Lab Publications
Archin N, Bar KJ, Burdo T, Caskey M, Chahroudi A, Farzan M, Ho YC, Jones RB, Kearney M, Kuritzkes D, Margolis D, Martinez-Picado J, Okoye A, Salgado M, Stevenson M. Highlights from the Tenth International Workshop on HIV Persistence during Therapy, December 13-16, 2022, Miami, Florida-USA. J Virus Erad. 2023 Mar;9(1):100315. doi: 10.1016/j.jve.2023.100315. eCollection 2023 Mar. PMCID: PMC9996320.
Lavinder TR, Fachko DN, Stanton J, Varco-Merth B, Smedley J, Okoye AA, Skalsky RL. Effects of Early Antiretroviral Therapy on the Composition and Diversity of the Fecal Microbiome of SIV-infected Rhesus Macaques (Macaca mulatta). Comp Med. 2022 Oct 1;72(5):287-297. doi: 10.30802/AALAS-CM-22-000020. Epub 2022 Sep 26. PMCID: PMC9827599.
Varco-Merth BD, Brantley W, Marenco A, Duell DD, Fachko DN, Richardson B, Busman-Sahay K, Shao D, Flores W, Engelman K, Fukazawa Y, Wong SW, Skalsky RL, Smedley J,
Axthelm MK, Lifson JD, Estes JD, Edlefsen PT, Picker LJ, Cameron CM, Henrich TJ, Okoye AA. Rapamycin limits CD4+ T cell proliferation in simian immunodeficiency virus-infected rhesus macaques on antiretroviral therapy. J Clin Invest. 2022 May 16;132(10). doi: 10.1172/JCI156063. PMCID: PMC9106346.
Okoye AA, Fromentin R, Takata H, Brehm JH, Fukazawa Y, Randall B, Pardons M, Tai V, Tang J, Smedley J, Axthelm M, Lifson JD, Picker LJ, Favre D, Trautmann L, Chomont N. The ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription. PLoS Pathog. 2022 Jan;18(1):e1010245. doi: 10.1371/journal.ppat.1010245. eCollection 2022 Jan. PubMed PMID: 35041707; PubMed Central PMCID: PMC8797195.
Haeseleer F, Fukazawa Y, Park H, Varco-Merth B, Rust BJ, Smedley JV, Eichholz K, Peterson CW, Mason R, Kiem HP, Roederer M, Picker LJ, Okoye AA, Corey L. Immune inactivation of anti-simian immunodeficiency virus chimeric antigen receptor T cells in rhesus macaques. Mol Ther Methods Clin Dev. 2021 Sep 10;22:304-319. doi: 10.1016/j.omtm.2021.06.008. eCollection 2021 Sep 10. PubMed PMID: 34485613; PubMed Central PMCID: PMC8403686.
Okoye AA, Duell DD, Fukazawa Y, Varco-Merth B, Marenco A, Behrens H, Chaunzwa M, Selseth AN, Gilbride RM, Shao J, Edlefsen PT, Geleziunas R, Pinkevych M, Davenport MP, Busman-Sahay K, Nekorchuk M, Park H, Smedley J, Axthelm MK, Estes JD, Hansen SG, Keele BF, Lifson JD, Picker LJ. CD8+ T cells fail to limit SIV reactivation following ART withdrawal until after viral amplification. J Clin Invest. 2021 Apr 15;131(8). doi: 10.1172/JCI141677. PubMed PMID: 33630764; PubMed Central PMCID: PMC8262469.
Gramatica A, Schwarzer R, Brantley W, Varco-Merth B, Sperber HS, Hull PA, Montano M, Migueles SA, Rosenthal D, Hogan LE, Johnson JR, Packard TA, Grimmett ZW, Herzig E, Besnard E, Nekorchuk M, Hsiao F, Deeks SG, Snape M, Kiernan B, Roan NR, Lifson JD, Estes JD, Picker LJ, Verdin E, Krogan NJ, Henrich TJ, Connors M, Ott M, Pillai SK, Okoye AA, Greene WC. Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity Ex Vivo and In Vivo. J Virol. 2021 Mar 25;95(8). doi: 10.1128/JVI.02393-20. Epub 2021 Feb 3. PMCID: PMC8103695.
Haeseleer F, Eichholz K, Tareen SU, Iwamoto N, Roederer M, Kirchhoff F, Park H, Okoye AA, Corey L. Real-Time Killing Assays to Assess the Potency of a New Anti-Simian Immunodeficiency Virus Chimeric Antigen Receptor T Cell. AIDS Res Hum Retroviruses. 2020 Dec;36(12):998-1009. doi: 10.1089/AID.2020.0163. Epub 2020 Nov 5. PMCID: PMC7703091.
Khanal S, Fennessey CM, O'Brien SP, Thorpe A, Reid C, Immonen TT, Smith R, Bess JW Jr, Swanstrom AE, Del Prete GQ, Davenport MP, Okoye AA, Picker LJ, Lifson JD, Keele BF. In Vivo Validation of the Viral Barcoding of Simian Immunodeficiency Virus SIVmac239 and the Development of New Barcoded SIV and Subtype B and C Simian-Human Immunodeficiency Viruses. J Virol. 2019 Dec 12;94(1). doi: 10.1128/JVI.01420-19. Print 2019 Dec 12. PMCID: PMC6912102.
Okoye AA, DeGottardi MQ, Fukazawa Y, Vaidya M, Abana CO, Konfe AL, Fachko DN, Duell DM, Li H, Lum R, Gao L, Park BS, Skalsky RL, Lewis AD, Axthelm MK, Lifson JD, Wong SW, Picker LJ. Role of IL-15 Signaling in the Pathogenesis of Simian Immunodeficiency Virus Infection in Rhesus Macaques. J Immunol. 2019 Dec 1;203(11):2928-2943. doi: 10.4049/jimmunol.1900792. Epub 2019 Oct 25. PubMed PMCID: PMC6864325.