Publications
Selected publications
Interferon regulatory factor 6 (IRF6) determines intestinal epithelial cell development and immunity. Wright AP, Harris S, Madden S, Reyes BR, Mulamula E, Gibson A, Rauch I, Constant DA, Nice TJ.Mucosal Immunol. 2024 Aug;17(4):633-650. doi: 10.1016/j.mucimm.2024.03.013. Epub 2024 Apr 9.
NAIP—NLRC4 Inflammasome Activation in Tuft Cells Activates a PGD2–ILC3 Signaling Circuit that Protects Against Enteric Infection Churchill M.J., Bauer R., Honodel R., Christopher T., Smita S., Warner L., Mooney B.M., Tait Wojno E.D., Rauch I. bioRxiv 2023.05.11.540443; [Preprint] doi: https://doi.org/10.1101/2023.05.11.54044
Inducing Pyroptosis with FlaTox, RodTox, or NeedleTox. Scott WP, Rauch I Methods Mol Biol. 2023;2641:27-36. doi: 10.1007/978-1-0716-3040-2_3. PMID: 37074639.
Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells. Naseer N, Zhang J, Bauer R, Constant DA, Nice TJ, Brodsky IE, Rauch I, Shin S.Infect Immun. 2022 Jun 9:e0066321. doi: 10.1128/iai.00663-21
Human NAIP/NLRC4 and NLRP3 inflammasomes detect Salmonella type III secretion system activities to restrict intracellular bacterial replication. Naseer N, Egan MS, Reyes Ruiz VM, Scott WP, Hunter EN, Demissie T, Rauch I, Brodsky IE, Shin S.PLoS Pathog. 2022 Jan 24;18(1):e1009718. doi: 10.1371/journal.ppat.1009718. PMID: 35073381
Inflammasome activation leads to cDC1-independent cross-priming of CD8 T cells by epithelial cell-derived antigen.Deets KA, Nichols Doyle R, Rauch I, Vance RE.Elife. 2021 Dec 23;10:e72082. doi: 10.7554/eLife.72082.PMID: 34939932
Epithelial pyroptosis in host defense. Churchill MJ, Mitchell PS, Rauch I. J Mol Biol. 2021 Oct 7:167278. doi: 10.1016/j.jmb.2021.167278. PMID: 34627788.
Innate immune sensing by epithelial barriers. Constant DA, Nice TJ, Rauch I. Curr Opin Immunol. 2021 Aug 12;73:1-8. doi: 10.1016/j.coi.2021.07.014. Epub ahead of print. PMID: 34392232.
PGD2 and CRTH2 counteract Type 2 cytokine-elicited intestinal epithelial responses during helminth infection. Oyesola OO, Shanahan MT, Kanke M, Mooney BM, Webb LM, Smita S, Matheson MK, Campioli P, Pham D, Früh SP, McGinty JW, Churchill MJ, Cahoon JL, Sundaravaradan P, Flitter BA, Mouli K, Nadjsombati MS, Kamynina E, Peng SA, Cubitt RL, Gronert K, Lord JD, Rauch I, von Moltke J, Sethupathy P, Tait Wojno ED. J Exp Med. 2021 Sep 6;218(9):e20202178. doi: 10.1084/jem.20202178.
NAIP-NLRC4-deficient mice are susceptible to shigellosis. Mitchell, P. S., Roncaioli, J. L., Turcotte, E. A., Goers, L., Chavez, R. A., Lee, A. Y., Lesser, C. F., Rauch, I., & Vance, R. E. (2020). eLife, 9, e59022.
The NAIP/NLRC4 inflammasome in infection and pathology. Review. Bauer R, Rauch I. Mol Aspects Med. 2020;100863. doi:10.1016/j.mam.2020.100863
NLRC4 inflammasome activation is NLRP3- and phosphorylation-independent during infection and does not protect from melanoma. Tenthorey JL, Chavez RA, Thompson TW, Deets KA, Vance RE, Rauch I. J Exp Med. 2020;217(7):e20191736. doi:10.1084/jem.20191736
Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila. Gonçalves, A. V., Margolis, S. R., Quirino, G., Mascarenhas, D., Rauch, I., Nichols, R. D., Ansaldo, E., Fontana, M. F., Vance, R. E., & Zamboni, D. S. PLoS Pathog. 2019;15(6):e1007886. Published 2019 Jun 28. PMID: 31251782 PMCID: PMC6622555 DOI: 10.1371/journal.ppat.1007886
NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8. Rauch I, Deets KA, Ji DX, von Moltke J, Tenthorey JL, Lee AY, Philip NH, Ayres JS, Brodsky IE, Gronert K, Vance RE. Immunity. 2017 Apr 18;46(4):649-659. doi: 10.1016/j.immuni.2017.03.016. Epub 2017 Apr 11.
PubMed PMID: 28410991; PubMed Central PMCID: PMC5476318.
NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo. Rauch I, Tenthorey JL, Nichols RD, Al Moussawi K, Kang JJ, Kang C, Kazmierczak BI, Vance RE.
J Exp Med. 2016 May 2;213(5):657-65. doi: 10.1084/jem.20151809. Epub 2016 Apr 4.
PubMed PMID: 27045008; PubMed Central PMCID: PMC4854734.