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Betz J, Behrens H, Harkness BM, Stutzman R, Chamberlain W, Blanco MP, Hegarty DM, Aicher SA, Galor A. Ocular Pain after Refractive Surgery: Interim Analysis of Frequency and Risk Factors. Ophthalmology. 2023 Feb 19:S0161-6420(23)00127-6. doi: 10.1016/j.ophtha.2023.02.016.

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Corty M.M., Hulegaard A.L., Hill J.Q., Sheehan A.E., Aicher S.A., Freeman M.R. Discoidin domain receptor regulates ensheathment, survival and caliber of peripheral axons. (2022) Development (Cambridge), 49 (23), art. no. dev200636. DOI: 10.1242/dev.200636

Denfeld, Q.E., Camacho, S.A., Dieckmann, N., Hiatt, S.O., Roberts Davis, M., Cramer, D.V., Rupert, A., Habecker, B.A., Lee, C.S. Background and Design of the Biological and Physiological Mechanisms of Symptom Clusters in Heart Failure (BIOMES-HF) Study. (2022) Journal of Cardiac Failure, 28 (6), pp. 973-981. DOI: 10.1016/j.cardfail.2022.01.003

Denfeld, Q.E., Lee, C.S., Habecker, B.A. A primer on incorporating sex as a biological variable into the conduct and reporting of basic and clinical research studies. (2022) American Journal of Physiology - Heart and Circulatory Physiology, 322 (3), pp. H350-H354. DOI: 10.1016/j.jacbts.2021.11.003

Dey A, Albert T, Kong RY, MacMillan SN, Moënne-Loccoz P, Lancaster KM, Goldberg DP. Direct Reduction of NO to N₂O by a Mononuclear Nonheme Thiolate Ligated Iron(II) Complex via Formation of a Metastable {FeNO}⁷ Complex. Inorg Chem. 2022 Sep 26;61(38):14909-14917. doi: 10.1021/acs.inorgchem.2c02383. Epub 2022 Sep 15. PMID: 36107151

Frank, J. A. Optofluidic neural interfaces for in vivo photopharmacology. Current Opinion in Pharmacology, 63 doi:10.1016/j.coph.2022.102195

Farley SE, Kyle JE, Leier HC, Bramer LM, Weinstein J, Bates TA, Lee JY, Metz TO, Schultz C, Tafesse FG. A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants. bioRxiv [Preprint]. 2022 Feb 15:2022.02.14.480430. doi: 10.1101/2022.02.14.480430. PMID: 35194611; PMCID: PMC8863149.Frey DL, Boutin S, Dittrich SA, Graeber SY, Stahl M, Wege S, Herth FJF, Sommerburg O, Schultz C, Mall MA, Dalpke AH. Relationship between airway dysbiosis, inflammation and lung function in adults with cystic fibrosis. J Cyst Fibros. 2021 Sep;20(5):754-760. doi: 10.1016/j.jcf.2020.12.022. Epub 2021 Jan 8. PMID: 33431308.

Fernández-Guasti, A., Quintanar, B. G., Reyes, R., Hernández, A., Chavira, R., & Roselli, C. E. Androgen receptors immunoreactivity in the rat brain of males with same-sex preference. Hormones and Behavior, 146 doi:10.1016/j.yhbeh.2022.105279

Ferrara, S. J., Chaudhary, P., DeBell, M. J., Marracci, G., Miller, H., Calkins, E., . . . Scanlan, T. S. TREM2 is thyroid hormone regulated making the TREM2 pathway druggable with ligands for thyroid hormone receptor. Cell Chemical Biology, 29(2), 239-248.e4. doi:10.1016/j.chembiol.2021.07.014

Frey, D. L., Bridson, C., Dittrich, S., Graeber, S. Y., Stahl, M., Wege, Schultz C., . . . Boutin, S. Changes in microbiome dominance are associated with declining lung function and fluctuating inflammation in people with cystic fibrosis. Frontiers in Microbiology, 13 doi:10.3389/fmicb.2022.885822

Hamity, M. V., Kolker, S. J., Hegarty, D. M., Blum, C., Langmack, L., Aicher, S. A., & Hammond, D. L. Nicotinamide riboside alleviates corneal and somatic hypersensitivity induced by paclitaxel in male rats. Investigative Ophthalmology and Visual Science, 63(1) doi:10.1167/IOVS.63.1.38

Hauke, S., Rada, J., Tihanyi, G., Schilling, D., & Schultz, C. ATP is an essential autocrine factor for pancreatic β-cell signaling and insulin secretion. Physiological Reports, 10(1) doi:10.14814/phy2.15159

Hegarty D.M., Carroll J.R., Nguyen D., Halls V.S., Robbins D.I., Price T.J., Dussor G., Aicher S.A. Resveratrol increases tear production and ocular pain after corneal abrasion in male, but not female, rats using a photorefractive keratectomy model. Experimental Eye Research, 225, art. no. 109281. DOI: 10.1016/j.exer.2022.109281

Heskett MB, Vouzas AE, Smith LG, Yates PA, Boniface C, Bouhassira EE, Spellman PT, Gilbert DM, Thayer MJ. Epigenetic control of chromosome-associated lncRNA genes essential for replication and stability. Nat Commun. 2022 Oct 22;13(1):6301. doi: 10.1038/s41467-022-34099-7.

Hogg SJ, Motorna O, Kearney CJ, Derrick EB, House IG, Todorovski I, Kelly MJ, Zethoven M, Bromberg KD, Lai A, Beavis PA, Shortt J, Johnstone RW, Vervoort SJ. Distinct modulation of IFNγ-induced transcription by BET bromodomain and catalytic P300/CBP inhibition in breast cancer. Clin Epigenetics. 2022 Jul 28;14(1):96. doi: 10.1186/s13148-022-01316-5. PMID: 35902886.

Ishibashi M., Keung J., Morgans C.W., Aicher S.A., Carroll J.R., Singer J.H., Jia L., Li W., Fahrenfort I., Ribelayga C.P., Massey S.C. Analysis of Rod/Cone Gap Junctions from the Reconstruction of Mouse Photoreceptor Terminals. (2022) eLife, 11, art. no. e73039. DOI: 10.7554/eLife.73039

Keddy, C., Shinde, P., Jones, K., Kaech, S., Somwar, R., Shinde, U., & Davare, M. A. Resistance profile and structural modeling of next-generation ROS1 tyrosine kinase inhibitors. Molecular Cancer Therapeutics, 21(2), 336-346. doi:10.1158/1535-7163.MCT-21-0395

Kelly MJ, Breathnach C, Tracey KJ, Donnelly SC. Manipulation of the inflammatory reflex as a therapeutic strategy. Cell Rep Med. 2022 Jul 19;3(7):100696. doi: 10.1016/j.xcrm.2022.100696. PMID: 35858588 Review.

Li, B.X., David, L.L., Davis, L.E., Xiao, X. Protein arginine methyltransferase 5 is essential for oncogene product EWSR1-ATF1-mediated gene transcription in clear cell sarcoma. 2022. Journal of Biological Chemistry, 298(10), art. no. 102434.

Liu GT, Kochlamazashvili G, Puchkov D, Müller R, Schultz C, Mackintosh AI, Vollweiter D, Haucke V, Soykan T. Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission. EMBO J. 2022 May 2;41(9):e109352. doi: 10.15252/embj.2021109352. Epub 2022 Mar 22. PMID: 35318705.

L S, V W, R S, Mj K, H P, Sjc T. Enhancing and assessing fidelity in the TANDEM (Tailored intervention for ANxiety and DEpression Management in COPD) trial: development of methods and recommendations for research design. BMC Med Res Methodol. 2022 Jun 6;22(1):163. doi: 10.1186/s12874-022-01642-5. PMID: 35668365 

Mammel A.E., Delgado K.C., Chin A.L., Condon A.F., Hill J.Q., Aicher S.A., Wang Y., Fedorov L.M., Robinson F.L. Distinct roles for the Charcot-Marie-Tooth disease-causing endosomal regulators Mtmr5 and Mtmr13 in axon radial sorting and Schwann cell myelination. (2022) Human Molecular Genetics, 31 (8), pp. 1216 - 1229. DOI: 10.1093/hmg/ddab311

Mansoor SE. How Structural Biology Has Directly Impacted Our Understanding of P2X Receptor Function and Gating. Methods Mol Biol. 2022;2510:1-29. doi: 10.1007/978-1-0716-2384-8_1. PMID: 35776317.

Margaroli C, Horati H, Garratt LW, Giacalone VD, Schofield C, Dittrich AS, Rosenow T, Dobosh BS, Lim HS, Frey DL, Veltman M, Silva GL, Brown MR, Schultz C, Tiddens HAWM, Ranganathan S, Chandler JD, Qiu P, Peng L, Scholte BJ, Mall MA, Kicic A, Guglani L, Stick SM, Janssens HM, Tirouvanziam R. Macrophage PD-1 associates with neutrophilia and reduced bacterial killing in early cystic fibrosis airway disease. J Cyst Fibros. 2022 Jun 19:S1569-1993(22)00588-4. doi: 10.1016/j.jcf.2022.06.001. PMID: 35732550. 

Martín-Acosta, P; Meng, Q.; Klimek, J.; Reddy, A. P.; David, L.; Petrie, S. K.; Li, B. X.; Xiao, X. “A Clickable Photoaffinity Probe of Betulinic Acid Identifies Tropomyosin as a Target”, Acta Pharm. Sin. B, 2022, 12, 2406-2416 PMID: 35646545 DOI: 10.1016/j.apsb.2021.12.008  (Impact factor: 14.9)

Matsumura, H., Faponle, A. S., Hagedoorn, P. -., Tosha, T., de Visser, S. P., & Moënne-Loccoz, P. Mechanism of substrate inhibition in cytochrome-c dependent NO reductases from denitrifying bacteria (cNORs). Journal of Inorganic Biochemistry, 231 doi:10.1016/j.jinorgbio.2022.111781

Mehra R., Tjurmina O.A., Ajijola O.A., Arora R., Bolser D.C., Chapleau M.W., Chen P.-S., Clancy C.E., Delisle B.P., Gold M.R., Goldberger J.J., Goldstein D.S., Habecker B.A., Handoko M.L., Harvey R., Hummel J.P., Hund T., Meyer C., Redline S., Ripplinger C.M., Simon M.A., Somers V.K., Stavrakis S., Taylor-Clark T., Undem B.J., Verrier R.L., Zucker I.H., Sopko G., Shivkumar K. Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop. (2022) JACC: Basic to Translational Science, 7 (3), pp. 265 - 293. DOI: 10.1016/j.jacbts.2021.11.003

Meier, A. A., Moon, H. -., Sabuncu, S., Singh, P., Ronnebaum, T. A., Ou, S., . . .Moënne-Loccoz, P., Mure, M. Insight into the spatial arrangement of the lysine tyrosylquinone and Cu2+ in the active site of lysyl oxidase-like 2. International Journal of Molecular Sciences, 23(22) doi:10.3390/ijms232213966

Mostofian, B., McFarland, R., Estelle, A., Howe, J., Barbar, E., Reichow, S. L., & Zuckerman, D. M. Continuum dynamics and statistical correction of compositional heterogeneity in multivalent IDP oligomers resolved by single-particle EM. Journal of Molecular Biology, 434(9) doi:10.1016/j.jmb.2022.167520

Nash G, Paidimuddala B, Zhang L. Structural aspects of the MHC expression control system. Biophys Chem. 2022 May;284:106781. doi: 10.1016/j.bpc.2022.106781. Epub 2022 Feb 15. Review. PubMed PMID: 35228036; PubMed Central PMCID: PMC8941990.

