Welcome
The Vaccine and Gene Therapy Institute at Oregon Health & Science University has assembled a multidisciplinary team of scientists to respond to serious viral disease threats, including AIDS, chronic viral infection-associated diseases, newly emerging viral diseases and infectious diseases of the elderly. Our programs are intended to span the continuum between basic and clinical science, in which discoveries are rapidly advanced from the level of molecular and cellular biology through animal models and ultimately into clinical testing. Learn more
VGTI Seminar Series
Recent publications
Lancet Microbe. February 27, 2025
Role of non-human primate models in accelerating research and developing countermeasures against Zika virus infection
bioRxiv. February 27, 2025
Comparative Molecular, Innate and Adaptive Impacts of Chemically Diverse STING Agonists
bioRxiv. February 22, 2025
Effect of obesity on the acute response to SARS-CoV-2 infection and development of post-acute sequelae of COVID-19 (PASC) in nonhuman primates
J Virol. January 31, 2025
Third intracellular loop of HCMV US28 is necessary for signaling and viral reactivation
Nat Commun. January 31, 2025
Rhesus Cytomegalovirus-encoded Fcy-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity
J Virol. January 21, 2025
Generation of chimeric forms of rhesus macaque Rhadinovirus expressing KSHV envelope glycoproteins gH and gL for utilization in an NHP model of infection
PLoS Pathog. January 16, 2025
Kaposio’s sarcoma-associated herpesvirus (KSHV) gB dictates a low-pH endocytotic entry pathway as revealed by a dual-fluorescent virus system and a rhesus monkey Rhadinovirus expressing KSHV gB
Nat Immunol. January 16, 2025
Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption
Science. January 3, 2025
Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein
Viruses. December 16, 2024
Sequence Analysis of microRNAs Encoded by Simian Lymphocrytoviruses
PLoS Pathog. December 11, 2024
Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34+ hematopoietic progenitor cells and humanized mice
J Virol. December 10, 2024
Third intracellular loop of HCMV US28 is necessary for signaling and viral reactivation
JCI Insight. December 6, 2024
Rapid systemic spread and minimal immune responses following SIVsab intrarectal transmission in African green monkeys
Nat Commun. December 4, 2024
Potent AMA1-specific human monoclonal antibody against Plasmodium vivax Pre-erythrocytic and Blood Stages
bioRxiv. December 3, 2024
The TLR7/8 agonist INI-4001 enhances the immunogenicity of a Powassan virus-like-particle vaccine
J Med Chem. December 2, 2024
4-Substituted-2-Thiazole Amides as Viral Replication Inhibitors of Alphaviruses
bioRxiv. November 27, 2024
Systemic exposure to COVID-19 virus-like particles modulates firing patterns of cortical neurons in the living mouse brain
Front Immunol. November 26, 2024
Effects of COVID-19 virus-like particles on the behavioral and cognitive performance of human apolipoprotein E targeted replacement mice
Nat Protoc. November 21, 2024
Biolayer interferometry for measuring the kinetics of protein-protein interactions and nanobody binding
Res Sq. November 12, 2024
A Covalent Chemical Probe for Chikungunya nsP2 Cysteine Protease with Antialphaviral Activity and Proteome-wide Selectivity
Clin Ther. November 2024
A Randomize Placebo-Controlled Trial of Leronlimab in Mild-To-Moderate COVID-19
Ways to Give
Donate to Vaccine and Gene Therapy Institute.
VGTI offers two options and account to consider when donating that serve differing purposes:
The VGTI Support Foundation Fund
Gifts to the VGTI Support Foundation Fund provides vital support that allows us find cures for life threatening infectious diseases. These funds help us to have necessary resources and create and conduct innovative infectious disease research studies, leading to the development of vaccines and cures.
The Jay Nelson Memorial Fund
Gifts to the Jay Nelson Memorial Fund supports providing education and learning opportunities for our current up and coming scientists with a focus on Herpesvirus.
Biographical Feature:
In memoriam Jay A. Nelson (1948–2024)
Your Gift Brings Hope, Please support our mission in memory of Jay Nelson. Your generosity will help support education and learning opportunities for our current up and coming scientists with a focus on Herpesvirus. Click to Donate
The VGTI Support Foundation Fund
Donate to VGTI
Your gifts help provide vital resources to conduct innovative research and more.
COVID-19 Efforts - Building a COVID Testing Lab