The Vollum Institute Story

Panoramic view of the city of Portland from the top of the Vollum Institute

At one point during the construction process, Laster brought Howard Vollum to the top floor of the new institute. There were no walls yet — and as they looked out over the city of Portland, Vollum said,

“Of all the things I’ve done, this is the one that gives me the greatest gratification.”

The Vollum Institute sits high on OHSU’s Marquam Hill campus — a distinguished collection of laboratories for basic science research and one of the country’s outstanding centers for investigating how the brain functions.

Key people who made the Vollum Institute a reality: James Castles, Howard & Jean Vollum, Sen. Mark Hatfield, Robert Frasca, Leonard Laster and Edward Herbert

The group responsible for getting the Vollum Institute off the ground: James Castles, Howard and Jean Vollum, Sen. Mark Hatfield, Robert Frasca, Leonard Laster and Edward Herbert

By unlikely chance, the lives of these Oregonians — a medical school president, the lawyer at a successful tech company, one of that tech company’s founding engineers and his civically-engaged wife, a powerful U.S. Senator and a visionary architect — intersected in 1981 when they came together to create this new institute on a campus that had not yet become the hotbed for biomedical research that it is today.

It began with a bold idea. Drawing upon his previous experiences at the Clinical Center of the National Institutes of Health, Dr. Leonard Laster, OHSU’s second president, proposed the formation of a new center of excellence to jump-start the research program at the university. The envisioned institute would focus on “molecular medicine,” an emerging discipline that was transforming the scientific basis of patient care in the early 1980’s.

At the time funding from the Oregon State Legislature sustained only a fraction of the university’s budget and private donations were almost nonexistent. In a fortuitous turn, Laster had been invited to serve on the Board of Tektronix Inc, a Beaverton, Oregon based technology company that manufactured oscilloscopes and other electronic testing and measuring devices. Tektronix was co-founded by the brilliant engineers M.J. “Jack” Murdock and Howard Vollum. While serving on the board, Laster met and became friends with Tektronix’ legal counsel, James Castles, who had been with Howard Vollum from the very beginning. Castles sat on the board of the M. J. Murdock Charitable Trust, established after the untimely death of Murdock in 1971, and with Castles’ guidance, Laster was able to secure a small seed grant from the Trust to get the ball rolling. Howard and Jean Vollum joined the effort with a generous donation to support initial planning and development of the institute. Mark O. Hatfield, Oregon’s senior senator at the time, secured federal funds to construct a building for the new laboratory.

With generous guidance from a leader in American architecture, Pietro Belluschi, Robert Frasca of Zimmer Gunsul Frasca (ZGF) was selected to design the new institute. Frasca, who had never designed a research facility, pioneered the novel design concept of open lab space, to foster an environment of “intellectual collaborations in the service of scientific discoveries”. The Vollum Institute was the first building to reflect this architectural philosophy, and it helped put ZGF on the map.

At one point during the construction process, Laster brought Howard Vollum to the top floor of the new institute. There were no walls yet — and as they looked out over the city of Portland, Vollum said “Of all the things I’ve done, this is the one that gives me the greatest gratification.” The Vollums’ unwavering support continued after Howard’s death in 1986 when an extraordinarily generous endowment to support the new institute’s research programs was established according to the provisions of his will.

The Vollum endowment and the building might have gone to waste, but for a stroke of fate that enabled OHSU to recruit Dr. Edward Herbert from the University of Oregon to head the laboratory. An outstanding scientist and a national leader in the field of molecular neurobiology, he turned down an attractive job at Harvard to become the founding director of the institute. With Herbert's appointment, enthusiasm began to swell among faculty and OHSU advocates off campus.

Herbert recruited an impressive group of colleagues, and he went on to give the Vollum Institute its scientific theme, its standards of excellence and its direction. But tragically, he died soon after the building opened in 1987, and Oregon and the scientific world lost a remarkable leader. After that terrible moment, good fortune returned when Laster’s successor, Dr. Peter Kohler, wisely selected Dr. Richard Goodman to be the second director of the Vollum in 1990. Goodman continued to establish the institute’s early directions and expanded upon them to include studies of gene regulation, characterization neurotransmitter receptors and transporters, elucidation of second messenger systems, and determination of ion channel function.

Over the years, the Vollum spread its influence throughout OHSU by catalyzing the recruitment of many top-notch individuals to other departments. Its early success encouraged the addition of many new facilities and programs that began a transformation that persists to the present. Starting as a fragile vision, the Vollum Institute has become an impressive reality with a bright and auspicious future that continues to unfold under the current leadership and vision of its third director, Dr. Marc Freeman.

— Adapted from “How the Vollum Began” by Leonard Laster, MD, 1996–1998 Vollum Institute Biennial Report