Oken AC, Krishnamurthy I, Savage JC, Lisi NE, Godsey MH, Mansoor SE. Molecular Pharmacology of P2X Receptors: Exploring Druggable Domains Revealed by Structural Biology. Front. Pharmacol., vol. 13, 17 June 2022.  doi.org/10.3389/fphar.2022.925880

Peacock DM, Kelly MJS, Shokat KM. Probing the KRas Switch II Groove by Fluorine NMR Spectroscopy. ACS Chem Biol. 2022 Sep 27. doi: 10.1021/acschembio.2c00566. Online ahead of print. PMID: 36166818.

Pritzl, S. D., Konrad, D. B., Ober, M. F., Richter, A. F., Frank, J. A., Nickel, B., . . . Lohmüller, T. Optical membrane control with red light enabled by red-shifted photolipids. Langmuir, 38(1), 385-393. doi:10.1021/acs.langmuir.1c02745

Qiu J., Bosch M.A., Stincic T.L., Hunker A.C., Zweifel L.S., Rønnekleiv O.K., Kelly M.J. CRISPR/SaCas9 mutagenesis of stromal interaction molecule 1 in proopiomelanocortin neurons increases glutamatergic excitability and protects against diet-induced obesity. (2022) Molecular Metabolism, 66, art. no. 101645. DOI: 10.1016/j.molmet.2022.101645.

Qiu, J., Stincic, T. L., Bosch, M. A., Connors, A. M., Petrie, S. K., Rønnekleiv, O. K., & Kelly, M. J. Deletion of Stim1 in hypothalamic arcuate nucleus Kiss1 neurons potentiates synchronous GCaMP activity and protects against diet-induced obesity. Journal of Neuroscience, 41(47), 9688-9701. doi:10.1523/JNEUROSCI.0622-21.2021

Quinn, J. F., Kelly, M. J., Harris, C. J., Hack, W., Gray, N. E., Kulik, V., . . . Copenhaver, P. F. The novel estrogen modulator STX attenuates amyloid-β neurotoxicity in the 5XFAD mouse model of Alzheimer's disease. Neurobiology of Disease, 174 doi:10.1016/j.nbd.2022.105888

Reddi R, Matulef K, Riederer EA, Whorton MR, Valiyaveetil FI. Structural basis for C-type inactivation in a Shaker family voltage-gated K+ channel. Sci. Adv.8, eabm8804(2022).DOI:10.1126/sciadv.abm8804

Riederer EA, Moënne-Loccoz P, Valiyaveetil FI. Distinct roles of the Na⁺ binding sites in the allosteric coupling mechanism of the glutamate transporter homolog, Glt_Ph. Proc Natl Acad Sci U S A. 2022 May 10;119(19):e2121653119. doi: 10.1073/pnas.2121653119. Epub 2022 May 4. PMID: 35507872.

Rodriguez KM, Cohen MS. Chemical genetic methodologies for identifying protein substrates of PARPs. Trends Biochem Sci. 2022 May;47(5):390-402. doi: 10.1016/j.tibs.2021.07.002.

Rønnekleiv, O. K., Qiu, J., & Kelly, M. J. Hypothalamic kisspeptin neurons and the control of homeostasis. Endocrinology (United States), 163(2) doi:10.1210/endocr/bqab253

Sacramento, J. J. D., Albert, T., Siegler, M., Moënne-Loccoz, P., & Goldberg, D. P. An iron(III) superoxide corrole from iron(II) and dioxygen. Angewandte Chemie - International Edition, 61(2) doi:10.1002/anie.202111492

Saito K, Dickey JE, Rodeghiero SR, Toth BA, Kelly MJ, Deng Y, Singh U, Deng G, Jiang J, Cui H. Hypomorphism of a novel long ERα isoform causes severe reproductive dysfunctions in female mice. Endocrinology. 2022 Oct 1:bqac160. doi: 10.1210/endocr/bqac160. Online ahead of print. PMID: 36181426

Schultz C, Farley SE, Tafesse FG. "Flash & Click": Multifunctionalized Lipid Derivatives as Tools To Study Viral Infections. J Am Chem Soc. 2022 Jul 28. doi: 10.1021/jacs.2c02705. Online ahead of print. PMID: 35900117 Review.

Schultz M, Müller R, Ermakova Y, Hoffmann JE, Schultz C. Membrane-Permeant, Bioactivatable Coumarin Derivatives for In-Cell Labelling. Chembiochem. 2022 Feb 23:e202100699. doi: 10.1002/cbic.202100699. Epub ahead of print. PMID: 35199435.

Schultz, C. Chemical tools for lipid cell biology. Accounts of Chemical Research, doi:10.1021/acs.accounts.2c00851

Sepe, J.J., Gardner, R.T., Blake, M.R., Brooks, D.M., Staffenson, M.A., Betts, C.B., Sivagnanam, S., Larson, W., Kumar, S., Bayles, R.G., Jin, H., Cohen, M.S., Coussens, L.M., Habecker, B.A. Therapeutics That Promote Sympathetic Reinnervation Modulate the Inflammatory Response After Myocardial Infarction. (2022) JACC: Basic to Translational Science, 7 (9), pp. 915-930. DOI: 10.1016/j.jacbts.2022.04.009.

Shi Z, Stornetta RL, Stornetta DS, Abbott SBG, Brooks VL. The arcuate nucleus: A site of synergism between Angiotensin II and leptin to increase sympathetic nerve activity and blood pressure in rats. Neurosci Lett. 2022 Aug 10;785:136773. doi: 10.1016/j.neulet.2022.136773. Epub 2022 Jul 6. PMID: 35809879

Shi Z, Stornetta DS, Stornetta RL, Brooks VL. Arcuate Angiotensin II Increases Arterial Pressure via Coordinated Increases in Sympathetic Nerve Activity and Vasopressin Secretion. eNeuro. 2022 Jan 20;9(1):ENEURO.0404-21.2021. doi: 10.1523/ENEURO.0404-21.2021. PMID: 34937769; PMCID: PMC8805192.

Shyng SL. K_ATP Channel Function: More than Meets the Eye. Function (Oxf). 2022 Jan 10;3(1):zqab070. doi: 10.1093/function/zqab070. PMID: 35059642; PMCID: PMC8759536.

Stincic TL, Bosch MA, Hunker AC, Juarez B, Connors AM, Zweifel LS, Rønnekleiv OK, Kelly MJ. CRISPR knockdown of Kcnq3 attenuates the M-current and increases excitability of NPY/AgRP neurons to alter energy balance. Mol Metab. 2021 Jul;49:101218. doi: 10.1016/j.molmet.2021.101218. Epub 2021 Mar 22. PMID: 33766732; PMCID: PMC8093934.

Stincic TL, Kelly MJ. Estrogenic regulation of reproduction and energy homeostasis by a triumvirate of hypothalamic arcuate neurons. J Neuroendocrinol. 2022 Jun;34(6):e13145. doi: 10.1111/jne.13145. Epub 2022 May 17.PMID: 35581942 Review.

Sung MW, Driggers CM, Mostofian B, Russo JD, Patton BL, Zuckerman DM, Shyng SL. Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K_ATP Channel. J Mol Biol. 2022 Oct 15;434(19):167789. doi: 10.1016/j.jmb.2022.167789. Epub 2022 Aug 11. PMID: 35964676.

Tassi Yunga S, Gower AJ, Melrose AR, Fitzgerald MK, Rajendran A, Lusardi TA, Armstrong RJ, Minnier J, Jordan KR, McCarty OJT, David LL, Wilmarth PA, Reddy AP, Aslan JE. Effects of ex vivo blood anticoagulation and preanalytical processing time on the proteome content of platelets. J Thromb Haemost. 2022 Jun;20(6):1437-1450. doi: 10.1111/jth.15694.

Vermehren-Schmaedick A, Olah MJ, Ramunno-Johnson D, Lidke KA, Cohen MS, Vu TQ. Molecular-Scale Dynamics of Long Range Retrograde Brain-Derived Neurotrophic Factor Transport Shaped by Cellular Spatial Context. Front Neurosci. 2022 Mar 31;16:835815. doi: 10.3389/fnins.2022.835815.

Vester K, Preußner M, Holton N, Feng S, Schultz C, Heyd F, Wahl MC. Recruitment of a splicing factor to the nuclear lamina for its inactivation. Commun Biol. 2022 Jul 22;5(1):736. doi: 10.1038/s42003-022-03689-y. PMID: 35869234.

Wagner, C., Balázs, A., Schatterny, J., Zhou-Suckow, Z., Duerr, J., Schultz, C., & Mall, M. A. Genetic deletion of Mmp9 does not reduce airway inflammation and structural lung damage in mice with cystic fibrosis-like lung disease. International Journal of Molecular Sciences, 23(21) doi:10.3390/ijms232113405

Welch, E. F., Rush, K. W., Arias, R. J., & Blackburn, N. J. Copper monooxygenase reactivity: Do consensus mechanisms accurately reflect experimental observations? Journal of Inorganic Biochemistry, 231 doi:10.1016/j.jinorgbio.2022.111780

Welch E.F., Rush K.W., Arias R.J., Blackburn N.J. Pre-Steady-State Reactivity of Peptidylglycine Monooxygenase Implicates Ascorbate in Substrate Triggering of the Active Conformer. (2022) Biochemistry, 61 (8), pp. 665 - 677. DOI: 10.1021/acs.biochem.2c00080

Wilmet B, Callebert J, Duvoisin R, Goulet R, Tourain C, Michiels C, Frederiksen H, Schaeffel F, Marre O, Sahel JA, Audo I, Picaud S, Zeitz C. Mice Lacking Gpr179 with Complete Congenital Stationary Night Blindness Are a Good Model for Myopia. Int J Mol Sci. 2022 Dec 22;24(1):219. doi: 10.3390/ijms24010219.

Yang HQ, Echeverry FA, ElSheikh A, Gando I, Anez Arredondo S, Samper N, Cardozo T, Delmar M, Shyng SL, Coetzee WA. Subcellular trafficking and endocytic recycling of K_ATP channels. Am J Physiol Cell Physiol. 2022 Jun 1;322(6):C1230-C1247. doi: 10.1152/ajpcell.00099.2022. Epub 2022 May 4. PMID: 35508187. Review.

