Klaus Früh, Ph.D.

Klaus Frueh headshot

Klaus Früh’s research focuses on understanding the molecular interaction between viral pathogens and their hosts, particularly the identification and characterization of viral gene products that modulate the innate and adaptive immune responses. This knowledge is translated into the development and improvement of cytomegalovirus (CMV)-vectored vaccines which are unique in their ability to persistently maintain an immune shield of so called effector memory T cells, including highly unconventional (MHC-II and MHC-E) restricted CD8+ T cells. CMV vectored vaccines have shown protection in non-human primate models of AIDS, TB, and Malaria and this novel vector concept is currently developed for both prophylactic and therapeutic vaccination against a number of chronic viral, bacterial and parasitic diseases as well as cancer.

Dr. Früh is also co-founder and board member of VIR Biotechnology, a biotechnology company that harnesses the power of the immune system to prevent and treat infectious diseases.

Biography

Klaus Früh received his Ph.D. from the University of Heidelberg in 1990. From 1991 to 1994 he was a postdoctoral scientist at the Scripps Research Institute in La Jolla, California. In 1994 he joined the R.W. Johnson Pharmaceutical Research Institute, where he directed the antiviral pharmaceutical research program. In 2000 he joined the OHSU Vaccine and Gene Therapy Institute as associate professor and ONPRC as associate scientist, at the same time becoming director of the Microarray Shared Resource. He was promoted to Professor and Senior Scientist in 2005.

Publications

  • Vashee S, Stockwell TB, Alperovich N, Denisova EA, GibsonDG, Cady KC, Miller K, Kannan K, Malouli D, Crawford LB, Voorhies AA, BrueningE, Caposio P, Früh K. Cloning, Assembly, and Modification of the Primary HumanCytomegalovirus Isolate Toledo by Yeast-Based Transformation-AssociatedRecombination. mSphere. 2017 Oct 4;2(5).pii: e00331-17. doi: 10.1128/mSphereDirect.00331-17. eCollection 2017 Sep-Oct[PMID: 28989973]

  • Früh K, Picker L. CD8+ T cell programming by cytomegalovirusvectors: applications in prophylactic and therapeutic vaccination. Curr OpinImmunol. 2017 Aug;47:52-56. doi: 10.1016/j.coi.2017.06.010. Epub 2017 Jul 19.Review. [PMID: 28734175]

  • Hansen SG, Piatak M, Ventura AB, Hughes CM, Gilbride RM,Ford JC, Oswald K, Shoemaker R, Li Y, Lewis MS, Gilliam AN, Xu G, Whizin N,Burwitz BJ, Planer SL, Turner JM, Legasse AW, Axthelm MK, Nelson JA, Früh K,Sacha JB, Estes JD, Keele BF, Edlefsen PT, Lifson JD, Picker LJ. Addendum:Immune clearance of highly pathogenic SIV infection. Nature. 2017 Jul 6;547(7661):123-124. doi:10.1038/nature22984. Epub 2017 Jun 21. [PMID: 28636599]

  • Dekhtiarenko I, Ratts RB, Blatnik R, Lee LN, Fischer S,Borkner L, Oduro JD, Marandu TF, Hoppe S, Ruzsics Z, Sonnemann JK, Mansouri M,Meyer C, Lemmermann NA, Holtappels R, Arens R, Klenerman P, Früh K, ReddehaseMJ, Riemer AB, Cicin-Sain L. Peptide Processing Is Critical for T-Cell MemoryInflation and May Be Optimized to Improve Immune Protection by CMV-BasedVaccine Vectors. PLoS Pathog. 2016 Dec 15;12(12):e1006072. doi:10.1371/journal.ppat.1006072. eCollection 2016 Dec. [PMID: 27977791]

  • Burwitz BJ, Malouli D, Bimber BN, Reed JS, Ventura AB,Hancock MH, Uebelhoer LS, Bhusari A, Hammond KB, Espinosa Trethewy RG, Klug A,Legasse AW, Axthelm MK, Nelson JA, Park BS, Streblow DN, Hansen SG, Picker LJ,Früh K, Sacha JB. Cross-Species Rhesus Cytomegalovirus Infection of CynomolgusMacaques. PLoS Pathog. 2016 Nov 9;12(11):e1006014. doi:10.1371/journal.ppat.1006014.[PMID: 27829026]

  • Nanes BA, Grimsley-Myers CM, Cadwell CM, Robinson BS, LoweryAM, Vincent PA, Mosunjac M, Früh K, Kowalczyk AP. p120-catenin regulatesVE-cadherin endocytosis and degradation induced by the Kaposisarcoma-associated ubiquitin ligase K5. Mol Biol Cell. 2017 Jan 1;28(1):30-40.doi: 10.1091/mbc.E16-06-0459.[PMID: 27798235]

  • Theiler J, Yoon H, Yusim K, Picker LJ, Fruh K, Korber B.Epigraph: A Vaccine Design Tool Applied to an HIV Therapeutic Vaccine and aPan-Filovirus Vaccine. Sci Rep. 2016 Oct 5;6:33987. doi:10.1038/srep33987.[PMID: 27703185]

