the in situ to invasive ductal breast carcinoma transition shaped by the immune system

    Molecular Cancer Research
    1. Anne Trinh
    2. Carlos R. Gil Del Alcazar
    3. Sachet A. Shukla
    4. Koei Chin
    5. Young Hwan Chang
    6. Guillaume Thibault
    7. Jennifer Eng
    8. Bojana Jovanovic
    9. C. Marcelo Aldaz
    10. So Yeon Park
    11. Joon Jeong
    12. Catherine Wu
    13. Joe Gray
    14. Kornelia Polyak