Yildirim AD, Citir M, Dogan AE, Veli Z, Yildirim Z, Tufanli O, Traynor Kaplan A, Schultz C, Erbay E. ER Stress-Induced Sphingosine-1-Phosphate Lyase Phosphorylation Potentiates the Mitochondrial Unfolded Protein Response. J Lipid Res. 2022 Sep 10:100279. doi: 10.1016/j.jlr.2022.100279. Online ahead of print. PMID: 36100091

Zhong, F., Albert, T., Moënne-Loccoz, P., & Pletneva, E. V. Influence of the interdomain interface on structural and redox properties of multiheme proteins. Inorganic Chemistry, 61(51), 20949-20963. doi:10.1021/acs.inorgchem.2c03427

Ahmad F, Wysocki RW, Fernandez JJ, Cohen MS, Simcock XC. Patient Perspectives on Telemedicine During the COVID-19 Pandemic. Hand (N Y). 2021 Sep 13:15589447211030692. doi: 10.1177/15589447211030692. Epub ahead of print. PMID: 34515550.

Amodei, R., Gribbin, K., He, W., Lindgren, I., Corder, K. R., Jonker, S. S., . . . Roselli, C. E. Role for kisspeptin and neurokinin b in regulation of luteinizing hormone and testosterone secretion in the fetal sheep. Endocrinology (United States), 161(4), 1-14. doi:10.1210/ENDOCR/BQAA013

Arttamangkul, S., Platt, E. J., Carroll, J., & Farrens, D. L. Functional independence of endogenous µ-and δ-opioid receptors co-expressed in cholinergic interneurons. ELife, 10 doi:10.7554/eLife.69740

Q Bartlett A, Vesco KK, Purnell JQ, Francisco M, Goddard E, Guan X, DeBarber A, Leo MC, Baetscher E, Rooney W, Naugler W, Guimaraes AR, Catalano P, Xia Z, Schedin P. Pregnancy and weaning regulate human maternal liver size and function. Proc Natl Acad Sci U S A. 2021 Nov 30;118(48):e2107269118. doi: 10.1073/pnas.2107269118. PMID: 34815335; PMCID: PMC8640831.

Bates, T.A., Weinstein, J.B., Farley, S., Leier, H.C., Messer, W.B., Tafesse, F.G. Cross-reactivity of SARS-CoV structural protein antibodies against SARS-CoV-2. Cell Reports, 2021, 108737, ISSN 2211-1247, https://doi.org/10.1016/j.celrep.2021.108737.

Bullock, C. X., Jamieson, C. S., Moënne-Loccoz, P., Taylor, B., Gonzalez, J. A. M., Draves, E. A., Kuo, L. Y. (2021) Sulfide oxidation by 2,6-bis[hydroxyl(methyl)amino]-4-morpholino-1,3,5-triazinatodioxomolybdenum(VI): mechanistic implications with DFT calculations for a new class of molybdenum(VI) complex, Inorg. Chem. 60,  7762-7772. https://doi.org/10.1021/acs.inorgchem.1c00145

Carbajo, C.G., Cornell , L.J., Madbouly, Y.,  Lai, Z.,  Yates, P.A., Tinti, M., Tiengwe, C. Novel aspects of iron homeostasis in pathogenic bloodstream form Trypanosoma brucei. PLoS Pathog. 17(6), e1009696. (2021), https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009696

Chaudhary, P., Marracci, G. H., Calkins, E., Pocius, E., Bensen, A. L., Scanlan, T. S., . . . Bourdette, D. N. Thyroid hormone and thyromimetics inhibit myelin and axonal degeneration and oligodendrocyte loss in EAE. Journal of Neuroimmunology, 352 doi:10.1016/j.jneuroim.2020.577468

Citir M, Müller R, Hauke S, Traynor-Kaplan A, Schultz C. Monitoring the cellular metabolism of a membrane-permeant photo-caged phosphatidylinositol 3,4,5-trisphosphate derivative. Chem Phys Lipids. 2021 Sep 9;241:105124. doi: 10.1016/j.chemphyslip.2021.105124. Epub ahead of print. PMID: 34509466.

Clyburn C, Sepe JJ, Habecker BA. What gets on the nerves of cardiac patients? Pathophysiological changes in cardiac innervation. J Physiol. 2022 Feb;600(3):451-461. doi: 10.1113/JP281118. Epub 2021 Dec 29. PMID: 34921407; PMCID: PMC8810748.

Cochrane VA, Yang Z, Dell'Acqua ML, Shyng SL. AKAP79/150 coordinates leptin-induced PKA signaling to regulate K_ATP channel trafficking in pancreatic β-cells. J Biol Chem. 2021 Jan-Jun;296:100442. doi: 10.1016/j.jbc.2021.100442. Epub 2021 Feb 19. PMID: 33617875; PMCID: PMC8010710.Dent, A. T., Brimberry, M., Albert, T., Lanzilotta, W. N., Moënne-Loccoz, P., Wilks, A. (2021) Axial heme coordination by the Tyr-His motif in the extracellular hemophore HasAp is critical for the release of heme to the HasR receptor of Pseudomonas aeruginosa, Biochemistry 60, in press. https://doi.org/10.1021/acs.biochem.1c00389

Cohen MS. Catching mono- and poly-ADP-ribose readers with synthetic ADP-ribose baits. Mol Cell. 2021 Nov 4;81(21):4351-4353. doi: 10.1016/j.molcel.2021.10.016. PMID: 34739826.

Cooper CM, Farrand AQ, Andresen MC, Beaumont E. Vagus nerve stimulation activates nucleus of solitary tract neurons via supramedullary pathways. J Physiol. 2021 Dec;599(23):5261-5279. doi: 10.1113/JP282064. Epub 2021 Nov 17. PMID: 34676533.

Cooper S, Wilmarth PA, Cunliffe JM, Klimek J, Pang J, Tassi Yunga S, Minnier J, Reddy A, David L, Aslan JE. Platelet proteome dynamics in hibernating 13-lined ground squirrels. Physiol Genomics. 2021 Nov 1;53(11):473-485. doi: 10.1152/physiolgenomics.00078.2021. Epub 2021 Oct 22. PMID: 34677084; PMCID: PMC8616595.

de Maria, A., Zientek, K. D., David, L. L., Wilmarth, P. A., Bhorade, A. M., Harocopos, G. J., . . . Bassnett, S. Compositional analysis of extracellular aggregates in the eyes of patients with exfoliation syndrome and exfoliation glaucoma. Investigative Ophthalmology and Visual Science, 62(15) doi:10.1167/iovs.62.15.27

Denfeld QE, Faulkner KM, Davis MR, Habecker BA, Chien CV, Gelow JM, Mudd JO, Hiatt SO, Grady KL, Lee CS. Exploring gender differences in trajectories of clinical markers and symptoms after left ventricular assist device implantation. Eur J Cardiovasc Nurs. 2021 Oct 27;20(7):648-656. doi: 10.1093/eurjcn/zvab032. PMID: 34080624; PMCID: PMC8557355.

Dent, A. T., Brimberry, M., Albert, T., Lanzilotta, W. N., Moënne-Loccoz, P., & Wilks, A. Axial heme coordination by the tyr-his motif in the extracellular hemophore HasAp is critical for the release of heme to the HasR receptor of pseudomonas aeruginosa. Biochemistry, 60(33), 2549-2559. doi:10.1021/acs.biochem.1c00389

Dey, A., Gordon, J. B., Albert, T., Sabuncu, S., Siegler, M. A., MacMillan, S. N., Lancaster, K. M., Moënne-Loccoz, P., Goldberg, D. P. (2021) A nonheme mononuclear {FeNO}⁷ complex that produces N₂O in the absence of an exogenous reductant, Angew. Chem. Int. Ed. 60, in press., https://doi.org/10.1002/anie.202109062

Driggers CM, Shyng SL. Production and purification of ATP-sensitive potassium channel particles for cryo-electron microscopy. Methods Enzymol. 2021;653:121-150. doi: 10.1016/bs.mie.2021.02.008. Epub 2021 Mar 22. PMID: 34099169. 

Echalier, C., Rutkowska, A., Kojic, A., Thomson, D. W., Edwards, L. J., McKay, B. S. J., Mülbaier, M., Schultz, C., Bergamini, G. amTCO, a new trans-cyclooctene derivative to study drug-target interactions in cells. Chem.Commun 57, 1814-1817 (2021). DOI: 10.1039/D0CC06709A

Farley, S., Laguerre, A., Schultz, C. Caged lipids for subcellular manipulation. Curr. Op. Chem. Biol. 65, 42-48 (2021), https://doi.org/10.1016/j.cbpa.2021.04.012

Fawley HA, Hegarty DM, Aicher SA, Beaumont E, Andresen MC Dedicated c-fiber vagal sensory afferent pathways to the paraventricular nucleus of the hypothalamus. Brain Research.  https://doi.org/10.1016/j.brainres.2021.147625.

Ferrara, S.J., Chaudhary, P., DeBell, M.J., Marracci, G., Miller, H., Calkins, E., Pocius, E., Napier, B.A., Emery, B., Bourdette, D., Scanlan. T.S. TREM2 is thyroid hormone regulated making the TREM2 pathway druggable with ligands for thyroid hormone receptor, Cell Chemical Biology, 2021, https://doi.org/10.1016/j.chembiol.2021.07.014.

Frey DL, Guerra M, Mall MA, Schultz C. Monitoring Neutrophil Elastase and Cathepsin G Activity in Human Sputum Samples. J Vis Exp. 2021 May 21;(171). doi: 10.3791/62193. PMID: 34096915.

Gordon JB, Albert T, Dey A, Sabuncu S, Siegler MA, Bill E, Moënne-Loccoz P, Goldberg DP. A Reactive, Photogenerated High-Spin (S = 2) Fe^IV(O) Complex via O₂ Activation. J Am Chem Soc. 2021 Dec 29;143(51):21637-21647. doi: 10.1021/jacs.1c10051. Epub 2021 Dec 16. PMID: 34913683.

Grasso M, Bond GJ, Kim YJ, Boyd S, Matson Dzebo M, Valenzuela S, Tsang T, Schibrowsky NA, Alwan KB, Blackburn NJ, Burslem GM, Wittung-Stafshede P, Winkler DD, Marmorstein R, Brady DC. The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation. J Biol Chem. 2021 Dec;297(6):101314. doi: 10.1016/j.jbc.2021.101314. Epub 2021 Oct 27. PMID: 34715128; PMCID: PMC8661025.

Harkness JH, Gonzales AE, Bushana PN, Jorgensen ET, Hegarty DM, DiNardo AA, Prochiantz A, Wisor JP, Aicher SA, Brown TE, Sorg BA (2021) Diurnal changes in perineuronal nets and parvalbumin neurons in the rat medial prefrontal cortex. Brain Struct Funct, 225:1135-1153.

Heskett MB, Spellman PT, Thayer MJ. Differential Allelic Expression among Long Non-Coding RNAs. Noncoding RNA. 2021 Oct 22;7(4):66. doi: 10.3390/ncrna7040066. PMID: 34698262; PMCID: PMC8544735.

