Select a tab to view the CPB labs working in that research discipline. As a department that promotes interdisciplinary research, a lab may appear in more than one discipline as appropriate.

The lab of Kimberly Beatty uses fluorescent probes to study the molecular basis of human diseases. Her lab investigates cellular protein organization across size scales and imaging platforms using novel genetic tags named VIP tags and is currently applied towards studying iron uptake and cancer signalling. In addition, her lab uses chemistry to study enzyme regulation and drug targets in Mycobacterium tuberculosis.
beattyk@ohsu.edu | Beatty Lab | @beattylab

The lab of Michael Cohen is interested in the fundamental metabolite NAD+ and its role in the essential post-translation modification known as APD-ribosylation through enzymes called PARPs. The lab has developed a suite of chemical biology approaches - including the “bump-hole” method - to study how ADP-ribosylation regulates proteins. Additionally, the Cohen lab is well known for the synthesis of isoform-specific inhibitors, which are important tools for probing the function of PARPs in cells and animals.
cohenmic@ohsu.edu | Cohen Lab | @MichaelNADbio

The lab of Braden Lobingier studies drug action at opioid and dopamine receptors (GPCRs). We specialize in combining chemical biology with proteomic and genomic techniques to identify the mechanisms of receptor function. In addition, we have a parallel research program focused on understanding a critical organelle called the endosome. We seek to understand how the endosome specifically controls GPCR function as well as its role in controlling membrane proteins broadly.
lobingib@ohsu.edu | Lobingier Lab

The lab of Pierre Moenne-Loccoz is interested in metalloproteins and metalloenzymes. We use spectroscopic techniques and time-resolved approaches to supplement structural knowledge obtained from X-ray crystallography or cryoEM to understand how metalloproteins contribute to the production, control, and detoxification of reactive nitrogen and oxygen species (RNS and ROS).
moennelo@ohsu.edu

The lab of Show-Ling Shyng is interested in ion channel regulation in the context of structure-function, disease mechanisms and therapeutics, with a focus on KATP channels in the pancreatic endocrine islets and the cardiovascular system. We use a combination of single-particle cryoEM, electrophysiology, chemical biology and live cell imaging approaches to study the gating and trafficking of KATP channels and to develop mechanism-based pharmacological agents for human diseases caused by KATP dysfunction.
shyngs@ohsu.edu | Shyng Lab

The lab of Matt Thayer studies the mechanisms that control chromosome replication timing, mono-allelic gene expression, and structural stability of mammalian chromosomes. We use somatic cell, molecular-genetic, and imaging approaches to identify and characterize human genes that control various aspects of chromosome dynamics. We have identified a family of lncRNA genes (ASynchronous replication and Autosomal RNA; ASAR) that control replication timing, mono-allelic gene expression, and structural stability of individual human chromosomes.
thayerm@ohsu.edu

The lab of Francis Valiyaveetil is interested in the molecular structure and function of ion channels and transporters. The lab combines structure determination with functional studies using electrophysiology and studies of protein dynamics using fluorescence spectroscopy. We are presently investigating the functional mechanisms that operate in voltage gated potassium channels and glutamate transporters.
valiyave@ohsu.edu | Valiyaveetil Lab

The lab of Liman Zhang uses structural biology (cryo-EM) and biochemistry to study the signal transduction in inflammation. Our lab investigates how pathogen and danger signals activate immuno-effectors to initiate inflammation responses, and how dysregulation of these signal transductions causes auto-inflammatory diseases.
zhanglim@ohsu.edu | Zhang Lab | @zhang_liman

The lab of Kimberly Beatty uses fluorescent probes to study the molecular basis of human diseases. Her lab investigates cellular protein organization across size scales and imaging platforms using novel genetic tags named VIP tags and is currently applied towards studying iron uptake and cancer signalling. In addition, her lab uses chemistry to study enzyme regulation and drug targets in Mycobacterium tuberculosis.
beattyk@ohsu.edu | Beatty Lab | @beattylab

