James Frank, Ph.D. joined the Department of Chemical Physiology and Biochemistry as Assistant Professor on July 1, 2021. The Frank lab develops light-sensitive small molecule probes to manipulate neurons with increased spatiotemporal precision. In particular, we focus on developing photo-switchable and photo-caged ligands which permit remote control over cannabinoid receptor (CBR) activity. We use these tools to understand the mechanisms by which cannabinoid signaling mediates the secretion of neurotransmitters and hormones from excitable cells, and how these concerted events drive behavior and energy homeostasis in vivo.