  • Sturgill ER, Malouli D, Hansen SG, Burwitz BJ, Seo S,Schneider CL, Womack JL, Verweij MC, Ventura AB, Bhusari A, Jeffries KM,Legasse AW, Axthelm MK, Hudson AW, Sacha JB, Picker LJ, Früh K. Natural KillerCell Evasion Is Essential for Infection by Rhesus Cytomegalovirus. PLoS Pathog.2016 Aug 31;12(8):e1005868. doi: 10.1371/journal.ppat.1005868.[PMID: 27580123]

  • Hansen SG, Wu HL, Burwitz BJ, Hughes CM, Hammond KB, VenturaAB, Reed JS, Gilbride RM, Ainslie E, Morrow DW, Ford JC, Selseth AN, Pathak R,Malouli D, Legasse AW, Axthelm MK, Nelson JA, Gillespie GM, Walters LC,Brackenridge S, Sharpe HR, López CA, Früh K, Korber BT, McMichael AJ,Gnanakaran S, Sacha JB, Picker LJ. Broadly targeted CD8⁺ T cell responsesrestricted by major histocompatibility complex E. Science. 2016 Feb12;351(6274):714-20. doi: 10.1126/science.aac9475.[PMID: 26797147]

  • Whitmer T, Malouli D, Uebelhoer LS, DeFilippis VR, Früh K,Verweij MC. The ORF61 Protein Encoded by Simian Varicella Virus andVaricella-Zoster Virus Inhibits NF-κB Signaling by Interfering with IκBα Degradation.J Virol. 2015 Sep;89(17):8687-700. doi: 10.1128/JVI.01149-15. [PMID: 26085158]

  • Verweij MC, Wellish M, Whitmer T, Malouli D, Lapel M, JonjićS, Haas JG, DeFilippis VR, Mahalingam R, Früh K. Varicella Viruses InhibitInterferon-Stimulated JAK-STAT Signaling through Multiple Mechanisms. PLoSPathog. 2015 May 14;11(5):e1004901. doi: 10.1371/journal.ppat.1004901.[PMID:25973608]

