Publications
Fibroblast-adapted human CMV vaccines elicit predominantly conventional CD8 T cell responses in humans.
Murray SE, Nesterenko PA, Vanarsdall AL, Munks MW, Smart SM, Veziroglu EM, Sagario LC, Lee R, Claas FHJ, Doxiadis IIN, McVoy MA, Adler SP, Hill AB.
J Exp Med. 2017 Jul 3;214(7):1889-1899. doi: 10.1084/jem.20161988. Epub 2017 May 31.
PMID: 28566275
Blocking Virus Replication during Acute Murine Cytomegalovirus Infection Paradoxically Prolongs Antigen Presentation and Increases the CD8+ T Cell Response by Preventing Type I IFN-Dependent Depletion of Dendritic Cells.
Loo CP, Snyder CM, Hill AB.
Journal of immunology (Baltimore, Md. : 1950). 2017; 198(1):383-393. NIHMSID: NIHMS825887
PubMed [journal]PMID: 27872208 PMCID: PMC5173475
A Phase 1 Study of 4 Live, Recombinant Human Cytomegalovirus Towne/Toledo Chimera Vaccines in Cytomegalovirus-Seronegative Men.
Adler SP, Manganello AM, Lee R, McVoy MA, Nixon DE, Plotkin S, Mocarski E, Cox JH, Fast PE, Nesterenko PA, Murray SE, Hill AB, Kemble G.
J Infect Dis. 2016 Nov 1;214(9):1341-1348. Epub 2016 Aug 11.
PMID: 27521362
Intratumoral Infection with Murine Cytomegalovirus Synergizes with PD-L1 Blockade to Clear Melanoma Lesions and Induce Long-term Immunity.
Erkes DA, Xu G, Daskalakis C, Zurbach KA, Wilski NA, Moghbeli T, Hill AB, Snyder CM.
Mol Ther. 2016 Aug;24(8):1444-55. doi: 10.1038/mt.2016.121. Epub 2016 Jun 10.
PMID: 27434584
Strength in Numbers: Visualizing CTL-Mediated Killing In Vivo.
Nolz JC, Hill AB.
Immunity. 2016 Feb 16;44(2):207-8. doi: 10.1016/j.immuni.2016.01.026.
PMID: 26885849
Cytokine-Mediated Activation of NK Cells during Viral Infection.
Freeman BE, Raué HP, Hill AB, Slifka MK.
Journal of virology. 2015; 89(15):7922-31.
PubMed [journal]PMID: 25995253 PMCID: PMC4505636
Cytomegalovirus-based cancer vaccines expressing TRP2 induce rejection of melanoma in mice.
Xu G, Smith T, Grey F, Hill AB.
Biochemical and biophysical research communications. 2013; 437(2):287-91. NIHMSID: NIHMS502319
PubMed [journal]PMID: 23811402 PMCID: PMC3756148
Competition for antigen at the level of the APC is a major determinant of immunodominance during memory inflation in murine cytomegalovirus infection.
Farrington LA, Smith TA, Grey F, Hill AB, Snyder CM.
Journal of immunology (Baltimore, Md. : 1950). 2013; 190(7):3410-6. NIHMSID: NIHMS443745
PubMed [journal]PMID: 23455500 PMCID: PMC3608834
Sustained CD8+ T cell memory inflation after infection with a single-cycle cytomegalovirus.
Snyder CM, Cho KS, Bonnett EL, Allan JE, Hill AB.
PLoS pathogens. 2011; 7(10):e1002295.
PubMed [journal]PMID: 21998590 PMCID: PMC3188546
Comparing the kinetics of NK cells, CD4, and CD8 T cells in murine cytomegalovirus infection.
Schlub TE, Sun JC, Walton SM, Robbins SH, Pinto AK, Munks MW, Hill AB, Brossay L, Oxenius A, Davenport MP.
Journal of immunology (Baltimore, Md. : 1950). 2011; 187(3):1385-92. NIHMSID: NIHMS510772
PubMed [journal]PMID: 21697462 PMCID: PMC3771860
Cross-presentation of a spread-defective MCMV is sufficient to prime the majority of virus-specific CD8+ T cells.
Snyder CM, Allan JE, Bonnett EL, Doom CM, Hill AB.