Jorgensen, E. T., Gonzalez, A. E., Harkness, J. H., Hegarty, D. M., Thakar, A., Burchi, D. J., Aicher SA, . . . Brown, T. E. Cocaine memory reactivation induces functional adaptations within parvalbumin interneurons in the rat medial prefrontal cortex. Addiction Biology, 26(3) doi:10.1111/adb.12947

Khazaei, H., Khazaei, D., Verma, R., Ng, J., Wilmarth, P. A., David, L. L., & Rosenbaum, J. T.  The potential of tear proteomics for diagnosis and management of orbital inflammatory disorders including graves’ ophthalmopathy. Experimental Eye Research, 213 doi:10.1016/j.exer.2021.108813

Kirby, I. T., Person, A., and Cohen, M. (2021). Rational Design of Selective Inhibitors of PARP4. RSC Med. Chem. 12 (11), 1950–1957. doi:10.1039/d1md00195g

Klünemann M, Andrejev S, Blasche S, Mateus A, Phapale P, Devendran S, Vappiani J, Simon B, Scott TA, Kafkia E, Konstantinidis D, Zirngibl K, Mastrorilli E, Banzhaf M, Mackmull MT, Hövelmann F, Nesme L, Brochado AR, Maier L, Bock T, Periwal V, Kumar M, Kim Y, Tramontano M, Schultz C, Beck M, Hennig J, Zimmermann M, Sévin DC, Cabreiro F, Savitski MM, Bork P, Typas A, Patil KR. Bioaccumulation of therapeutic drugs by human gut bacteria. Nature. 2021 Sep;597(7877):533-538. doi: 10.1038/s41586-021-03891-8. Epub 2021 Sep 8. PMID: 34497420.

Ladyman, S.R. and V.L. Brooks. Central actions of insulin during pregnancy and lactation. J. Neurendocrinology. 33(4):e12946. doi: 10.1111/jne.12946. Epub (2021).

Laguerre, A., Keutler, K., Hauke, S., Schultz, C. Regulation of calcium oscillations in ß-cells by co-activated cannabinoid receptors. Cell Chem. Biol. 28, 88-96 (2021) DOI: 10.1016/j.chembiol.2020.10.006; PMID: 33147441

Lebowitz JJ, Trinkle M, Bunzow JR, Balcita-Pedicino JJ, Hetelekides S, Robinson B, De La Torre S, Aicher SA, Sesack SR, Williams JT. Subcellular localization of D2 receptors in the murine substantia nigra. Brain Struct Funct. 2022 Apr;227(3):925-941. doi: 10.1007/s00429-021-02432-3. Epub 2021 Dec 2. PMID: 34854963; PMCID: PMC8930450.

Levine, S.R, Beatty, K.E.  Investigating b-lactam drug targets in Mycobacterium tuberculosis using chemical probes."  ACS Infect. Dis. 7(2), 461-470 (2021).  

Levine, A., Liktor-Busa, E., Lipinski, A. A., Couture, S., Balasubramanian, S., Aicher, S. A., . . . Largent-Milnes, T. M.  Sex differences in the expression of the endocannabinoid system within V1M cortex and PAG of sprague dawley rats. Biology of Sex Differences, 12(1) doi:10.1186/s13293-021-00402-2

Miller, K. R., Biswas, S., Jasniewski, A., Follmer, A. H., Biswas, A., Albert, T., Sabuncu, S., Bominaar, E. L., Hendrich, M. P., Moënne-Loccoz, P., Borovik, A.S. (2021) Artificial metalloproteins with dinuclear iron-hydroxido centers, J. Am. Chem. Soc. 143, 2384-2393. https://dx.doi.org/10.1021%2Fjacs.0c12564

Mueller, R., Kojic, A., Citir, M., Schultz, C. Synthesis and cellular labeling of multifunctional phosphatidylinositol bis- and trisphosphate derivatives. Angew. Chem. Int. Engl., (2021). Accepted

Olaopa MA, Ai T, Chao B, Xiao X, Vatta M, Habecker BA. Phosphorylation of Lamin A/C at serine 22 modulates Na_v 1.5 function. Physiol Rep. 2021 Nov;9(22):e15121. doi: 10.14814/phy2.15121. PMID: 34806324; PMCID: PMC8606869.

Pitch, S. G., Yao, W., Szundi, I., Fay, J., Chen, E., Shumate, A., . . . Farrens, D. L. Functional integrity of membrane protein rhodopsin solubilized by styrene-maleic acid copolymer. Biophysical Journal, 120(16), 3508-3515. doi:10.1016/j.bpj.2021.05.008 (2021)

Qiu, J., Stincic, T.L., Bosch, M.A., Connors, A.M., Kaech Petrie, S. Rønnekleiv, O.K., Kelly, M.J. Deletion of Stim1 in hypothalamic arcuate nucleus Kiss1 neurons potentiates synchronous GCaMP activity and protects against diet-induced obesity. Journal of Neuroscience 15 October 2021, JN-RM-0622-21; DOI: 10.1523/JNEUROSCI.0622-21.2021

Qu, K., Ke, Z., Zila, V., Anders-Össwein, M., Glass, B., Mücksch, F., Müller, R., Schultz, C., Müller, B., Kräusslich, H.G., Briggs, J.A.G. Maturation of the matrix and viral membrane of HIV-1. Science 373, 700-704 (2021). DOI: 10.1126/science.abe6821

Reinkemeier, C. D., Koehler, C., Sauter, P. F., Shymanska, N. V., Echalier, C., Rutkowska, A., Will, D. W., Schultz, C., Lemke, E. A. Synthesis and evaluation of novel ring-strained non-canonical amino acids for residue-specific bioorthogonal reactions in living cells. Chem. Eur. J. 27, 6094-6099 (2021).

Rickert-Zacharias, V., Schultz, M., Mall, M. A., & Schultz, C. Visualization of ectopic serine protease activity by förster resonance energy transfer-based reporters. ACS Chemical Biology, 16(11), 2174-2184. doi:10.1021/acschembio.1c00168

Rodriguez KM, Buch-Larsen SC, Kirby IT, Siordia I, Hutin D, Rasmussen M, Grant DM, David LL, Matthews J, Lund Nielsen M. Cohen MS. Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets. eLife 2021;10:e60480.

Rønnekleiv, O.K. and  Kelly, M.J. Estradiol protects hypothalamic neurons against insulin resistance. In: George Fink, editor, Stress: Genetics, Epigenetics and Genomics,  Handbook of Stress, Vol. 4, Chapter 14: Estradiol protects Hypothalamic Neurons against Insulin Resistance, pp. 159-164. Elsevier 2021, (February).

Saint-Martin C, Cauchois-Le Mière M, Rex E, Soukarieh O, Arnoux JB, Buratti J, Bouvet D, Frébourg T, Gaildrat P, Shyng SL, Bellanné-Chantelot C, Martins A. Functional characterization of ABCC8 variants of unknown significance based on bioinformatics predictions, splicing assays, and protein analyses: Benefits for the accurate diagnosis of congenital hyperinsulinism. Hum Mutat. 2021 Apr;42(4):408-420. doi: 10.1002/humu.24164. Epub 2021 Jan 28. PMID: 33410562; PMCID: PMC8049974.

Sarott, R.C., Viray, A.E.G., Pfaff, P., Sadybekov, A., Rajic, G., Katrich, V., Carreira, E.M., Frank, J.A. Optical Control of Cannabinoid Receptor 2-Mediated Ca²⁺ Release Enabled By Synthesis of Photoswitchable Probes. J. Am. Chem. Soc. 143, 746-743 (2021), http://doi.org/10.1021/jacs.0c08926

Savage, J. C., Shinde, P., Yao, Y., Davare, M. A., & Shinde, U. A broccoli aptamer chimera yields a fluorescent K+sensor spanning physiological concentrations. Chemical Communications, 57(11), 1344-1347. doi:10.1039/d0cc07042d

Shi, Z., A.C. Bonillas, J. Wong, S.L. Padilla, and V.L. Brooks. Neuropeptide Y suppresses thermogenic and cardiovascular sympathetic nerve activity via Y1 receptors in the paraventricular nucleus and dorsomedial hypothalamus. J. Neurendocrinology Jun 21:e13006. doi: 10.1111/jne.13006. (published online ahead of print) (2021).

Sileikyte, J., Sundalam, S., David, L.L., Cohen, M.S. Chemical Proteomics Approach for Profiling the NAD Interactome. J. Am. Chem. Soc. 2021.
DOI: 10.1021/jacs.1c01302

Stincic, T.L., Bosch, M.A., Hunker, A.C., Juarez, B., Connors, A.M., Zweifel, L.S., Rønnekleiv, O.K. and Kelly, M.J. CRISPR Knockdown of Kcnq3 Attneuates the M-current in NPY/AgRP Neurons. Mol. Metab. Epub 2021, March 22; PMCID: PMC8093934.

Stincic, T. L., Rønnekleiv, O. K., & Kelly, M. J. Membrane and nuclear initiated estrogenic regulation of homeostasis. Steroids, 168 doi:10.1016/j.steroids.2019.108428

Stincic, T.L., Qiu, J., Connors, A.M.; Kelly, M.J., and Rønnekleiv, O.K.  Arcuate and Preoptic kisspeptin neurons exhibit differential projections to hypothalamic nuclei and exert opposite postsynaptic effect on hypothalamic paraventricular and dorsomedial nuclei in the female mouse. eNeuro, 2021; doi 10.1523/ENEURO.0093-21.2021. Online ahead of print. PMC in progress.

Sung MW, Yang Z, Driggers CM, Patton BL, Mostofian B, Russo JD, Zuckerman DM, Shyng SL. Vascular K_ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides. Proc Natl Acad Sci U S A. 2021 Nov 2;118(44):e2109441118. doi: 10.1073/pnas.2109441118. PMID: 34711681.

Szundi, I., Pitch, S. G., Chen, E., Farrens, D. L., & Kliger, D. S.  Styrene-maleic acid copolymer effects on the function of the GPCR rhodopsin in lipid nanoparticles. Biophysical Journal, 120(20), 4337-4348. doi:10.1016/j.bpj.2021.09.012

Tian, S., Fan, R., Albert, T., Khade, R. L., Dai, H., Harnden, K. A., Hosseinzadeh, P., Liu, J., Nilges, M. J., Zhang, Y., Moënne-Loccoz, P., Guo, Y., Lu, Y. (2021) Stepwise nitrosylation of the nonheme iron site in an engineered azurin and a molecular basis for nitric oxide signaling mediated by nonheme iron proteins, Chem. Sci. 12, 6569-6579. https://dx.doi.org/10.1039%2Fd1sc00364j

Tibbitts DC, Aicher SA, Sugg J, Handloser K, Booth LD, Bradley RD (2021) Program evaluation of trauma-informed yoga for vulnerable populations. Eval Program Plann, 88: 101946.

Tobias, J., Rajic, G., Viray, A.E.G., Icka-Araki, D., Frank, J. Genetically-targeted photorelease of endocannabinoids enables optical control of GPR55 in pancreatic β-cells. Chem. Sci. 2021, Accepted Manuscript.