  • Malouli D, Howell GL, Legasse AW, Kahl C, Axthelm MK, Hansen SG, Früh K. Full genome sequence analysis of a novel adenovirus of rhesus macaque origin indicates a new simian adenovirus type and species, Virol Rep. 2014 Sep;3-4:18-29. (doi: 10.1016/j.virep.2014.10.001) [PMID: 25530944PMCID: PMC4266990]
  • Luteijn RD, Hoelen H, Kruse E, van Leeuwen WF, Grootens J, Horst D, Koorengevel M, Drijfhout JW, Kremmer E, Früh K, Neefjes JJ, Killian A, Lebbink RJ, Ressing ME, Wiertz EJ. Cowpox virus protein CPXV012 eludes CTLs by blocking ATP binding to TAP. J Immunol. 2014 Aug 15;193(4):1578-89. (doi: 10.4049/jimmunol.1400964) Epub 2014 Jul 14. [PMID: 25024387]
  • Malouli D, Hansen SG, Nakayasu ES, Marshall EE, Hughes CM, Lewis MS, Axthelm MK, Viswanathan K, Siess D, Barry PA, Diamond D, DeFilippis VR, Smith RD, Picker LJ*, and Früh K*. Cytomegalovirus pp65 limits dissemination but is dispensable for persistence, J. Clin. Invest., 2014 May 1;124(5):1928-44. Epub 2014 Apr 1 (doi:10.1172/JCI67420). [PMID: 24691437;PMCID:PMC4002596]. (*co-corresponding authors). Journal Impact Factor 13.765
  • Alzhanova D, Hammarlund E, Reed J, Meermeier E, Rawlings S, Ray CA, Edwards DM, Bimber B, Legasse A, Planer S, Sprague J, Axthelm MK, Pickup DJ, Lewinsohn DM, Gold MC, Wong SW, Sacha JB, Slifka MK2, Früh K. T cell inactivation by poxviral B22 family proteins increases viral virulence. PLoS Pathog. 2014 May 15;10(5):e1004123. (doi: 10.1371/journal.ppat.1004123) eCollection 2014.
  • Smith JL, Stein DA, Shum D, Fischer MA, Radu C, Bhinder B, Djaballah H, Nelson JA, Früh K, Hirsch AJ. Inhibition of dengue virus replication by a class of small-molecule compounds that antagonize dopamine receptor d4 and downstream mitogen-activated protein kinase signaling. J Virol. 2014 May;88(10):5533-42 (DOI: 10.1128/JVI.00365-14) [PMID: 24599995; PMCID: PMC4019099]
  • Hansen SG, Piatak M Jr, Ventura AB, Hughes CM, Gilbride RM, Ford JC, Oswald K, Shoemaker R, Li Y, Lewis MS, Gilliam AN, Xu G, Whizin N, Burwitz BJ, Planer SL, Turner JM, Legasse AW, Axthelm MK, Nelson JA, Früh K, Sacha JB, Estes JD, Keele BF, Edlefsen PT, Lifson JD, Picker LJ; Immune clearance of highly pathogenic SIV infection. Nature. 2013 Oct 3;502(7469): 100-4 (DOI 10.1038/nature12519) [PMID: 24025770; PMCID: PMC3849456]
  • Fischer MA, Smith JL, Shum D, Stein DA, Parkins C, Bhinder B, Radu C, Hirsch AJ, Djaballah H, Nelson JA, Früh K. Flaviviruses are sensitive to inhibition of thymidine synthesis pathways. J Virol. 2013 Sep; 87(17):9411-9. (DOI: 10.1128/JVI.00101-13) [PMID: 23824813; PMCID: PMC3754125]
  • Feng P, Moses A, Früh K. Evasion of adaptive and innate immune response mechanisms by γ-herpesviruses. Curr Opin Virol. 2013 Jun; 3(3):285-95. (DOI: 10.1016/j.coviro.2013.05.011) [PMID: 23735334]
  • Lenac Roviš T1, Bailer SM, Pothineni VR, Ouwendijk WJ, Šimić H, Babić M, Miklić K, Malić S, Verweij MC, Baiker A, Gonzalez O, von Brunn A, Zimmer R, Früh K, Verjans GM, Jonjić S, Haas J. Comprehensive analysis of varicella-zoster virus proteins using a new monoclonal antibody collection. J Virol. 2013 Jun;87(12):6943-54. (DOI: 10.1128/JVI.00407-13) [PMID: 23596286; PMCID: PMC3676123]
  • Hansen SG, Sacha JB, Hughes CM, Ford JC, Burwitz BJ, Scholz I, Gilbride RM, Lewis MS, Gilliam AN, Ventura AB, Malouli D, Xu G, Richards R, Whizin N, Reed JS, Hammond KB, Fischer M, Turner JM, Legasse AW, Axthelm MK, Edlefsen PT, Nelson JA, Lifson JD, Früh K, Picker LJ. Cytomegalovirus vectors violate CD8+ T-cell epitope recognition paradigms. Science. 2013 May 24; 340(6135): 1-17. PMCID: PMC3816976
  • Lazear HM, Lancaster A, Wilkins C, Suthar MS, Huang A, Vick SC, Clepper L, Thackray L, Brassil MM, Virgin HW, Nikolich-Zugich J, Moses AV, Gale M Jr, Früh K, Diamond MS. IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling. PLoS Pathog. 2013 Jan;9(1):e1003118 (DOI: 10.1371/journal.ppat.1003118) [PMID: 23300459]
  • Bourgeois-Daigneault MC, Pezeshki AM, Galbas T, Houde M, Baril M, Früh K, Amrani A, Ishido S, Lamarre D, Thibodeau J; Tollip-induced down-regulation of MARCH1. Results Immunol. 2013 Feb 20;3:17-25 (DOI: 10.1016/j.rinim.2013.02.002) [PMID: 24600555; PMCID: PMC3908327]