The lab of Michael Cohen is interested in the fundamental metabolite NAD+ and its role in the essential post-translation modification known as APD-ribosylation through enzymes called PARPs. The lab has developed a suite of chemical biology approaches - including the “bump-hole” method - to study how ADP-ribosylation regulates proteins. Additionally, the Cohen lab is well known for the synthesis of isoform-specific inhibitors, which are important tools for probing the function of PARPs in cells and animals.
cohenmic@ohsu.edu | Cohen Lab | @MichaelNADbio

The lab of James Frank centers around cannabinoid receptors and how they are activated by their endogenous lipid ligands to affect biomolecule secretion in the brain and in the pancreas. The lab builds and evaluates new small molecule-based photoactivatable tools using chemistry, molecular biology, imaging, whole-cell electrophysiology, and in vivo behavioural experiments.
frankja@ohsu.edu | Frank Lab | @jF-lab

The lab of Braden Lobingier studies drug action at opioid and dopamine receptors (GPCRs). We specialize in combining chemical biology with proteomic and genomic techniques to identify the mechanisms of receptor function. In addition, we have a parallel research program focused on understanding a critical organelle called the endosome. We seek to understand how the endosome specifically controls GPCR function as well as its role in controlling membrane proteins broadly.
lobingib@ohsu.edu | Lobingier Lab

The lab of Tom Scanlan is best known for the synthesis of prodrugs to manipulate thyroid hormone receptors in the brain and the periphery and to bring these compounds to patients.
scanlant@ohsu.edu

The lab of Carsten Schultz currently works on pancreatic extracellular signaling, protease activity as a marker for cancer and lung inflammation, the development of novel lipid tools to analyze lipid-interactomes in virus-infected cells and patients and intracellular lipid metabolism and trafficking. The lab uses a combination of organic chemistry, molecular biology and live-cell and tissue slice imaging.
schulcar@ohsu.edu

The lab of Francis Valiyaveetil is interested in the molecular structure and function of ion channels and transporters. The lab combines structure determination with functional studies using electrophysiology and studies of protein dynamics using fluorescence spectroscopy. We are presently investigating the functional mechanisms that operate in voltage gated potassium channels and glutamate transporters.
valiyave@ohsu.edu | Valiyaveetil Lab

The labs of Xiangshu Xiao and Bingbing Li focus on medicinal chemistry and pharmacology applied to cancer research, in particular clear-cell carcinoma, breast and ovarian cancer.
xiaoxi@ohsu.edu | lib@ohsu.edu | Xiao Lab

The Sue Aicher lab specializes in studies on neural circuits in rodent model systems. We collaborate extensively with other groups within the department and across the country. We also study ocular pain in humans and rodents, looking for molecular and biological mechanisms of pain. Our experimental techniques include tract tracing, immunocytochemistry, confocal and electron microscopy.
aichers@ohsu.edu | Aicher Lab

The lab of Michael Cohen is interested in the fundamental metabolite NAD+ and its role in the essential post-translation modification known as APD-ribosylation through enzymes called PARPs. The lab has developed a suite of chemical biology approaches - including the “bump-hole” method - to study how ADP-ribosylation regulates proteins. Additionally, the Cohen lab is well known for the synthesis of isoform-specific inhibitors, which are important tools for probing the function of PARPs in cells and animals.
cohenmic@ohsu.edu | Cohen Lab | @MichaelNADbio

The lab of Robert Duvoisin studies visual neuroscience. Our research is focused on synaptic transmission between photoreceptor cells and bipolar cells in the retina, which represents the first stage of image processing in the visual system. The lab employs electrophysiological, immunohistochemical, and biochemical techniques to pursue a comprehensive understanding of the physiology and structural organization of these specialized sensory synapses in both healthy and disease states.
duvoisin@ohsu.edu | Duvoisin Lab

The Beth Habecker lab is studying nerves that control the heart. We are trying to understand how neuron-heart interactions during injury and disease contribute to bad outcomes and are asking if we can fix nerves to prevent cardiac damage.| habecker@ohsu.edu | Habecker Lab | @habeckerlab

