Bochart, R., Armantrout, K., Crank, H., Tonelli, R., Shriver-Munsch, C., Swanson, T., Fischer, M., Wu, H., Axthelm, M., Sacha, J.B. and Smedley, J.V, Identification of Vancomycin Resistance in Methicillin-resistant Staphylococcus aureus in two macaque species and decolonization and long-term prevention of recolonization in Cynomolgus Macaques (Macaca fascicularis). Front. Immunol., 22 August 2023 Sec. Viral Immunology Volume 14 – 2023; doi: 10.3389/fimmu.2023.1244637

Wu HL, Busman-Sahay K, Weber WC, Waytashek CM, Boyle CD, Bateman KB, Reed JS, Hwang JM, Shriver-Munsch C, Swanson T, Northrup M, Armantrout K, Price H, Robertson-LeVay M, Uttke S, Kumar MR, Fray EJ, Taylor-Brill S, Bondoc S, Agnor R, Junell SL, Legasse AW, Moats C, Bochart RM, Sciurba J, Bimber BN, Sullivan MN, Dozier B, MacAllister RP, Hobbs TR, Martin LD, Panoskaltsis-Mortari A, Colgin LMA, Siliciano RF, Siliciano JD, Estes JD, Smedley JV, Axthelm MK, Meyers G, Maziarz RT, Burwitz BJ, Stanton JJ, Sacha JB. Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected ART-suppressed macaques. Immunity. 2023 May 13;. doi: 10.1016/j.immuni.2023.04.019. PubMed PMID: 37236188.

Ricciardi MJ, Rust LN, Pedreño-Lopez N, Yusova S, Biswas S, Webb GM, Gonzalez-Nieto L, Voigt TB, Louw JJ, Laurino FD, DiBello JR, Raué HP, Barber-Axthelm AM, Chun K, Uttke S, Raphael LMS, Yrizarry-Medina A, Rosen BC, Agnor R, Gao L, Labriola C, Axthelm M, Smedley J, Julander JG, Bonaldo MC, Walker LM, Messaoudi I, Slifka MK, Burton DR, Kallas EG, Sacha JB, Watkins DI, Burwitz BJ. Therapeutic neutralizing monoclonal antibody administration protects against lethal yellow fever virus infection. Sci Transl Med. 2023 Mar 29;15(689):eade5795. doi: 10.1126/scitranslmed.ade5795. Epub 2023 Mar 29. PubMed PMID: 36989376.

Malouli D, Gilbride RM, Wu HL, Hwang JM, Maier N, Hughes CM, Newhouse D, Morrow D, Ventura AB, Law L, Tisoncik-Go J, Whitmore L, Smith E, Golez I, Chang J, Reed JS, Waytashek C, Weber W, Taher H, Uebelhoer LS, Womack JL, McArdle MR, Gao J, Papen CR, Lifson JD, Burwitz BJ, Axthelm MK, Smedley J, Früh K, Gale M Jr, Picker LJ, Hansen SG, Sacha JB. Cytomegalovirus-vaccine-induced unconventional T cell priming and control of SIV replication is conserved between primate species. Cell Host Microbe. 2022 Aug 12;. doi: 10.1016/j.chom.2022.07.013. [Epub ahead of print] PubMed PMID: 35981532.

Smedley JV, Bochart RM, Fischer M, Funderburgh H, Kelly V, Crank H, Armantrout K, Shiel O, Robertson-LeVay M, Sternberger N, Schmaling B, Roberts S, Sekiguchi V, Reusz M, Schwartz T, Meyer KA, Webb G, Gilbride RM, Dambrauskas N, Andrade D, Wood M, Labriola C, Axthelm M, Derby N, Varco-Merth B, Fukazawa Y, Hansen S, Sacha JB, Sodora DL, Sather DN. Optimization and use of near infrared imaging to guide lymph node collection in rhesus macaques (Macaca mulatta). J Med Primatol. 2022 Jul 15;. doi: 10.1111/jmp.12605. [Epub ahead of print] PubMed PMID: 35841132.

Hansen SG, Hancock MH, Malouli D, Marshall EE, Hughes CM, Randall KT, Morrow D, Ford JC, Gilbride RM, Selseth AN, Trethewy RE, Bishop LM, Oswald K, Shoemaker R, Berkemeier B, Bosche WJ, Hull M, Silipino L, Nekorchuk M, Busman-Sahay K, Estes JD, Axthelm MK, Smedley J, Shao D, Edlefsen PT, Lifson JD, Früh K, Nelson JA, Picker LJ. Myeloid cell tropism enables MHC-E-restricted CD8+ T cell priming and vaccine efficacy by the RhCMV/SIV vaccine. Sci Immunol. 2022 Jun 24;7(72):eabn9301. doi: 10.1126/sciimmunol.abn9301. Epub 2022 Jun 17. PubMed PMID: 35714200.