  • Pantanowitz L, Moses AV, Früh K. CD31 immunohistochemical staining in Kaposi Sarcoma. Arch Pathol Lab Med. 2012 Nov; 136(11):1329; author reply 1330 (DOI: 10.5858/arpa.2012-0153-LE) [PMID: 23106575]
  • Malouli D, Nakayasu ES, Viswanathan K, Camp DG 2nd, Chang WL, Barry PA, Smith RD, Früh K. Reevaluation of the coding potential and proteomic analysis of the BAC-derived rhesus cytomegalovirus strain 68-1. J Virol. 2012 Sep; 86(17): 8959-73. [PMCID: PMC3416160]
  • Viswanathan K, Smith MS, Malouli D, Mansouri M, Nelson JA, Früh K. BST2/Tetherin enhances entry of human cytomegalovirus. PLoS Pathog. 2011 Nov; 7(11): e1002332. PMCID: PMC3207899
  • Stein DA, Perry ST, Buck MD, Oehmen CS, Fischer MA, Poore E, Smith JL, Lancaster AM, Hirsch AJ, Slifka MK, Nelson JA, Shresta S, Früh K. Inhibition of dengue virus infections in cell cultures and in AG129 mice by a small interfering RNA targeting a highly conserved sequence. J Virol. 2011 Oct; 85(19): 10154-66. PMCID: PMC3196423
  • Richards R, Scholz I, Powers C, Skach WR, Früh K. The cytoplasmic domain of rhesus cytomegalovirus Rh178 interrupts translation of major histocompatibility class I leader peptide-containing proteins prior to translocation. J Virol. 2011 Sep; 85(17): 8766-76. PMCID: PMC3165821
  • Sugaya M, Reed S, Rose PP, de la Motte S, Raggo CM, Kurtz SE, Moses AV, Früh K, Blauvelt A. Kaposi's sarcoma and human dermal microvascular endothelial cells infected with Kaposi's sarcoma-associated herpesvirus express CCL21. J Dermatol Sci. 2011 Feb; 61(2): 139-42. PMCID: PMC3399906
  • Gustin JK, Moses AV, Früh K, Douglas JL. Viral takeover of the host ubiquitin system. Front Microbiol. 2011; 2: 161. PMCID: PMC3147166
  • Alzhanova D, Früh K. Modulation of the host immune response by cowpox virus. Microbes Infect. 2010 Nov; 12(12-13): 900-9. Review. PMCID: PMC3500136
  • DeFilippis VR, Sali T, Alvarado D, White L, Bresnahan W, Früh K. Activation of the interferon response by human cytomegalovirus occurs via cytoplasmic double-stranded DNA but not glycoprotein B. J Virol. 2010 Sep; 84(17): 8913-25. PMCID: PMC2919031
  • Viswanathan K, Früh K, DeFilippis V. Viral hijacking of the host ubiquitin system to evade interferon responses. Curr Opin Microbiol. 2010 Aug; 13(4): 517-23. Review. PMCID: PMC2939720
  • Douglas JL, Gustin JK, Viswanathan K, Mansouri M, Moses AV, Früh K. The great escape: viral strategies to counter BST-2/tetherin. PLoS Pathog. 2010 May 13; 6(5): e1000913. Review. PMCID: PMC2869331
  • Hansen SG, Powers CJ, Richards R, Ventura AB, Ford JC, Siess D, Axthelm MK, Nelson JA, Jarvis MA, Picker LJ, Früh K. Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus. Science. 2010 Apr 2; 328(5974): 102-6. PMCID: PMC2883175
  • Früh K, Finlay B, McFadden G. On the road to systems biology of host-pathogen interactions. Future Microbiol. 2010 Feb; 5(2): 131-3. PMID: 20143936
  • DeFilippis VR, Alvarado D, Sali T, Rothenburg S, Früh K. Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1. J Virol. 2010 Jan; 84(1): 585-98. PMCID: PMC2798427
  • Alzhanova D, Edwards DM, Hammarlund E, Scholz IG, Horst D, Wagner MJ, Upton C, Wiertz EJ, Slifka MK, Früh K. Cowpox virus inhibits the transporter associated with antigen processing to evade T cell recognition. Cell Host Microbe. 2009 Nov 19; 6(5): 433-45. PMCID: PMC2791678
  • Mansouri M, Viswanathan K, Douglas JL, Hines J, Gustin J, Moses AV, Früh K. Molecular mechanism of BST2/tetherin downregulation by K5/MIR2 of Kaposi's sarcoma-associated herpesvirus. J Virol. 2009 Oct; 83(19): 9672-81. PMCID: PMC2748026
  • Douglas JL, Viswanathan K, McCarroll MN, Gustin JK, Früh K, Moses AV. Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a {beta}TrCP-dependent mechanism. J Virol. 2009 Aug; 83(16): 7931-47. PMCID: PMC2715753
  • Vomaske J, Melnychuk RM, Smith PP, Powell J, Hall L, DeFilippis V, Früh K, Smit M, Schlaepfer DD, Nelson JA, Streblow DN. Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type-specific motility. PLoS Pathog. 2009 Feb; 5(2): e1000304. PMCID: PMC2637432
  • Powers CJ, Früh K. Signal peptide-dependent inhibition of MHC class I heavy chain translation by rhesus cytomegalovirus. PLoS Pathog. 2008 Oct 3; 4(10): e1000150. PMCID: PMC2542416
