Lab publications
1. Picker LJ, Lifson JD, Gale, Jr. M, Hansen SG, Klaus Früh. Programming Cytomegalovirus as an HIV Vaccine. Trends Immunol, 44(4):287-304, 2023. doi: 10.1016/j.it.2023.02.001. Epub 2023 Mar 7. [PMID: 36894436; PMCID: PMC10089689].
2. Hansen SG, Hancock MH, Malouli D, Marshall E.E., Hughes CM, Randall KT, Morrow D, Ford JC, Gilbride RM, Selseth AN, Espinosa Trethewy R, Bishop LM, Oswald K, Shoemaker R, Berkemeier B, Bosche WJ, Hull M, Silipino L, Nekorchuk M, Busman-Sahay K, Estes JD, Axthelm MK, Smedley J, Shao D, Edlefsen PT, Lifson JD, Früh K, Nelson JA, and Picker LJ. Myeloid cell tropism enables MHC-E-restricted CD8+ T cell priming and vaccine efficacy by the RhCMV/SIV vaccine, Science Immunol., 7(72):eabn9301, 2022. Epub 2022 Jun 17. doi: 10.1126/sciimmunol.abn9301. [PMID: 35714200; PMCID: PMC9387538]
3. Malouli D, Hansen SG, Hancock MH, Hughes CM, Ford JC, Gilbride RM, Ventura AB, Morrow D, Randall KT, Taher H, Uebelhoer LS, McArdle MR, Papen CR, Espinosa Trethewy R, Oswald K, Shoemaker R, Berkemeier B, Bosche WJ, Hull M, Greene JM, Axthelm MK, Shao J, Edlefsen PT, Grey F, Nelson JA, Lifson JD, Streblow D, Sacha JB, Früh K, and Picker LJ. Cytomegaloviral determinants of CD8+ T cell programming and RhCMV/SIV vaccine efficacy, Science Immunol., 6, eabg5413 (2021) [PMID: 33766849; PMCID: PMC8244349] doi:10.1126/sciimmunol.abg5413
4. Verweij M, Hansen SG, Iyer R, John N, Malouli D, Morrow D, Scholz I, Womack J, Abdulhaqq S, Gilbride RM, Hughes CM, Ventura AB, Ford JC, Selseth AN, Oswald K, Shoemaker R, Berkemeier B, Bosche WJ, Hull M, Shao J, Sacha JB, Axthelm MK, Edlefsen PT, Lifson JD and Picker LJ, and Früh K Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy, Science, 10.1126/science.abe9233 (2021). [PMID: 33766941; PMCID: PMC8354429]
5. Okoye AA, Duell DD, Fukazawa Y, Varco-Merth B, Marenco A, Behrens H, Chaunzwa M, Selseth AN, Gilbride RM, Shao J, Edlefsen PT, Geleziunas R, Pinkevych M, Davenport MP, Busman-Sahay K, Nekorchuk M, Park H, Smedley J, Axthelm MA, Estes JD, Hansen SG, Keele BF, Lifson JD and Picker LJ. CD8+ T cells are ineffective at limiting SIV reactivation following ART withdrawal until after viral amplification and spread, J. Clin. Invest., 131(8):e141677, 2021. https://doi.org/10.1172/JCI141677. [PMID: 33630764; PMCID: PMC8262469]
6. Hansen SG, Marshall EE, Malouli D, Ventura AB, Hughes CM, Ainslie E, Ford JC, Morrow D, Gilbride RM, Jin Y. Bae JY, Legasse AW, Oswald K, Shoemaker R, Berkemeier B, Bosche WJ, Hull M, Womack J, Shao J, Edlefsen PT, Reed JS, Burwitz BJ, Sacha JB, Axthelm MK, Früh K, Lifson JD, and Picker LJ. A live-attenuated RhCMV/SIV vaccine shows long-term efficacy against heterologous SIV challenge, Sci. Transl. Med., 11, eaaw2607, 2019. doi: 10.1126/scitranslmed.aaw2607. [PMID: 31316007; PMCID: PMC6788755]
7. Okoye AA, Hansen SG, Vaidya M, Fukazawa Y, Park HM, Duell DM, Lum R, Hughes CM, Ventura AB, Ainslie E, Ford JC, Morrow D, Gilbride RM, Legasse AW, Hesselgesser J, Geleziunas, Li Y, Oswald K, Shoemaker R, Fast R, Bosche WJ, Borate BR, Edlefsen PT, Axthelm MK, Picker LJ, and Lifson JD. Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound, Nature Medicine, 24(9):1430-1440, 2018. doi: 10.1038/s41591-018-0130-7. [PMID: 30082858; PMCID: PMC6389357].
