Publications

2023

  • Liu, DA; Tao, K; Wu, B; Yu, Z; Szczepaniak, M; Rames, M; Yang, C;  Svitkina, T; Zhu, Y; Xu, F; Nan, XL; and Wei Guo* 2023. A Phosphoinositide Switch Mediates Exocyst Recruitment to Multivesicular Endosomes for Exosome Secretion. Nature Communications, 14 (1): 6883 (2023). view online
  • Biswas, S; Mandal, G; Anadon, CM; Chaurio, RA; Lopez-Bailon, LU; Nagy, MZ; Mine, JA; Hänggi, K; Sprenger, KB; Innamarato, P; Harro, CM;  Powers, JJ;  Johnson, J; Fang, B; Eysha, M; Nan, XL; Li, R; Perez, BA; Curiel, TJ; Yu, X; Rodriguez, PC; and Conejo-Garcia, JR*. Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers. Immunity (2023). view online 
  • Rames, MJ; Kenison, JP¶; Heineck, D¶; Civitci, F; Szczepaniak, M; Zheng, T; Shangguan, J; Zhang, Y; Tao, K; Esener, S; and Nan, XL*. Multiplexed and Millimeter-scale Fluorescence Nanoscopy of Cells and Tissue Sections via Prism-Illumination and Microfluidics-Enhanced DNA-PAINT. Chem. Biomed. Imaging (2023). (¶: equal contribution) view online 
  • Palani, S; Kenison, J; Sabuncu, S; Huang, T; Civitci, F; Esener, S; and Nan, XL*. Multispectral Localized Surface Plasmon Resonance (msLSPR) Reveals and Overcomes Spectral and Sensing Heterogeneities of Single Gold Nanoparticles. ACS Nano, 17(3), 2266 (2023). view online

2022

  • Koester, AM†; Szczepaniak, M†; and Nan, XL*. Fast and multiplexed super resolution imaging of fixed and immunostained cells with DNA-PAINT-ERS. Current Protocols (Molecular and Cell Biology section), 2 (11), 1-25 (2022). (†: equal contribution authors). view online
  • Kim, S*; Palani, S; Civitci, F; Nan, XL*; and Ibsen, S*. A versatile synthetic pathway for producing mesostructured plasmonic nanostructures. Small, 2203940 (2022). view online
  • Phelps, C†; Huang, T†; Wang, J; and Nan, XL*. Multipair Föster resonance energy transfer via spectrally resolved single-molecule detection. J. Phys. Chem. B., 126(31), 5765 (2022). view online
  • Koester, AM; Tao, K; Szczepaniak, M; Rames, MJ; and Nan, XL*. Nanoscopic spatial association between Ras and phosphatidylserine on the cell membrane studied with multicolor super resolution microscopy. Biomolecules, 12(8), 1033 (2022). view online
  • Johnson, Brett E et al. An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer. Cell Reports Medicine, 3(2), 100525 (2022). view online

  • Ozdemir, ES; Koester, AM; Nan, XL*. Ras multimers on the membrane: many ways for a heart-to-heart conversation. Genes, 13, 219 (2022). view online

2021

  • Zheng, F; Kelly, MR; Ramms, DJ; Heintschel, ML; Tao, K; Tutuncuoglu, B; Lee, JJ; ...; Nan, XL;  Fraley, SI; Gutkind, SJ; Nevan, K; Ideker, T. Interpretation of cancer mutations using a multiscale map of protein systems. Science, 374(6563), eabf3067. view online
  • Lovell, TC; Bolton, SG; Kenison, JP; Shangguan, J; Otteson, CE; Civitci, F; Nan, XL*, Pluth, MD*, & Jasti, R*. Subcellular Targeted Nanohoop for One- and Two-Photon Live Cell Imaging. ACS Nano, 15(9), 15285–15293. view online
  • Wang, J*; Randolph, S; Wu, Q; Botman, A; Schardt, J; Bouchet-Marquis, C; Nan, XL; Rue, C; & Straw, M. Reactive oxygen FIB spin milling enables correlative workflow for 3D super-resolution light microscopy and serial FIB/SEM of cultured cells. Scientific Reports, 11(1), 1–16. view online