Biswas S, Rust LN, Wettengel JM, Yusova S, Fischer M, Carson JN, Johnson J, Wei L, Thode T, Kaadige MR, Sharma S, Agbaria M, Bimber BN, Tu T, Protzer U, Ploss A, Smedley JV, Golomb G, Sacha JB, Burwitz BJ. Long-term hepatitis B virus infection of rhesus macaques requires suppression of host immunity. Nat Commun. 2022 May 30;13(1):2995. doi: 10.1038/s41467-022-30593-0. PubMed PMID: 35637225; PubMed Central PMCID: PMC9151762.

Moats C, Cook K, Armantrout K, Crank H, Uttke S, Maher K, Bochart RM, Lawrence G, Axthelm MK, Smedley JV. Antimicrobial prophylaxis does not improve post-surgical outcomes in SIV/SHIV-uninfected or SIV/SHIV-infected macaques (Macaca mulatta and Macaca fascicularis) based on a retrospective analysis. PLoS One. 2022;17(4):e0266616. doi: 10.1371/journal.pone.0266616. eCollection 2022. PubMed PMID: 35442982; PubMed Central PMCID: PMC9020680.

Okoye AA, Fromentin R, Takata H, Brehm JH, Fukazawa Y, Randall B, Pardons M, Tai V, Tang J, Smedley J, Axthelm M, Lifson JD, Picker LJ, Favre D, Trautmann L, Chomont N. The ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription. PLoS Pathog. 2022 Jan;18(1):e1010245. doi: 10.1371/journal.ppat.1010245. eCollection 2022 Jan. PubMed PMID: 35041707; PubMed Central PMCID: PMC8797195.

Haeseleer F, Fukazawa Y, Park H, Varco-Merth B, Rust BJ, Smedley JV, Eichholz K, Peterson CW, Mason R, Kiem HP, Roederer M, Picker LJ, Okoye AA, Corey L. Immune inactivation of anti-simian immunodeficiency virus chimeric antigen receptor T cells in rhesus macaques. Mol Ther Methods Clin Dev. 2021 Jun 24;22:304-319. doi: 10.1016/j.omtm.2021.06.008. PMID: 34485613; PMCID: PMC8403686.

Chang XL, Webb GM, Wu HL, Greene JM, Abdulhaqq S, Bateman KB, Reed JS, Pessoa C, Weber WC, Maier N, Chew GM, Gilbride RM, Gao L, Agnor R, Giobbi T, Torgerson J, Siess D, Burnett N, Fischer M, Shiel O, Moats C, Patterson B, Dhody K, Kelly S, Pourhassan N, Magnani DM, Smedley J, Bimber BN, Haigwood NL, Hansen SG, Brown TR, Ndhlovu LC, Sacha JB. Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission. Nat Commun. 2021 Jun 7;12(1):3343. doi: 10.1038/s41467-021-23697-6. PMID: 34099693; PMCID: PMC8184841.

Bochart RM, Busman-Sahay K, Bondoc S, Morrow DW, Ortiz AM, Fennessey CM, Fischer MB, Shiel O, Swanson T, Shriver-Munsch CM, Crank HB, Armantrout KM, Barber-Axthelm AM, Langner C, Moats CR, Labriola CS, MacAllister R, Axthelm MK, Brenchley JM, Keele BF, Estes JD, Hansen SG, Smedley JV. Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques. PLoS Pathog. 2021 May;17(5):e1009565. doi: 10.1371/journal.ppat.1009565. eCollection 2021 May. PMID: 33970966; PMCID: PMC8148316.

Moats CR, Randall KT, Swanson TM, Crank HB, Armantrout KM, Barber-Axthelm AM, Burnett ND, Hobbs TR, Martin LD, Gilbride RM, Hansen S, Smedley JV. Non-bronchoscopic Bronchoalveolar Lavage as a Refinement for Safely Obtaining High-quality Samples from Macaques. Comp Med. 2020 Dec 1;70(6):520-525. doi: 10.30802/AALAS-CM-99-990066. Epub 2020 Nov 5. PMID: 33153516; PMCID: PMC7754202.