The lab of Catherine Morgans studies visual neuroscience. Our research is focused on synaptic transmission between photoreceptor cells and bipolar cells in the retina, which represents the first stage of image processing in the visual system. The lab employs electrophysiological, immunohistochemical, and biochemical techniques to pursue a comprehensive understanding of the physiology and structural organization of these specialized sensory synapses in both health and disease states.
morgansc@ohsu.edu

The lab of Show-Ling Shyng is interested in ion channel regulation in the context of structure-function, disease mechanisms and therapeutics, with a focus on KATP channels in the pancreatic endocrine islets and the cardiovascular system. We use a combination of single-particle cryoEM, electrophysiology, chemical biology and live cell imaging approaches to study the gating and trafficking of KATP channels and to develop mechanism-based pharmacological agents for human diseases caused by KATP dysfunction.
shyngs@ohsu.edu | Shyng Lab

The lab of Francis Valiyaveetil is interested in the molecular structure and function of ion channels and transporters. The lab combines structure determination with functional studies using electrophysiology and studies of protein dynamics using fluorescence spectroscopy. We are presently investigating the functional mechanisms that operate in voltage gated potassium channels and glutamate transporters.
valiyave@ohsu.edu | Valiyaveetil Lab

The Structural Biology-focused research groups in CPB cover a variety of research topics, and are supported by state-of-the-art cryo-EM facilities, including on-site access to OHSU’s Multiscale Microscopy Core (MMC) and the Pacific Northwest Cryo-EM Center (PNCC), and high-performance computing through OHSU’s Advanced Computing Center (ACC). 

The lab of Steven E. Mansoor uses techniques in structural biology (X-ray crystallography and single particle cryogenic electron microscopy), electrophysiology, ligand binding assays and rational drug-design to study the structure, function, and signaling of ion channels and G-protein coupled receptors of the cardiovascular and central nervous systems. The overarching goals are to identify and develop novel, high-affinity, subtype-selective small molecule agonists and antagonists for the treatment of conditions such as angina, hypertension, platelet aggregation, vascular inflammation and neuroinflammation.
mansoors@ohsu.edu | Mansoor Lab | @MansoorLabOHSU | @mansoor_steven

The lab of Pierre Moenne-Loccoz is interested in metalloproteins and metalloenzymes. We use spectroscopic techniques and time-resolved approaches to supplement structural knowledge obtained from X-ray crystallography or cryoEM to understand how metalloproteins contribute to the production, control, and detoxification of reactive nitrogen and oxygen species (RNS and ROS).
moennelo@ohsu.edu

The lab of Steve Reichow applies cutting-edge methods in cryo-EM, MD simulation and biophysical methods to characterize the inner-workings of macromolecular machines. We specialize in the mechanisms of membrane channel gating and cell-signaling events that orchestrate a wide range of physiological processes. We are also interested in understanding the molecular basis of age-related protein aggregation events associated with disease. 
reichow@ohsu.edu | Reichow Lab | @reichowlab

The lab of Show-Ling Shyng is interested in ion channel regulation in the context of structure-function, disease mechanisms and therapeutics, with a focus on KATP channels in the pancreatic endocrine islets and the cardiovascular system. We use a combination of single-particle cryoEM, electrophysiology, chemical biology and live cell imaging approaches to study the gating and trafficking of KATP channels and to develop mechanism-based pharmacological agents for human diseases caused by KATP dysfunction.
shyngs@ohsu.edu | Shyng Lab

The lab of Francis Valiyaveetil is interested in the molecular structure and function of ion channels and transporters. The lab combines structure determination with functional studies using electrophysiology and studies of protein dynamics using fluorescence spectroscopy. We are presently investigating the functional mechanisms that operate in voltage gated potassium channels and glutamate transporters.
valiyave@ohsu.edu | Valiyaveetil Lab

The lab of Liman Zhang uses structural biology (cryo-EM) and biochemistry to study the signal transduction in inflammation. Our lab investigates how pathogen and danger signals activate immuno-effectors to initiate inflammation responses, and how dysregulation of these signal transductions causes auto-inflammatory diseases.
zhanglim@ohsu.edu | Zhang Lab | @zhang_liman