Walcheck MT, Matkowskyj KA, Turco A, Blaine-Sauer S, Nukaya M, Noel J, Ronnekleiv OK, Ronnekleiv-Kelly SM. Sex-dependent development of Kras-induced anal squamous cell carcinoma in mice. PLoS One. 2021 Nov 4;16(11):e0259245. doi: 10.1371/journal.pone.0259245. PMID: 34735515; PMCID: PMC8568287.

Woo MS, Ufer F, Rothammer N, Di Liberto G, Binkle L, Haferkamp U, Sonner JK, Engler JB, Hornig S, Bauer S, Wagner I, Egervari K, Raber J, Duvoisin RM, Pless O, Merkler D, Friese MA. Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation. J Exp Med. 218:e20201290 (2021). doi: 10.1084/jem.20201290. PMID: 33661276; PMCID: PMC7938362.

Amodei R, Gribbin K, He W, Lindgren I, Corder KR, Jonker SS, Estill CT, Coolen LM, Lehman MN, Whitler W, Stormshak F, Roselli CE. Role for Kisspeptin and Neurokinin B in Regulation of Luteinizing Hormone and Testosterone Secretion in the Fetal Sheep. Endocrinology. 2020 Feb 1.

Balamurugan K, Kavitha B, Yang Z, Mohan V, Radha V, Shyng SL. Functional characterization of activating mutations in the sulfonylurea receptor 1 (ABCC8) causing neonatal diabetes mellitus in Asian Indian children. Pediatr Diabetes. 2019 Jun;20(4):397-407. 

Basappa J, Citir M, Zhang Q, Wang HY, Liu X, Melnikov O, Yahya H, Stein F, Muller R, Traynor-Kaplan A, Schultz C, Wasik MA, Ptasznik A. ACLY is the novel signaling target of PIP₂/PIP₃ and Lyn in acute myeloid leukemia. Heliyon. 2020;6(5):e03910. Published 2020 May 7.

Beatty, K. E. Fluorescent probes for investigating peptidoglycan biosynthesis in mycobacteria. Current Opinion in Chemical Biology, 57, 50-57. doi:10.1016/j.cbpa.2020.04.006

Bittner T, Wittwer C, Hauke S, Wohlwend D, Mundinger S, Dutta AK, Bezold D, Dürr T, Friedrich T, Schultz C, Jessen HJ. Photolysis of Caged Inositol Pyrophosphate InsP₈ Directly Modulates Intracellular Ca²⁺ Oscillations and Controls C2AB Domain Localization. J Am Chem Soc. 2020;142(24):10606-10611.

Boodhansingh KE, Kandasamy B, Mitteer L, Givler S, De Leon DD, Shyng SL, Ganguly A, Stanley CA. Novel dominant KATP channel mutations in infants with congenital hyperinsulinism: Validation by in vitro expression studies and in vivo carrier phenotyping. Am J Med Genet A. 2019 Nov;179(11):2214-2227.

Brooks VL, Fu Q, Shi Z, Heesch CM. Adaptations in autonomic nervous system regulation in normal and hypertensive pregnancy. Handb Clin Neurol. 2020;171:57-84.

Brooks, V.L., Q. Fu, Z. Shi, and C.M. Heesch. Adaptations in autonomic nervous system regulation in normal and hypertensive pregnancy. In: Steegers, E.A.P., Cipolla, M.J., Miller, E.C. (Eds.), Neurology and Pregnancy: Pathophysiology and Patient Care. Handbook of Clinical Neurology, Vol. 171, pp. 57-86 (2020).

Cochrane VA, Wu Y, Yang Z, ElSheikh A, Dunford J, Kievit P, Fortin DA, Shyng SL. Leptin modulates pancreatic β-cell membrane potential through Src kinase-mediated phosphorylation of NMDA receptors. J Biol Chem. 2020 Oct 9:jbc.RA120.015489.

Doh, J. K., Tobin, S. J., & Beatty, K. E.. MiniVIPER is a peptide tag for imaging and translocating proteins in cells. Biochemistry, 59(33), 3051-3059. doi:10.1021/acs.biochem.0c00526

Dziuba D, Hoffmann JE, Hentze MW, Schultz C. A Genetically Encoded Diazirine Analogue for RNA-Protein Photo-crosslinking. Chembiochem. 2020;21(1-2):88-93.

Frank, J. A., Antonini, M. -., Chiang, P. -., Canales, A., Konrad, D. B., Garwood, I. C., . . . Anikeeva, P. In vivo photopharmacology enabled by multifunctional fibers. ACS Chemical Neuroscience, 11(22), 3802-3813. doi:10.1021/acschemneuro.0c00577

Fernandez, T. J., De Maria, M., & Lobingier, B. T.  A cellular perspective of bias at G protein-coupled receptors. Protein Science, 29(6), 1345-1354. doi:10.1002/pro.3872

Ferrara, S. J., & Scanlan, T. S. A CNS-targeting prodrug strategy for nuclear receptor modulators. Journal of Medicinal Chemistry, 63(17), 9742-9751. doi:10.1021/acs.jmedchem.0c00868

Gachkar, S., Oelkrug, R., Herrmann, B., Scanlan, T. S., Sun, Q., Biebermann, H., . . . Mittag, J. N- and O-acetylated 3-iodothyronamines have no metabolic or thermogenic effects in male mice. European Thyroid Journal, 9(2), 57-66. doi:10.1159/000504887

Guerra, M., Halls, V., Schatterny, J., Hagner, M., Mall, M. A., Schultz C. Protease FRET reporters targeting neutrophil extracellular traps. J. Am. Chem. Soc. 142, 20299-20305 (2020). DOI: 10.1021/jacs.0c08130

Guyenet, P.G, R.L. Stornetta, G.M.P.R Souza, S.B.G. Abbott, and V.L. Brooks. Neuronal networks in hypertension:  Recent Advances. Hypertension. 76: 300-311 (2020).

Guyenet PG, Stornetta RL, Souza GMPR, Abbott SBG, Brooks VL. Neuronal Networks in Hypertension: Recent Advances. Hypertension. 2020;76(2):300-311.

Hagner M, Frey DL, Guerra M, Dittrich AS, Halls VS, Wege S, Herth FJF, Schultz C, Mall MA. New method for rapid and dynamic quantification of elastase activity on sputum neutrophils from patients with cystic fibrosis using flow cytometry. Eur Respir J. 2020;55(4):1902355. Published 2020 Apr 30.

Hamid SM, Citir M, Terzi EM, Cimen I, Yildirim Z, Dogan AE, Kocaturk B, Onat UI, Arditi M, Weber C, Traynor-Kaplan A, Schultz C, Erbay E. Inositol-requiring enzyme-1 regulates phosphoinositide signaling lipids and macrophage growth. EMBO Rep. 2020 Nov 2;21(12):e51462.

Hartley MD, Shokat MD, DeBell MJ, Banerji T, Kirkemo LL, Scanlan TS. Pharmacological Complementation Remedies an Inborn Error of Lipid Metabolism. Cell Chem Biol. 2020;27(5):551-559.e4.

Heskett MB, Smith LG, Spellman P, Thayer MJ. Reciprocal monoallelic expression of ASAR lncRNA genes controls replication timing of human chromosome 6. RNA. 2020;26(6):724-738.

Hobbs SJ, Harbour JC, Yates PA, Ortiz D, Landfear SM, Nolz JC. Vaccinia Virus Vectors Targeting Peptides for MHC Class II Presentation to CD4⁺ T Cells. Immunohorizons. 2020;4(1):1-13. Published 2020 Jan 2.

Hong X, Daiker J, Sadilek M, DeBarber AE, Chiang J, Duan J, Bootsma AH, Huidekoper HH, Vaz FM, Gelb MH. Toward newborn screening of cerebrotendinous xanthomatosis: results of a biomarker research study using 32,000 newborn dried blood spots [published online ahead of print, 2020 Jun 10]. Genet Med.

Huey J, Keutler K, Schultz C. Chemical Biology Toolbox for Studying Pancreatic Islet Function - A Perspective. Cell Chem Biol. 2020;27(8):1015-1031

Jacobson DA, Shyng SL. Ion Channels of the Islets in Type 2 Diabetes. J Mol Biol. 2020;432(5):1326-1346.

J.K. Doh, S.J. Tobin, K.E. Beatty.  “MiniVIPER is a peptide tag for imaging and translocating proteins in cells."  Biochemistry 59(33), 3051-3059 (2020).

Jorgensen ET, Gonzalez AE, Harkness JH, Hegarty DM, Thakar A, Burchi DJ, Aadland JA, Aicher SA, Sorg BA, Brown TE. Cocaine memory reactivation induces functional adaptations within parvalbumin interneurons in the rat medial prefrontal cortex [published online ahead of print, 2020 Aug 4]. Addict Biol. 2020;e12947.

K.E. Beatty.  “Fluorescent probes for investigating peptidoglycan biosynthesis in mycobacteria.”  Current Opinion in Chemical Biology, 57, 50-57 (2020).

Laguerre A, Keutler K, Hauke S, Schultz C. Regulation of Calcium Oscillations in β-Cells by Co-activated Cannabinoid Receptors. Cell Chem Biol. 2020 Nov 2:S2451-9456(20)30422-0.

Licon MH, Yates PA. Purine-responsive expression of the Leishmania donovani NT3 purine nucleobase transporter is mediated by a conserved RNA stem-loop. J Biol Chem. 2020;295(25):8449-8459.

Martin GM, Sung MW, Shyng SL. Pharmacological chaperones of ATP-sensitive potassium channels: Mechanistic insight from cryoEM structures. Mol Cell Endocrinol. 2020;502:110667.

Martín-Acosta P, Xiao X. PROTACs to address the challenges facing small molecule inhibitors. Eur J Med Chem. 2020 Nov 5:112993

Morstein J, Dacheux MA, Norman DD, Shemet A, Donthamsetti PC, Citir M, Frank JA, Schultz C, Isacoff EY, Parrill AL, Tigyi GJ, Trauner D. Optical Control of Lysophosphatidic Acid Signaling. J Am Chem Soc. 2020;142(24):10612-10616.

Müller R, Citir M, Hauke S, Schultz C. Synthesis and Cellular Labeling of Caged Phosphatidylinositol Derivatives. Chemistry. 2020 Jan 7;26(2):384-389.

Qiu J, Bosch MA, Zhang C, Rønnekleiv OK, Kelly MJ. Estradiol Protects Neuropeptide Y/Agouti-Related Peptide Neurons against Insulin Resistance in Females. Neuroendocrinology. 2020;110(1-2):105-118.

Roselli, C. E.  Programmed for preference: The biology of same-sex attraction in rams. Neuroscience and Biobehavioral Reviews, 114, 12-15. doi:10.1016/j.neubiorev.2020.03.032

Savage JC , Davare MA , Shinde U . Subtle sequence variations alter tripartite complex kinetics and G-quadruplex dynamics in RNA aptamer Broccoli. Chem Commun (Camb). 2020 Feb 28;56(17):2634-2637.

