Portland Alcohol Research Center Research Resources
Data Sharing
The Portland Alcohol Research Center (PARC) submits data to established and centralized archives according to data type. We continue to integrate and store larger collections of data in-house that are available to PARC researchers and other researchers by request.
Animal Models
The PARC has utilized a number of genetic mouse models relevant to alcohol use over the years of its existence, as well as non-human primate model of low and heavy drinking.
Mouse genetic models developed locally by PARC researchers are available to the broader research community. Tissue samples and complete data sets on a variety of alcohol-related phenotypes associated with these mouse models are available upon request. Please contact Center Administrator, Josh Merrick atmerrick@ohsu.edu For additional information, go to the Animal Models page.
The Monkey Alcohol Tissue Research Resource (MATRR) has brain and body tissue as well as complete alcohol self-administration data sets from rhesus macaques under alcohol self-administration protocols. Visit the website to obtain information about available tissues and data, and about how to gain access.
High-Confidence Strain-Specific Splicing Events in Founder Strains of CC, DO, and HS-CC
High-Confidence Strain Specific Splicing (SSS) Events Found within the Founder Strains of the Collaborative Cross (CC), Diversity Outbred (DO), and Heterogeneous Stock Collaborative Cross (HS-CC)
The CC is a large panel of recombinant inbred mouse strains, specifically designed to provide a systems genetics resource for the study of complex traits. From the CC, a systematic cross-breeding approach was taken to develop the heterogeneous DO population, largely comparable to the HS-CC population developed by the PARC. The founder strains used for the creation of the CC, DO and HS-CC include five classical inbred laboratory strains [C57BL/6 (B6), 129S1/SvlmJ (129), A/J (AJ), NOD/LtJ (NOD), and NZO/HILtJ (NZO)] and three wild-derived inbred strains [CAST/EiJ (CAST), PWK/PhJ (PWK) and WSB/EiJ (WSB)]. These strains were chosen to maximize diversity and representation of the genetic variance available in the house mouse (Mus musculus), the most commonly used type of mouse used in scientific research. Through deep transcriptome sequencing, a large number of high-confidence SSS events were identified within each strain. High-confidence SSS events are defined as exon-exon junctions that 1) are uniquely found in one strain, 2) had a read coverage ≥ 10 and 3) are defined by a canonical splice site. These data are useful for research focused on genetic factors that influence trait variability (e.g., differences in voluntary alcohol consumption).