Publications
Selected publications
Discovery of a Novel Antimalarial Chemotype: Dual-function Acridone Derivatives
Kelly, JX, Smilkstein, MJ, Brun, R, Wittlin, S, Cooper, RA, Lane, KD, Janowsky, A, Johnson, RA, Dodean, RA, Winter, R, Hinrichs, DJ, and Riscoe, MK,, 2009, Nature 459: 270-273.
Chemical genetics of Plasmodium falciparum
Guiguemde WA, Shelat AA, Bouck D, Duffy S, Crowther GJ, Davis PH, Smithson DC, Connelly M, Clark J, Zhu F, Jiménez-Díaz MB, Martinez MS, Wilson EB, Tripathi AK, Gut J, Sharlow ER, Bathurst I, El Mazouni F, Fowble JW, Forquer I, McGinley PL, Castro S, Angulo-Barturen I, Ferrer S, Rosenthal PJ, Derisi JL, Sullivan DJ, Lazo JS, Roos DS, Riscoe MK, Phillips MA, Rathod PK, Van Voorhis WC, Avery VM, Guy RK, 2010, Nature 465: 311-5.
Optimization of Endochin-like Quinolones for Antimalarial Activity
Winter, RW, Kelly, JX, Smilkstein, MJ, Koop, DR, Hinrichs, DJ and Riscoe, MK, 2011, Experimental Parasitology 127:545-551.
Sontochin as a guide to development of drugs against chloroquine resistant malaria
Pou S, Winter, RW, Nilsen, A, Kelly, JX, Li, Y, Doggett, JS, Riscoe, EW, Wegmann, KW, Hinrichs, DJ, and Riscoe, MK, 2012, Antimicrobial Agents and Chemotherapy 56(7):3475-80.
Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis.
Doggett, JS, Nilsen, A, Forquer, I, Wegmann, KW, Jones-Brando, L, Yolken, RH, Bordon, C, Charman, SA, Katneni, K, Schultz T, Burrows, J, Hinrichs, DJ, Meunier B, Carruthers, VB, and Riscoe, MK, 2012, Proceedings of the National Academy of Science, USA. 109(39):15936-41.
Quinolone-3-diarylethers: A new class of antimalarial drug
A. Nilsen, A. N. LaCrue, K. L. White, I. P. Forquer, R. M. Cross, J. Marfurt, M. W. Mather, M. J. Delves, D. M. Shackleford, F. E. Saenz, J. M. Morrisey, J. Steuten, T. Mutka, Y. Li, G. Wirjanata, E. Ryan, S. Duffy, J. X. Kelly, B. F. Sebayang, A.-M. Zeeman, R. Noviyanti, R. E. Sinden, C. H. M. Kocken, R. N. Price, V. M. Avery, I. Angulo-Barturen, M. B. Jiménez-Díaz, S. Ferrer, E. Herreros, L. M. Sanz, F.-J. Gamo, I. Bathurst, J. N. Burrows, P. Siegl, R. K. Guy, R. W. Winter, A. B. Vaidya, S. A. Charman, D. E. Kyle, R. Manetsch, M. K. Riscoe, 2013, Science Translational Medicine 5, 177ra37.
Discovery, Synthesis, and Optimization of Antimalarial 4(1H)-Quinolone-3-Diarylethers
Aaron Nilsen, Galen P. Miley, Isaac P. Forquer, Michael W. Mather, Kasiram Katneni, Yuexin Li, Sovitj Pou, April M. Pershing, Allison M. Stickles, Eileen Ryan, Jane Xu Kelly, J. Stone Doggett, Karen L. White, David J. Hinrichs, Rolf W. Winter, Susan A. Charman, Lev N. Zakharov, Ian Bathurst, Jeremy N. Burrows, Akhil B. Vaidya, and Michael K. Riscoe, 2014, Journal of Medicinal Chemistry 57 (9), 3818-3834.