Zhong Lab

Senior Scientist and Principal Investigator: Haining Zhong

Video abstract from our paper in Neuron

Opening graphic from the "A highly sensitive A-kinase activity reporter for imaging neuromodulatory events in awake mice" video abstract in Neuron

"A highly sensitive A-kinase activity reporter for imaging neuromodulatory events in awake mice" appeared in the August 22, 2018 issue of the journal Neuron.

Authors are Lei Ma, Bart C. Jongbloets, Wei-Hong Xiong, Joshua B. Melander, Maozhen Qin, Tess J. Lameyer, Madeleine F. Harrison, Boris V. Zemelman, Tianyi Mao* and Haining Zhong*. (* co-senior authors)

The video is approximately 6 minutes long.

Current lab members

Brecklyn Beighle

Brecklyn Beighle (beighle AT ohsu.edu)
BA, Lewis & Clark College

Brecklyn joined the Zhong lab in June 2023 and plans to ultimately pursue an advanced degree. She graduated from Lewis & Clark College in May 2023 with a B.A. in Biology. Brecklyn worked for a biotech company in the summer of 2022 that developed a compact device to detect viral infections using PCR. She was captain of her college soccer team and continues to play recreationally. Away from work, you can find Brecklyn testing new recipes or running and hiking the local trails.

Dr Helen Guo head shot

Helen/Lanboling Guo (guol AT ohsu.edu)
Ph.D., Nanyang Technological University

Helen joined the Zhong lab in April 2024 as a postdoctoral fellow. She earned her Ph.D. in Neuroscience from the School of Biological Science, Nanyang Technological University in Singapore, where she studied how interneurons in the cerebellum are involved in non-motor functions. She then went to the Lee Kong Chian School of Medicine at the same University, studied cerebellar-related motor control, and tested behaviors and vasculature changes in several disease models. In the Zhong lab, Helen plans to explore the role of PKA in neuronal activities during locomotion with two-photon imaging. Outside the lab, Helen likes cooking and hiking.

Maozhen Qin in the Mao and Zhong Labs

Maozhen Qin (qinm AT ohsu.edu)
Bachelor in Nursing

Maozhen obtained a bachelor's degree in nursing in China and has been working as a research assistant since 2008. She joined the Mao and Zhong labs in 2011 where she quickly became the "go-to" person for genotyping, culturing slices, performing animal surgeries, and maintaining the inventory of lab supplies. She became lab manager in 2014. Outside of work, Maozhen enjoys camping and hiking.

Takaki Yahiro head shot

Takaki Yahiro (yahiro AT ohsu.edu)
M.D., Ph.D.

Takaki joined the Zhong lab in October 2023 as a postdoctoral fellow. He received his M.D., Ph.D. from Nagoya University in Japan, where his graduate study focused on the afferent neural pathway for behavioral thermoregulation. He will investigate the PKC-mediated neural modulation in the cortex with a newly improved PKC sensor and in vivo 2-photon lifetime. Outside the lab, Takaki often explores restaurants and tries new cuisines in Portland.

Tin-Long Yiu

Tin-Long Yiu (yiu AT ohsu.edu)
B.Sc., University College London

Tin joined the Zhong Lab in summer 2020 as a graduate student. He earned his B.Sc. in Neuroscience from University College London, where he studied the role of Purkinje cell activity in timed sensorimotor association in the laboratory of Professor Michael Häusser. For his graduate work, Tin will use two-photon imaging, Neuropixels recording and optogenetics to investigate how cerebellar computations are influenced by neuromodulation during sensorimotor learning. Outside of the lab, Tin enjoys playing basketball and Go.

Yizhou Zhuo head shot

Yizhou Zhuo (zhuoy AT ohsu.edu)
Ph.D., Peking University

Yizhou joined Zhong lab in July 2024 as a postdoctoral fellow. She earned her Ph.D. at the School of Life Sciences, Peking University, where her graduate study mainly focuses on the development of genetically-encoded dopamine sensors. Yizhou developed a suite of green and red dopamine sensors that enable sensitive dopamine detection across multiple brain areas and dual-color imaging in combined use with other optical sensors in vivo, which therefore provide a robust tool for better understanding the dopamine system. Yizhou plans to continuously work on tool development but shifting her interest from generating optical sensors for probing extracellular transmission to optical actuators that are able to manipulate intracellular signaling processes. Outside of work, Yizhou enjoys traveling and tasty foods.

Contact information

Lab phone number
503-494-9185

Lab location
Vollum Room 3427 (north)

Faculty support
Teresa Newton
Grants/Contracts Coordinator
Email: newtont@ohsu.edu
Phone: 503-494-5458

Mailing address
Haining Zhong Lab
Vollum Institute, OHSU
3181 SW Sam Jackson Park Rd.
Mail code L474
Portland, OR 97239-3098

Shipping address
Haining Zhong Lab
Vollum Institute, OHSU
3181 SW Sam Jackson Park Rd.
Dock 4, Vollum Rm. 3427
Portland, OR 97239-3098

Vollum Institute

3232 SW Research Drive
Portland, Oregon 97239

Name Years in Lab Lab Position Current Position
Geng-Lin Li 2011 Research Associate Assistant Professor, University of Massachusetts Amherst
Guang Yang 2011–2012 Postdoc Postdoc, Shriners Hospitals for Children, Portland
Brian Long 2010–2013 Postdoc Scientist II, Allen Institute for Brain Science, Seattle
Shane Tillo 2010–2013 NGP Ph.D. Student Principle Investigator, Montana Molecular, LLC
Sheng Miao 2013–2015 Postdoc Postdoc, Salk Institute for Biological Studies
Dale Fortin 2012–2016 Postdoc Adjunct Faculty, Washington State University at Vancouver
Joshua Melander 2014–2017 Research Assistant Graduate Student, Stanford University
Weihong Xiong 2015–2020 Staff Scientist Data science industry
Crystian Massengill 2018–2021 Sr. Research Assistant Graduate Student, Harvard Program in Neuroscience