  • Mansouri M, Rose PP, Moses AV, Früh K. Remodeling of endothelial adherens junctions by Kaposi's sarcoma-associated herpesvirus. J Virol. 2008 Oct; 82(19): 9615-28. PMCID: PMC2546942
  • Hammarlund E, Dasgupta A, Pinilla C, Norori P, Früh K, Slifka MK. Monkeypoxvirus evades antiviral CD4+ and CD8+ T cell responses by suppressing cognate Tcell activation. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38): 14567-72. PMCID: PMC2567221
  • Powers C, Früh K. Rhesus CMV: an emerging animal model for human CMV. Med Microbiol Immunol. 2008 Jun; 197(2): 109-15. Review. PMCID: PMC2746484
  • Streblow DN, van Cleef KW, Kreklywich CN, Meyer C, Smith P, Defilippis V, Grey F, Früh K, Searles R, Bruggeman C, Vink C, Nelson JA, Orloff SL. Rat cytomegalovirus gene expression in cardiac allograft recipients is tissue specific and does not parallel the profiles detected in vitro. J Virol. 2007 Apr;81(8):3816-26. [PMID: 17251289, PMCID: PMC1866122] Epub 2007 Jan 24.
  • Streblow DN, Kreklywich CN, Andoh T, Moses AV, Dumortier J, Smith PP, Defilippis V, Früh K, Nelson JA, Orloff SL. The role of angiogenic and wound repair factors during CMV-accelerated transplant vascular sclerosis in rat cardiac transplants. Am J Transplant. 2008 Feb; 8(2): 277-87. PMID: 18093265
  • Powers C, DeFilippis V, Malouli D, Früh K. Cytomegalovirus immune evasion. Curr Top Microbiol Immunol. 2008; 325: 333-59. Review. PMID: 18637515 Viswanathan K, Früh K. Viral proteomics: global evaluation of viruses and their interaction with the host. Expert Rev Proteomics. 2007 Dec; 4(6): 815-29. Review. PMID: 18067418
  • Medigeshi GR, Lancaster AM, Hirsch AJ, Briese T, Lipkin WI, Defilippis V, Früh K, Mason PW, Nikolich-Zugich J, Nelson JA. West Nile virus infection activates the unfolded protein response, leading to CHOP induction and apoptosis. J Virol. 2007 Oct; 81(20): 10849-60. PMCID: PMC2045561
  • Rose PP, Bogyo M, Moses AV, Früh K. Insulin-like growth factor II receptor-mediated intracellular retention of cathepsin B is essential for transformation of endothelial cells by Kaposi's sarcoma-associated herpesvirus. J Virol. 2007 Aug; 81(15): 8050-62. PMCID: PMC1951299
  • Rose PP, Carroll JM, Carroll PA, DeFilippis VR, Lagunoff M, Moses AV, Roberts CT Jr, Früh K. The insulin receptor is essential for virus-induced tumorigenesis of Kaposi's sarcoma. Oncogene. 2007 Mar 29; 26(14): 1995-2005. PMID: 17001305
  • Dasgupta A, Hammarlund E, Slifka MK, Früh K. Cowpox virus evades CTL recognition and inhibits the intracellular transport of MHC class I molecules. J Immunol. 2007 Feb 1; 178(3): 1654-61. Erratum in: J Immunol. 2007 Apr 15; 178(8):5401. PMID: 17237415
  • Shibatani T, Carlson EJ, Larabee F, McCormack AL, Früh K, Skach WR. Global organization and function of mammalian cytosolic proteasome pools: Implications for PA28 and 19S regulatory complexes. Mol Biol Cell. 2006 Dec; 17(12): 4962-71. PMCID: PMC1679665
  • Bartee E, McCormack A, Früh K. Quantitative membrane proteomics reveals new cellular targets of viral immune modulators. PLoS Pathog. 2006 Oct; 2(10): e107. PMCID: PMC1626102
  • Mansouri M, Douglas J, Rose PP, Gouveia K, Thomas G, Means RE, Moses AV, Früh K. Kaposi sarcoma herpesvirus K5 removes CD31/PECAM from endothelial cells. Blood. 2006 Sep 15; 108(6): 1932-40. PMCID: PMC1635550
  • DeFilippis V and Früh K. Host cell targets for antiviral therapy: an update. Future Virology. 2006 July; 1(4): 509-518, doi 10.2217/17460794.1.4.509
  • DeFilippis VR, Robinson B, Keck TM, Hansen SG, Nelson JA, Früh K. Interferon regulatory factor 3 is necessary for induction of antiviral genes during human cytomegalovirus infection. J Virol. 2006 Jan; 80(2): 1032-7. PMCID: PMC1346858
  • DeFilippis VR, Früh K. Rhesus cytomegalovirus particles prevent activation of interferon regulatory factor 3. J Virol. 2005 May; 79(10): 6419–31. PMCID: PMC1091669
  • Hirsch AJ, Medigeshi GR, Meyers HL, DeFilippis V, Früh K, Briese T, Lipkin WI, Nelson JA. The Src family kinase c-Yes is required for maturation of West Nile virus particles. J Virol. 2005 Sep; 79(18): 11943-51. PMCID: PMC1212629
  • Raggo C, Ruhl R, McAllister S, Koon H, Dezube BJ, Früh K, Moses AV. Novel cellular genes essential for transformation of endothelial cells by Kaposi's sarcoma-associated herpesvirus. Cancer Res. 2005 Jun 15; 65(12): 5084-95. PMID: 15958552