8. Hansen SG, Zak DE, Xu G, Ford JC, Marshall EE, Malouli D, Gilbride RM, Hughes CM, Ventura AB, Ainslie E, Randall KT, Selseth AN, Rundstrom P, Herlache L, Lewis MS, Park H, Planer SL, Turner JM, Fischer M, Armstrong C, Zweig RC, Sylwester AW, Legasse AW, Messerle M, Jarvis MA, Amon LM, Aderem A, Alter G, Laddy DJ, Stone M, Bonavia A, Evans TG, Messerle M, Jarvis MA, Früh K, Axthelm MK, Edlefsen PT and Picker LJ. Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine, Nature Medicine, 24:130-143, 2018. doi:10.1038/nm.4473. [PMID: 29334373; PMCID: PMC5909823]
9. Hansen SG, Wu HL, Burwitz BJ, Hughes CM, Hammond KB, Ventura AB, Reed JS, Gilbride RM, Ainslie E, Morrow DW, Ford JC, Selseth AN, Pathak R, Malouli D, Legasse AW, Axthelm MK, Nelson JA, Gillespie GM, Walters LC, Brackenridge S, Sharpe HR, López CA, Früh K, Korber B, McMichael AJ, Gnanakaran S, Sacha JB, and Picker LJ. Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex-E, Science, 351:714-720, 2016. doi: 10.1126/ science.aac9475. [PMID: 26797147; PMCID: PMC4769032]
10. Fukazawa Y, Lum R, Okoye AA, Park H, Matsuda K, Bae JY, Hagen SI, Shoemaker R, Deleage C, Lucero C, Morcock D, Swanson T, Legasse AW, Axthelm MK, Hesselgesser J, Geleziunas R, Hirsch VM, Edlefsen PT, Piatak Jr. M, Lifson JD, and Picker LJ. B cell follicle sanctuary permits persistent productive SIV infection in elite controllers, Nature Medicine, 21:132-9, 2015. doi:10.1038/nm.3781. [PMID: 25599132; PMCID: PMC4320022].
11. Hansen SG, Piatak, Jr. M, Ventura AB, Hughes CM, Gilbride RM, Ford JC, Oswald K, Shoemaker R, Li Y, Lewis MS, Gilliam AN, Xu G, Whizin N, Planner SL, Turner JM, Legasse AW, Axthelm MK, Fukazawa Y, Park H, Edlefsen PT, Nelson JA, Früh K, Sacha JB, Estes JD, Lifson JD, and Picker LJ. Immune clearance of highly pathogenic SIV infection. Nature, 502:100-104, 2013. doi:10.1038/nature12519. [PMID: 24025770; PMCID: PMC3849456].
12. Hansen SG, Sacha JB, Hughes CM, Ford JC, Burwitz BJ, Scholz I, Gilbride RM, Lewis MS, Gilliam AN, Ventura AB, Malouli D, Xu G, Richards R, Whizin N, Reed JS, Hammond KB, Fischer M, Turner JM, Legasse AW, Axthelm MK, Edlefsen PT, Nelson JA, Lifson JD, Früh K, and Picker LJ. Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms. Science, 340(6135):1237874, 2013. doi: 10.1126/science.1237874. [PMID: 23704576; PMCID: PMC3816976].