2020

  • Civitci, F†; Shangguan, J†; Zheng, T†; Tao, K†, Rames, M; Kenison, J; Zhang, Y; Wu, L; Phelps, C; Esener, S; Nan, XL*. Fast and multiplexed superresolution imaging with DNA-PAINT-ERS. Nature Communications. 11(1), 1-8 (2020). view online
  • Iizuka, S; Leon, RP; Gribbin, KP; Zhang, Y; Navarro, J; Smith, R; Devlin, K; Wang, LG; Gibbs, SL; Korkola, J; Nan, XL; Courtneidge, SA. Crosstalk between invadopodia and the extracellular matrix. European J. Cell Biol., 99 (7), 151122 (2020). view online. Originally posted on bioRxiv, 2020.02.26.966762.

2019

  • Sutton, M; Lu Z; Li, YC; Zhou, Y; Huang, T; Reger, AS; Hurwitz, AM; Palzkill, T; Logsdon, C; Liang, XW; Gray, JW; Nan, XL; Hancock, JF; Wahl, GM; Bast Jr., RC. DiRAS3 (ARHI) blocks RAS/MAPK signaling by binding directly to RAS and disrupting RAS clusters. Cell Reports, 29 (11), 3448-4359 (2019). DOI: view online
  • Mitrugno, A; Tunga, SY; Sylman, J; Zilberman-Rudenko, J; Shirai, T; Hebert, J; Kayton, R; Zhang, Y; Nan, XL; Shatzel, J; Esener, S; Duvernay, M; Hamm, H; Gruber, A; Williams, C; Takata, Y; Armstrong,R; Morgan, T; and McCarty, OJT. The role of coagulation and platelets in colon cancer-associated thrombosis. Am. J. Phys. Cell. Phys. 316(2): C264-C273, 2019. view online
  • Lee, Y; Phelps, C; Huang, T; Mostofian, B; Wu, L; Zhang, Y; Tao, K; Chang, YH; Stork, PJS; Gray, JW; Zuckerman, DM*, Nan, XL*. High-throughput single-particle tracking reveals nested membrane domains that dictates KRasG12D diffusion and trafficking. eLife, 8:e46393, view online. Originally posted on BioRxiv (https://doi.org/10.1101/552075).
  • Mulqueen, RM; DeRosa, BA;  Thornton, CA; Sayar, Z; Torkenczy, KA; Fields, AJ; Wright, KM; Nan, XL; Ramji, R; Steemers, FJ; O'Roak, BJ; Adey, AC. Improved single-cell ATAC-seq reveals chromatin dynamics of in vitro corticogenesis. BioRxiv 637256

2018

  • Su, YL; Pelz, C; Huang, T; Torkenczy, K; Wang, XY; Cherry, A; Daniel CJ; Liang, J; Nan, XL; Dai, MS; Adey, A; Impey, S; Sears, RC. Pos-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular response to environmental signals. Genes & Dev. 2018 Nov 1;32(21-22):1398-1419. view online
  • Bittel, AM; Salvidar, IS; Dolman, NJ; Nan XL; Gibbs, SL*. Superresolution microscopy with novel BODIPY-based fluorophores. PLoS ONE 13(10): e0206104. view online
  • Yu, GT; Rao, L; Wu, H; Yang, LL; Bu, LL; Deng, WW; Wu, L; Nan, XL; Zhang, WF; Zhao, XZ, Liu, W; Sun, ZJ. Myeloid-derived suppressor cell membrane-coated magnetic nanoparticles for cancer theranostics by inducing macrophage polarization and synergizing immunogenic cell death. Adv. Func. Mat. 1801389 (2018). view online
  • Huang, T; Phelps, C; Wang, J; Lin, LJ; Bittel, A; Scott, Z; Jacques, S; Gibbs, SL; Gray, JW; Nan, XL*. Simultaneous multicolor single-molecule tracking with single-laser excitation via spectral imaging. Biophys. J., 114, 301 (2018). view online