  • DeFilippis V, Früh K. Rhesus cytomegalovirus particles prevent activation of interferon regulatory factor 3. J Virol. 2005 May; 79(10): 6419-31. PMCID: PMC1091669
  • Shibatani T, David LL, McCormack AL, Früh K, Skach WR. Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. Biochemistry. 2005 Apr 26;44(16):5982-92. PMID: 15835887
  • Pande NT, Powers C, Ahn K, Früh K. Rhesus cytomegalovirus contains functional homologues of US2, US3, US6, and US11. J Virol. 2005 May; 79(9): 5786-98. PMCID: PMC1082751
  • McAllister SC, Früh K, Moses AV. Functional genomics and the development of pathogenesis-targeted therapies for Kaposi's sarcoma. Pharmacogenomics. 2005 Apr; 6(3): 235-44. Review. PMID: 16013955
  • Nerenberg BT, Taylor J, Bartee E, Gouveia K, Barry M, Früh K. The poxviral RING protein p28 is a ubiquitin ligase that targets ubiquitin to viral replication factories. J Virol. 2005 Jan; 79(1): 597-601. PMCID: PMC538746
  • Rue CA, Jarvis MA, Knoche AJ, Meyers HL, DeFilippis VR, Hansen SG, Wagner M, Früh K, Anders DG, Wong SW, Barry PA, Nelson JA. A cyclooxygenase-2 homologue encoded by rhesus cytomegalovirus is a determinant for endothelial cell tropism. J Virol. 2004 Nov; 78(22): 12529-36. PMCID: PMC525102
  • McAllister SC, Hansen SG, Ruhl RA, Raggo CM, DeFilippis VR, Greenspan D, Früh K, Moses AV. Kaposi sarcoma-associated herpesvirus (KSHV) induces heme oxygenase-1 expression and activity in KSHV-infected endothelial cells. Blood. 2004 May 1; 103(9): 3465-73. PMID: 14726403
  • Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Früh K. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. J Virol. 2004 Feb; 78(3): 1109-20. PMCID: PMC321412
  • DeFilippis V, Raggo C, Moses A, Früh K. Functional genomics in virology and antiviral drug discovery. Trends Biotechnol. 2003 Oct; 21(10): 452-7. Review. PMID: 14512232
  • Mansouri M, Bartee E, Gouveia K, Hovey Nerenberg BT, Barrett J, Thomas L, Thomas G, McFadden G, Früh K. The PHD/LAP-domain protein M153R of myxomavirus is a ubiquitin ligase that induces the rapid internalization and lysosomal destruction of CD4. J Virol. 2003 Jan; 77(2): 1427-40. PMCID: PMC140772
  • Moses AV, Jarvis MA, Raggo C, Bell YC, Ruhl R, Luukkonen BG, Griffith DJ, Wait CL, Druker BJ, Heinrich MC, Nelson JA, Früh K. A functional genomics approach to Kaposi's sarcoma. Ann N Y Acad Sci. 2002 Dec; 975: 180-91. PMID:12538164
  • Früh K, Bartee E, Gouveia K, Mansouri M. Immune evasion by a novel family of viral PHD/LAP-finger proteins of gamma-2 herpesviruses and poxviruses. Virus Res. 2002 Sep; 88(1-2): 55-69. Review. PMID: 12297327
  • Moses AV, Jarvis MA, Raggo C, Bell YC, Ruhl R, Luukkonen BG, Griffith DJ, Wait CL, Druker BJ, Heinrich MC, Nelson JA, Früh K. Kaposi's sarcoma-associated herpesvirus-induced upregulation of the c-kit proto-oncogene, as identified by gene expression profiling, is essential for the transformation of endothelial cells. J Virol. 2002 Aug; 76(16): 8383-99. PMCID: PMC155158
  • Paulson E, Tran C, Collins K, Früh K. KSHV-K5 inhibits phosphorylation of the major histocompatibility complex class I cytoplasmic tail. Virology. 2001 Sep 30; 288(2): 369-78. PMID: 11601908
  • Simmen KA, Singh J, Luukkonen BG, Lopper M, Bittner A, Miller NE, Jackson MR, Compton T, Früh K. Global modulation of cellular transcription by human cytomegalovirus is initiated by viral glycoprotein B. Proc Natl Acad Sci U S A. 2001 Jun 19; 98(13): 7140-5. PMCID: PMC34636
  • Früh K, Simmen K, Luukkonen BG, Bell YC, Ghazal P. Virogenomics: a novel approach to antiviral drug discovery. Drug Discov Today. 2001 Jun 1; 6(12): 621-627. PMID: 11408198
  • Gruhler A, Peterson PA, Früh K. Human cytomegalovirus immediate early glycoprotein US3 retains MHC class I molecules by transient association. Traffic. 2000 Apr; 1(4): 318-25. PMID: 11208117
  • Gruhler A, Früh K. Control of MHC class I traffic from the endoplasmic reticulum by cellular chaperones and viral anti-chaperones. Traffic. 2000 Apr; 1(4): 306-11. Review. PMID: 11208115
  • Huard B, Früh K. A role for MHC class I down-regulation in NK cell lysis of herpes virus-infected cells. Eur J Immunol. 2000 Feb; 30(2): 509-15. PMID:10671206
