Publications from the Mansoor lab

Oken AC, Krishnamurthy I, Savage JC, Lisi NE, Godsey MH, Mansoor SE.Molecular Pharmacology of P2X Receptors: Exploring Druggable Domains Revealed by Structural Biology. Frontiers in Pharmacology. 2022 Jun 17;13. doi: 10.3389/fphar.2022.925880

Mansoor SE. How Structural Biology Has Directly Impacted Our Understanding of P2X Receptor Function and Gating. Methods Mol Biol. 2022;2510:1-29. doi: 10.1007/978-1-0716-2384-8_1. PMID: 35776317.

McCarthy AE, Yoshioka C, Mansoor SE. Full-Length P2X₇ Structures Reveal How Palmitoylation Prevents Channel Desensitization. Cell. 2019 Oct 17;179(3):659-670.e13. doi: 10.1016/j.cell.2019.09.017. Epub 2019 Oct 3. PMID: 31587896; PMCID: PMC7053488.

Mansoor SE, Lü W, Oosterheert W, Shekhar M, Tajkhorshid E, Gouaux E. X-ray structures define human P2X(3) receptor gating cycle and antagonist action. Nature. 2016 Oct 6;538(7623):66-71. doi: 10.1038/nature19367. Epub 2016 Sep 14. PMID: 27626375; PMCID: PMC5161641.

Publications from Mansoor lab members

O'Connell ME, Sridharan D, Driscoll T, Krishnamurthy I, Perry WG, Applewhite DA. The Drosophila protein, Nausicaa, regulates lamellipodial actin dynamics in a Cortactin-dependent manner. Biol Open. 2019 Jun 17;8(6):bio038232. doi: 10.1242/bio.038232. PMID: 31164339; PMCID: PMC6602326.

Godsey MH, Davulcu O, Nix JC, Skalicky JJ, Brüschweiler RP, Chapman MS. The Sampling of Conformational Dynamics in Ambient-Temperature Crystal Structures of Arginine Kinase. Structure. 2016 Oct 4;24(10):1658-1667. doi: 10.1016/j.str.2016.07.013. Epub 2016 Sep 1. PMID: 27594681; PMCID: PMC5052116.

Mansoor AM, Mansoor SE. Images in clinical medicine. Lancisi's Sign. N Engl J Med. 2016 Jan 14;374(2):e2. doi: 10.1056/NEJMicm1502066. PMID: 26760104.

Mansoor AM, Mansoor SE. Images in clinical medicine. Quincke's pulse. N Engl J Med. 2013 Aug 15;369(7):e8. doi: 10.1056/NEJMicm1215624. PMID: 23944324.

Mansoor SE, Dewitt MA, Farrens DL. Distance mapping in proteins using fluorescence spectroscopy: the tryptophan-induced quenching (TrIQ) method. Biochemistry. 2010 Nov 16;49(45):9722-31. doi: 10.1021/bi100907m. Epub 2010 Oct 26. PMID: 20886836; PMCID: PMC3938424.

Godsey MH, Minasov G, Shuvalova L, Brunzelle JS, Vorontsov II, Collart FR, Anderson WF. The 2.2 A resolution crystal structure of Bacillus cereus Nif3-family protein YqfO reveals a conserved dimetal-binding motif and a regulatory domain. Protein Sci. 2007 Jul;16(7):1285-93. doi: 10.1110/ps.062674007. PMID: 17586767; PMCID: PMC2206684.

Mansoor SE, Palczewski K, Farrens DL. Rhodopsin self-associates in asolectin liposomes. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3060-5. doi: 10.1073/pnas.0511010103. Epub 2006 Feb 21. PMID: 16492772; PMCID: PMC1413906.

Godsey MH, Ort S, Sabini E, Konrad M, Lavie A. Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: illuminating the role of main-chain reorganization. Biochemistry. 2006 Jan 17;45(2):452-61. doi: 10.1021/bi0518646. PMID: 16401075.

Mansoor SE, Farrens DL. High-throughput protein structural analysis using site-directed fluorescence labeling and the bimane derivative (2-pyridyl)dithiobimane. Biochemistry. 2004 Jul 27;43(29):9426-38. doi:
10.1021/bi036259m. PMID: 15260485.

Godsey MH, Zheleznova Heldwein EE, Brennan RG. Structural biology of bacterial multidrug resistance gene regulators. J Biol Chem. 2002 Oct 25;277(43):40169-72. doi: 10.1074/jbc.R200018200. Epub 2002 Aug 22. PMID: 12186881.

Mansoor SE, McHaourab HS, Farrens DL. Mapping proximity within proteins using fluorescence spectroscopy. A study of T4 lysozyme showing that tryptophan residues quench bimane fluorescence. Biochemistry. 2002 Feb 26;41(8):2475-84. doi: 10.1021/bi011198i. PMID: 11851393.

Godsey MH, Baranova NN, Neyfakh AA, Brennan RG. Crystal structure of MtaN, a global multidrug transporter gene activator. J Biol Chem. 2001 Dec 14;276(50):47178-84. doi: 10.1074/jbc.M105819200. Epub 2001 Oct 1. PMID: 11581256.

Craig JC, Schumacher MA, Mansoor SE, Farrens DL, Brennan RG, Goodman RH. Consensus and variant cAMP-regulated enhancers have distinct CREB-binding properties. J Biol Chem. 2001 Apr 13;276(15):11719-28. doi: 10.1074/jbc.M010263200. Epub 2000 Dec 27. PMID: 11134034.

Godsey MH, Baranova NN, Neyfakh AA, Brennan RG. Crystallization and preliminary X-ray diffraction studies on the DNA-binding domain of the multidrug transporter activation protein (MtaN) from Bacillus subtilis. Acta Crystallogr D Biol Crystallogr. 2000 Nov;56(Pt 11):1456-8. doi: 10.1107/s0907444900010295. PMID: 11053850.

Mansoor SE, McHaourab HS, Farrens DL. Determination of protein secondary structure and solvent accessibility using site-directed fluorescence labeling. Studies of T4 lysozyme using the fluorescent probe monobromobimane. Biochemistry. 1999 Dec 7;38(49):16383-93. doi: 10.1021/bi991331v. PMID: 10587464.