Comprehensive genomics services for research scientists and clinicians
The Integrated Genomics Laboratory, or IGL, is home to shared technology resources and support services for structural and functional genomics studies at OHSU. The IGL consists of three service centers:
- Massively Parallel Sequencing Shared Resource (MPSSR)
- RNA and DNA Services (formerly the GPSR and DNA Services Core)
Under the IGL structure, core leadership and staff are able to provide efficient, coordinated support to OHSU investigators from nucleic acid extraction to data generation and - with designated institutional support – to invest time in strategic resource development and a robust infrastructure.
The Integrated Genomics Lab is located on the 5th floor of Richard Jones Hall on OHSU's Marquam Hill campus.
Integrated Genomics Laboratory staff
Publication Highlights
High-throughput robust single-cell DNA methylation profiling with sciMETv2 | Nature Communications
RNA-Seq of human whole blood: Evaluation of globin RNA depletion on Ribo-Zero library method
RNA-seq from archival FFPE breast cancer samples: molecular pathway fidelity and novel discovery
Validation of MicroRNA Biomarkers for Alzheimer’s Disease in Human Cerebrospinal Fluid
Mission
Facilitate research at OHSU by providing technologies, services, and expertise for genome-wide and targeted RNA and DNA analysis offered through a coordinated pipeline of services which can be accessed at whatever point researcher requires
News and upcoming events
Upcoming events
June 5, 2024: High Throughput Single-Cell RNA and Methylation Analysis
Join us at the OHSU Knight Cancer Research Building on June 5 for an insightful Lunch and Learn on Scale Bio's parallelized barcoding single-cell technology. This event is for anyone looking to better understand our RNA & Methylation applications. Our goal is to inspire and educate researchers on how these methodologies can help optimize your experiments and show you how they are being integrated at OHSU.
Presenters will be Melanie Masuda, Director, Market Development at Scale Bio, Itallia Pacentine, Computational Biologist II, from the OHSU Braun Lab and Robert Searles, Director at OHSU Integrated Genomics Laboratory.
- Time: Event is 11-12 PST, with a lunch hour from 12-1 pm.
- Location: Knight Cancer Research Building is 2720 S Moody Ave. Portland, OR 97201
- please come to the front door of address listed, and somebody will let you in.
- Parking: Any external folks attending will need to find street parking for this event on Meade Street, this is city pay-to-park spots, or they may pay to park at the RLSB underground parking garage next door to the KCRB. Entry to this parking is also on Meade Street.
Past events
April 25, 2024: OHSU Epigenetics Symposium
The OHSU Epigenetics Symposium, organized by the KCVI Epigenetics Consortium, will feature keynote addresses by Dr. Marisa Bartolomei (University of Pennsylvania) and Dr. Joe Ecker (UC San Diego). The program also includes presentations from researchers focused on epigenetics and a poster session featuring graduate students, postdocs, and research staff. A reception will be held at the conclusion of the event.
- Details here
- Please, register using the link on the flyer or here: https://lp.constantcontactpages.com/ev/reg/7n3hr8f
April 24, 2024: Biostatistics Shared Resource Virtual Seminar
The OHSU Knight Cancer Institute’s Biostatistics Shared Resource (BSR) and the Oregon National Primate Research Center’s (ONPRC) Bioinformatics and Biostatistics Core (BBC) are hosting a seminar to share their advice for bulk and single cell RNA-seq projects. Topics covered include experimental design considerations, general analysis pipeline, and how investigators should interpret the delivered results.
- Questions should be directed to BSR-Admin@ohsu.edu
- Please, find the WebEx link in the flyer /sites/default/files/2024-04/BSR_Monthly%20series_April.pdf
January 29, 2024: Sample size considerations for “omics” data
"Omics" studies often involve hundreds of outcome measures, rendering traditional power analysis insufficient. This talk tackles this challenge by exploring how strategic choices in sample size and analysis methods can navigate data complexity and maximize the chance of uncovering meaningful discoveries. Basic power analysis knowledge is recommended.
Presented by Jack Wiedrick, M.S. M.A. of the Biostatistics, Epidemiology, and Research Design (BERD) Program
May 17, 2023: PacBio Discoveries Roadshow
September 20, 2023: Single-cell RNAsequencing: From START to FINISH
Are you thinking about performing a single-cell RNA Sequencing experiment? This symposium on Wednesday September 20th, from 9:00 AM to 4:00 PM, will feature sessions on multiple aspects of a single-cell RNA sequencing experiment including experimental design, experiment day, and bioinformatic analysis. Single-cell RNA sequencing product vendors will present on topics that include selecting the best single-cell RNA sequencing experimental approach for your experimental question, tips on sample preparation, and bioinformatic solutions. Finally, multiple investigators from OHSU will share about their successes with single-cell RNA sequencing.
May 24th, 2022: Portland Multiomics Discovery Symposium
Symposium to learn how Chromium single cell and Visium spatial solutions from 10x Genomics can help you push the boundaries of your research.
- Sponsored by 10x Genomics and hosted by OHSU Knight Cancer Institute.
- See 10x Genomics presentation here
June 2, 2022: Symposium on Approaches on Single-Cell Analysis
October 25, 2022: IGL Single Cell and Spatial Transcriptomic Workshop
Information and technical planning support for single cell and spatial transcriptomics studies at OHSU.
OHSU Speakers: Aude Chiot, PhD & Jonathan Nelson, PhD
Wednesday, May 19th, 2021: NanoString nCounter® Webinar
Overview of nCounter® technology, panels, customization options, and services available through the Gene Profiling Shared Resource. See this webinar and more in the Assays of Interest section on the GPSR website.
December 2nd, 2021 OCTRI Research Forum: Power and Sample Size 101
See the recording of this research forum
Please see the Winter 2022 Integrated Genomics Laboratory Newsletter for updates on new equipment, core operations, and more!