  • Preckel T, Fung-Leung WP, Cai Z, Vitiello A, Salter-Cid L, Winqvist O, Wolfe TG, Von Herrath M, Angulo A, Ghazal P, Lee JD, Fourie AM, Wu Y, Pang J, Ngo K, Peterson PA, Früh K, Yang Y. Impaired immunoproteasome assembly and immune responses in PA28-/- mice. Science. 1999 Dec 10; 286(5447): 2162-5. PMID:10591649
  • Früh K, Gruhler A, Krishna RM, Schoenhals GJ. A comparison of viral immune escape strategies targeting the MHC class I assembly pathway. Immunol Rev. 1999 Apr; 168: 157-66. Review. PMID: 10399072
  • Früh K, Yang Y. Antigen presentation by MHC class I and its regulation by interferon gamma. Curr Opin Immunol. 1999 Feb; 11(1): 76-81. Review. PMID: 10047537
  • Schoenhals GJ, Krishna RM, Grandea AG 3rd, Spies T, Peterson PA, Yang Y, Früh K. Retention of empty MHC class I molecules by tapasin is essential to reconstitute antigen presentation in invertebrate cells. EMBO J. 1999 Feb 1; 18(3): 743-53. PMCID: PMC1171167
  • Chambers J, Angulo A, Amaratunga D, Guo H, Jiang Y, Wan JS, Bittner A, Früh K, Jackson MR, Peterson PA, Erlander MG, Ghazal P. DNA microarrays of the complex human cytomegalovirus genome: profiling kinetic class with drug sensitivity of viral gene expression. J Virol. 1999 Jul;73(7):5757-66. PMCID: PMC112636
  • Suh WK, Derby MA, Cohen-Doyle MF, Schoenhals GJ, Früh K, Berzofsky JA, Williams DB. Interaction of murine MHC class I molecules with tapasin and TAP enhances peptide loading and involves the heavy chain alpha3 domain. J Immunol. 1999 Feb 1; 162(3): 1530-40. PMID: 9973410
  • Blevitt JM, Früh K, Glass C, Jackson MR, Peterson PA, Huang S. A fluorescence-based high throughput screen for the transporter associated with antigen processing. J Biomol Screen. 1999; 4(2): 87-91. PMID: 10838416
  • Grandea AG 3rd, Comber PG, Wenderfer SE, Schoenhals G, Früh K, Monaco JJ, Spies T. Sequence, linkage to H2-K, and function of mouse tapasin in MHC class I assembly. Immunogenetics. 1998 Sep; 48(4): 260-5. PMID: 9716645
  • Tomazin R, van Schoot NE, Goldsmith K, Jugovic P, Sempé P, Früh K, Johnson DC. Herpes simplex virus type 2 ICP47 inhibits human TAP but not mouse TAP. J Virol. 1998 Mar; 72(3): 2560-3. PMCID: PMC109564
  • Ahn K, Gruhler A, Galocha B, Jones TR, Wiertz EJ, Ploegh HL, Peterson PA, Yang Y, Früh K. The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP. Immunity. 1997 May; 6(5): 613-21. PMID: 9175839
  • Früh K, Ahn K, Peterson PA. Inhibition of MHC class I antigen presentation by viral proteins. J Mol Med (Berl). 1997 Jan; 75(1): 18-27. Review. PMID: 9020380
  • Ahn K, Angulo A, Ghazal P, Peterson PA, Yang Y, Früh K. Human cytomegalovirus inhibits antigen presentation by a sequential multistep process. Proc Natl Acad Sci U S A. 1996 Oct 1; 93(20): 10990-5. PMCID: PMC38271
  • Armandola EA, Momburg F, Nijenhuis M, Bulbuc N, Früh K, Hämmerling GJ. A point mutation in the human transporter associated with antigen processing (TAP2) alters the peptide transport specificity. Eur J Immunol. 1996 Aug; 26(8): 1748-55. PMID: 8765016
  • Ahn K, Erlander M, Leturcq D, Peterson PA, Früh K, Yang Y. In vivo characterization of the proteasome regulator PA28. J Biol Chem. 1996 Jul 26; 271(30): 18237-42. PMID: 8663520
  • Ahn K, Meyer TH, Uebel S, Sempé P, Djaballah H, Yang Y, Peterson PA, Früh K, Tampé R. Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47. EMBO J. 1996 Jul 1; 15(13): 3247-55. PMCID: PMC451885
  • Yang Y, Früh K, Ahn K, Peterson PA. In vivo assembly of the proteasomal complexes, implications for antigen processing. J Biol Chem. 1995 Nov 17; 270(46): 27687-94. PMID: 7499235
  • Früh K, Ahn K, Djaballah H, Sempé P, van Endert PM, Tampé R, Peterson PA, Yang Y. A viral inhibitor of peptide transporters for antigen presentation. Nature. 1995 Jun 1; 375(6530): 415-8. PMID: 7760936
  • Aschoff A, Kremer P, Benesch C, Früh K, Klank A, Kunze S. Overdrainage and shunt technology. A critical comparison of programmable, hydrostatic and variable-resistance valves and flow-reducing devices. Childs Nerv Syst. 1995 Apr; 11(4): 193-202. PMID: 7621479
