Welcome

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The Vaccine and Gene Therapy Institute at Oregon Health & Science University has assembled a multidisciplinary team of scientists to respond to serious viral disease threats, including AIDS, chronic viral infection-associated diseases, newly emerging viral diseases and infectious diseases of the elderly. Our programs are intended to span the continuum between basic and clinical science, in which discoveries are rapidly advanced from the level of molecular and cellular biology through animal models and ultimately into clinical testing. Learn more

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Recent publications

Microbiol Spectr. September 30, 2024
Pre-challenge gut microbial signature predicts RhCMV/SIV vaccine efficacy in rhesus macaques

Mabs. September 26, 2024
FcRn-enhancing mutations lead to increased and prolonged levels of the HIV CCR5-blocking monoclonal antibody leronlimab in the fetuses and newborns of pregnant rhesus macaques

BioDrugs. September 18, 2024
Chikungunya Virus Vaccines: A Review of IXCHIQ and PXVX0317 from Pre-Clinical Evaluation to Licensure

Nat Immunol. September 12, 2024
Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption

mBio. September 6, 2024
Bystander monocytic cells drive infection-independent NLRP3 inflammasome response to SARS-CoV-2

Cell. September 5, 2024
Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5

Cell. September 5, 2024
Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype

Journal of Virology. August 2024
Regulation of the cell surface expression of classical and non-classical MHC proteins by the human cytomegalovirus UL40 and rhesus cytomegalovirus Rh67 proteins

J Virol. August 29, 2024
A nanobody interaction with SARS-COV-2 Spike allows the versatile targeting of lentivirus vectors

JCI Insight. August 27, 2024
Immune perturbation following SHIV infection is greater in newborn macaques than in infants

PLoS Pathog. August 22, 2024
Impact of alemtuzumab-mediated lymphocyte depletion on SIV reservoir establishment and persistence

Science. August 9, 2024
Engineered deletions of HIV replicate conditionally to reduce disease in nonhuman primates

JCI Insight. August 8, 2024
Effect of metabolic status on response to SIV infection and antiretroviral therapy in nonhuman primates

PLoS Pathog. August 8, 2024
HIV transcription persists in the brain of virally suppressed people with HIV

Vaccines, August 2024
The Approved Live-Attenuated Chikungunya Virus Vaccine (IXCHIQ®) Elicits Cross-Neutralizing Antibody Breadth Extending to Multiple Arthritogenic Alphaviruses Similar to the Antibody Breadth Following Natural Infection

Frontiers in Immunology, August 2024
Viral escape mutations do not account for non-protection from SIVmac239 challenge in RhCMV/SIV vaccinated rhesus macaques

Nat Commun. July 19, 2024
Cytomegalovirus vaccine vector-induced effector memory CD4 + T cells protect cynomolgus macaques from lethal aerosolized heterologous avian influenza challenge

Cell. July 18, 2024
Analysis of the diverse antigenic landscape of the malaria protein RH5identifies a potent vaccine-induced human public antibody clonotype

Cell. July 17, 2024
Natural Malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5

Antiviral Res. June 24, 2024
KDM5A/B contribute to HIV-1 latent infection and survival of HIV-1 infected cells

View all publications

Ways to Give

Donate to Vaccine and Gene Therapy Institute.
VGTI offers two options and account to consider when donating that serve differing purposes:

The VGTI Support Foundation Fund
Gifts to the VGTI Support Foundation Fund provides vital support that allows us find cures for life threatening infectious diseases.  These funds help us to have necessary resources and create and conduct innovative infectious disease research studies, leading to the development of vaccines and cures. 

The Jay Nelson Memorial Fund
Gifts to the Jay Nelson Memorial Fund supports providing education and learning opportunities for our current up and coming scientists with a focus on Herpesvirus.

Click to Donate

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Your Gift Brings Hope, Please support our mission in memory of Jay Nelson. Your generosity will help support education and learning opportunities for our current up and coming scientists with a focus on Herpesvirus. Click to Donate

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The VGTI Support Foundation Fund

Donate to VGTI

Your gifts help provide vital resources to conduct innovative research and more.

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COVID-19 Efforts - Building a COVID Testing Lab