Gary Ciment, Ph.D.
Professor Emeritus, Department of Cell, Developmental and Cancer Biology 
Email: cimentgary@gmail.com

Dr. Gary Ciment continues to consult for Aves Labs -- an antibody production company that he founded in 1995 and served as Scientific Director for over 20 years.  This consulting work involves advising them on new products, and performing peptide analysis.  In addition, Dr. Ciment has been an active consultant at the National Brain Injury Institute of Houston, TX, helping them analyze white matter deficits in their patients, in keeping with his having chaired the Neuroscience course for medical students for 30 years at OHSU.

Reid S. (Sam) Connell Jr.
Professor Emeritus

Sara Courtneidge, Ph.D., D.Sc., FAACR
Professor Emeritus, Department of Cell, Developmental and Cancer Biology 
Email: courtneidge@ohsu.edu

Sara A. Courtneidge was born in the UK, and received her B.Sc. from the University of Leeds and her Ph.D. from the National Institute for Medical Research, London. Following postdoctoral study at the University of California, San Francisco, and an independent position at the National Institute for Medical Research, she joined the European Molecular Biology Laboratory in Heidelberg, Germany in 1985, where she rose to the position of Senior Scientist. Changing course in 1994, Dr. Courtneidge joined SUGEN Inc., where as Chief Scientist she guided novel kinase discovery and validation efforts in oncology. From 2001-2005 she was Distinguished Scientific Investigator at the Van Andel Research Institute in Grand Rapids, Michigan, and from 2005-2014 she served as Professor and Director of the Tumor Microenvironment and Metastasis Program, and Director of Academic Affairs, at the Sanford|Burnham Medical Research Institute. She joined OHSU in 2014, where she was an Associate Director of Translational Sciences for the Knight Cancer Institute, a Professor in the Department of Cell, Developmental & Cancer Biology, and a member of the Center for Spatial Systems Biomedicine. Dr. Courtneidge’s laboratory has studied the Src family of protein tyrosine kinases for a number of years, and has contributed to the understanding of Src transformation, regulation, substrate selection and function. Her research on Src and its substrates focused on cancer invasion and metastasis, with particular emphasis on the role of membrane structures called podosomes or invadopodia. She also retained an interest in translational research, with the goal of defining novel therapeutic points of intervention for cancer treatment. Dr. Courtneidge’s contributions to cancer research have been recognized with numerous honors, including election to the European Molecular Biology Organization, the Jubilee Lecture and Harden Medal of the British Biochemical Society, the Feodor Lynen Lecture and Lynen Medal, an honorary doctorate from the University of Leeds, and, most recently, the 2015 AACR-WICR Charlotte Friend Memorial Lectureship.

Bruce Magun, Ph.D.
Professor Emeritus, Department of Cell, Developmental and Cancer Biology
Email: bmagun@comcast.net

Dr. Magun joined the School of Medicine in 1984 as Professor and Chair of Cell and Developmental Biology. After 26 years as Chair, he has the distinction of being among the longest-serving chairs in the history of the School of Medicine. Dr. Magun's research was focused on the role of stress signals in the development of cancer and inflammatory disease. A theme of his research program was the identification of small molecule inhibitors that may suppress the inflammatory response of specific cancer therapeutic compounds. Dr. Magun, along with the members of CDB primary faculty, contributed significantly to teaching many courses in both the graduate studies and medical degree programs, and to related activities in the educational mission. 

Rich Maurer, Ph.D.
Professor Emeritus, Department of Cell, Developmental and Cancer Biology 
Email: richm-pdx@comcast.net

Dr. Maurer joined the OHSU faculty in 1993 as a Professor. From 1995 to 2002, he served as Associate Dean for Graduate Studies and has also served on many school committees, including leadership searches and departmental reviews. His research was focused on intracellular signaling pathways and the related events which mediate pituitary hormone expression.

Karin Rodland, PhD
Professor Emeritus, Department of Cell, Developmental and Cancer Biology
Fellow, Pacific Northwest National Laboratory
Email: rodland@ohsu.edu

Complete bibliography

Biography

After receiving her A.B. summa cum laude from Hood College in 1970, Karin Rodland earned her PhD from Syracuse University in 1974. She completed two years of post-doctoral research at Syracuse as a recipient of a Public Health Service Research Service Award from the National Cancer Institute before joining the faculty at Reed College in Portland in 1979.  Rodland joined OHSU as a research assistant professor in the Cell and Developmental Biology department in 1985 and was promoted to associate professor in 1991. In 2001 she joined the Biological Sciences Division at the Pacific Northwest National Laboratory and was promoted to Laboratory Fellow in 2008. Rodland was granted a joint appointment at OHSU as an Affiliate Professor in Cell, Developmental, and Cancer Biology in 2015 and served as the founding Director of the OHSU-PNNL Precision Medicine Innovation CoLaboratory, a joint effort dedicated to improving patient outcomes through the integration of cutting edge technologies in integrated omics, imaging, and data analysis. She was granted the title of Professor Emeritus at OHSU in 2020.