Schafer, C. T., Shumate, A., & Farrens, D. L. Novel fluorescent GPCR biosensor detects retinal equilibrium binding to opsin and active G protein and arrestin signaling conformations. Journal of Biological Chemistry, 295(51), 17486-17496. doi:10.1074/jbc.RA120.014631

Shi Z, Pelletier NE, Wong J, Li B, Sdrulla AD, Madden CJ, Marks DL, Brooks VL. Leptin increases sympathetic nerve activity via induction of its own receptor in the paraventricular nucleus. Elife. 2020 Jun 15;9:e55357.

Shi Z, Wong J, Brooks VL. Obesity: sex and sympathetics. Biol Sex Differ. 2020;11(1):10. Published 2020 Mar 11.

Shi Z, Zhao D, Cassaglia PA, Brooks VL. Sites and sources of sympathoexcitation in obese male rats: role of brain insulin. Am J Physiol Regul Integr Comp Physiol. 2020 Jan 22.

Somwar, R., Hofmann, N. E., Smith, B., Odintsov, I., Vojnic, M., Linkov, I., Shinde U., Davare, M. A. NTRK kinase domain mutations in cancer variably impact sensitivity to type I and type II inhibitors. Communications Biology, 3(1) doi:10.1038/s42003-020-01508-w

Spannl, S., Buhl, T., Nellas, I., Zeidan, S. A., Venkatesan Iyer, K., Khaliullina, H., Schultz, C., Nadler, A., Dye, N. A., Eaton, S. Glycolysis regulates Hedgehog signalling via the plasma membrane potential. EMBO J. 39, e101767 (2020)

Tapa S, Wang L, Francis Stuart SD, Wang Z, Jiang Y, Habecker BA, Ripplinger CM. Adrenergic supersensitivity and impaired neural control of cardiac electrophysiology following regional cardiac sympathetic nerve loss. Sci Rep. 2020 Nov 2;10(1):18801.

Thomas C, Aller SG, Beis K, Carpenter EP, Chang G, Chen L, Dassa E, Dean M, Duong Van Hoa F, Ekiert D, Ford R, Gaudet R, Gong X, Holland IB, Huang Y, Kahne DK, Kato H, Koronakis V, Koth CM, Lee Y, Lewinson O, Lill R, Martinoia E, Murakami S, Pinkett HW, Poolman B, Rosenbaum D, Sarkadi B, Schmitt L, Schneider E, Shi Y, Shyng SL, Slotboom DJ, Tajkhorshid E, Tieleman DP, Ueda K, Váradi A, Wen PC, Yan N, Zhang P, Zheng H, Zimmer J, Tampé R. Structural and functional diversity calls for a new classification of ABC transporters. FEBS Lett. 2020 Dec;594(23):3767-3775. doi: 10.1002/1873-3468.13935. Epub 2020 Oct 26. PMID: 32978974.

Varin J, Reynolds MM, Bouzidi N, Tick S, Wohlschlegel J, Becquart O, Michiels C, Dereure O, Duvoisin RM, Morgans CW, Sahel JA, Samaran Q, Guillot B, Pulido JS, Audo I, Zeitz C. Identification and characterization of novel TRPM1 autoantibodies from serum of patients with melanoma-associated retinopathy [published correction appears in PLoS One. 2020 May 13;15(5):e0233424]. PLoS One. 2020;15(4):e0231750. Published 2020 Apr 23.

Webster, C. M., Tworig, J., Caval-Holme, F., Morgans, C. W., & Feller, M. B. The impact of steroid activation of TRPM3 on spontaneous activity in the developing retina. ENeuro, 7(2) doi:10.1523/ENEURO.0175-19.2020

Wakeham, C. M., Ren, G., & Morgans, C. W. Expression and distribution of trophoblast glycoprotein in the mouse retina. Journal of Comparative Neurology, 528(10), 1660-1671. doi:10.1002/cne.24850

Wang H, Loerke D, Bruns C, Müller R, Koch PA, Puchkov D, Schultz C, Haucke V. Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway. J Biol Chem. 2020 Jan 24;295(4):1091-1104.

Wang L, Olivas A, Francis Stuart SD, Tapa S, Blake MR, Woodward WR, Habecker BA, Ripplinger CM. Cardiac sympathetic nerve transdifferentiation reduces action potential heterogeneity after myocardial infarction. Am J Physiol Heart Circ Physiol. 2020 Mar 1;318(3):H558-H565.

Wang W, Cho H, Kim D, Park Y, Moon JH, Lim SJ, Yoon SM, McCane M, Aicher SA, Kim S, Emery B, Lee JW, Lee S, Park Y, Lee SK (2020) PCR2 Acts as a critical timer that drives oligodendrocyte fate over astrocyte identity by repressing the notch pathway.  Cell Reports, Sep 15; 32(11):108147. doi:10.1016/j.celrep.2020.108147. PMC8070886

Yang P, Lockard R, Titus H, Hiblar J, Weller K, Wafai D, Weleber RG, Duvoisin RM, Morgans CW, Pennesi ME. Suppression of cGMP-Dependent Photoreceptor Cytotoxicity With Mycophenolate Is Neuroprotective in Murine Models of Retinitis Pigmentosa. Invest Ophthalmol Vis Sci. 61:25 (2020). doi: 10.1167/iovs.61.10.25. PMID: 32785677; PMCID: PMC7441375.

Alwan KB, Welch EF, Blackburn NJ. Catalytic M Center of Copper Monooxygenases Probed by Rational Design. Effects of Selenomethionine and Histidine Substitution on Structure and Reactivity. Biochemistry. 2019 Nov 5; 58(44):4436-4446.

Alwan KB, Welch EF, Arias RJ, Gambill BF, Blackburn NJ. Rational Design of a Histidine-Methionine Site Modeling the M-Center of Copper Monooxygenases in a Small Metallochaperone Scaffold. Biochemistry. 2019 Jul 16;58(28):3097-3108.

Barahman M, Zhang W, Harris HY, Aiyer A, Kabarriti R, Kinkhabwala M, Roy-Chowdhury N, Beck AP, Scanlan TS, Roy-Chowdhury J, Asp P, Guha C. Radiation-primed hepatocyte transplantation in murine monogeneic dyslipidemia normalizes cholesterol and prevents atherosclerosis. J Hepatol. 2019 Jun;70(6):1170-1179.

Baser A, Skabkin M, Kleber S, Dang Y, Gülcüler Balta GS, Kalamakis G, Göpferich M, Ibañez DC, Schefzik R, Lopez AS, Bobadilla EL, Schultz C, Fischer B, Martin-Villalba A. Onset of differentiation is post-transcriptionally controlled in adult neural stem cells. Nature. 2019 Feb;566(7742):100-104.

Chattergoon NN, Louey S, Scanlan T, Lindgren I, Giraud GD, Thornburg KL. Thyroid hormone receptor function in maturing ovine cardiomyocytes. J Physiol. 2019 Apr;597(8):2163-2176.

Cochrane V, Shyng SL. Leptin-induced Trafficking of KATP Channels: A Mechanism to Regulate Pancreatic β-cell Excitability and Insulin Secretion. Int J Mol Sci. 2019 May 30;20(11):2660.

Duvoisin RM, Ren G, Haley TL, Taylor MH, Morgans CW. TRPM1 Autoantibodies in Melanoma Patients Without Self-Reported Visual Symptoms. Invest Ophthalmol Vis Sci. 2019;60(6):2330-2335.

Ermakova YG, Mishina NM, Schultz C, Belousov VV. Visualization of Intracellular Hydrogen Peroxide with the Genetically Encoded Fluorescent Probe HyPer in NIH-3T3 Cells. Methods Mol Biol. 2019;1982:259-274.

Hartley MD, Banerji T, Tagge IJ, Kirkemo LL, Chaudhary P, Calkins E, Galipeau D, Shokat MD, DeBell MJ, Van Leuven S, Miller H, Marracci G, Pocius E, Banerji T, Ferrara SJ, Meinig JM, Emery B, Bourdette D, Scanlan TS. Myelin repair stimulated by CNS-selective thyroid hormone action. JCI Insight. 2019 Apr 18;4(8):e126329.

Guerra M, Frey D, Hagner M, Dittrich S, Paulsen M, Mall MA, Schultz C. Cathepsin G Activity as a New Marker for Detecting Airway Inflammation by Microscopy and Flow Cytometry. ACS Cent Sci. 2019;5(3):539-548.

Hauke S, Dutta AK, Eisenbeis VB, Bezold D, Bittner T, Wittwer C, Thakor D, Pavlovic I, Schultz C, Jessen HJ. Photolysis of cell-permeant caged inositol pyrophosphates controls oscillations of cytosolic calcium in a β-cell line. Chem Sci. 2019;10(9):2687-2692. Published 2019 Jan 10.

Jiang M, Yan Y, Yang K, Liu Z, Qi J, Zhou H, Qian N, Zhou Q, Wang T, Xu X, Xiao X, Deng L. Small molecule nAS-E targeting cAMP response element binding protein (CREB) and CREB-binding protein interaction inhibits breast cancer bone metastasis. J Cell Mol Med. 2019 Feb;23(2):1224-1234. 

Laguerre A, Hauke S, Qiu J, Kelly MJ, Schultz C. Photorelease of 2-Arachidonoylglycerol in Live Cells. J Am Chem Soc. 2019;141(42):16544-16547

Margaroli C, Garratt LW, Horati H, Dittrich AS, Rosenow T, Montgomery ST, Frey DL, Brown MR, Schultz C, Guglani L, Kicic A, Peng L, Scholte BJ, Mall MA, Janssens HM, Stick SM, Tirouvanziam R. Elastase Exocytosis by Airway Neutrophils Is Associated with Early Lung Damage in Children with Cystic Fibrosis. Am J Respir Crit Care Med. 2019 Apr 1;199(7):873-881.

Martin GM, Sung MW, Yang Z, Innes LM, Kandasamy B, David LL, Yoshioka C, Shyng SL. Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM. Elife. 2019 Jul 25;8:e46417.

McDonald SK, Levitz TS, Valiyaveetil FI. A Shared Mechanism for the Folding of Voltage-Gated K⁺ Channels. Biochemistry. 2019;58(12):1660-1671

Meinig JM, Ferrara SJ, Banerji T, Banerji T, Sanford-Crane HS, Bourdette D, Scanlan TS. Structure-Activity Relationships of Central Nervous System Penetration by Fatty Acid Amide Hydrolase (FAAH)-Targeted Thyromimetic Prodrugs. ACS Med Chem Lett. 2018 Dec 4;10(1):111-116.

Mücksch F, Citir M, Lüchtenborg C, Glass B, Traynor-Kaplan A, Schultz C, Brügger B, Kräusslich HG. Quantification of phosphoinositides reveals strong enrichment of PIP₂ in HIV-1 compared to producer cell membranes. Sci Rep. 2019;9(1):17661. Published 2019 Nov 27.