2017

  • Ritchie, C; Mack, A; Harper, L; Alfadhli, A; Stork, PJS; Nan, XL; Barklis, E*. Analysis of K-Ras Interactions by biotin ligase tagging. Cancer Genomics Proteomics. 14, 225 (2017). view online
  • Zhang, Y; Huang, T; Jorgens, DM; Nickerson, A; Lin, LJ; Pelz, J; Gray, JW; Lopez, CS*; Nan, XL*. Quantitating morphological changes in biological samples during scanning electron microscopy sample preparation with correlative super-resolution microscopy. PLoS One, 12(5), e0176839 (2017). view online
  • Creech, MK†; Wang, J†; Nan, XL*; Gibbs, SL*. Superresolution imaging of clinical formalin fixed paraffin embedded breast cancer with single molecule localization microscopy. Sci. Rep., 7, 40766 (2017). view online

2016

  • Bittel, AM; Nickerson, A; Saldivar, IS; Dolman, NJ; Nan, XL; Gibbs, SL. Methodology for quantitative characterization of fluorophore photoswitching to predict superresolution microscopy image quality. Sci. Rep., 6, 29687 (2016). View online
  • Sylman, JL; Daalkhaijav, U; Zhang, Y; Gray, EM; Farhang, PA; Chu, TT; Zilberman-Rudenko, J; Puy, C; Tucker, EI; Smith, SA; Morrissey, JH; Walker, TW; Nan, XL; Gruber, A; McCarty, OJT. Differential roles of Coagulation Factor XI and XII in regulating the physical biology of fibrin. Ann. Biomed. Eng., 45(5), 1328(2016). View online
  • Chen, M; Peters, A; Huang, T; Nan, XL*. Ras dimer formation as a new signaling mechanism and potential cancer therapeutic target. mini-Review in Medicinal Chemistry, 16, 391(2016). View online
  • Peters, A; Nickerson, A; Lin, LJ; Nan, XL*. Quantitative superresolution microscopy for cancer biology and medicine. In Super-resolution Imaging in Medicine and Biology. Edited by Alberto Diaspro and Marc AMJ van Zandvoort. Taylor & Francis Books, Inc. (2016).

2015

  • Nan, XL*; Meyer-Tamguney, T ; Collisson, EA ; Lin, LJ ; Pitt, C ; Galeas, J ; Lewis, S ; Gray, JW*; McCormick, F*; Chu, S*. Ras-GTP dimers activate the mitogen-activated protein kinase (MAPK) pathway. PNAS, 112(26), 7996 (2015). 
    Also view the commentary on our article, 'Seeing is believing - Ras dimers visualized in live cells' by Drs. Mark Philips and Channing Der.
  • Nickerson, A; Huang, T; Lin, LJ; Nan, XL*. Photoactivated localization microscopy with bimolecular fluorescence complementation (BiFC-PALM). J. Vis. Exp., 106, e53154 (2015). doi: 10.3791/53154
  • Baker-Groberg, S; Phillips, KG; Healy, LD; Itakura, A; Porter, JE; Newton, PK; Nan, XL; McCarty, OJT. Critical behavior of subcellular density organization during neutrophil activation and migration. Cellular and Molecular Bioengineering, 8(4), 543 (2015).

2014

  • Nickerson, A; Huang, T; Lin, LJ; Nan, XL*. Photoactivated localization microscopy with bimolecular fluorescence complementation (BiFC-PALM) for nanoscale imaging of protein-protein interactions in cells. PLoS ONE. 9(6), e100589 (2014). View online

2013

  • Nan, XL*; Collisson, EA; Kuo, SYL ; Huang, J; Meyer, TM; Liphardt, J; McCormick, F; Gray, JW; Chu, S. Quantitative single-molecule superresolution imaging allows visualization of Raf dimerization and signaling. PNAS, 110(46), 18519 (2013). Highlighted in Sci. Transl Med: 5, 211ec187 (2013). View online
  • Itakura, A; Aslan, JE; Kusanto, BT; Phillips, KG; Nan, XL; Insall, RH; Chernoff, JC; McCarty, OJT. p21-activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils. PLoS ONE, 8(9), e73063:1 (2013). View online
  • Ying, H; Nan, XL; Sengupta, P; Lippincott-Schwartz, J ; Cang, H. Accelerating 3B single molecule super-resolution microscopy with cloud computing. Nature Methods, 10, 96 (2013). View online

Prior to OHSU