PloS one. 2010; 5(3):e9681.
PubMed [journal]PMID: 20300633 PMCID: PMC2837378
Immunology of Infectious Diseases
Farrington LA, O'Neill G, Hill AB.
Kaufman SH, Rouse BT, Sacks DL, editors.
Washington DC: ASM Press; 2010.
Viral immune evasion.
Investigation of the impact of the common animal facility contaminant murine norovirus on experimental murine cytomegalovirus infection.
Doom CM, Turula HM, Hill AB.
Virology. 2009; 392(2):153-61. NIHMSID: NIHMS136478
PubMed [journal]PMID: 19647849 PMCID: PMC4482231
CD4+ T cell help has an epitope-dependent impact on CD8+ T cell memory inflation during murine cytomegalovirus infection.
Snyder CM, Loewendorf A, Bonnett EL, Croft M, Benedict CA, Hill AB.
Journal of immunology (Baltimore, Md. : 1950). 2009; 183(6):3932-41. NIHMSID: NIHMS149757
PubMed [journal]PMID: 19692644 PMCID: PMC2766182
Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 correlates with the NK cell antiviral response.
Kielczewska A, Pyzik M, Sun T, Krmpotic A, Lodoen MB, Munks MW, Babic M, Hill AB, Koszinowski UH, Jonjic S, Lanier LL, Vidal SM.
The Journal of experimental medicine. 2009; 206(3):515-23.
PubMed [journal]PMID: 19255146 PMCID: PMC2699136
Memory inflation during chronic viral infection is maintained by continuous production of short-lived, functional T cells.
Snyder CM, Cho KS, Bonnett EL, van Dommelen S, Shellam GR, Hill AB.
Immunity. 2008; 29(4):650-9. NIHMSID: NIHMS74806
PubMed [journal]PMID: 18957267 PMCID: PMC2583440
The dynamics of mouse cytomegalovirus-specific CD4 T cell responses during acute and latent infection.
Walton SM, Wyrsch P, Munks MW, Zimmermann A, Hengel H, Hill AB, Oxenius A.
Journal of immunology (Baltimore, Md. : 1950). 2008; 181(2):1128-34.
PubMed [journal]PMID: 18606665
Subdominant CD8 T-cell epitopes account for protection against cytomegalovirus independent of immunodomination.
Holtappels R, Simon CO, Munks MW, Thomas D, Deegen P, Kühnapfel B, Däubner T, Emde SF, Podlech J, Grzimek NK, Oehrlein-Karpi SA, Hill AB, Reddehase MJ.
Journal of virology. 2008; 82(12):5781-96.
PubMed [journal]PMID: 18367531 PMCID: PMC2395166
MHC class I immune evasion in MCMV infection.
Doom CM, Hill AB.
Medical microbiology and immunology. 2008; 197(2):191-204.
PubMed [journal]PMID: 18330598
T cell acquisition of APC membrane can impact interpretation of adoptive transfer experiments using CD45 congenic mouse strains.
Cho KS, Hill AB.
Journal of immunological methods. 2008; 330(1-2):137-45.
PubMed [journal]PMID: 18178216
The role of NKG2D signaling in inhibition of cytotoxic T-lymphocyte lysis by the Murine cytomegalovirus immunoevasin m152/gp40.
Pinto AK, Jamieson AM, Raulet DH, Hill AB.
Journal of virology. 2007; 81(22):12564-71.
PubMed [journal]PMID: 17855532 PMCID: PMC2169000
DNA immunization using highly conserved murine cytomegalovirus genes encoding homologs of human cytomegalovirus UL54 (DNA polymerase) and UL105 (helicase) elicits strong CD8 T-cell responses and is protective against systemic challenge.
Morello CS, Kelley LA, Munks MW, Hill AB, Spector DH.
Journal of virology. 2007; 81(14):7766-75.
PubMed [journal]PMID: 17507492 PMCID: PMC1933361
Viral interference with antigen presentation does not alter acute or chronic CD8 T cell immunodominance in murine cytomegalovirus infection.
Munks MW, Pinto AK, Doom CM, Hill AB.
Journal of immunology (Baltimore, Md. : 1950). 2007; 178(11):7235-41.