Munnur D, Bartlett E, Mikolčević P, Kirby IT, Matthias Rack JG, Mikoč A, Cohen MS, Ahel I. Reversible ADP-ribosylation of RNA. Nucleic Acids Res. 2019 Jun 20;47(11):5658-5669. 

Riederer EA, Valiyaveetil FI. Investigation of the allosteric coupling mechanism in a glutamate transporter homolog via unnatural amino acid mutagenesis. Proc Natl Acad Sci U S A. 2019;116(32):15939-15946.

Rønnekleiv OK, Qiu J, Kelly MJ. Arcuate Kisspeptin Neurons Coordinate Reproductive Activities with Metabolism. Semin Reprod Med. 2019 May;37(3):131-140.

Savage JC, Shinde P, Bächinger HP, Davare MA, Shinde U. A ribose modification of Spinach aptamer accelerates lead(ii) cation association in vitro. Chem Commun (Camb). 2019 May 25;55(42):5882-5885.

Sharon F. Freedman, Charlotte Brennand, John Chiang, Andrea DeBarber, Monte A. Del Monte, P. Barton Duell, John Fiorito, Randall Marshall. Prevalence of Cerebrotendinous Xanthomatosis Among Patients Diagnosed With Acquired Juvenile-Onset Idiopathic Bilateral Cataracts. JAMA Ophthalmol. 2019 Sep 19;137(11):1312-1316.

Shi Z, Cassaglia PA, Pelletier NE, Brooks VL. Sex differences in the sympathoexcitatory response to insulin in obese rats: role of neuropeptide Y. J Physiol. 2019;597(6):1757-1775.

Shi Z, Hansen KM, Bullock KM, Morofuji Y, Banks WA, Brooks VL. Resistance to the sympathoexcitatory effects of insulin and leptin in late pregnant rats. J Physiol. 2019;597(15):4087-4100

Šileikytė J, Devereaux J, de Jong J, Schiavone M, Jones K, Nilsen A, Bernardi P, Forte M, Cohen MS. Second-Generation Inhibitors of the Mitochondrial Permeability Transition Pore with Improved Plasma Stability. ChemMedChem. 2019 Sep 6.

Smith TJ, Scanlan TS, Fernando R. Response to Letter to the Editor: "Elevated Serum Tetrac in Graves Disease: Potential Pathogenic Role in Thyroid-Associated Ophthalmopathy". J Clin Endocrinol Metab. 2019 Apr 1;104(4):1077-1078. 

Stincic TL, Rønnekleiv OK, Kelly MJ. Membrane and nuclear initiated estrogenic regulation of homeostasis. Steroids. 2019 Jun 20:108428.

Bayles R.G., Olivas A., Denfeld Q., Woodward W.R., Fei S.S., Gao L., Habecker B.A. (2018) Transcriptomic and neurochemical analysis of the stellate ganglia in mice highlights sex differences. Scientific Reports, 8(1):8963. d

Carter-O’Connell, I.O., Vermehren-Schmaedick, A, Jin, H, Haihong Jin, Morgan, R.K., David, L.L., Cohen, M.S Combining Chemical Genetics with Proximity-Dependent Labeling Reveals Cellular Targets of Poly(ADP-ribose) Polymerase 14 (PARP14)., ACS Chemical Biology, Article ASAP (2018).

Chacón KN, Perkins J, Mathe Z, Alwan K, Ho EN, Ucisik MN, Merz KM, BlackburnNJ. Trapping intermediates in metal transfer reactions of the CusCBAF export pump of Escherichia coli. Commun Biol. 2018 Nov 14

Cohen, M.S., Stewart, M.L., Goodman, R.H., Cambronne, X.A. “Methods for using a genetically encoded fluorescent biosensor to monitor nuclear NAD,” Methods in Molecular Biology, 1813, 391 (2018).  Kirby, I.T., Morgan, R.K., and Cohen, M.S. “A simple, sensitive, and generalizable plate assay for screening PARP inhibitors,” Methods in Molecular Biology, 1813, 245 (2018).  

DeBarber AE, Kalfon L, Fedida A, Fleisher Sheffer V, Ben Haroush S, Chasnyk N, Shuster Biton E, Mandel H, Jeffries K, Shinwell ES, Falik-Zaccai TC. Newborn screening for cerebrotendinous xanthomatosis is the solution for early identification and treatment. J Lipid Res. 2018 Nov;59(11):2214-2222.

Denfeld, Q.E., Habecker B.A., and Woodward, W.R. (2018) Measurement of Plasma Norepinephrine and 3,4-Dihydroxyphenylglycol: Method Development for a Translational Research Study. BMC Research Notes, 11(1):248. 

Devereaux J, Ferrara SJ, Scanlan TS. Quantification of Thyromimetic Sobetirome Concentration in Biological Tissue Samples. Methods Mol Biol. 2018;1801:193-206. 

Francis Stuart SD, Wang L, Woodard WR, Ng GA, Habecker BA, Ripplinger CM. Age-related changes in cardiac electrophysiology and calcium handling in response to sympathetic nerve stimulation. J Physiol. 2018 Jun 25. doi: 10.1113/JP276396. [Epub ahead of print] PubMed PMID: 29938794.Veruki ML, Zhou Y, Castilho Á, Morgans CW, Hartveit E. Extrasynaptic NMDA receptors on rod pathway amacrine cells: molecular composition, activation, and signaling. J Neurosci. 2018 Nov 20. pii: 2267-18. 

Frank, J., Broichhagen, J., Yushchenko, D., Trauner, D.,  Schultz, C., Hodson, D. Optical tools for understanding the complexity of beta cell signaling and insulin release. Nat. Rev. Endocrinol. (2018) accepted

Gehrig S, Duerr J, Weitnauer M, Wagner CJ, Graeber SY, Schatterny J, Hirtz S, Belaaouaj A, Dalpke AH, Schultz C, Mall MA. Lack of neutrophil elastase reduces inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in mice with cystic fibrosis-like lung disease. Am J Respir Crit Care Med. 2014 May 1;189(9):1082-92. 

Hauke, S., Keutler, K., Yushchenko, D., Schultz, C. Endogenous Fatty Acids are Essential Autocrine Signaling Factors of Pancreatic β-Cells and Insulin Secretion. Diabetes 67, (2018). 

Heck AL, Crestani CC, Fernández-Guasti A, Larco DO, Mayerhofer A, Roselli CE. Neuropeptide and steroid hormone mediators of neuroendocrine regulation. J Neuroendocrinol. 2018 Apr 12:e12599. 

Hegarty DM, Hermes SM, Morgan MM, Aicher SA (2018) Acute hyperalgesia and delayed dry eye after corneal abrasion injury. Pain Reports June 20, 2018 

Hoffmann, J.-E., Dziuba, D., Stein, F., Schultz, C. A bifunctional noncanonical amino acid: synthesis, expression and residue-specific proteome-wide incorporation. Biochemistry (2018). In press

Infield DT, Matulef K, Galpin JD, Lam K, Tajkhorshid E, Ahern CA, Valiyaveetil FI. Main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor. Nat Commun. 2018 Nov 29;9(1):5055. 

Jiang M, Yan Y, Yang K, Liu Z, Qi J, Zhou H, Qian N, Zhou Q, Wang T, Xu X, Xiao X, Deng L. Small molecule nAS-E targeting cAMP response element binding protein (CREB) and CREB-binding protein interaction inhibits breast cancer bone metastasis. J Cell Mol Med. 2018 Nov 20. 

Kath, C., Mueller, R., Schultz, C., Haucke, V., Eickholt, B., Schmoranzer, J. PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules. PLoS One 13, e0193257 (2018). 

Kelly MJ, Qiu J, Rønnekleiv OK.TRPCing around the hypothalamus. Front Neuroendocrinol. 2018 May 31. pii: S0091-3022(18)30042-6. 

Kirby, I.T. and Cohen, M.S. "Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapeutics." Current Topics in Microbiology and Immunology, (2018). Cohen, M.S. and Chang, P. “Insights into the biogenesis, function, and regulation of ADP-ribosylation,” Nature Chemical Biology, 14, 236 (2018). 

Kirby, I. T., Kojic, A., Arnold, M. R., Thorsell, A.-G., Karlberg, T., Vermehren-Schmaedick, A., Sreenivasan, R., Schultz, C., Schüler, H., Cohen M. S.  A potent and selective PARP11 inhibitor suggests coupling between cellular localization and catalytic activity. Cell Chem. Biol. (2018). accepted

Komegae EN, Farmer DGS, Brooks VL, McKinley MJ, McAllen RM, Martelli D. Vagal afferent activation suppresses systemic inflammation via the splanchnic anti-inflammatory pathway. Brain Behav Immun. 2018 Oct;73:441-449. 

Laguerre A, Schultz C. Novel lipid tools and probes for biological investigations. Curr Opin Cell Biol. 2018 Aug;53:97-104. 

Li, B. X.;* Chen, J.;Chao, B.;Zheng, Y.;Xiao, X.* "A Lamin-Binding Ligand Inhibits Homologous Recombination Repair of DNA Double-Strand Breaks" ACS Cent. Sci. 2018.

Matulef K, Valiyaveetil FI. Patch-Clamp Recordings of the KcsA K(+) Channel in Unilamellar Blisters. Methods Mol Biol. 2018;1684:181-191. 

Meng, Q.;Li, B. X.; Xiao, X. "Towards Developing Chemical Modulators of Hsp60 as Potential Therapeutics" Front. Mol. Biosci., 2018.

Mohammed M, Madden CJ, Andresen MC, Morrison SF. Activation of TRPV1 in nucleus tractus solitarius reduces brown adipose tissue thermogenesis, arterial pressure, and heart rate. Am J Physiol Regul Integr Comp Physiol. 2018 Jul 1;315(1):R134-R143. 

Qiu J, Bosch MA, Meza C, Navarro UV, Nestor CC, Wagner EJ, Rønnekleiv OK, Kelly MJ. Estradiol Protects Proopiomelanocortin Neurons Against Insulin Resistance. Endocrinology. 2018 Feb 1;159(2):647-664. 

Riederer EA, Focke PJ, Georgieva ER, Akyuz N, Matulef K, Borbat PP, Freed JH, Blanchard SC, Boudker O, Valiyaveetil FI. A facile approach for the in vitro assembly of multimeric membrane transport proteins. Elife. 2018 Jun 11;7. pii: e36478. 

Roselli CE. Neurobiology of gender identity and sexual orientation. J Neuroendocrinol. 2018 Jul;30(7):e12562. 

Sanford-Crane, H.; Pejovic, T.; Xiao, X. "Drugging Homologous Recombination: Back to the Future" Future Medicinal Chemistry, 2018, 10, 1279-1281.

Scully CM, Estill CT, Amodei R, McKune A, Gribbin KP, Meaker M, Stormshak F, Roselli CE. Early prenatal androgen exposure reduces testes size and sperm concentration in sheep without altering neuroendocrine differentiation and masculine sexual behavior. Domest Anim Endocrinol. 2018 Jan;62:1-9. 

