SIREN - About Us
About The Network
The Center for Policy and Research in Emergency Medicine (CPR-EM) at the OHSU Department of Emergency Medicine has been announced as Hub site of the newly formed nationwide Emergency Care Clinical Trials Network funded by the National Institutes of Health. Commonly known as SIREN, this network will support randomized trials of interventions for acutely ill patients in pre-hospital, emergency department, and intensive care unit settings. The OHSU Hub will coordinate enrollment at the following partner sites: Duke University Medical Center; Kaweah Delta Health Care District; Ohio State University Medical Center; University of Alabama Medical Center; University of Utah Medical Center; University of Wisconsin Medical Center; University of Rochester Medical Center; and Wake Forest Baptist Health.
"We're working closely with strong academic institutions. What we find may change medical practices across the country, and we know that academic medical center are committed to finding the best way of managing emergency health care." ~Dr. Sun
Mohamud Daya, M.D., a Professor of Emergency Medicine in the OHSU school of Medicine, is the grant recipient who will be coordinating the OHSU research hub-network for the five-year duration of the program.
The SIREN network is funded by the National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH), under award number U24NS100657.
Bory Kea, M.D., M.C.R., F.A.C.E.P. – Principal Investigator
Dr. Kea is an Associate Professor of Emergency Medicine and Director of Clinical Trials for Emergency Medicine at Oregon Health & Science University (OHSU)1. She is board-certified in Emergency Medicine and is recognized for her expertise in emergency medicine practice, cardiovascular disease and health, stroke prevention, and clinical research, including the use of qualitative interviews to identify barriers and gaps in care.
Dr. Kea has served as site Principal Investigator (PI) for multiple diagnostic and interventional studies, collaborating across departments and institutions to enroll patients in sepsis, COVID-19, and heart failure research. She is the Multiple Principal Investigator (MPI) of the OHSU Hub for the Strategies to Innovate Emergency Care Clinical Trials Network (SIREN), a network of hospitals conducting emergency care research, where OHSU is the highest enrolling hub among 13 national sites. Her site was also the fourth-highest enrolling site for the C3PO convalescent plasma trial for COVID-19. Dr. Kea’s research training includes an NHLBI-funded Resuscitation Outcomes Consortium (ROC) fellowship at OHSU, an NHLBI K12 institutional scholarship, and an NHLBI K08 award.
Her research interests include leading multidisciplinary teams, transitions of care, development and implementation of risk stratification scores, and innovative strategies to improve emergency care outcomes and clinical trial research. Additionally, Dr. Kea serves on the OHSU Research Data Governance Committee, supporting and shaping institutional research data practices, stewardship, and infrastructure, including data sharing and artificial intelligence initiatives.
Mohamud Daya, M.D., M.S. - Principal Investigator
Dr. Daya is a Professor of Emergency Medicine in the DEM at OHSU and is board certified in Emergency Medicine with sub-specialty certification in EMS. He will serve as a SIREN MPI, and lead site recruitment, protocol implementation, and quality assurance efforts for all EMS trials. In addition to actively practicing emergency medicine, he also serve as the EMS medical director for multiple fire agencies in the Portland metro region and the Medical Director for the Washington County 911 Center. He has served as the PI for the Portland ROC site, Portland PAD Trial site and site Co-PI for the VOICE-3 study and REACT study. Daya is also a consultant from Oregon for the PNW Heart Rescue Project. He has received the EMS Medical Director of the year award for Oregon in 2009. In 2015, Daya ranked 49th nationally among EM principal investigators in total NIH funding. Currently he serves as a facilitator for the Pragmatic Airway in Resuscitation Trial (ROC PART) and is a co-investigator for the ROC TXA in TBI study.
Craig Newgard, M.D., M.P.H., Co-Investigator
Dr. Newgard is a Professor in the Department of Emergency Medicine at OHSU, an emergency physician, previous EMS provider, Director of the OHSU Center for Policy and Research in Emergency Medicine , PI for the OHSU K12 Career Development Program in Emergency Care Research and Co-I of the Portland ROC site. Dr. Newgard will serve as Co-I and will contribute his content, methodologic, and logistic expertise to the OHSU SIREN hub
Jenny Cook, G.C.P.H., Hub Project Manager
Ms. Cook was Project Coordinator for the OHSU NETT hub and OHSU VOICES III site, and a former EMS provider. She has supported OHSU NETT and ROC teams with EFIC community consultation and public disclosure. She has extensive research experience conducting data abstraction, quality assurance, consenting patients and families, team training, and manuscript preparation, writing, and submission. Ms. Cook will continue similar roles as SIREN Project Coordinator.
Denise Griffiths, C.C.R.P., Grants, Contracts & Finance manager
Ms. Griffiths is OHSU DEM Research Manager and the Portland ROC site Project Manager. She has over 20 years of experience managing emergency care research studies, and she oversees the administration of all OHSU DEM research. Ms. Griffiths has expertise in grant preparation, regulatory processes including EFIC community consultation and public disclosure, budget preparation and reconciliation, subcontracts, data use agreements, data abstraction and entry, quality assurance, patient consent and follow up, personnel management, and writing group participation. She will support the management of SIREN trials.