Erin Dueber, Ph.D. is a Distinguished Scientist and Director of the Biological Chemistry Department, with a joint appointment in the Structural Biology Department, at Genentech in South San Francisco, CA. Dr. Dueber received her Ph.D. in Biophysics from UCSF (Prof. David Agard, thesis advisor) and completed an independent Miller Postdoctoral Fellowship at UC Berkeley (Prof. James Berger, host). She joined Genentech in 2008 where she has worked primarily on discovery projects aimed at understanding the molecular mechanisms underlying cell signaling pathways. These efforts include determining the mechanism of action of IAP antagonists, the structure and activation mechanism of TBK1, and the activation and pore-forming mechanism of GSDMD. More recently, Dr. Dueber’s lab demonstrated a proof-of-concept for engineering target degradation via direct proteasome engagement.