  • Jackson MR, Früh K, Karlsson L, Teyton L, Yang Y, Peterson PA. Assembly and intracellular transport of MHC class I and class II molecules. Cold Spring Harb Symp Quant Biol. 1995; 60: 249-61. Review. PMID: 8824398
  • Wang K, Früh K, Peterson PA, Yang Y. Nucleotide binding of the C-terminal domains of the major histocompatibility complex-encoded transporter expressed in Drosophila melanogaster cells. FEBS Lett. 1994 Aug 22; 350(2-3): 337-41. Erratum in: FEBS Lett 1994 Oct 17; 353(2): 230. PMID: 8070589
  • Früh K, Gossen M, Wang K, Bujard H, Peterson PA, Yang Y. Displacement of housekeeping proteasome subunits by MHC-encoded LMPs: a newly discovered mechanism for modulating the multicatalytic proteinase complex. EMBO J. 1994 Jul 15; 13(14): 3236-44. PMCID: PMC395220
  • Suh WK, Cohen-Doyle MF, Früh K, Wang K, Peterson PA, Williams DB. Interaction of MHC class I molecules with the transporter associated with antigen processing. Science. 1994 May 27; 264(5163): 1322-6. PMID: 8191286
  • Schumacher TN, Kantesaria DV, Heemels MT, Ashton-Rickardt PG, Shepherd JC,Früh K, Yang Y, Peterson PA, Tonegawa S, Ploegh HL. Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator. J Exp Med. 1994 Feb 1; 179(2): 533-40. PMCID: PMC2191358
  • Scarselli E, Tolle R, Koita O, Diallo M, Müller HM, Früh K, Doumbo O, Crisanti A, Bujard H. Analysis of the human antibody response to thrombospondin-related anonymous protein of Plasmodium falciparum. Infect Immun. 1993 Aug; 61(8): 3490-5. PMCID: PMC281027
  • Tolle R, Früh K, Doumbo O, Koita O, N'Diaye M, Fischer A, Dietz K, Bujard H. A prospective study of the association between the human humoral immune response to Plasmodium falciparum blood stage antigen gp190 and control of malarial infections. Infect Immun. 1993 Jan; 61(1): 40-7. PMCID: PMC302685
  • Früh K, Yang Y, Arnold D, Chambers J, Wu L, Waters JB, Spies T, Peterson PA. Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome subunits. J Biol Chem. 1992 Nov 5; 267(31): 22131-40. PMID: 1429565
  • Yang Y, Früh K, Chambers J, Waters JB, Wu L, Spies T, Peterson PA. Major histocompatibility complex (MHC)-encoded HAM2 is necessary for antigenic peptide loading onto class I MHC molecules. J Biol Chem. 1992 Jun 15; 267(17): 11669-72. PMID: 1339432
  • Yang Y, Waters JB, Früh K, Peterson PA. Proteasomes are regulated by interferon gamma: implications for antigen processing. Proc Natl Acad Sci U S A.1992 Jun 1; 89(11): 4928-32. PMCID: PMC49201
  • von Brunn A, Früh K, Müller HM, Zentgraf HW, Bujard H. Epitopes of the human malaria parasite P. falciparum carried on the surface of HBsAg particles elicit an immune response against the parasite. Vaccine. 1991 Jul; 9(7): 477-84. PMID: 1716808
  • Früh K, Doumbo O, Müller HM, Koita O, McBride J, Crisanti A, Touré Y, Bujard H. Human antibody response to the major merozoite surface antigen of Plasmodium falciparum is strain specific and short-lived. Infect Immun. 1991 Apr; 59(4): 1319-24. PMCID: PMC257845
  • Müller HM, Früh K, Doumbo O, Lyon JA, Bujard H. The human antibody response against the major merozoite surface antigen of P. falciparum is mainly directed against non-conserved sequences. Behring Inst Mitt. 1991 Feb; (88): 157-60. PMID: 2049033
  • Crisanti A, Früh K, Müller HM, Bujard H. The T cell reactivity against the major merozoite protein of Plasmodium falciparum. Immunol Lett. 1990 Aug; 25(1-3): 143-8. PMID: 1704343
  • Müller HM, Früh K, von Brunn A, Esposito F, Lombardi S, Crisanti A, Bujard H. Development of the human immune response against the major surface protein (gp190) of Plasmodium falciparum. Infect Immun. 1989 Dec; 57(12): 3765-9. PMCID: PMC259902
  • Früh K, Müller HM, Bujard H, Crisanti A. A new tool for the serodiagnosis of acute Plasmodium falciparum malaria in individuals with primary infection. J Immunol Methods. 1989 Aug 15; 122(1): 25-32. PMID: 2668417
  • Moos M, Tacke R, Scherer H, Teplow D, Früh K, Schachner M. Neural adhesion molecule L1 as a member of the immunoglobulin superfamily with binding domains similar to fibronectin. Nature. 1988 Aug 25; 334(6184): 701-3. PMID: 3412448
  • Tacke R, Moos M, Teplow DB, Früh K, Scherer H, Bach A, Schachner M. Identification of cDNA clones of the mouse neural cell adhesion molecule L1.Neurosci Lett. 1987 Nov 10; 82(1): 89-94. PMID: 2447532