Fisher BS, Dambrauskas N, Trakhimets O, Andrade DV, Smedley J, Sodora DL, Sather DN. Oral Immunization with HIV-1 Envelope SOSIP trimers elicits systemic immune responses and cross-reactive anti-V1V2 antibodies in non-human primates. PLoS One. 2020;15(5):e0233577. doi: 10.1371/journal.pone.0233577. eCollection 2020. PMID: 32470041; PMCID: PMC7259690.

Manuzak JA, Zevin AS, Cheu R, Richardson B, Modesitt J, Hensley-McBain T, Miller C, Gustin AT, Coronado E, Gott T, Fang M, Cartwright M, Wangari S, Agricola B, May D, Smith E, Hampel HB, Gale M, Cameron CM, Cameron MJ, Smedley J, Klatt NR. Antibiotic-induced microbiome perturbations are associated with significant alterations to colonic mucosal immunity in rhesus macaques. Mucosal Immunol. 2020 May;13(3):471-480. doi: 10.1038/s41385-019-0238-1. Epub 2019 Dec 4. PMID: 31797911; PMCID: PMC7183431.

Webb GM, Molden J, Busman-Sahay K, Abdulhaqq S, Wu HL, Weber WC, Bateman KB, Reed JS, Northrup M, Maier N, Tanaka S, Gao L, Davey B, Carpenter BL, Axthelm MK, Stanton JJ, Smedley J, Greene JM, Safrit JT, Estes JD, Skinner PJ, Sacha JB. The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques. PLoS Pathog. 2020 Mar;16(3):e1008339. doi: 10.1371/journal.ppat.1008339. eCollection 2020 Mar. PMID: 32163523; PMCID: PMC7093032.

Bar KJ, Coronado E, Hensley-McBain T, O'Connor MA, Osborn JM, Miller C, Gott TM, Wangari S, Iwayama N, Ahrens CY, Smedley J, Moats C, Lynch RM, Haddad EK, Haigwood NL, Fuller DH, Shaw GM, Klatt NR, Manuzak JA. Simian-Human Immunodeficiency Virus SHIV.CH505 Infection of Rhesus Macaques Results in Persistent Viral Replication and Induces Intestinal Immunopathology. J Virol. 2019 Sep 15;93(18). doi: 10.1128/JVI.00372-19. Print 2019 Sep 15. PMID: 31217249; PMCID: PMC6714786.

Yee JL, Prongay K, Miles B, Smedley J, Hansen SG, Axthelm MK, Ardeshir A, Van Rompay KKA, Timmel G, Roberts JA. Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates. J Med Primatol. 2019 Aug;48(4):260-263. doi: 10.1111/jmp.12420. Epub 2019 May 6. PMID: 31056769; PMCID: PMC7012381.

Deleage C, Immonen TT, Fennessey CM, Reynaldi A, Reid C, Newman L, Lipkey L, Schlub TE, Camus C, O'Brien S, Smedley J, Conway JM, Del Prete GQ, Davenport MP, Lifson JD, Estes JD, Keele BF. Defining early SIV replication and dissemination dynamics following vaginal transmission. Sci Adv. 2019 May;5(5):eaav7116. doi: 10.1126/sciadv.aav7116. eCollection 2019 May. PMID: 31149634; PMCID: PMC6541462.

Hensley-McBain T, Berard AR, Manuzak JA, Miller CJ, Zevin AS, Polacino P, Gile J, Agricola B, Cameron M, Hu SL, Estes JD, Reeves RK, Smedley J, Keele BF, Burgener AD, Klatt NR. Intestinal damage precedes mucosal immune dysfunction in SIV infection. Mucosal Immunol. 2018 Sep;11(5):1429-1440. doi: 10.1038/s41385-018-0032-5. Epub 2018 Jun 15. PMID: 29907866; PMCID: PMC6162106.

O'Connor MA, Tisoncik-Go J, Lewis TB, Miller CJ, Bratt D, Moats CR, Edlefsen PT, Smedley J, Klatt NR, Gale M Jr, Fuller DH. Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques. Nat Commun. 2018 Aug 22;9(1):3371. doi: 10.1038/s41467-018-05826-w. PMID: 30135445; PMCID: PMC6105614.

Marshall VA, Labo N, Hao XP, Holdridge B, Thompson M, Miley W, Brands C, Coalter V, Kiser R, Anver M, Golubeva Y, Warner A, Jaffe ES, Piatak M Jr, Wong SW, Ohlen C, MacAllister R, Smedley J, Deleage C, Del Prete GQ, Lifson JD, Estes JD, Whitby D. Gammaherpesvirus infection and malignant disease in rhesus macaques experimentally infected with SIV or SHIV. PLoS Pathog. 2018 Jul;14(7):e1007130. doi: 10.1371/journal.ppat.1007130. eCollection 2018 Jul. PMID: 30001436; PMCID: PMC6042791.

