Publications

Selected publications

Honkala A, Tailor D, Malhotra SV*. Guanylate-Binding Protein 1: a multifaceted cytokine-induced GTPase. Frontiers in Immunology (2020) 10, 3139.

Yadav Y, Sharma D, Kumar K, Kumar V, Jha A, Prasad AK, Len C, Malhotra SV, Wengel J, Parmar VS.  Synthetic, Structural, and Anticancer Activity Evaluation Studies on Novel Pyrazolylnucleosides. Molecules (2019) 24, 3922; doi:10.3390/molecules24213922

Resendez A, Tailor D, Graves E, Malhotra SV*, Radiosensitization of head and neck squamous cell carcinoma (HNSCC) by a natural product derived podophyllotoxin. ACS Medicinal Chemistry Letters (2019), 10(9), 1314-1321.

Rice MA, Malhotra SV1, Stoyanova T*. Second-generation antiandrogens: from discovery to standard of care in castration resistant prostate cancer. Frontiers in Oncology. (2019), 9, 801.

Pandrala M, Resendez A, Malhotra SV*. Polypyridyl Iridium(III) Based Catalysts for Highly Chemoselective Hydrogenation of Aldehydes. J Catalysis (2019), 378, 283-288.

Banister SD, Krishna Kumar K, Kumar V, Kobilka BK, Malhotra SV*. Selective modulation of the cannabinoid type 1 (CB1) receptor as an emerging platform for the treatment of neuropathic pain. MedChemComm (2019), 10(5), 647-659.

Resendez A, Malhotra SV*. Boronic Acid Appended Naphthyl-Pyridinium Receptors as Chemosensors Sugars. Scientific Reports. (2019); 9(1):6651.

Kumar V, LaJevic M, Pandrala M, Jacobo SA, Malhotra SV*, Zabel BA*. Novel CMKLR1 Inhibitors for Application in Demyelinating Disease. Scientific Reports (2019); 9(1):7178.

Krishna Kumar K, Shalev-Benami M, Robertson MJ, Hu H, Banister SD, Hollingsworth SA, Latorraca NR, Kato HE, Hilger D, Maeda S, Weis WI, Farrens DL, Dror RO, Malhotra SV1,2, Kobilka BK*, Skiniotis G*. Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex. Cell (2019); 176(3):448-58.

Mani V, Lyu Z, Kumar V, Ercal B, Chen H, Malhotra SV*, Demirci U*. Epithelial-to-Mesenchymal Transition (EMT) and Drug Response in Dynamic Bioengineered Lung Cancer Microenvironment. Advanced Biosystems (2019); 3 (1800223).

Moses MA, Kim YS, Rivera-Marquez GM, Oshima N, Watson MJ, Beebe KE, Wells C, Lee S, Zuehlke AD, Shao H, Bingman III WE, Kumar V, Malhotra SV1, Weigel NL, Gestwicki JE, Trepel JB, Neckers LM*. Targeting the Hsp40/Hsp 70 Chaperone Axis as a novel strategy to Treat Castration-Resistant prostate cancer. Cancer Research (2018); 78(14):4022-35.

Going C, Tailor D, Kumar V, Birk A, Pandrala M, Rice M, Stoyanova T, Malhotra SV*, Pitteri S*. Quantitative Proteomic Profiling Reveals Key Pathways in the Anti-cancer Action of Methoxychalcone Derivatives in Triple Negative Breast Cancer. Journal of Proteome Research (2018); 17(10):3574-3585.

Mohamed AA, Xavier CP, Sukumar G, Tan SH, Ravindranath L, Seraj N, Kumar V, Sreenath T, McLeod DG, Petrovics G, Rosner IL, Srivastava M, Strovel J, Malhotra SV, LaRonde NA, Dobi A, Dalgard CL, Srivastava S*. Identification of a Small Molecule that Selectively Inhibits ERG-Positive Cancer Cell Growth. Cancer Research (2018); 78(13):3659-71.