PubMed [journal]PMID: 17513772
Immunodominance in the T-Cell Response to Herpesviruses
Munks MW, Hill AB. 2006. Chapter 12: Immunodominance in the T Cell Response to Herpesviruses.
From Immunodominance: The Choice of the Immune System. Wiley-VCH. Edited by JA Frelinger.
Coordinated function of murine cytomegalovirus genes completely inhibits CTL lysis.
Pinto AK, Munks MW, Koszinowski UH, Hill AB.
Journal of immunology (Baltimore, Md. : 1950). 2006; 177(5):3225-34.
PubMed [journal]PMID: 16920962
Four distinct patterns of memory CD8 T cell responses to chronic murine cytomegalovirus infection.
Munks MW, Cho KS, Pinto AK, Sierro S, Klenerman P, Hill AB.
Journal of immunology (Baltimore, Md. : 1950). 2006; 177(1):450-8.
PubMed [journal]PMID: 16785542
Cellular and molecular requirements for association of the murine cytomegalovirus protein m4/gp34 with major histocompatibility complex class I molecules.
Lu X, Kavanagh DG, Hill AB.
Journal of virology. 2006; 80(12):6048-55.
PubMed [journal]PMID: 16731943 PMCID: PMC1472582
Murine cytomegalovirus interference with antigen presentation contributes to the inability of CD8 T cells to control virus in the salivary gland.
Lu X, Pinto AK, Kelly AM, Cho KS, Hill AB.
Journal of virology. 2006; 80(8):4200-2.
PubMed [journal]PMID: 16571839 PMCID: PMC1440476
Genome-wide analysis reveals a highly diverse CD8 T cell response to murine cytomegalovirus.
Munks MW, Gold MC, Zajac AL, Doom CM, Morello CS, Spector DH, Hill AB.
Journal of immunology (Baltimore, Md. : 1950). 2006; 176(6):3760-6.
PubMed [journal]PMID: 16517745
Viral interference with antigen presentation to CD8+ T cells: lessons from cytomegalovirus.
Pinto AK, Hill AB.
Viral immunology. 2005; 18(3):434-44.
PubMed [journal]PMID: 16212522
4-1BB and OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime, poxvirus boost vaccine.
Munks MW, Mourich DV, Mittler RS, Weinberg AD, Hill AB.
Immunology. 2004; 112(4):559-66.
PubMed [journal]PMID: 15270726 PMCID: PMC1782516
Murine cytomegalovirus interference with antigen presentation has little effect on the size or the effector memory phenotype of the CD8 T cell response.
Gold MC, Munks MW, Wagner M, McMahon CW, Kelly A, Kavanagh DG, Slifka MK, Koszinowski UH, Raulet DH, Hill AB.
Journal of immunology (Baltimore, Md. : 1950). 2004; 172(11):6944-53.
PubMed [journal]PMID: 15153514
Spermine compaction is an efficient and economical method of producing vaccination-grade DNA.
Mourich DV, Munks MW, Murphy JC, Willson RC, Hill AB.
Journal of immunological methods. 2003; 274(1-2):257-64.
PubMed [journal]PMID: 12609551
Effective inhibition of K(b)- and D(b)-restricted antigen presentation in primary macrophages by murine cytomegalovirus.
LoPiccolo DM, Gold MC, Kavanagh DG, Wagner M, Koszinowski UH, Hill AB.
Journal of virology. 2003; 77(1):301-8.
PubMed [journal]PMID: 12477835 PMCID: PMC140608
Viral interference with antigen presentation.
Yewdell JW, Hill AB.
Nature immunology. 2002; 3(11):1019-25.
PubMed [journal]PMID: 12407410
The murine cytomegalovirus immunomodulatory gene m152 prevents recognition of infected cells by M45-specific CTL but does not alter the immunodominance of the M45-specific CD8 T cell response in vivo.
Gold MC, Munks MW, Wagner M, Koszinowski UH, Hill AB, Fling SP.
Journal of immunology (Baltimore, Md. : 1950). 2002; 169(1):359-65.
PubMed [journal]PMID: 12077265
Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors.
Arase H, Mocarski ES, Campbell AE, Hill AB, Lanier LL.
Science (New York, N.Y.). 2002; 296(5571):1323-6.