Grant R, Keele B, Kuller L, Watanabe R, Perret A, Smedley J. Identification of novel simian endogenous retroviruses that are indistinguishable from simian retrovirus (SRV) on current SRV diagnostic assays. J Med Primatol. 2017 Aug;46(4):158-161. doi: 10.1111/jmp.12297. PMID: 28748668; PMCID: PMC6186174.

Zevin AS, Moats C, May D, Wangari S, Miller C, Ahrens J, Iwayama N, Brown M, Bratt D, Klatt NR, Smedley J. Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques. J Vis Exp. 2017 May 2;(123). doi: 10.3791/55617. PMID: 28518089; PMCID: PMC5565146.

Soge OO, No D, Michael KE, Dankoff J, Lane J, et al. Transmission of MDR MRSA between primates, their environment and personnel at a United States primate center. J Antimicrob Chemother. 2016 Oct;71(10):2798-803. PMID: 27439524; PMCID: PMC5031921.

Del Prete GQ, Smedley J, Macallister R, Jones GS, Li B, et al. Short Communication: Comparative Evaluation of Coformulated Injectable Combination Antiretroviral Therapy Regimens in Simian Immunodeficiency Virus-Infected Rhesus Macaques. AIDS Res Hum Retroviruses. 2016 Feb;32(2):163-8. PMID: 26150024; PMCID: PMC4761795.

Smedley J, Macalister R, Wangari S, Gathuka M, Ahrens J, et al. Laparoscopic Technique for Serial Collection of Para-Colonic, Left Colic, and Inferior Mesenteric Lymph Nodes in Macaques. PLoS One. 2016;11(6):e0157535. PMID: 27309717; PMCID: PMC4911112.

Hao XP, Lucero CM, Turkbey B, Bernardo ML, Morcock DR, et al. Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection. Nat Commun. 2015 Aug 18;6:8020. PMID: 26282376; NIHMSID: NIHMS706816; PMCID: PMC4544774.

Sankineni S, Smedley J, Bernardo M, Brown AM, Johnson L, et al. Ferumoxytol as an intraprostatic MR contrast agent for lymph node mapping of the prostate: a feasibility study in non-human primates. Acta Radiol. 2015 May 26; PMID: 26013022.

Del Prete GQ, Park H, Fennessey CM, Reid C, Lipkey L, et al. Molecularly tagged simian immunodeficiency virus SIVmac239 synthetic swarm for tracking independent infection events. J Virol. 2014 Jul;88(14):8077-90. PMID: 24807714; PMCID: PMC4097795.

Hatziioannou T, Del Prete GQ, Keele BF, Estes JD, McNatt MW, et al. HIV-1-induced AIDS in monkeys. Science. 2014 Jun 20;344(6190):1401-5. PMID: 24948736; NIHMSID: NIHMS647819; PMCID: PMC4266393.

Smedley J, Turkbey B, Bernardo ML, Del Prete GQ, Estes JD, et al. Tracking the luminal exposure and lymphatic drainage pathways of intravaginal and intrarectal inocula used in nonhuman primate models of HIV transmission. PLoS One. 2014;9(3):e92830. PMID: 24667371; PMCID: PMC3965472.

Waldmann TA, Lugli E, Roederer M, Perera LP, Smedley JV, et al. Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques. Blood. 2011 May 5;117(18):4787-95. PubMed PMID: 21385847; PubMed Central PMCID: PMC3100690.

Lugli E, Goldman CK, Perera LP, Smedley J, Pung R, et al. Transient and persistent effects of IL-15 on lymphocyte homeostasis in nonhuman primates. Blood. 2010 Oct 28;116(17):3238-48. PMID: 20631381; PMCID: PMC2995354.

Zielinski RJ, Smedley JV, Perera PY, Silvera PM, Waldmann TA, et al. Smallpox vaccine with integrated IL-15 demonstrates enhanced in vivo viral clearance in immunodeficient mice and confers long term protection against a lethal monkeypox challenge in cynomolgus monkeys. Vaccine. 2010 Oct 8;28(43):7081-91. PMID: 20728526; NIHMSID: NIHMS229767; PMCID: PMC2952667.

Estes JD, Harris LD, Klatt NR, Tabb B, Pittaluga S, et al. Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections. PLoS Pathog. 2010 Aug 19;6(8):e1001052. PMID: 20808901; PMCID: PMC2924359.