Jun JH, Kumar V, Dexheimer TS, Wedlich I, Nicklaus MC, Pommier Y, Malhotra SV*. Synthesis, anti-cancer screening and tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibition activity of novel piperidinyl sulfamides. Eur J Pharm Sci (2018); 111:337-348.

Ferroni C*, Pepe A, Kim YS, Lee S, Guerrini A, Parenti MD, Tesei A, Zamagni A, Cortesi M, Zaffaroni N, De Cesare M, Beretta GL, Trepel JB, Malhotra SV1, Varichi G*. 1,4-Substituted Triazoles as Nonsteroidal Anti-Androgens for Prostate Cancer Treatment. J Med Chem (2017); 60(7):3082-3093.

Sharma GVM*, Kumar KS, Reddy SV, Nagalingam A, Cunningham KM, Ummanni R, Hugel H, Sharma D*, Malhotra SV*. Synthesis and Biological Evaluation of Triazole-Vanillin Molecular Hybrids as Anti-Cancer Agents. Current Bioactive Compounds (2017); 13(3), 223-235.

Avtanski DB, Nagalingam A, Tomaszewski JE, Risbood P, Difillippantonio MJ, Saxena NK*, Malhotra SV*, Sharma D*. Indolo-pyrido-isoquinolin based alkaloid inhibits growth, invasion and migration of breast cancer cells via activation of p53-miR34a axis.  Molecular Oncology (2016); 10(7):1118-1132.

Sekar TV, Foygel K, Devulapally R, Kumar V, Malhotra S, Massoud TF, Paulmurugan R*, Molecular Imaging Biosensor Monitors p53 Sumoylation in Cells and Living Mice. Analytical Chemistry (2016); 88(23):11420-11428.

Kandi SK, Manohar S, Velez Gerena CE, Zayas B, Malhotra SV*, Rawat DS*. C5-curcuminoid-4-aminoquinoline based molecular hybrids: design, synthesis and mechanistic investigation of anticancer activity. New Journal of Chemistry (2015); 39(1), 224-234.

Malhotra SV*, Kumar V, Velez C, Zayas B. Imidazolium-derived ionic salts induce inhibition of cancerous cell growth through apoptosis. Medicinal Chemistry Communications (2014); 5(9), 1404-1409.

Manohar S, Pepe A, Vélez Gerena CE, Zayas B, Malhotra SV*, Rawat DS*. Anticancer activity of 4-aminoquinoline-triazine based molecular hybrids. RSC Advances (2014); 4(14), 7062-7067.

Kim JH, Thimmulappa RK*, Kumar V, Cui W, Kumar S, Kombairaju P, Zhang H, Margolick J, Matsui W, Macvittie T, Malhotra SV*, Biswal S*. NRF2-​mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation. The Journal of Clinical Investigation (2014); 124(2), 730-741.

Sharma GVM,* Ramesh A, Singh A, Srikanth G, Jayaram V, Duscharla D.  Jun JH, Ummanni R,* Malhotra SV*. Imidazole derivatives show anticancer potential by inducing apoptosis and cellular senescence. Medicinal Chemistry Communications (2014); 5(11), 1751-1760.

CoAndreoli M, Persico M, Kumar A, Orteca N, Kumar V, Pepe A, Mahalingam S, Alegria AE, Petrella L, Sevciunaite L, Camperchioli A, Mariani M, Dato AD, Novellino E, Scambia G, Malhotra SV*, Ferlini C*, Fattorusso C*. Identification of the First Inhibitor of the GBP1:PIM1 Interaction. Implications for the Development of a New Class of Anticancer Agents Against Paclitaxel Resistant Cancer Cells. Journal of Medicinal Chemistry (2014); 57(19): 7916–7932.

Malhotra SV*, Brown HC. C2-Symmetric N,N'-bis(terpenyl)ethylenediamines-Synthesis and Application in the Enantioselective Nitroaldol Reaction. RSC Advances (2014); 4, 14264-14269.