PubMed [journal]PMID: 11950999
Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin.
Gao B, Adhikari R, Howarth M, Nakamura K, Gold MC, Hill AB, Knee R, Michalak M, Elliott T.
Immunity. 2002; 16(1):99-109.
PubMed [journal]PMID: 11825569
The multiple immune-evasion genes of murine cytomegalovirus are not redundant: m4 and m152 inhibit antigen presentation in a complementary and cooperative fashion.
Kavanagh DG, Gold MC, Wagner M, Koszinowski UH, Hill AB.
The Journal of experimental medicine. 2001; 194(7):967-78.
PubMed [journal]PMID: 11581318 PMCID: PMC2193484
The murine cytomegalovirus immune evasion protein m4/gp34 forms biochemically distinct complexes with class I MHC at the cell surface and in a pre-Golgi compartment.
Kavanagh DG, Koszinowski UH, Hill AB.
Journal of immunology (Baltimore, Md. : 1950). 2001; 167(7):3894-902.
PubMed [journal]PMID: 11564807
Evasion of cytotoxic T lymphocytes by murine cytomegalovirus.
Kavanagh DG, Hill AB.
Seminars in immunology. 2001; 13(1):19-26.
PubMed [journal]PMID: 11289796
Bovine herpesvirus-1 infection affects the peptide transport activity in bovine cells.
Hinkley S, Hill AB, Srikumaran S.
Virus Res. 1998 Jan;53(1):91-6.
PMID: 9617772
A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surface.
Kleijnen MF, Huppa JB, Lucin P, Mukherjee S, Farrell H, Campbell AE, Koszinowski UH, Hill AB, Ploegh HL.
EMBO J. 1997 Feb 17;16(4):685-94.
PMID: 9049298
Herpes simplex virus blocks intracellular transport of HLA-G in placentally derived human cells.
Schust DJ, Hill AB, Ploegh HL.
J Immunol. 1996 Oct 15;157(8):3375-80.
PMID: 8871634
Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP.
Tomazin R, Hill AB, Jugovic P, York I, van Endert P, Ploegh HL, Andrews DW, Johnson DC.
EMBO J. 1996 Jul 1;15(13):3256-66.
PMID: 8670826
Mechanisms of interference with the MHC class I-restricted pathway of antigen presentation by herpesviruses.
Hill AB
Immunology and Cell Biology (1996) 74, 523-526
Class I major histocompatibility complex-restricted cytotoxic T lymphocytes specific for Epstein-Barr virus (EBV)-transformed B lymphoblastoid cell lines against which they were raised.
Hill AB, Lee SP, Haurum JS, Murray N, Yao QY, Rowe M, Signoret N, Rickinson AB, McMichael AJ.
J Exp Med. 1995 Jun 1;181(6):2221-8.
PMID: 7539044
Herpes simplex virus turns off the TAP to evade host immunity.
Hill A, Jugovic P, York I, Russ G, Bennink J, Yewdell J, Ploegh H, Johnson D.
Nature. 1995; 375(6530):411-5.
PubMed [journal]PMID: 7760935
HLA class I molecules are not transported to the cell surface in cells infected with herpes simplex virus types 1 and 2.
Hill AB, Barnett BC, McMichael AJ, McGeoch DJ.
J Immunol. 1994 Mar 15;152(6):2736-41.
PMID: 8144880
Restimulated memory Tc cells have a higher apparent avidity of interaction with targets than primary virus-immune Tc cells as indicated by anti-CD8 blocking.
Hill AB, Blanden RV, Parrish CR, Müllbacher A.
Immunol Cell Biol. 1992 Aug;70 ( Pt 4):259-65.
PMID: 1330899
Broad cross-reactivity with marked fine specificity in the cytotoxic T cell response to flaviviruses.
Hill AB, Müllbacher A, Parrish C, Coia G, Westaway EG, Blanden RV.
J Gen Virol. 1992 May;73 ( Pt 5):1115-23.
PMID: 1375278
Alloreactive cytotoxic T cells recognize MHC class I antigen without peptide specificity.
Müllbacher A, Hill AB, Blanden RV, Cowden WB, King NJ, Hla RT.
J Immunol. 1991 Sep 15;147(6):1765-72.
PMID: 1890303