Summary of Research

Rodland’s research focuses on signal transduction pathways that regulate proliferation in normal and malignant cells. The Rodland lab at OHSU identified genetic promoter elements responsive to growth factors and extracellular calcium, characterized the signaling mechanisms by which EGF, TGF-beta and calcium induced transcription, and further characterized the signaling mechanisms used by the G-protein coupled calcium-sensing receptor, including cross-talk with the EGF receptor.  Since joining PNNL, she has adopted a systems biology approach to signal transduction, using comprehensive global proteomics and phosphoproteomics to study signal transduction pathways in a variety of cancers, with an emphasis on female reproductive cancers. Most recently, she is studying drug resistance mechanisms in acute myeloid leukemia, including the role of stromal growth factors in the early stages of resistance.

Recognition: Human Proteome Organization (HUPO) Award for Distinguished Proteomic Sciences 2020, PNNL Laboratory Director’s Award for Lifetime Achievement in Science and Technology, 2021, American Association for the Advancement of Science Fellow, 2011

Selected Publications:

Joshi SK, Nechiporuk T, Bottomly D, Piehowski PD, Reisz JA, Pittsenbarger J, Kaempf A, Gosline SJC, Wang YT, Hansen JR, Gritsenko MA, Hutchinson C, Weitz KK, Moon J, Cendali F, Fillmore TL, Tsai CF, Schepmoes AA, Shi T, Arshad OA, McDermott JE, Babur O, Watanabe-Smith K, Demir E, D'Alessandro A, Liu T, Tognon CE, Tyner JW, McWeeney SK, Rodland KD, Druker BJ, Traer E. The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance. Cancer Cell. 2021 Jul 12;39(7):999-1014.e8. doi: 10.1016/j.ccell.2021.06.003. Epub 2021 Jun 24. PMID: 34171263; PMCID: PMC8686208

Wang LB, Karpova A, Gritsenko MA, Kyle JE, Cao S, Li Y, Rykunov D, Colaprico A, Rothstein JH, Hong R, Stathias V, Cornwell M, Petralia F, Wu Y, Reva B, Krug K, Pugliese P, Kawaler E, Olsen LK, Liang WW, Song X, Dou Y, Wendl MC, Caravan W, Liu W, Cui Zhou D, Ji J, Tsai CF, Petyuk VA, Moon J, Ma W, Chu RK, Weitz KK, Moore RJ, Monroe ME, Zhao R, Yang X, Yoo S, Krek A, Demopoulos A, Zhu H, Wyczalkowski MA, McMichael JF, Henderson BL, Lindgren CM, Boekweg H, Lu S, Baral J, Yao L, Stratton KG, Bramer LM, Zink E, Couvillion SP, Bloodsworth KJ, Satpathy S, Sieh W, Boca SM, Schürer S, Chen F, Wiznerowicz M, Ketchum KA, Boja ES, Kinsinger CR, Robles AI, Hiltke T, Thiagarajan M, Nesvizhskii AI, Zhang B, Mani DR, Ceccarelli M, Chen XS, Cottingham SL, Li QK, Kim AH, Fenyö D, Ruggles KV, Rodriguez H, Mesri M, Payne SH, Resnick AC, Wang P, Smith RD, Iavarone A, Chheda MG, Barnholtz-Sloan JS, Rodland KD, Liu T, Ding L. “Proteogenomic and metabolomic characterization of human glioblastoma”. Cancer Cell. 2021 Apr 12;39(4):509-528.e20. doi: 10.1016/j.ccell.2021.01.006. Epub 2021 Feb 11. PMID: 33577785; PMCID: PMC8044053.

JE McDermott, OA. Arshad, VA. Petyuk, Yi Fu, MA. Gritsenko, TR. Clauss, RJ. Moore, AA. Schepmoes, Rui Zhao¹, ME. Monroe, M Schnaubelt, C-F Tsai, SH. Payne, C Huang, L-B Wang, S Foltz, M Wyczalkowski, Y Wu, E Song, MA. Brewer, M Thiagarajan, CR. Kinsinger, AI. Robles, ES. Boja, H Rodriguez, DW. Chan, B Zhang, Z Zhang, L Ding, RD. Smith, Tao Liu^,, KD Rodland^. “Proteogenomic characterization of ovarian high-grade serous cancer implicates mitotic kinases, replication stress in observed chromosomal instability” Cell Reports Medicine 2020

McNeil, S., Hobson, S, Nipper, V., and Rodland, K. D. 1998. Functional calcium sensing receptors in rat fibroblasts are required for activation of SRC kinase and MAP kinase in response to extracellular calcium. J. Biol. Chem. 273: 1114-1120.