Slaker ML, Jorgensen ET, Hegarty DM, Liu X, Kong Y, Zhang F, Linhardt RJ, Brown TE, Aicher SA, Sorg BA. Cocaine Exposure Modulates Perineuronal Nets and Synaptic Excitability of Fast-Spiking Interneurons in the Medial Prefrontal Cortex. eNeuro. 2018 Oct 4;5(5). pii: ENEURO.0221-18.2018. 

Stincic TL, Grachev P, Bosch MA, Rønnekleiv OK, Kelly MJ. Estradiol Drives the Anorexigenic Activity of Proopiomelanocortin Neurons in Female Mice. eNeuro. 2018 Oct 10;5(4). pii: ENEURO.0103-18.2018. 

Torres ERS, Akinyeke T, Stagaman K, Duvoisin RM, Meshul CK, Sharpton TJ, Raber J. Effects of Sub-Chronic MPTP Exposure on Behavioral and Cognitive Performance and the Microbiome of Wild-Type and mGlu8 Knockout Female and Male Mice. Front Behav Neurosci. 2018 Jul 18;12:140.   

Vazquez MJ, Toro CA, Castellano JM, Ruiz-Pino F, Roa J, Beiroa D, Heras V, Velasco I, Dieguez C, Pinilla L, Gaytan F, Nogueiras R, Bosch MA, Rønnekleiv OK, Lomniczi A, Ojeda SR, Tena-Sempere M. SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression. Nat Commun. 2018 Oct 10;9(1):4194. 

Winters BL, Gregoriou GC, Kissiwaa SA, Wells OA, Medagoda DI, Hermes SM, Burford NT, Alt A, Aicher SA, Bagley EE. Endogenous opioids regulate moment-to-moment neuronal communication and excitability. Nat Commun. 2017 Mar 22;8:14611. 

Hegarty DM, Hermes SM, Yang K, Aicher SA. Select noxious stimuli induce changes on corneal nerve morphology. J Comp Neurol. 2017 Jun 1;525(8):2019-2031. 

McDougall SJ, Guo H, Andresen MC. Dedicated C-fibre viscerosensory pathways to central nucleus of the amygdala. J Physiol. 2017 Feb 1;595(3):901-917. 

Hofmann ME, Andresen MC. Dynasore blocks evoked release while augmenting spontaneous synaptic transmission from primary visceral afferents. PLoS One. 2017 Mar 30;12(3):e0174915.  

Beaumont E, Campbell RP, Andresen MC, Scofield S, Singh K, Libbus I, KenKnight BH, Snyder L, Cantrell N. Cervical vagus nerve stimulation augments spontaneous discharge in second- and higher-order sensory neurons in the rat nucleus of the solitary tract. Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H354-H367. 

Shi Z, Madden CJ, Brooks VL. Arcuate neuropeptide Y inhibits sympathetic nerve activity via multiple neuropathways. J Clin Invest. 2017 Jun 30;127(7):2868-2880.   

Morgan, R.K, and Cohen, M.S. “Detecting protein ADP-ribosylation using a clickable aminooxy probe,” Methods in Molecular Biology, 1601, 71 (2017).

Cohen, M.S. “Axon Degeneration: Too Much NMN is Actually Bad,” Current Biology, 27, R310 (2017).

Thorsell, A.G., Ekblad, T. Karlberg, T., Low, M., Pinto, A.F., Tresaugues, L., Moche, M.,Cohen, M.S., and Schuler, H. “Structural Basis for Potency and Promiscuity in Poly)ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors,” Journal of Medicinal Chemistry, 60, 1262 (2017).

Cambronne, X.A.*,Stewart, M.L., Kim, D., Jones-Brunette, A.M., Morgan, R.K., Farrens, D.L.,Cohen, M.S.*, Goodman, R.H. "Biosensor reveals multiple sources for mitochondrial NAD+," Science 352, 1474 (2016). *corresponding authors Featured in: Perspectives: Science, 352, 1396 (2017) and Research Highlights: Nature Methods, 13, 610 (2017)

Hitchcock P, Mathur A, Bennett J, Cameron P, Chow C, Clifford P, Duvoisin R, Feig A, Finneran K, Klotz DM, McGee R, O'Riordan M, Pfund C, Pickett C, Schwartz N, Street NE, Watkins E, Wiest J, Engelke D. The future of graduate and postdoctoral training in the biosciences. Elife. 2017 Oct 19;6. pii: e32715.  

Duvoisin RM, Haley TL, Ren G, Strycharska-Orczyk I, Bonaparte JP, Morgans CW. Autoantibodies in Melanoma-Associated Retinopathy Recognize an Epitope Conserved Between TRPM1 and TRPM3. Invest Ophthalmol Vis Sci. 2017 May 1;58(5):2732-2738. 

Vaseghi, M., Yagishita, D., Rajendran, P.J., Woodward, W.R., Hamon, D., Yamakawa, K., Irie, T., Habecker B.A., and Shivkumar, K.Parasympathetic Dysfunction and Mechanistic Basis of Anti-arrhythmic Effects of Vagal Nerve Stimulation Following Myocardial Infarction.  JCI Insight. 2017 Aug 17;2(16). pii: 86715. 

Murphy, S.R., Wang, L., Wang, Z., Domondon, P., Lang, D., Habecker, B.A., Myles, R.C., and Ripplinger, C.M. (2017) β-adrenergic inhibition prevents action potential and calcium handling changes during regional myocardial ischemia.  Frontiers in Physiology, Aug 28;8:630. 

Parrish, D.C., Olivas, A., Francis Stuart, S.D., Wang, L., Nykjaer, A., Ripplinger, C.M., and Habecker, B.A. (2018) Transient denervation of viable myocardium after myocardial infarction does not alter arrhythmia susceptibility. AJP:Heart and Circulatory Physiology. 314(3):H415-H423. 

Padilla SL, Qiu J, Nestor CC, Zhang C, Smith AW, Whiddon BB, Rønnekleiv OK, Kelly MJ, Palmiter RD. AgRP to Kiss1 neuron signaling links nutritional state and fertility. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2413-2418. 

Asquith M, Davin S, Stauffer P, Michell C, Janowitz C, Lin P, Ensign-Lewis J, Kinchen JM, Koop DR, Rosenbaum JT. Intestinal Metabolites Are Profoundly Altered in the Context of HLA-B27 Expression and Functionally Modulate Disease in a Rat Model of Spondyloarthritis. Arthritis Rheumatol. 2017 Oct;69(10):1984-1995. 

Al-Uzri A, Freeman KA, Wade J, Clark K, Bleyle LA, Munar M, Koop DR. Longitudinal study on the use of dried blood spots for home monitoring in children after kidney transplantation. Pediatr Transplant. 2017 Sep;21(6). 

Frueh L, Li Y, Mather MW, Li Q, Pou S, Nilsen A, Winter RW, Forquer IP, Pershing AM, Xie LH, Smilkstein MJ, Caridha D, Koop DR, Campbell RF, Sciotti RJ, Kreishman-Deitrick M, Kelly JX, Vesely B, Vaidya AB, Riscoe MK. Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria. ACS Infect Dis. 2017 Oct 13;3(10):728-735. 

Mirto AJ, Austin KJ, Uthlaut VA, Roselli CE, Alexander BM. Fos Expression in the Olfactory Pathway of High- and Low-Sexually Performing Rams Exposed to Urine from Estrous or Ovariectomized Ewes. Appl Anim Behav Sci. 2017 Jan;186:22-28. 

Kramer AC, Mirto AJ, Austin KJ, Roselli CE, Alexander BM. Tyrosine hydroxylase in the ventral tegmental area of rams with high or low libido-A role for dopamine. Anim Reprod Sci. 2017 Dec;187:152-158. 

Meinig JM, Ferrara SJ, Banerji T, Banerji T, Sanford-Crane HS, Bourdette D, Scanlan TS. Targeting Fatty-Acid Amide Hydrolase with Prodrugs for CNS-Selective Therapy. ACS Chem Neurosci. 2017 Nov 15;8(11):2468-2476. 

Yu, X., Akbarzadeh, R., Pieper, M., Scholzen, T., Gehrig, S., Schultz, C., Zillikens, D., König, P., Petersen, F. Neutrophil adhesion is a prerequisite for antibody-mediated proteolytic tissue damage in experimental models of epidermolysis bullosa acquisita. J. Invest. Dermatol. (2018). 

Marat, A., Wallroth, A., Lo, W.-T., Mueller, R., Norata, G. D., Falasca, M., Schultz, C., Haucke, V. "Phosphatidylinositol 3,4-bisphosphate represses nutrient signaling by mTORC1" Science 356, 968-972 (2017).

Frank,, J. A., Yushchenko, D. A., Fine, N. H. F., Duca, M., Citir, M., Broichhagen, J., Hodson, D. J., Schultz, C., Trauner, D. Optical control of GPR40 signalling in pancreatic ß-cells. Chem. Sci. 8, 7604-7610 (2017). 

Müksch, F., Laketa, V., Müller, B., Schultz, C., Kräusslich, H.-G. Synchronized HIV assembly by tunable PIP2 changes reveals PIP2 requirement for stable Gag anchoring. eLife 6, e25287 (2017).

Zuidscherwoude, M., Dunlock, V.-M. E., van den Bogaart, G., van Deventer, S.J., van der Schaaf, A., van Oostrum, J., Goedhart, J., In 't Hout, J., Hämmerling, G. J., Tanaka, S., Nadler, A., Schultz, C., Wright, M. D., Adjobo-Hermans, M. J. W., van Spriel, A. B. Tetraspanin microdomains control localized protein kinase C signaling in B cells. Sci. Signal. 10, eaag2755 (2017).

Walter*, A., Mueller, R., Wierda, K. D. B., Tawfik, B., Pinheiro, P. S., Nadler, A., Ziomkiewicz, I., Kruse, M., Reither, G., Rettig, J., Haucke, V., Hille, B., Schultz*, C., Soerensen*, J. Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis, eLife 6, e30203 (2017). 

Dittrich, A. S., Kuehbandner, I., Gehrig, S., Rickert-Zacharias, V., Twigg, M., Wege, S., Taggert, C., Herth, F., Schultz, C., Mall, M. Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis. Eur. Resp. J. 29, pii 1701910 (2018). 

Bogdanova, Y. A., Schultz, C., Belousov, V. V. Local Generation and Imaging of Hydrogen Peroxide in Living Cells. Curr. Protocols Chem. Biol. 9, 117-127 (2017)

Kratochvil HT, Maj M, Matulef K, Annen AW, Ostmeyer J, Perozo E, Roux B, Valiyaveetil FI, Zanni MT. Probing the Effects of Gating on the Ion Occupancy of the K(+) Channel Selectivity Filter Using Two-Dimensional Infrared Spectroscopy. J Am Chem Soc. 2017 Jul 5;139(26):8837-8845. 

Valiyaveetil FI. A glimpse into the C-type-inactivated state for a Potassium Channel. Nat Struct Mol Biol. 2017 Oct 5;24(10):787-788.